Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
Identifieur interne : 001A71 ( Istex/Checkpoint ); précédent : 001A70; suivant : 001A72Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital
Auteurs : Kuo-Ming Yeh [Taïwan] ; Tzong-Shi Chiueh [Taïwan] ; L. K. Siu [Taïwan] ; Jung-Chung Lin [Taïwan] ; Paul K. S. Chan [Hong Kong] ; Ming-Yieh Peng [Taïwan] ; Hsiang-Lin Wan [Taïwan] ; Jenn-Han Chen [Taïwan] ; Bor-Shen Hu [Taïwan] ; Cherng-Lih Perng [Taïwan] ; Jang-Jih Lu [Taïwan] ; Feng-Yee Chang [Taïwan]Source :
- Journal of Antimicrobial Chemotherapy [ 0305-7453 ] ; 2005.
Abstract
Objectives: To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment. Methods: Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT–PCR. Serial serum samples obtained from the recipients of the convalescent plasma were collected to undertake real-time quantitative RT–PCR for SARS-CoV for direct measurement of viral concentration. Specific immunoglobulin IgM and IgG concentrations were titrated using an antigen microarray developed in-house. Results: Viral load dropped from 495 × 103, 76 × 103 or 650 × 103 copies/mL to zero or 1 copy/mL one day after transfusion. Anti-SARS-CoV IgM and IgG also increased in a time-dependent manner following transfusion. All three patients survived. One HCW became pregnant subsequently, delivering 13 months after discharge. Positive anti-SARS-CoV IgG was detected in the newborn. Passive transfer of anti-SARS-CoV antibody from the mother was considered as a possibility. Conclusions: All infected HCW whose condition had progressed severely and who had failed to respond to the available treatment, survived after transfusion with convalescent plasma.
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DOI: 10.1093/jac/dki346
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Chan</name></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8C4BE9D3612E9AEE9DF80F5D9A729AB416644B0C</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1093/jac/dki346</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-CFV4L59Z-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000259</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000259</idno><idno type="wicri:Area/Istex/Curation">000259</idno><idno type="wicri:Area/Istex/Checkpoint">001A71</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital</title><author><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation></author><author><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L. K." last="Siu">L. K. Siu</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Clinical Research, National Health Research Institutes, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Hong Kong</country><wicri:regionArea>Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation></author><author><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Biochip R & D Center, School of Dentistry, Tri-Service General Hospital, National Defense Medical Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Infectious Diseases, Taipei Municipal Hoping Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Taïwan</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Neihu, Taipei, 114</wicri:regionArea><wicri:noRegion>114</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Antimicrobial Chemotherapy</title><title level="j" type="abbrev">J. Antimicrob. Chemother.</title><idno type="ISSN">0305-7453</idno><idno type="eISSN">1460-2091</idno><imprint><publisher>Oxford University Press</publisher><date type="e-published">2005</date><date type="published">2005</date><biblScope unit="vol">56</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="919">919</biblScope><biblScope unit="page" to="922">922</biblScope></imprint><idno type="ISSN">0305-7453</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-7453</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: To describe the immunological responses and clinical outcome of coronavirus (SARS) infected healthcare workers (HCW) who had been administered with convalescent plasma as a treatment. Methods: Convalescent plasma (500 mL) was obtained from each of three SARS patients and transfused into the three infected HCW. Donors were blood type O and seronegative for hepatitis B and C, HIV, syphilis and human T-cell lymphotropic virus types I and II (HTLV-I and -II). Serum antibody (IgG) titre was >640. Apharesis was performed with a CS 3000 plus cell separator followed by the forming of the convalescent phase plasma. As part of the routine check with donated plasma, the convalescent plasma was confirmed free of residual SARS-CoV by RT–PCR. Serial serum samples obtained from the recipients of the convalescent plasma were collected to undertake real-time quantitative RT–PCR for SARS-CoV for direct measurement of viral concentration. Specific immunoglobulin IgM and IgG concentrations were titrated using an antigen microarray developed in-house. Results: Viral load dropped from 495 × 103, 76 × 103 or 650 × 103 copies/mL to zero or 1 copy/mL one day after transfusion. Anti-SARS-CoV IgM and IgG also increased in a time-dependent manner following transfusion. All three patients survived. One HCW became pregnant subsequently, delivering 13 months after discharge. Positive anti-SARS-CoV IgG was detected in the newborn. Passive transfer of anti-SARS-CoV antibody from the mother was considered as a possibility. Conclusions: All infected HCW whose condition had progressed severely and who had failed to respond to the available treatment, survived after transfusion with convalescent plasma.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>Taïwan</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Taïwan"><noRegion><name sortKey="Yeh, Kuo Ming" sort="Yeh, Kuo Ming" uniqKey="Yeh K" first="Kuo-Ming" last="Yeh">Kuo-Ming Yeh</name></noRegion><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name><name sortKey="Chang, Feng Yee" sort="Chang, Feng Yee" uniqKey="Chang F" first="Feng-Yee" last="Chang">Feng-Yee Chang</name><name sortKey="Chen, Jenn Han" sort="Chen, Jenn Han" uniqKey="Chen J" first="Jenn-Han" last="Chen">Jenn-Han Chen</name><name sortKey="Chiueh, Tzong Shi" sort="Chiueh, Tzong Shi" uniqKey="Chiueh T" first="Tzong-Shi" last="Chiueh">Tzong-Shi Chiueh</name><name sortKey="Hu, Bor Shen" sort="Hu, Bor Shen" uniqKey="Hu B" first="Bor-Shen" last="Hu">Bor-Shen Hu</name><name sortKey="Lin, Jung Chung" sort="Lin, Jung Chung" uniqKey="Lin J" first="Jung-Chung" last="Lin">Jung-Chung Lin</name><name sortKey="Lu, Jang Jih" sort="Lu, Jang Jih" uniqKey="Lu J" first="Jang-Jih" last="Lu">Jang-Jih Lu</name><name sortKey="Peng, Ming Yieh" sort="Peng, Ming Yieh" uniqKey="Peng M" first="Ming-Yieh" last="Peng">Ming-Yieh Peng</name><name sortKey="Perng, Cherng Lih" sort="Perng, Cherng Lih" uniqKey="Perng C" first="Cherng-Lih" last="Perng">Cherng-Lih Perng</name><name sortKey="Siu, L K" sort="Siu, L K" uniqKey="Siu L" first="L. K." last="Siu">L. K. Siu</name><name sortKey="Wan, Hsiang Lin" sort="Wan, Hsiang Lin" uniqKey="Wan H" first="Hsiang-Lin" last="Wan">Hsiang-Lin Wan</name></country><country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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