Protective effects of glycyrrhizic acid by rectal treatment on a TNBS‐induced rat colitis model
Identifieur interne : 000732 ( Istex/Checkpoint ); précédent : 000731; suivant : 000733Protective effects of glycyrrhizic acid by rectal treatment on a TNBS‐induced rat colitis model
Auteurs : Ying Liu [République populaire de Chine] ; Jin Xiang [République populaire de Chine] ; Min Liu [République populaire de Chine] ; Shi Wang [République populaire de Chine] ; Robert J. Lee [États-Unis] ; Hong Ding [République populaire de Chine]Source :
- Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 2011-03.
English descriptors
- Teeft :
- Acid, Bowel, Bowel disease, Colitic, Colitic rats, Colitis, Colitis model, Colon, Colon tissue, Colon weight, Cytokine, Diammonium glycyrrhizinate, Fetal calf serum, Glycyrrhizic, Glycyrrhizic acid, Intestinal, Lymphocyte, Macrophage, Mucosal, Normal group, Oral treatment, Pharmacol, Physiol, Physiol gastrointest liver physiol, Physiological saline, Protective effects, Rat, Rectal, Rectal administration, Rectal glycyrrhizic acid, Rectal glycyrrhizic acid treatment, Rectal treatment, Rectally, Saline solution, Spleen, Sulfasalazine, Tnbs, Tnbs group, Ulcerative colitis, Unit length, Wuhan, Wuhan university.
Abstract
Objectives The research compared rectal and oral treatments with glycyrrhizic acid for trinitrobenzene sulfonic acid (TNBS)‐induced colitis in rats. Methods Wistar rats were randomly divided into seven groups: one normal and six with colitis, including TNBS, glycyrrhizic acid (2, 10 and 50 mg/kg, rectally treated and 10 mg/kg, orally treated) and sulfasalazine (positive control, 225 mg/kg rectally treated) groups. Colitis was induced by colonic administration of TNBS in 30% ethanol. Key findings There were significant pathological changes in colon in TNBS‐treated groups, and rectal glycyrrhizic acid significantly attenuated colitis. Myeloperoxidase, tumour necrosis factor‐α and interleukin‐1β of colon tissue or serum in the rectal glycyrrhizic acid groups were markedly reduced when compared with the TNBS group, and lower than in the orally treated glycyrrhizic acid group. It was further noted that, in vitro, glycyrrhizic acid (up to 100 µg/ml) inhibited interleukin‐6 and elevated interleukin‐10 production in lipopolysaccharide‐activated macrophages, and significantly inhibited proliferation of spleen lymphocytes, suggesting the immunoregulatory function of glycyrrhizic acid. Conclusions Rectally administered glycyrrhizic acid has significant protective effects against TNBS‐induced colitis in rats, and the rectal route may be a complementary treatment for inflammatory bowel disease.
