Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection
Identifieur interne : 000768 ( Istex/Corpus ); précédent : 000767; suivant : 000769Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection
Auteurs : Paul K. S. Chan ; Esther Y. M. Liu ; Danny T. M. Leung ; Jo L. K. Cheung ; C. H. Ma ; Frankie C. H. Tam ; Mamie Hui ; John S. Tam ; Pak Leong LimSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2005-02.
English descriptors
- Teeft :
- Antibody response, Assay, Chan, Chinese university, Clin, Clin diagn, Coronavirus, Coronavirus nucleocapsid protein, Early samples, Elisarstm, Enzyme immunoassay, Hong kong, Iggene, Immunoassay, Novel coronavirus, Nucleocapsid, Nucleocapsid protein, Peiris, Recombinant, Respiratory syndrome, Respiratory syndrome coronavirus, Sars, Sars patients, Serum samples, Syndrome, Wales hospital, Wang.
Abstract
A high throughput accurate assay for anti‐SARS‐CoV IgG detection is needed for large‐scale epidemiological studies. The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20254
Links to Exploration step
ISTEX:24A6F87DD48E97A7192641B87F192C01D9752EA4Le document en format XML
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Chan</name><affiliation><mods:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: paulkschan@cuhk.edu.hk</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.===</mods:affiliation></affiliation></author><author><name sortKey="Liu, Esther Y M" sort="Liu, Esther Y M" uniqKey="Liu E" first="Esther Y. M." last="Liu">Esther Y. M. 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S." last="Chan">Paul K. S. Chan</name><affiliation><mods:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: paulkschan@cuhk.edu.hk</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.===</mods:affiliation></affiliation></author><author><name sortKey="Liu, Esther Y M" sort="Liu, Esther Y M" uniqKey="Liu E" first="Esther Y. M." last="Liu">Esther Y. M. Liu</name><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Leung, Danny T M" sort="Leung, Danny T M" uniqKey="Leung D" first="Danny T. M." last="Leung">Danny T. M. Leung</name><affiliation><mods:affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Cheung, Jo L K" sort="Cheung, Jo L K" uniqKey="Cheung J" first="Jo L. K." last="Cheung">Jo L. K. Cheung</name><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Ma, C H" sort="Ma, C H" uniqKey="Ma C" first="C. H." last="Ma">C. H. 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Tam</name><affiliation><mods:affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Hui, Mamie" sort="Hui, Mamie" uniqKey="Hui M" first="Mamie" last="Hui">Mamie Hui</name><affiliation><mods:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name><affiliation><mods:affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author><author><name sortKey="Lim, Pak Leong" sort="Lim, Pak Leong" uniqKey="Lim P" first="Pak Leong" last="Lim">Pak Leong Lim</name><affiliation><mods:affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="181">181</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody response</term><term>Assay</term><term>Chan</term><term>Chinese university</term><term>Clin</term><term>Clin diagn</term><term>Coronavirus</term><term>Coronavirus nucleocapsid protein</term><term>Early samples</term><term>Elisarstm</term><term>Enzyme immunoassay</term><term>Hong kong</term><term>Iggene</term><term>Immunoassay</term><term>Novel coronavirus</term><term>Nucleocapsid</term><term>Nucleocapsid protein</term><term>Peiris</term><term>Recombinant</term><term>Respiratory syndrome</term><term>Respiratory syndrome coronavirus</term><term>Sars</term><term>Sars patients</term><term>Serum samples</term><term>Syndrome</term><term>Wales hospital</term><term>Wang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A high throughput accurate assay for anti‐SARS‐CoV IgG detection is needed for large‐scale epidemiological studies. The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>sars</json:string><json:string>nucleocapsid</json:string><json:string>chan</json:string><json:string>elisarstm</json:string><json:string>coronavirus</json:string><json:string>respiratory syndrome</json:string><json:string>assay</json:string><json:string>iggene</json:string><json:string>hong kong</json:string><json:string>nucleocapsid protein</json:string><json:string>wang</json:string><json:string>sars patients</json:string><json:string>peiris</json:string><json:string>immunoassay</json:string><json:string>recombinant</json:string><json:string>clin</json:string><json:string>serum samples</json:string><json:string>wales hospital</json:string><json:string>syndrome</json:string><json:string>chinese university</json:string><json:string>antibody response</json:string><json:string>coronavirus nucleocapsid protein</json:string><json:string>early samples</json:string><json:string>novel coronavirus</json:string><json:string>clin diagn</json:string><json:string>respiratory syndrome coronavirus</json:string><json:string>enzyme immunoassay</json:string></teeft></keywords><author><json:item><name>Paul K.S. Chan</name><affiliations><json:string>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>E-mail: paulkschan@cuhk.edu.hk</json:string><json:string>Correspondence address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.===</json:string></affiliations></json:item><json:item><name>Esther Y.M. Liu</name><affiliations><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Danny T.M. Leung</name><affiliations><json:string>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Jo L.K. Cheung</name><affiliations><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>C.H. Ma</name><affiliations><json:string>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Frankie C.H. Tam</name><affiliations><json:string>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Mamie Hui</name><affiliations><json:string>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>John S. Tam</name><affiliations><json:string>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item><json:item><name>Pak Leong Lim</name><affiliations><json:string>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>coronavirus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>diagnosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>enzyme immunoassay</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SARS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>serology</value></json:item></subject><articleId><json:string>JMV20254</json:string></articleId><arkIstex>ark:/67375/WNG-JHHBX7C5-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A high throughput accurate assay for anti‐SARS‐CoV IgG detection is needed for large‐scale epidemiological studies. The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>6.568</score><pdfWordCount>2828</pdfWordCount><pdfCharCount>17137</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>594 x 792 pts</pdfPageSize><pdfWordsPerPage>707</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>145</abstractWordCount><abstractCharCount>999</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection</title><pmid><json:string>15602743</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>75</volume><issue>2</issue><pages><first>181</first><last>184</last><total>4</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>2000</json:string><json:string>2005</json:string></date><geogName></geogName><orgName><json:string>Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</json:string><json:string>The Chinese University</json:string><json:string>Wales Hospital, Shatin, New Territories, Hong Kong SAR, China A</json:string><json:string>Wiley-Liss, Inc</json:string><json:string>World Health Organization</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Hong Kong</json:string><json:string>T.M. 