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Detection of human coronavirus NL63 in young children with bronchiolitis

Identifieur interne : 000D21 ( Istex/Corpus ); précédent : 000D20; suivant : 000D22

Detection of human coronavirus NL63 in young children with bronchiolitis

Auteurs : Takashi Ebihara ; Rika Endo ; Xiaoming Ma ; Nobuhisa Ishiguro ; Hideaki Kikuta

Source :

RBID : ISTEX:DE5E583C58518D5F0DDF06E31274894C439D3B08

English descriptors

Abstract

HCoV‐NL63, the fourth human coronavirus, has been isolated recently from children with respiratory tract infections, including upper respiratory infection, bronchiolitis, and pneumonia. The virus has been also detected in immunocompromised adults with respiratory tract infections. A total of 118 nasopharyngeal swab samples from 118 hospitalized young children aged less than 2 years with bronchiolitis who were not infected with human respiratory syncytial virus, influenza A or B, or human metaneumovirus were selected. Three (2.5%) of the 118 samples were positive for HCoV‐NL63 by reverse transcription‐polymerase chain reaction tests. HCoV‐NL63 may be one of the causative agents of bronchiolitis in young children. J. Med. Virol. 75:463–465, 2005. © 2005 Wiley‐Liss, Inc.

Url:
DOI: 10.1002/jmv.20289

Links to Exploration step

ISTEX:DE5E583C58518D5F0DDF06E31274894C439D3B08

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<titleInfo>
<title>Differential detection of rhinoviruses and enteroviruses RNA sequences associated with classical immunofluorescence assay detection of respiratory virus antigens in nasopharyngeal swabs from infants with bronchiolitis</title>
</titleInfo>
<name type="personal">
<namePart type="given">L</namePart>
<namePart type="family">Andreoletti</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Lesay</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">A</namePart>
<namePart type="family">Deschildre</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">V</namePart>
<namePart type="family">Lambert</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">A</namePart>
<namePart type="family">Dewilde</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">P</namePart>
<namePart type="family">Wattre</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Andreoletti L, Lesay M, Deschildre A, Lambert V, Dewilde A, Wattre P. 2000. Differential detection of rhinoviruses and enteroviruses RNA sequences associated with classical immunofluorescence assay detection of respiratory virus antigens in nasopharyngeal swabs from infants with bronchiolitis. J Med Virol 61: 341–346.</note>
<part>
<date>2000</date>
<detail type="volume">
<caption>vol.</caption>
<number>61</number>
</detail>
<extent unit="pages">
<start>341</start>
<end>346</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>J Med Virol</title>
</titleInfo>
<part>
<date>2000</date>
<detail type="volume">
<caption>vol.</caption>
<number>61</number>
</detail>
<extent unit="pages">
<start>341</start>
<end>346</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit2">
<titleInfo>
<title>Human metapneumovirus infection in Japanese children</title>
</titleInfo>
<name type="personal">
<namePart type="given">T</namePart>
<namePart type="family">Ebihara</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">R</namePart>
<namePart type="family">Endo</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">H</namePart>
<namePart type="family">Kikuta</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">N</namePart>
<namePart type="family">Ishiguro</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">H</namePart>
<namePart type="family">Ishiko</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Hara</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Y</namePart>
<namePart type="family">Takahashi</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">K</namePart>
<namePart type="family">Kobayashi</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ebihara T, Endo R, Kikuta H, Ishiguro N, Ishiko H, Hara M, Takahashi Y, Kobayashi K. 2004. Human metapneumovirus infection in Japanese children. J Clin Microbiol 42: 126–132.</note>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages">
<start>126</start>
<end>132</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>J Clin Microbiol</title>
</titleInfo>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages">
<start>126</start>
<end>132</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit3">
<titleInfo>
<title>A previously undescribed coronavirus associated with respiratory disease in humans</title>
</titleInfo>
<name type="personal">
<namePart type="given">RA</namePart>
<namePart type="family">Fouchier</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">NG</namePart>
<namePart type="family">Hartwig</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">TM</namePart>
<namePart type="family">Bestebroer</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">B</namePart>
<namePart type="family">Niemeyer</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JC</namePart>
<namePart type="family">de Jong</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JH</namePart>
<namePart type="family">Simon</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">AD</namePart>
<namePart type="family">Osterhaus</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Fouchier RA, Hartwig NG, Bestebroer TM, Niemeyer B, de Jong JC, Simon JH, Osterhaus AD. 2004. A previously undescribed coronavirus associated with respiratory disease in humans. Proc Natl Acad Sci USA 101: 6212–6216.</note>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages">
