Nucleocapsid proteins: roles beyond viral RNA packaging
Identifieur interne : 000549 ( Istex/Corpus ); précédent : 000548; suivant : 000550Nucleocapsid proteins: roles beyond viral RNA packaging
Auteurs : Binbin Ding ; Yali Qin ; Mingzhou ChenSource :
- Wiley Interdisciplinary Reviews: RNA [ 1757-7004 ] ; 2016-03.
Abstract
Viral nucleocapsid proteins (NCs) enwrap the RNA genomes of viruses to form NC–RNA complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral RNA, NCs also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins. Additionally, NCs can inhibit interferon signaling response and function in cell stress response, such as inducing apoptosis. Finally, NCs can be the target of vaccines, benefiting from their conserved gene sequences. Here, we summarize important findings regarding the additional functions of NCs as much more than structural RNA‐binding proteins, with specific emphasis on (1) their association with the viral life cycle, (2) their association with host cells, and (3) as ideal candidates for vaccine development. WIREs RNA 2016, 7:213–226. doi: 10.1002/wrna.1326 For further resources related to this article, please visit the WIREs website.
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DOI: 10.1002/wrna.1326
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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><p>Viral nucleocapsid proteins (<hi rend="fc">NCs</hi>) enwrap the <hi rend="fc">RNA</hi> genomes of viruses to form <hi rend="fc">NC–RNA</hi> complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral <hi rend="fc">RNA</hi>, <hi rend="fc">NCs</hi> also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins. Additionally, <hi rend="fc">NCs</hi> can inhibit interferon signaling response and function in cell stress response, such as inducing apoptosis. Finally, <hi rend="fc">NCs</hi> can be the target of vaccines, benefiting from their conserved gene sequences. Here, we summarize important findings regarding the additional functions of <hi rend="fc">NCs</hi> as much more than structural <hi rend="fc">RNA</hi>‐binding proteins, with specific emphasis on (1) their association with the viral life cycle, (2) their association with host cells, and (3) as ideal candidates for vaccine development. <hi rend="italic">WIREs RNA</hi> 2016, 7:213–226. doi: 10.1002/wrna.1326</p><p>For further resources related to this article, please visit the <ref type="url">http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1325</ref>.</p></abstract><textClass><keywords rend="articleCategory"><term>Advanced Review</term></keywords><keywords rend="tocHeading1"><term>Advanced Reviews</term></keywords></textClass><textClass><keywords ana="subject"><term ref="http://psi.wiley.com/subject/17577004/RDAD">RNA–Protein Complexes</term><term ref="http://psi.wiley.com/subject/17577004/RDAE">Protein–RNA Interactions—Functional Implications</term><term 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Complexes</subject><subject href="http://psi.wiley.com/subject/17577004/RDAE">Protein–RNA Interactions—Functional Implications</subject><subject href="http://psi.wiley.com/subject/17577004/REAF">Translation Regulation</subject></subjectInfo><linkGroup><link type="toTypesetVersion" href="file:WRNA.WRNA1326.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Nucleocapsid proteins: roles beyond viral <fc>RNA</fc> packaging</title><title type="short">Nucleocapsid proteins</title></titleGroup><creators><creator creatorRole="author" xml:id="wrna1326-cr-0001" affiliationRef="#wrna1326-aff-0001"><personName><givenNames>Binbin</givenNames><familyName>Ding</familyName></personName></creator><creator creatorRole="author" xml:id="wrna1326-cr-0002" affiliationRef="#wrna1326-aff-0001"><personName><givenNames>Yali</givenNames><familyName>Qin</familyName></personName></creator><creator creatorRole="author" xml:id="wrna1326-cr-0003" affiliationRef="#wrna1326-aff-0001" corresponding="yes"><personName><givenNames>Mingzhou</givenNames><familyName>Chen</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="CN" type="organization" xml:id="wrna1326-aff-0001"><orgDiv>State Key Laboratory of Virology, College of Life Sciences</orgDiv><orgName>Wuhan University</orgName><address><city>Wuhan</city><country>People's Republic of China</country></address></affiliation></affiliationGroup><fundingInfo><fundingAgency fundRefName="National Science Foundation" funderDoi="10.13039/100000001">China Natural Science Foundation</fundingAgency><fundingNumber>81471939</fundingNumber><fundingNumber>81271816</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Major State Basic Research Development Program (973 Program)</fundingAgency><fundingNumber>2012CB518906</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><p>Viral nucleocapsid proteins (<fc>NCs</fc>) enwrap the <fc>RNA</fc> genomes of viruses to form <fc>NC–RNA</fc> complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral <fc>RNA</fc>, <fc>NCs</fc> also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins. Additionally, <fc>NCs</fc> can inhibit interferon signaling response and function in cell stress response, such as inducing apoptosis. Finally, <fc>NCs</fc> can be the target of vaccines, benefiting from their conserved gene sequences. Here, we summarize important findings regarding the additional functions of <fc>NCs</fc> as much more than structural <fc>RNA</fc>‐binding proteins, with specific emphasis on (1) their association with the viral life cycle, (2) their association with host cells, and (3) as ideal candidates for vaccine development. <i>WIREs RNA</i> 2016, 7:213–226. doi: 10.1002/wrna.1326</p><p>For further resources related to this article, please visit the <url href="http://wires.wiley.com/remdoi.cgi?doi=10.1002/wrna.1325">WIREs website</url>.</p></abstract></abstractGroup></contentMeta><noteGroup xml:id="wrna1326-ntgp-0001"><note xml:id="wrna1326-note-0001" numbered="no">Conflict of interest: The authors have declared no conflicts of interest for this article.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Nucleocapsid proteins: roles beyond viral RNA packaging</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Nucleocapsid proteins</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Nucleocapsid proteins: roles beyond viral RNA packaging</title></titleInfo><name type="personal"><namePart type="given">Binbin</namePart><namePart type="family">Ding</namePart><affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yali</namePart><namePart type="family">Qin</namePart><affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mingzhou</namePart><namePart type="family">Chen</namePart><affiliation>State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China</affiliation><affiliation>E-mail: chenmz@whu.edu.cn</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">Hoboken, USA</placeTerm></place><dateIssued encoding="w3cdtf">2016-03</dateIssued><dateCreated encoding="w3cdtf">2015-12-07</dateCreated><dateCaptured encoding="w3cdtf">2015-08-07</dateCaptured><dateValid encoding="w3cdtf">2015-11-17</dateValid><copyrightDate encoding="w3cdtf">2016</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Viral nucleocapsid proteins (NCs) enwrap the RNA genomes of viruses to form NC–RNA complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral RNA, NCs also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins. Additionally, NCs can inhibit interferon signaling response and function in cell stress response, such as inducing apoptosis. Finally, NCs can be the target of vaccines, benefiting from their conserved gene sequences. Here, we summarize important findings regarding the additional functions of NCs as much more than structural RNA‐binding proteins, with specific emphasis on (1) their association with the viral life cycle, (2) their association with host cells, and (3) as ideal candidates for vaccine development. WIREs RNA 2016, 7:213–226. doi: 10.1002/wrna.1326 For further resources related to this article, please visit the WIREs website.</abstract><note type="funding">China Natural Science Foundation - No. 81471939; No. 81271816; </note><note type="funding">Major State Basic Research Development Program (973 Program) - No. 2012CB518906; </note><relatedItem type="host"><titleInfo><title>Wiley Interdisciplinary Reviews: RNA</title></titleInfo><titleInfo type="abbreviated"><title>WIREs RNA</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>index-terms</genre><topic authorityURI="http://psi.wiley.com/subject/17577004/RDAD">RNA–Protein Complexes</topic><topic authorityURI="http://psi.wiley.com/subject/17577004/RDAE">Protein–RNA Interactions—Functional Implications</topic><topic authorityURI="http://psi.wiley.com/subject/17577004/REAF">Translation Regulation</topic></subject><subject><genre>article-category</genre><topic>Advanced Review</topic><topic>Advanced Reviews</topic></subject><identifier type="ISSN">1757-7004</identifier><identifier type="eISSN">1757-7012</identifier><identifier type="DOI">10.1002/(ISSN)1757-7012</identifier><identifier type="PublisherID">WRNA</identifier><part><date>2016</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>213</start><end>226</end><total>1</total></extent></part></relatedItem><identifier type="istex">4394720C92CDBCD6FF9BB984081DE4E519053F1E</identifier><identifier type="ark">ark:/67375/WNG-LJ893H0M-7</identifier><identifier type="DOI">10.1002/wrna.1326</identifier><identifier type="ArticleID">WRNA1326</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2016 Wiley Periodicals, Inc.© 2016 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LJ893H0M-7/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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