Human metapneumovirus: a new respiratory pathogen
Identifieur interne : 000737 ( Istex/Corpus ); précédent : 000736; suivant : 000738Human metapneumovirus: a new respiratory pathogen
Auteurs : S. Broor ; P. Bharaj ; H. S. ChaharSource :
- Journal of Biosciences [ 0250-5991 ] ; 2008-11-01.
English descriptors
Abstract
Abstract: Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults. The virus belongs to the family Paramyxoviridae, sub family Pneumovirinae and genus Metapneumovirus. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. F gene is the most conserved among different lineages and efforts are underway to design recombination vaccine using F gene.
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DOI: 10.1007/s12038-008-0067-y
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Broor</name><affiliation><mods:affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: shobha.broor@gmail.com</mods:affiliation></affiliation></author><author><name sortKey="Bharaj, P" sort="Bharaj, P" uniqKey="Bharaj P" first="P." last="Bharaj">P. Bharaj</name><affiliation><mods:affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</mods:affiliation></affiliation></author><author><name sortKey="Chahar, H S" sort="Chahar, H S" uniqKey="Chahar H" first="H. S." last="Chahar">H. S. Chahar</name><affiliation><mods:affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Biosciences</title><title level="j" type="abbrev">J Biosci</title><idno type="ISSN">0250-5991</idno><idno type="eISSN">0973-7138</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>India</pubPlace><date type="published" when="2008-11-01">2008-11-01</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="483">483</biblScope><biblScope unit="page" to="493">493</biblScope></imprint><idno type="ISSN">0250-5991</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0250-5991</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute respiratory infections</term><term>human metapneumovirus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults. The virus belongs to the family Paramyxoviridae, sub family Pneumovirinae and genus Metapneumovirus. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. F gene is the most conserved among different lineages and efforts are underway to design recombination vaccine using F gene.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>S. 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The virus belongs to the family Paramyxoviridae, sub family Pneumovirinae and genus Metapneumovirus. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. 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type="issue-article-count">19</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>India</pubPlace><date type="published" when="2008-11-01"></date><biblScope unit="volume">33</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="483">483</biblScope><biblScope unit="page" to="493">493</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults. The virus belongs to the family Paramyxoviridae, sub family Pneumovirinae and genus Metapneumovirus. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. F gene is the most conserved among different lineages and efforts are underway to design recombination vaccine using F gene.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Acute respiratory infections</term></item><item><term>human metapneumovirus</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations used</head><item><term>ALRI</term><term>acute lower respiratory tract infection</term></item><item><term>APV</term><term>avian pneumoviruses</term></item><item><term>ARI</term><term>acute respiratory tract infection</term></item><item><term>CPE</term><term>cytopathic effect</term></item><item><term>hMPV</term><term>human metapneumovirus</term></item><item><term>RSV</term><term>respiratory syncytial virus</term></item><item><term>RT-PCR</term><term>reverse tracriptase-polymerase chain reaction</term></item><item><term>SARS</term><term>severe acute respiratory syndrome</term></item><item><term>SH</term><term>small hydrophobic</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Life Sciences</head><item><term>Cell Biology</term></item><item><term>Microbiology</term></item><item><term>Plant Sciences</term></item><item><term>Zoology</term></item><item><term>Biomedicine general</term></item><item><term>Life Sciences, general</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-11-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-51MSPDP2-N/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ 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TocLevels="0"><ArticleID>67</ArticleID><ArticleDOI>10.1007/s12038-008-0067-y</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">Human metapneumovirus: a new respiratory pathogen</ArticleTitle><ArticleFirstPage>483</ArticleFirstPage><ArticleLastPage>493</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2008</Year><Month>12</Month><Day>20</Day></RegistrationDate><OnlineDate><Year>2008</Year><Month>12</Month><Day>24</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Indian Academy of Sciences</CopyrightHolderName><CopyrightYear>2008</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><FamilyName>Broor</FamilyName></AuthorName><Contact><Fax>91-11-26588663</Fax><Email>shobha.broor@gmail.com</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>P.</GivenName><FamilyName>Bharaj</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><GivenName>S.</GivenName><FamilyName>Chahar</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Microbiology</OrgDivision><OrgName>All India Institute of Medical Sciences</OrgName><OrgAddress><City>New Delhi</City><Postcode>110 029</Postcode><Country Code="IN">India</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults. The virus belongs to the family <Emphasis Type="Italic">Paramyxoviridae</Emphasis>, sub family <Emphasis Type="Italic">Pneumovirinae</Emphasis> and genus <Emphasis Type="Italic">Metapneumovirus</Emphasis>. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. F gene is the most conserved among different lineages and efforts are underway to design recombination vaccine using F gene.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>Acute respiratory infections</Keyword><Keyword>human metapneumovirus</Keyword></KeywordGroup><AbbreviationGroup><Heading>Abbreviations used</Heading><DefinitionList><DefinitionListEntry><Term>ALRI</Term><Description><Para>acute lower respiratory tract infection</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>APV</Term><Description><Para>avian pneumoviruses</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>ARI</Term><Description><Para>acute respiratory tract infection</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>CPE</Term><Description><Para>cytopathic effect</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>hMPV</Term><Description><Para>human metapneumovirus</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>RSV</Term><Description><Para>respiratory syncytial virus</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>RT-PCR</Term><Description><Para>reverse tracriptase-polymerase chain reaction</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>SARS</Term><Description><Para>severe acute respiratory syndrome</Para></Description></DefinitionListEntry><DefinitionListEntry><Term>SH</Term><Description><Para>small hydrophobic</Para></Description></DefinitionListEntry></DefinitionList></AbbreviationGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Human metapneumovirus: a new respiratory pathogen</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Human metapneumovirus: a new respiratory pathogen</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">S.</namePart><namePart type="family">Broor</namePart><affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</affiliation><affiliation>E-mail: shobha.broor@gmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bharaj</namePart><affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="given">S.</namePart><namePart type="family">Chahar</namePart><affiliation>Department of Microbiology, All India Institute of Medical Sciences, 110 029, New Delhi, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">India</placeTerm></place><dateIssued encoding="w3cdtf">2008-11-01</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Human metapneumovirus is a recently recognized pathogen of acute respiratory tract infection (ARI) in children as well as elderly and immunocompromised adults. The virus belongs to the family Paramyxoviridae, sub family Pneumovirinae and genus Metapneumovirus. Through genetic analysis it has been characterized into two groups A and B which are further divided into four sub-lineages. The virus is difficult to grow in tissue culture and hence reverse transcriptase-polymerase chain reaction (RT-PCR) for N and L gene is the method of choice for diagnosis. The virus has been seen in all countries with seasonal distribution in winter months for temperate and spring/summer for tropical countries. F gene is the most conserved among different lineages and efforts are underway to design recombination vaccine using F gene.</abstract><subject lang="en"><genre>Keywords</genre><topic>Acute respiratory infections</topic><topic>human metapneumovirus</topic></subject><subject><genre>Abbreviations used</genre><topic>ALRI : acute lower respiratory tract infection</topic><topic>APV : avian pneumoviruses</topic><topic>ARI : acute respiratory tract infection</topic><topic>CPE : cytopathic effect</topic><topic>hMPV : human metapneumovirus</topic><topic>RSV : respiratory syncytial virus</topic><topic>RT-PCR : reverse tracriptase-polymerase chain reaction</topic><topic>SARS : severe acute respiratory syndrome</topic><topic>SH : small hydrophobic</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biosciences</title></titleInfo><titleInfo type="abbreviated"><title>J Biosci</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2008-12-24</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><subject><genre>Life Sciences</genre><topic>Cell Biology</topic><topic>Microbiology</topic><topic>Plant Sciences</topic><topic>Zoology</topic><topic>Biomedicine general</topic><topic>Life Sciences, general</topic></subject><identifier type="ISSN">0250-5991</identifier><identifier type="eISSN">0973-7138</identifier><identifier type="JournalID">12038</identifier><identifier type="IssueArticleCount">19</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>2008</date><detail type="volume"><number>33</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>483</start><end>493</end></extent></part><recordInfo><recordOrigin>Indian Academy of Sciences, 2008</recordOrigin></recordInfo></relatedItem><identifier type="istex">983C9A34BF0396BA001A2EADAAFFE9FA04AE236E</identifier><identifier type="ark">ark:/67375/VQC-51MSPDP2-N</identifier><identifier type="DOI">10.1007/s12038-008-0067-y</identifier><identifier type="ArticleID">67</identifier><identifier type="ArticleID">s12038-008-0067-y</identifier><accessCondition type="use and reproduction" contentType="copyright">Indian Academy of Sciences, 2008</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Indian Academy of Sciences, 2008</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-51MSPDP2-N/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Human metapneumovirus: a new respiratory pathogen
}}
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