<start>6212</start>
<end>6216</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Proc Natl Acad Sci USA</title>
</titleInfo>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>101</number>
</detail>
<extent unit="pages">
<start>6212</start>
<end>6216</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit4">
<titleInfo>
<title>Impact of respiratory virus infections on persons with chronic underlying conditions</title>
</titleInfo>
<name type="personal">
<namePart type="given">WP</namePart>
<namePart type="family">Glezen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">SB</namePart>
<namePart type="family">Greenberg</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RL</namePart>
<namePart type="family">Atmar</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">PA</namePart>
<namePart type="family">Piedra</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RB</namePart>
<namePart type="family">Couch</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Glezen WP, Greenberg SB, Atmar RL, Piedra PA, Couch RB. 2000. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 283: 499–505.</note>
<part>
<date>2000</date>
<detail type="volume">
<caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages">
<start>499</start>
<end>505</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>JAMA</title>
</titleInfo>
<part>
<date>2000</date>
<detail type="volume">
<caption>vol.</caption>
<number>283</number>
</detail>
<extent unit="pages">
<start>499</start>
<end>505</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit5">
<titleInfo>
<title>Virologic studies of acute respiratory disease in young adults. V. Coronavirus 229E infections during six years of surveillance</title>
</titleInfo>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Hambre</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Beem</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hambre D, Beem M. 1972. Virologic studies of acute respiratory disease in young adults. V. Coronavirus 229E infections during six years of surveillance. Am J Epidemiol 96: 94–106.</note>
<part>
<date>1972</date>
<detail type="volume">
<caption>vol.</caption>
<number>96</number>
</detail>
<extent unit="pages">
<start>94</start>
<end>106</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Am J Epidemiol</title>
</titleInfo>
<part>
<date>1972</date>
<detail type="volume">
<caption>vol.</caption>
<number>96</number>
</detail>
<extent unit="pages">
<start>94</start>
<end>106</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit6">
<titleInfo>
<title>Coronaviridae</title>
</titleInfo>
<name type="personal">
<namePart type="given">KV</namePart>
<namePart type="family">Holmes</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">MC</namePart>
<namePart type="family">Lai</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book-chapter</genre>
<relatedItem type="host">
<titleInfo>
<title>Fields virology</title>
</titleInfo>
<originInfo>
<publisher>Lippincott‐Raven Press</publisher>
<place>
<placeTerm type="text">Philadelphia</placeTerm>
</place>
</originInfo>
<part>
<date>1996</date>
<detail type="volume">
<caption>vol.</caption>
<number>1</number>
</detail>
<extent unit="pages">
<start>1075</start>
<end>1093</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit7">
<titleInfo>
<title>Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children</title>
</titleInfo>
<name type="personal">
<namePart type="given">T</namePart>
<namePart type="family">Jartti</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">P</namePart>
<namePart type="family">Lehtinen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">T</namePart>
<namePart type="family">Vuorinen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">R</namePart>
<namePart type="family">Osterback</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">B</namePart>
<namePart type="family">van den Hoogen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">AD</namePart>
<namePart type="family">Osterhaus</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">O</namePart>
<namePart type="family">Ruuskanen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Jartti T, Lehtinen P, Vuorinen T, Osterback R, van den Hoogen B, Osterhaus AD, Ruuskanen O. 2004. Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis 10: 1095–1101.</note>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages">
<start>1095</start>
<end>1101</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Emerg Infect Dis</title>
</titleInfo>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages">
<start>1095</start>
<end>1101</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit8">
<titleInfo>
<title>A novel coronavirus associated with severe acute respiratory syndrome</title>
</titleInfo>
<name type="personal">
<namePart type="given">TG</namePart>
<namePart type="family">Ksiazek</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Erdman</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">CS</namePart>
<namePart type="family">Goldsmith</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">SR</namePart>
<namePart type="family">Zaki</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">T</namePart>
<namePart type="family">Peret</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">S</namePart>
<namePart type="family">Emery</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">S</namePart>
<namePart type="family">Tong</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">C</namePart>
