The influence of pregnancy on systemic immunity
Identifieur interne : 001053 ( Istex/Corpus ); précédent : 001052; suivant : 001054The influence of pregnancy on systemic immunity
Auteurs : Michael Pazos ; Rhoda S. Sperling ; Thomas M. Moran ; Thomas A. KrausSource :
- Immunologic Research [ 0257-277X ] ; 2012-12-01.
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Abstract
Abstract: Adaptations in maternal systemic immunity are presumed to be responsible for observed alterations in disease susceptibility and severity as pregnancy progresses. Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.
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DOI: 10.1007/s12026-012-8303-9
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ISTEX:956A1A41BBFA9F09B3EC093C3F27318B0BDB8911Le document en format XML
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Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Michael Pazos</name><affiliations><json:string>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, 10029, New York, NY, USA</json:string></affiliations></json:item><json:item><name>Rhoda S. Sperling</name><affiliations><json:string>Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, 10029, New York, NY, USA</json:string></affiliations></json:item><json:item><name>Thomas M. Moran</name><affiliations><json:string>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, 10029, New York, NY, USA</json:string><json:string>E-mail: Thomas.Moran@mssm.edu</json:string></affiliations></json:item><json:item><name>Thomas A. Kraus</name><affiliations><json:string>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. 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Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. 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Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Gestation</term></item><item><term>Immunology</term></item><item><term>Th2</term></item><item><term>Fetus</term></item><item><term>Placenta</term></item><item><term>Pregnancy</term></item><item><term>Inflammation</term></item><item><term>Immunosuppression</term></item></list></keywords></textClass><textClass><keywords scheme="Journal-Subject-Collection"><list><label>Medicine</label><item><term>SC11</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Internal Medicine</term></item><item><term>Immunology</term></item><item><term>Medicine/Public Health, general</term></item><item><term>Allergology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-12-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-CFL45KJW-B/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>New York</PublisherLocation></PublisherInfo><Journal OutputMedium="All"><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>12026</JournalID><JournalPrintISSN>0257-277X</JournalPrintISSN><JournalElectronicISSN>1559-0755</JournalElectronicISSN><JournalTitle>Immunologic Research</JournalTitle><JournalAbbreviatedTitle>Immunol Res</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Internal Medicine</JournalSubject><JournalSubject Type="Secondary">Immunology</JournalSubject><JournalSubject Type="Secondary">Medicine/Public Health, general</JournalSubject><JournalSubject Type="Secondary">Allergology</JournalSubject><SubjectCollection Code="Medicine">SC11</SubjectCollection></JournalSubjectGroup></JournalInfo><Volume OutputMedium="All"><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>54</VolumeIDStart><VolumeIDEnd>54</VolumeIDEnd><VolumeIssueCount>3</VolumeIssueCount></VolumeInfo><Issue IssueType="Combined" OutputMedium="All"><IssueInfo IssueType="Combined" TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>3</IssueIDEnd><IssueTitle Language="En">Special Issue: Immunology at Mount Sinai</IssueTitle><IssueArticleCount>29</IssueArticleCount><IssueHistory><OnlineDate><Year>2012</Year><Month>10</Month><Day>17</Day></OnlineDate><PrintDate><Year>2012</Year><Month>10</Month><Day>16</Day></PrintDate><CoverDate><Year>2012</Year><Month>12</Month></CoverDate><PricelistYear>2012</PricelistYear></IssueHistory><IssueCopyright><CopyrightHolderName>Springer Science+Business Media New York</CopyrightHolderName><CopyrightYear>2012</CopyrightYear></IssueCopyright></IssueInfo><IssueHeader><EditorGroup><Editor><EditorName DisplayOrder="Western"><GivenName>Lloyd</GivenName><FamilyName>Mayer</FamilyName></EditorName></Editor><Editor><EditorName DisplayOrder="Western"><GivenName>Sergio</GivenName><FamilyName>A. 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Moran</Heading><Para><Figure Category="Standard" Float="No" ID="Figa"><MediaObject ID="MO1"><ImageObject Color="Color" FileRef="MediaObjects/12026_2012_8303_Figa_HTML.jpg" Format="JPEG" Rendition="HTML" Type="Halftone"></ImageObject></MediaObject></Figure></Para></FormalPara></Biography></Author><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>Thomas</GivenName><GivenName>A.</GivenName><FamilyName>Kraus</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Microbiology</OrgDivision><OrgName>Mount Sinai School of Medicine</OrgName><OrgAddress><Street>1 Gustave L. Levy Place</Street><Postbox>Box 1124</Postbox><City>New York</City><State>NY</State><Postcode>10029</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Obstetrics, Gynecology, and Reproductive Sciences</OrgDivision><OrgName>Mount Sinai School of Medicine</OrgName><OrgAddress><City>New York</City><State>NY</State><Postcode>10029</Postcode><Country Code="US">USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>Adaptations in maternal systemic immunity are presumed to be responsible for observed alterations in disease susceptibility and severity as pregnancy progresses. Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Gestation</Keyword><Keyword>Immunology</Keyword><Keyword>Th2</Keyword><Keyword>Fetus</Keyword><Keyword>Placenta</Keyword><Keyword>Pregnancy</Keyword><Keyword>Inflammation</Keyword><Keyword>Immunosuppression</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The influence of pregnancy on systemic immunity</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The influence of pregnancy on systemic immunity</title></titleInfo><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Pazos</namePart><affiliation>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, 10029, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rhoda</namePart><namePart type="given">S.</namePart><namePart type="family">Sperling</namePart><affiliation>Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, 10029, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Thomas</namePart><namePart type="given">M.</namePart><namePart type="family">Moran</namePart><affiliation>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, 10029, New York, NY, USA</affiliation><affiliation>E-mail: Thomas.Moran@mssm.edu</affiliation><role><roleTerm type="text">author</roleTerm></role><description>Thomas M. Moran</description></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="given">A.</namePart><namePart type="family">Kraus</namePart><affiliation>Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1124, 10029, New York, NY, USA</affiliation><affiliation>Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, 10029, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2012-12-01</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Adaptations in maternal systemic immunity are presumed to be responsible for observed alterations in disease susceptibility and severity as pregnancy progresses. Epidemiological evidence as well as animal studies have shown that influenza infections are more severe during the second and third trimesters of pregnancy, resulting in greater morbidity and mortality, although the reason for this is still unclear. Our laboratory has taken advantage of 20 years of experience studying the murine immune response to respiratory viruses to address questions of altered immunity during pregnancy. With clinical studies and unique animal model systems, we are working to define the mechanisms responsible for altered immune responses to influenza infection during pregnancy and what roles hormones such as estrogen or progesterone play in these alterations.</abstract><note>Immunology at Mount Sinai</note><subject lang="en"><genre>Keywords</genre><topic>Gestation</topic><topic>Immunology</topic><topic>Th2</topic><topic>Fetus</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Inflammation</topic><topic>Immunosuppression</topic></subject><relatedItem type="host"><titleInfo><title>Immunologic Research</title></titleInfo><titleInfo type="abbreviated"><title>Immunol Res</title></titleInfo><name type="personal"><namePart type="given">Lloyd</namePart><namePart type="family">Mayer</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Sergio</namePart><namePart type="family">A. Lira</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Adrian</namePart><namePart type="family">Ting</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Patricia</namePart><namePart type="family">Cortes</namePart><role><roleTerm type="text">editor</roleTerm></role></name><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2012-10-17</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><subject><genre>Journal-Subject-Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="Medicine">SC11</topic></subject><subject><genre>Medicine & Public Health</genre><topic>Internal Medicine</topic><topic>Immunology</topic><topic>Medicine/Public Health, general</topic><topic>Allergology</topic></subject><identifier type="ISSN">0257-277X</identifier><identifier type="eISSN">1559-0755</identifier><identifier type="JournalID">12026</identifier><identifier type="IssueArticleCount">29</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>2012</date><detail type="issue"><title>Special Issue: Immunology at Mount Sinai</title></detail><detail type="volume"><number>54</number><caption>vol.</caption></detail><detail type="issue"><number>1-3</number><caption>no.</caption></detail><extent unit="pages"><start>254</start><end>261</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media New York, 2012</recordOrigin></recordInfo></relatedItem><identifier type="istex">956A1A41BBFA9F09B3EC093C3F27318B0BDB8911</identifier><identifier type="ark">ark:/67375/VQC-CFL45KJW-B</identifier><identifier type="DOI">10.1007/s12026-012-8303-9</identifier><identifier type="ArticleID">8303</identifier><identifier type="ArticleID">s12026-012-8303-9</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2012</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, LLC, 2012</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-CFL45KJW-B/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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