Coronavirus infection and hospitalizations for acute respiratory illness in young children
Identifieur interne : 000E86 ( Istex/Corpus ); précédent : 000E85; suivant : 000E87Coronavirus infection and hospitalizations for acute respiratory illness in young children
Auteurs : H. Keipp B. Talbot ; James E. Crowe Jr. ; Kathryn M. Edwards ; Marie R. Griffin ; Yuwei Zhu ; Geoffrey A. Weinberg ; Peter G. Szilagyi ; Caroline B. Hall ; Amy B. Podsiad ; Marika Iwane ; John V. WilliamsSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2009-05.
English descriptors
- Teeft :
- Care unit, Clinical features, Common colds, Cooperative agreement, Coronavirus, Coronavirus infection, Coronavirus infections, Coronaviruses, Discharge diagnoses, Disease control, Grant number, Grant numbers, Grant sponsor, Hcov, Hcov strains, Healthy children, Hong kong, Hospital admission, Hospitalization, Human coronavirus, Human coronavirus infections, Human coronaviruses, Human metapneumovirus, Infection, Iwane, Kawasaki syndrome, Novel coronavirus, Prospective study, Respiratory syncytial virus, Respiratory tract infections, Vaccine surveillance network, Vanderbilt university, Virol, Young children.
Abstract
There is only limited knowledge on the burden of disease due to both new (HCoV‐NL63 and HKU‐1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population‐based surveillance study over a 2‐year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real‐time RT‐PCR for HCoV‐NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV‐associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6–23 months, and 24–59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children. J. Med. Virol. 81:853–856, 2009. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21443
Links to Exploration step
ISTEX:C255134BF2912C26CB35EF4AB919950A12E327AELe document en format XML
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Crowe Jr.</name><affiliation><mods:affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name><affiliation><mods:affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Griffin, Marie R" sort="Griffin, Marie R" uniqKey="Griffin M" first="Marie R." last="Griffin">Marie R. Griffin</name><affiliation><mods:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Yuwei" sort="Zhu, Yuwei" uniqKey="Zhu Y" first="Yuwei" last="Zhu">Yuwei Zhu</name><affiliation><mods:affiliation>Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Weinberg, Geoffrey A" sort="Weinberg, Geoffrey A" uniqKey="Weinberg G" first="Geoffrey A." last="Weinberg">Geoffrey A. 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Podsiad</name><affiliation><mods:affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Iwane, Marika" sort="Iwane, Marika" uniqKey="Iwane M" first="Marika" last="Iwane">Marika Iwane</name><affiliation><mods:affiliation>National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</mods:affiliation></affiliation></author><author><name sortKey="Williams, John V" sort="Williams, John V" uniqKey="Williams J" first="John V." last="Williams">John V. Williams</name><affiliation><mods:affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation><affiliation><mods:affiliation>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">81</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="853">853</biblScope><biblScope unit="page" to="856">856</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-05">2009-05</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Care unit</term><term>Clinical features</term><term>Common colds</term><term>Cooperative agreement</term><term>Coronavirus</term><term>Coronavirus infection</term><term>Coronavirus infections</term><term>Coronaviruses</term><term>Discharge diagnoses</term><term>Disease control</term><term>Grant number</term><term>Grant numbers</term><term>Grant sponsor</term><term>Hcov</term><term>Hcov strains</term><term>Healthy children</term><term>Hong kong</term><term>Hospital admission</term><term>Hospitalization</term><term>Human coronavirus</term><term>Human coronavirus infections</term><term>Human coronaviruses</term><term>Human metapneumovirus</term><term>Infection</term><term>Iwane</term><term>Kawasaki syndrome</term><term>Novel coronavirus</term><term>Prospective study</term><term>Respiratory syncytial virus</term><term>Respiratory tract infections</term><term>Vaccine surveillance network</term><term>Vanderbilt university</term><term>Virol</term><term>Young children</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is only limited knowledge on the burden of disease due to both new (HCoV‐NL63 and HKU‐1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population‐based surveillance study over a 2‐year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real‐time RT‐PCR for HCoV‐NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV‐associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6–23 months, and 24–59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children. J. Med. 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Keipp B. Talbot</name><affiliations><json:string>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</json:string><json:string>E-mail: keipp.talbot@vanderbilt.edu</json:string><json:string>Correspondence address: A2200 MCN, 1161 21st Avenue South, Nashville, TN 37232.===</json:string></affiliations></json:item><json:item><name>James E. Crowe Jr.