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Emerging Infectious Diseases</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation><affiliation><orgName type="department">Department of Microbiology</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Esther Y.M.</forename><surname>Liu</surname></persName><affiliation><orgName type="department">Department of Microbiology</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Danny T.M.</forename><surname>Leung</surname></persName><affiliation><orgName type="laboratory">Clinical Immunology Unit</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Jo L.K.</forename><surname>Cheung</surname></persName><affiliation><orgName type="department">Department of Microbiology</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">C.H.</forename><surname>Ma</surname></persName><affiliation><orgName type="laboratory">Clinical Immunology Unit</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Frankie C.H.</forename><surname>Tam</surname></persName><affiliation><orgName type="laboratory">Clinical Immunology Unit</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Mamie</forename><surname>Hui</surname></persName><affiliation><orgName type="division">Centre for Emerging Infectious Diseases</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation><affiliation><orgName type="department">Department of Microbiology</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales 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China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Pak Leong</forename><surname>Lim</surname></persName><affiliation><orgName type="laboratory">Clinical Immunology Unit</orgName><orgName type="institution">The Chinese University of Hong Kong</orgName><orgName type="institution">Prince of Wales Hospital</orgName><address><addrLine>Shatin</addrLine><addrLine>New Territories, Hong Kong SAR, China</addrLine><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><idno type="istex">24A6F87DD48E97A7192641B87F192C01D9752EA4</idno><idno type="ark">ark:/67375/WNG-JHHBX7C5-D</idno><idno type="DOI">10.1002/jmv.20254</idno><idno type="unit">JMV20254</idno><idno type="toTypesetVersion">file:JMV.JMV20254.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno 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Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">coronavirus</term><term xml:id="kwd2">diagnosis</term><term xml:id="kwd3">enzyme immunoassay</term><term xml:id="kwd4">SARS</term><term xml:id="kwd5">serology</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-JHHBX7C5-D/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. 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number="1080"></count></countGroup><titleGroup><title type="main" xml:lang="en">Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection</title><title type="short" xml:lang="en">SARS‐CoV IgG Assay</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Paul K.S.</givenNames><familyName>Chan</familyName></personName><contactDetails><email>paulkschan@cuhk.edu.hk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Esther Y.M.</givenNames><familyName>Liu</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Danny T.M.</givenNames><familyName>Leung</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Jo 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The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SARS‐CoV IgG Assay</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection</title></titleInfo><name type="personal"><namePart type="given">Paul K.S.</namePart><namePart type="family">Chan</namePart><affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><affiliation>E-mail: paulkschan@cuhk.edu.hk</affiliation><affiliation>Correspondence address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Esther Y.M.</namePart><namePart type="family">Liu</namePart><affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danny T.M.</namePart><namePart type="family">Leung</namePart><affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jo L.K.</namePart><namePart type="family">Cheung</namePart><affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.H.</namePart><namePart type="family">Ma</namePart><affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frankie C.H.</namePart><namePart type="family">Tam</namePart><affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mamie</namePart><namePart type="family">Hui</namePart><affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John S.</namePart><namePart type="family">Tam</namePart><affiliation>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pak Leong</namePart><namePart type="family">Lim</namePart><affiliation>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2005-02</dateIssued><dateValid encoding="w3cdtf">2004-10-15</dateValid><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm 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The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</abstract><note type="funding">Research Grants Council of the Hong Kong Special Administrative Region - No. CUHK4527/03M; </note><subject lang="en"><genre>keywords</genre><topic>coronavirus</topic><topic>diagnosis</topic><topic>enzyme immunoassay</topic><topic>SARS</topic><topic>serology</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>181</start><end>184</end><total>4</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Immunofluorescence assay for serologic diagnosis of SARS</title></titleInfo><name type="personal"><namePart type="given">PKS</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RCW</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RKY</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VCY</namePart><namePart type="family">Chow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Hui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Yap</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FW</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Sung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Tam</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chan PKS, Ng KC, Chan RCW, Lam RKY, Chow VCY, Hui M, Wu A, Lee N, Yap HY, Cheng FW, Sung JJ, Tam JS. 2004a. Immunofluorescence assay for serologic diagnosis of SARS. 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