Url:
DOI: 10.1111/j.2042-7158.2010.01185.x
Affiliations:
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Lee</name></author><author><name sortKey="Ding, Hong" sort="Ding, Hong" uniqKey="Ding H" first="Hong" last="Ding">Hong Ding</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5D8B315E115C65E3CC5DF1EFE70E7AB8A184FFE1</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.2042-7158.2010.01185.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-95JZJQHG-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E77</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E77</idno><idno type="wicri:Area/Istex/Curation">001E77</idno><idno type="wicri:Area/Istex/Checkpoint">000732</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000732</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Protective effects of glycyrrhizic acid by rectal treatment on a TNBS‐induced rat colitis model</title><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Xiang, Jin" sort="Xiang, Jin" uniqKey="Xiang J" first="Jin" last="Xiang">Jin Xiang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Wang, Shi" sort="Wang, Shi" uniqKey="Wang S" first="Shi" last="Wang">Shi Wang</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Lee, Robert J" sort="Lee, Robert J" uniqKey="Lee R" first="Robert J." last="Lee">Robert J. Lee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ding, Hong" sort="Ding, Hong" uniqKey="Ding H" first="Hong" last="Ding">Hong Ding</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Pharmacy and Pharmacology</title><title level="j" type="alt">JOURNAL OF PHARMACY AND PHARMACOLOGY</title><idno type="ISSN">0022-3573</idno><idno type="eISSN">2042-7158</idno><imprint><biblScope unit="vol">63</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="439">439</biblScope><biblScope unit="page" to="446">446</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-03">2011-03</date></imprint><idno type="ISSN">0022-3573</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3573</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid</term><term>Bowel</term><term>Bowel disease</term><term>Colitic</term><term>Colitic rats</term><term>Colitis</term><term>Colitis model</term><term>Colon</term><term>Colon tissue</term><term>Colon weight</term><term>Cytokine</term><term>Diammonium glycyrrhizinate</term><term>Fetal calf serum</term><term>Glycyrrhizic</term><term>Glycyrrhizic acid</term><term>Intestinal</term><term>Lymphocyte</term><term>Macrophage</term><term>Mucosal</term><term>Normal group</term><term>Oral treatment</term><term>Pharmacol</term><term>Physiol</term><term>Physiol gastrointest liver physiol</term><term>Physiological saline</term><term>Protective effects</term><term>Rat</term><term>Rectal</term><term>Rectal administration</term><term>Rectal glycyrrhizic acid</term><term>Rectal glycyrrhizic acid treatment</term><term>Rectal treatment</term><term>Rectally</term><term>Saline solution</term><term>Spleen</term><term>Sulfasalazine</term><term>Tnbs</term><term>Tnbs group</term><term>Ulcerative colitis</term><term>Unit length</term><term>Wuhan</term><term>Wuhan university</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives The research compared rectal and oral treatments with glycyrrhizic acid for trinitrobenzene sulfonic acid (TNBS)‐induced colitis in rats. Methods Wistar rats were randomly divided into seven groups: one normal and six with colitis, including TNBS, glycyrrhizic acid (2, 10 and 50 mg/kg, rectally treated and 10 mg/kg, orally treated) and sulfasalazine (positive control, 225 mg/kg rectally treated) groups. Colitis was induced by colonic administration of TNBS in 30% ethanol. Key findings There were significant pathological changes in colon in TNBS‐treated groups, and rectal glycyrrhizic acid significantly attenuated colitis. Myeloperoxidase, tumour necrosis factor‐α and interleukin‐1β of colon tissue or serum in the rectal glycyrrhizic acid groups were markedly reduced when compared with the TNBS group, and lower than in the orally treated glycyrrhizic acid group. It was further noted that, in vitro, glycyrrhizic acid (up to 100 µg/ml) inhibited interleukin‐6 and elevated interleukin‐10 production in lipopolysaccharide‐activated macrophages, and significantly inhibited proliferation of spleen lymphocytes, suggesting the immunoregulatory function of glycyrrhizic acid. Conclusions Rectally administered glycyrrhizic acid has significant protective effects against TNBS‐induced colitis in rats, and the rectal route may be a complementary treatment for inflammatory bowel disease.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Hubei</li><li>Ohio</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name></region><name sortKey="Ding, Hong" sort="Ding, Hong" uniqKey="Ding H" first="Hong" last="Ding">Hong Ding</name><name sortKey="Ding, Hong" sort="Ding, Hong" uniqKey="Ding H" first="Hong" last="Ding">Hong Ding</name><name sortKey="Liu, Min" sort="Liu, Min" uniqKey="Liu M" first="Min" last="Liu">Min Liu</name><name sortKey="Wang, Shi" sort="Wang, Shi" uniqKey="Wang S" first="Shi" last="Wang">Shi Wang</name><name sortKey="Xiang, Jin" sort="Xiang, Jin" uniqKey="Xiang J" first="Jin" last="Xiang">Jin Xiang</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Lee, Robert J" sort="Lee, Robert J" uniqKey="Lee R" first="Robert J." last="Lee">Robert J. 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