<namePart type="family">Urbani</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JA</namePart>
<namePart type="family">Comer</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">W</namePart>
<namePart type="family">Lim</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">PE</namePart>
<namePart type="family">Rollin</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">SF</namePart>
<namePart type="family">Dowell</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">AE</namePart>
<namePart type="family">Ling</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">CD</namePart>
<namePart type="family">Humphrey</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">WJ</namePart>
<namePart type="family">Shieh</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">J</namePart>
<namePart type="family">Guarner</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">CD</namePart>
<namePart type="family">Paddock</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">P</namePart>
<namePart type="family">Rota</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">B</namePart>
<namePart type="family">Fields</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">J</namePart>
<namePart type="family">DeRisi</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JY</namePart>
<namePart type="family">Yang</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">N</namePart>
<namePart type="family">Cox</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JM</namePart>
<namePart type="family">Hughes</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JW</namePart>
<namePart type="family">LeDuc</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">WJ</namePart>
<namePart type="family">Bellini</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">LJ</namePart>
<namePart type="family">Anderson</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, Urbani C, Comer JA, Lim W, Rollin PE, Dowell SF, Ling AE, Humphrey CD, Shieh WJ, Guarner J, Paddock CD, Rota P, Fields B, DeRisi J, Yang JY, Cox N, Hughes JM, LeDuc JW, Bellini WJ, Anderson LJ. 2003. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 348: 1953–1966.</note>
<part>
<date>2003</date>
<detail type="volume">
<caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages">
<start>1953</start>
<end>1966</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>N Engl J Med</title>
</titleInfo>
<part>
<date>2003</date>
<detail type="volume">
<caption>vol.</caption>
<number>348</number>
</detail>
<extent unit="pages">
<start>1953</start>
<end>1966</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit9">
<titleInfo>
<title>Seroepidemiologic studies of coronavirus infection in adults and children</title>
</titleInfo>
<name type="personal">
<namePart type="given">K</namePart>
<namePart type="family">McIntosh</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">AZ</namePart>
<namePart type="family">Kapikian</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">HC</namePart>
<namePart type="family">Turner</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">JW</namePart>
<namePart type="family">Hartley</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RH</namePart>
<namePart type="family">Parrott</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RM</namePart>
<namePart type="family">Chanock</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McIntosh K, Kapikian AZ, Turner HC, Hartley JW, Parrott RH, Chanock RM. 1970. Seroepidemiologic studies of coronavirus infection in adults and children. Am J Epidemiol 91: 585–592.</note>
<part>
<date>1970</date>
<detail type="volume">
<caption>vol.</caption>
<number>91</number>
</detail>
<extent unit="pages">
<start>585</start>
<end>592</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Am J Epidemiol</title>
</titleInfo>
<part>
<date>1970</date>
<detail type="volume">
<caption>vol.</caption>
<number>91</number>
</detail>
<extent unit="pages">
<start>585</start>
<end>592</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit10">
<titleInfo>
<title>Coronavirus infection in acute lower respiratory tract disease of infants</title>
</titleInfo>
<name type="personal">
<namePart type="given">K</namePart>
<namePart type="family">McIntosh</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RK</namePart>
<namePart type="family">Chao</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">HE</namePart>
<namePart type="family">Krause</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">R</namePart>
<namePart type="family">Wasil</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">HE</namePart>
<namePart type="family">Mocega</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">MA</namePart>
<namePart type="family">Mufson</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">McIntosh K, Chao RK, Krause HE, Wasil R, Mocega HE, Mufson MA. 1974. Coronavirus infection in acute lower respiratory tract disease of infants. J Infect Dis 130: 502–507.</note>
<part>
<date>1974</date>
<detail type="volume">
<caption>vol.</caption>
<number>130</number>
</detail>
<extent unit="pages">
<start>502</start>
<end>507</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>J Infect Dis</title>
</titleInfo>
<part>
<date>1974</date>
<detail type="volume">
<caption>vol.</caption>
<number>130</number>
</detail>
<extent unit="pages">
<start>502</start>
<end>507</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit11">
<titleInfo>
<title>Acute viral infections of upper respiratory tract in elderly people living in the community: Comparative, prospective, population based study of disease burden</title>