</name><affiliations><json:string>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string><json:string>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Kathryn M. Edwards</name><affiliations><json:string>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Marie R. Griffin</name><affiliations><json:string>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</json:string><json:string>Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Yuwei Zhu</name><affiliations><json:string>Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Geoffrey A. Weinberg</name><affiliations><json:string>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</json:string></affiliations></json:item><json:item><name>Peter G. Szilagyi</name><affiliations><json:string>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</json:string></affiliations></json:item><json:item><name>Caroline B. Hall</name><affiliations><json:string>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</json:string></affiliations></json:item><json:item><name>Amy B Podsiad</name><affiliations><json:string>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Marika Iwane</name><affiliations><json:string>National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</json:string></affiliations></json:item><json:item><name>John V. Williams</name><affiliations><json:string>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string><json:string>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>acute respiratory infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>OC43</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>229E</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HCoV‐NL63</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HCoV‐HKU</value></json:item></subject><articleId><json:string>JMV21443</json:string></articleId><arkIstex>ark:/67375/WNG-KDWPPPM7-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>There is only limited knowledge on the burden of disease due to both new (HCoV‐NL63 and HKU‐1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population‐based surveillance study over a 2‐year period from children aged >5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real‐time RT‐PCR for HCoV‐NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children >2 years of age. Rates of HCoV‐associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged >6 months, 6–23 months, and 24–59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children. J. Med. 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Respiratory specimens and clinical data were prospectively collected in an active, population‐based surveillance study over a 2‐year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real‐time RT‐PCR for HCoV‐NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV‐associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6–23 months, and 24–59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children. J. Med. 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Keipp B.</namePart><namePart type="family">Talbot</namePart><affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><affiliation>E-mail: keipp.talbot@vanderbilt.edu</affiliation><affiliation>Correspondence address: A2200 MCN, 1161 21st Avenue South, Nashville, TN 37232.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James E.</namePart><namePart type="family">Crowe Jr.</namePart><affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><affiliation>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn M.</namePart><namePart type="family">Edwards</namePart><affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie R.</namePart><namePart type="family">Griffin</namePart><affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><affiliation>Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yuwei</namePart><namePart type="family">Zhu</namePart><affiliation>Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geoffrey A.</namePart><namePart type="family">Weinberg</namePart><affiliation>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter G.</namePart><namePart type="family">Szilagyi</namePart><affiliation>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caroline B.</namePart><namePart type="family">Hall</namePart><affiliation>Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amy B</namePart><namePart type="family">Podsiad</namePart><affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marika</namePart><namePart type="family">Iwane</namePart><affiliation>National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John V.</namePart><namePart type="family">Williams</namePart><affiliation>Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><affiliation>Departments of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-05</dateIssued><dateValid encoding="w3cdtf">2009-01-01</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">1</extent><extent unit="references">31</extent><extent unit="words">1122</extent></physicalDescription><abstract lang="en">There is only limited knowledge on the burden of disease due to both new (HCoV‐NL63 and HKU‐1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population‐based surveillance study over a 2‐year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real‐time RT‐PCR for HCoV‐NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV‐associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6–23 months, and 24–59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children. J. Med. Virol. 81:853–856, 2009. © 2009 Wiley‐Liss, Inc.</abstract><note type="content">*The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the CDC.</note><note type="funding">Cooperative Agreements with the Centers for Disease Control and Prevention (partial support)</note><note type="funding">NIH/VTEU - No. N01 AI‐25462; </note><note type="funding">CDC cooperative agreement (Vanderbilt University) - No. U38/CCU417958; No. U01/IP000022; </note><note type="funding">CDC cooperative agreement (University of Rochester) - No. U38/CCU217969; No. U01/IP000017; </note><note type="funding">NIH/NIAID (to H.K.B.T.) - No. 5K23AI074863‐02; </note><note type="funding">NIH/NCRR - No. 5 K12 RR017697‐05; </note><subject lang="en"><genre>keywords</genre><topic>acute respiratory infection</topic><topic>OC43</topic><topic>229E</topic><topic>HCoV‐NL63</topic><topic>HCoV‐HKU</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. 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