Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
Identifieur interne : 000F55 ( Istex/Corpus ); précédent : 000F54; suivant : 000F56Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
Auteurs : O. B. Kazakova ; N. I. Medvedeva ; I. P. Baikova ; G. A. Tolstikov ; T. V. Lopatina ; M. S. Yunusov ; L. ZaprutkoSource :
- Russian Journal of Bioorganic Chemistry [ 1068-1620 ] ; 2010-11-01.
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Abstract
Abstract: The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.
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DOI: 10.1134/S1068162010060142
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ISTEX:34D4DA499DBFF3BC66609D6B9BB9488977EB80C5Le document en format XML
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Zaprutko</name><affiliation><mods:affiliation>Organic Chemistry Department, Poznan University of Medical Sciences, Poznan, Poland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Russian Journal of Bioorganic Chemistry</title><title level="j" type="abbrev">Russ J Bioorg Chem</title><idno type="ISSN">1068-1620</idno><idno type="eISSN">1608-330X</idno><imprint><publisher>SP MAIK Nauka/Interperiodica</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2010-11-01">2010-11-01</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="771">771</biblScope><biblScope unit="page" to="778">778</biblScope></imprint><idno type="ISSN">1068-1620</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1068-1620</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antiviral activity</term><term>triterpenoids</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>O. B. Kazakova</name><affiliations><json:string>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</json:string><json:string>E-mail: obf@anrb.ru</json:string></affiliations></json:item><json:item><name>N. I. Medvedeva</name><affiliations><json:string>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</json:string></affiliations></json:item><json:item><name>I. P. Baikova</name><affiliations><json:string>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</json:string></affiliations></json:item><json:item><name>G. A. 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CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>O.</GivenName><GivenName>B.</GivenName><FamilyName>Kazakova</FamilyName></AuthorName><Contact><Phone>(347)2356066</Phone><Fax>(347)2356066</Fax><Email>obf@anrb.ru</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>N.</GivenName><GivenName>I.</GivenName><FamilyName>Medvedeva</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>I.</GivenName><GivenName>P.</GivenName><FamilyName>Baikova</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><GivenName>A.</GivenName><FamilyName>Tolstikov</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>T.</GivenName><GivenName>V.</GivenName><FamilyName>Lopatina</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>M.</GivenName><GivenName>S.</GivenName><FamilyName>Yunusov</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>L.</GivenName><FamilyName>Zaprutko</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Institute of Organic Chemistry, Ufa Scientific Center</OrgDivision><OrgName>Russian Academy of Sciences</OrgName><OrgAddress><Street>pr. Oktyabrya 71</Street><City>Ufa</City><Postcode>450054</Postcode><Country Code="RU">Russia</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Organic Chemistry Department</OrgDivision><OrgName>Poznan University of Medical Sciences</OrgName><OrgAddress><City>Poznan</City><Country Code="PL">Poland</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-<Emphasis Type="Italic">ortho</Emphasis>-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>triterpenoids</Keyword><Keyword>antiviral activity</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>Original Russian Text © O.B. Kazakova, N.I. Medvedeva, I.P. Baikova, G.A. Tolstikov, T.V. Lopatina, M.S. Yunusov, L. Zaprutko, 2010, published in Bioorganicheskaya Khimiya, 2010, Vol. 36, No. 6, pp. 841–848.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">O.</namePart><namePart type="given">B.</namePart><namePart type="family">Kazakova</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><affiliation>E-mail: obf@anrb.ru</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="given">I.</namePart><namePart type="family">Medvedeva</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="given">P.</namePart><namePart type="family">Baikova</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="given">A.</namePart><namePart type="family">Tolstikov</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="given">V.</namePart><namePart type="family">Lopatina</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="given">S.</namePart><namePart type="family">Yunusov</namePart><affiliation>Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, 450054, Ufa, Russia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Zaprutko</namePart><affiliation>Organic Chemistry Department, Poznan University of Medical Sciences, Poznan, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>SP MAIK Nauka/Interperiodica</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateCreated encoding="w3cdtf">2010-03-18</dateCreated><dateIssued encoding="w3cdtf">2010-11-01</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.</abstract><subject lang="en"><genre>Keywords</genre><topic>triterpenoids</topic><topic>antiviral activity</topic></subject><relatedItem type="host"><titleInfo><title>Russian Journal of Bioorganic Chemistry</title></titleInfo><titleInfo type="abbreviated"><title>Russ J Bioorg Chem</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2010-11-19</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><subject><genre>Life Sciences</genre><topic>Biomedicine general</topic><topic>Organic Chemistry</topic><topic>Bioorganic Chemistry</topic><topic>Biochemistry, general</topic></subject><identifier type="ISSN">1068-1620</identifier><identifier type="eISSN">1608-330X</identifier><identifier type="JournalID">11171</identifier><identifier type="IssueArticleCount">16</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2010</date><detail type="volume"><number>36</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>771</start><end>778</end></extent></part><recordInfo><recordOrigin>Pleiades Publishing, Ltd., 2010</recordOrigin></recordInfo></relatedItem><identifier type="istex">34D4DA499DBFF3BC66609D6B9BB9488977EB80C5</identifier><identifier type="ark">ark:/67375/VQC-5DHJFL46-M</identifier><identifier type="DOI">10.1134/S1068162010060142</identifier><identifier type="ArticleID">6183</identifier><identifier type="ArticleID">S1068162010060142</identifier><accessCondition type="use and reproduction" contentType="copyright">Pleiades Publishing, Ltd., 2010</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Pleiades Publishing, Ltd., 2010</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-5DHJFL46-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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