SARS: clinical features and diagnosis
Identifieur interne : 002202 ( Istex/Checkpoint ); précédent : 002201; suivant : 002203SARS: clinical features and diagnosis
Auteurs : David Shu-Cheong Hui [Hong Kong] ; Poon-Chuen Wong ; Chen Wang [République populaire de Chine]Source :
- Respirology [ 1323-7799 ] ; 2003-11.
Abstract
Severe acute respiratory syndrome (SARS) is a highly infectious disease with a significant morbidity and case fatality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache and dyspnoea. Less common symptoms include sputum production, sore throat, coryza, dizziness, nausea, vomiting and diarrhoea. Older subjects may present with decrease in general well‐being, poor feeding, fall/fracture and delirium, without the typical febrile response. Common laboratory features include lymphopenia with depletion of CD4 and CD8 lymphocytes, thrombocytopenia, prolonged activated partial thromboplastin time, elevated D‐Dimer, elevated alanine transminases, lactate dehydrogenase and creatinine kinase. The constellation of compatible clinical and laboratory findings, together with the rather characteristic radiological features especially on HRCT and the lack of clinical response to broad‐spectrum antibiotics, should quickly arouse suspicion of SARS. The positivity rates of urine, nasophargyngeal aspirate and stool specimen have been reported to be 42%, 68% and 97%, respectively, on day 14 of illness, whereas serology for confirmation may take 28 days to reach a detection rate above 90%. Recently, quantitative measurement of blood SARS CoV RNA with real‐time RT‐PCR technique has been developed with a detection rate of 80% as early as day 1 of hospital admission but the detection rates drop to 75% and 42% on day 7 and day 14, respectively.
Url:
DOI: 10.1046/j.1440-1843.2003.00520.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS: clinical features and diagnosis</title><author><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name></author><author><name sortKey="Wong, Poon Huen" sort="Wong, Poon Huen" uniqKey="Wong P" first="Poon-Chuen" last="Wong">Poon-Chuen Wong</name></author><author><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A21DEDE5FD65299954B3EABA1AD4C8DF6FA0AE66</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1046/j.1440-1843.2003.00520.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-NB5JB9X1-5/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000939</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000939</idno><idno type="wicri:Area/Istex/Curation">000939</idno><idno type="wicri:Area/Istex/Checkpoint">002202</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002202</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">SARS: clinical features and diagnosis</title><author><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name><affiliation wicri:level="4"><orgName type="university">Université chinoise de Hong Kong</orgName><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country></affiliation></author><author><name sortKey="Wong, Poon Huen" sort="Wong, Poon Huen" uniqKey="Wong P" first="Poon-Chuen" last="Wong">Poon-Chuen Wong</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Respirology</title><title level="j" type="alt">RESPIROLOGY</title><idno type="ISSN">1323-7799</idno><idno type="eISSN">1440-1843</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">s1</biblScope><biblScope unit="page" from="S20">S20</biblScope><biblScope unit="page" to="S24">S24</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2003-11">2003-11</date></imprint><idno type="ISSN">1323-7799</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1323-7799</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly infectious disease with a significant morbidity and case fatality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache and dyspnoea. Less common symptoms include sputum production, sore throat, coryza, dizziness, nausea, vomiting and diarrhoea. Older subjects may present with decrease in general well‐being, poor feeding, fall/fracture and delirium, without the typical febrile response. Common laboratory features include lymphopenia with depletion of CD4 and CD8 lymphocytes, thrombocytopenia, prolonged activated partial thromboplastin time, elevated D‐Dimer, elevated alanine transminases, lactate dehydrogenase and creatinine kinase. The constellation of compatible clinical and laboratory findings, together with the rather characteristic radiological features especially on HRCT and the lack of clinical response to broad‐spectrum antibiotics, should quickly arouse suspicion of SARS. The positivity rates of urine, nasophargyngeal aspirate and stool specimen have been reported to be 42%, 68% and 97%, respectively, on day 14 of illness, whereas serology for confirmation may take 28 days to reach a detection rate above 90%. Recently, quantitative measurement of blood SARS CoV RNA with real‐time RT‐PCR technique has been developed with a detection rate of 80% as early as day 1 of hospital admission but the detection rates drop to 75% and 42% on day 7 and day 14, respectively.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Wong, Poon Huen" sort="Wong, Poon Huen" uniqKey="Wong P" first="Poon-Chuen" last="Wong">Poon-Chuen Wong</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name></noRegion><name sortKey="Hui, David Shu Heong" sort="Hui, David Shu Heong" uniqKey="Hui D" first="David Shu-Cheong" last="Hui">David Shu-Cheong Hui</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Chen" sort="Wang, Chen" uniqKey="Wang C" first="Chen" last="Wang">Chen Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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