Prophylaxis and Therapy for Chikungunya Virus Infection
Identifieur interne : 000B82 ( Istex/Checkpoint ); précédent : 000B81; suivant : 000B83Prophylaxis and Therapy for Chikungunya Virus Infection
Auteurs : Thérèse Couderc ; Nassirah Khandoudi ; Marc Grandadam [France] ; Catherine Visse ; Nicolas Gangneux ; Sébastien Bagot ; Jean-François Prost ; Marc Lecuit [France]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2009.
Abstract
BackgroundChikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for a massive outbreak of infection in the Indian Ocean region and India that has a very significant potential to spread globally because of the worldwide distribution of its mosquito vectors. CHIKV induces a usually self-limited disease in humans that is characterized by fever, arthralgia, myalgia, and rash; however, cases of severe CHIKV infection have recently been described, particularly in adults with underlying condition and neonates born to viremic mothers MethodsHuman polyvalent immunoglobulins were purified from plasma samples obtained from donors in the convalescent phase of CHIKV infection, and the preventive and curative effects of these immunoglobulins were investigated in 2 mouse models of CHIKV infection that we developed ResultsCHIKV immunoglobulins contain anti-CHIKV antibodies and exhibit a high in vitro neutralizing activity and a powerful prophylactic and therapeutic efficacy against CHIKV infection in vivo, including in the neonate ConclusionsAdministration of CHIKV immunoglobulins may constitute a safe and efficacious prevention strategy and treatment for individuals exposed to CHIKV who are at risk of severe infection, such as neonates born to viremic mothers and adults with underlying conditions. These results provide a proof-of-concept for purifying human immunoglobulins from plasma samples from patients in the convalescent phase of an emerging infectious disease for which neither prevention nor treatment is available
Url:
DOI: 10.1086/600381
Affiliations:
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first="Sébastien" last="Bagot">Sébastien Bagot</name></author><author><name sortKey="Prost, Jean Francois" sort="Prost, Jean Francois" uniqKey="Prost J" first="Jean-François" last="Prost">Jean-François Prost</name></author><author><name sortKey="Lecuit, Marc" sort="Lecuit, Marc" uniqKey="Lecuit M" first="Marc" last="Lecuit">Marc Lecuit</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:707697FCFB4752A0D1959B646EF6CF25D3712965</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1086/600381</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-ZSJCSLR3-V/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001832</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001832</idno><idno type="wicri:Area/Istex/Curation">001832</idno><idno type="wicri:Area/Istex/Checkpoint">000B82</idno><idno type="wicri:explorRef" wicri:stream="Istex" 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xml:lang="fr">France</country><wicri:regionArea>Service de Santé des Armées, Laboratoire de Virologie, Institut de Médecine Tropicale, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Visse, Catherine" sort="Visse, Catherine" uniqKey="Visse C" first="Catherine" last="Visse">Catherine Visse</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Gangneux, Nicolas" sort="Gangneux, Nicolas" uniqKey="Gangneux N" first="Nicolas" last="Gangneux">Nicolas Gangneux</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Bagot, Sebastien" sort="Bagot, Sebastien" uniqKey="Bagot S" first="Sébastien" last="Bagot">Sébastien Bagot</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Prost, Jean Francois" sort="Prost, Jean Francois" uniqKey="Prost J" first="Jean-François" last="Prost">Jean-François Prost</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Lecuit, Marc" sort="Lecuit, Marc" uniqKey="Lecuit M" first="Marc" last="Lecuit">Marc Lecuit</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="4"><orgName type="university">Université Paris-Descartes</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2009</date><biblScope unit="vol">200</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="516">516</biblScope><biblScope unit="page" to="523">523</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">BackgroundChikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for a massive outbreak of infection in the Indian Ocean region and India that has a very significant potential to spread globally because of the worldwide distribution of its mosquito vectors. CHIKV induces a usually self-limited disease in humans that is characterized by fever, arthralgia, myalgia, and rash; however, cases of severe CHIKV infection have recently been described, particularly in adults with underlying condition and neonates born to viremic mothers MethodsHuman polyvalent immunoglobulins were purified from plasma samples obtained from donors in the convalescent phase of CHIKV infection, and the preventive and curative effects of these immunoglobulins were investigated in 2 mouse models of CHIKV infection that we developed ResultsCHIKV immunoglobulins contain anti-CHIKV antibodies and exhibit a high in vitro neutralizing activity and a powerful prophylactic and therapeutic efficacy against CHIKV infection in vivo, including in the neonate ConclusionsAdministration of CHIKV immunoglobulins may constitute a safe and efficacious prevention strategy and treatment for individuals exposed to CHIKV who are at risk of severe infection, such as neonates born to viremic mothers and adults with underlying conditions. These results provide a proof-of-concept for purifying human immunoglobulins from plasma samples from patients in the convalescent phase of an emerging infectious disease for which neither prevention nor treatment is available</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Paris</li></settlement><orgName><li>Université Paris-Descartes</li></orgName></list><tree><noCountry><name sortKey="Bagot, Sebastien" sort="Bagot, Sebastien" uniqKey="Bagot S" first="Sébastien" last="Bagot">Sébastien Bagot</name><name sortKey="Couderc, Therese" sort="Couderc, Therese" uniqKey="Couderc T" first="Thérèse" last="Couderc">Thérèse Couderc</name><name sortKey="Gangneux, Nicolas" sort="Gangneux, Nicolas" uniqKey="Gangneux N" first="Nicolas" last="Gangneux">Nicolas Gangneux</name><name sortKey="Khandoudi, Nassirah" sort="Khandoudi, Nassirah" uniqKey="Khandoudi N" first="Nassirah" last="Khandoudi">Nassirah Khandoudi</name><name sortKey="Prost, Jean Francois" sort="Prost, Jean Francois" uniqKey="Prost J" first="Jean-François" last="Prost">Jean-François Prost</name><name sortKey="Visse, Catherine" sort="Visse, Catherine" uniqKey="Visse C" first="Catherine" last="Visse">Catherine Visse</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Grandadam, Marc" sort="Grandadam, Marc" uniqKey="Grandadam M" first="Marc" last="Grandadam">Marc Grandadam</name></region><name sortKey="Lecuit, Marc" sort="Lecuit, Marc" uniqKey="Lecuit M" first="Marc" last="Lecuit">Marc Lecuit</name><name sortKey="Lecuit, Marc" sort="Lecuit, Marc" uniqKey="Lecuit M" first="Marc" last="Lecuit">Marc Lecuit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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