</titleInfo>
<name type="personal">
<namePart type="given">KG</namePart>
<namePart type="family">Nicholson</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">J</namePart>
<namePart type="family">Kent</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">V</namePart>
<namePart type="family">Hammersley</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">E</namePart>
<namePart type="family">Cancio</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Nicholson KG, Kent J, Hammersley V, Cancio E. 1997. Acute viral infections of upper respiratory tract in elderly people living in the community: Comparative, prospective, population based study of disease burden. BMJ 315: 1060–1064.</note>
<part>
<date>1997</date>
<detail type="volume">
<caption>vol.</caption>
<number>315</number>
</detail>
<extent unit="pages">
<start>1060</start>
<end>1064</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>BMJ</title>
</titleInfo>
<part>
<date>1997</date>
<detail type="volume">
<caption>vol.</caption>
<number>315</number>
</detail>
<extent unit="pages">
<start>1060</start>
<end>1064</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit12">
<titleInfo>
<title>Association of rhinovirus infection with increased disease severity in acute bronchiolitis</title>
</titleInfo>
<name type="personal">
<namePart type="given">NG</namePart>
<namePart type="family">Papadopoulos</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Moustaki</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Tsolia</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">A</namePart>
<namePart type="family">Bossios</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">E</namePart>
<namePart type="family">Astra</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">A</namePart>
<namePart type="family">Prezerakou</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Gourgiotis</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Kafetzis</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, Prezerakou A, Gourgiotis D, Kafetzis D. 2002. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 165: 1285–1289.</note>
<part>
<date>2002</date>
<detail type="volume">
<caption>vol.</caption>
<number>165</number>
</detail>
<extent unit="pages">
<start>1285</start>
<end>1289</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Am J Respir Crit Care Med</title>
</titleInfo>
<part>
<date>2002</date>
<detail type="volume">
<caption>vol.</caption>
<number>165</number>
</detail>
<extent unit="pages">
<start>1285</start>
<end>1289</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit13">
<titleInfo>
<title>Identification of a new human coronavirus</title>
</titleInfo>
<name type="personal">
<namePart type="given">L</namePart>
<namePart type="family">van der Hoek</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">K</namePart>
<namePart type="family">Pyrc</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">MF</namePart>
<namePart type="family">Jebbink</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">W</namePart>
<namePart type="family">Vermeulen‐Oost</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">RJ</namePart>
<namePart type="family">Berkhout</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">KC</namePart>
<namePart type="family">Wolthers</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">PM</namePart>
<namePart type="family">Wertheim‐van Dillen</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">J</namePart>
<namePart type="family">Kaandorp</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">J</namePart>
<namePart type="family">Spaargaren</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">B</namePart>
<namePart type="family">Berkhout</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">van der Hoek L, Pyrc K, Jebbink MF, Vermeulen‐Oost W, Berkhout RJ, Wolthers KC, Wertheim‐van Dillen PM, Kaandorp J, Spaargaren J, Berkhout B. 2004. Identification of a new human coronavirus. Nat Med 10: 368–373.</note>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages">
<start>368</start>
<end>373</end>
</extent>
</part>
<relatedItem type="host">
<titleInfo>
<title>Nat Med</title>
</titleInfo>
<part>
<date>2004</date>
<detail type="volume">
<caption>vol.</caption>
<number>10</number>
</detail>
<extent unit="pages">
<start>368</start>
<end>373</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit14">
<titleInfo>
<title>Human metapneumovirus as a causative agent of acute bronchiolitis in infants</title>
</titleInfo>
<name type="personal">
<namePart type="given">P</namePart>
<namePart type="family">Xepapadaki</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">S</namePart>
<namePart type="family">Psarras</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">A</namePart>
<namePart type="family">Bossios</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">M</namePart>
<namePart type="family">Tsolia</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Gourgiotis</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">G</namePart>
<namePart type="family">Liapi‐Adamidou</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">AG</namePart>
<namePart type="family">Constantopoulos</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">D</namePart>
<namePart type="family">Kafetzis</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">NG</namePart>
<namePart type="family">Papadopoulos</namePart>
<role>
<roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
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