SrasV1, Hal, Curation, bibRecord, 000173

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Identifieur interne : 000173 ( Hal/Curation ); précédent : 000172; suivant : 000174

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Auteurs : Bruno Coutard [France] ; Coralie Valle [France] ; Xavier De Lamballerie [France] ; Bruno Canard [France] ; Nabil Seidah [Canada] ; E. Decroly [France]

Source :

Antiviral Research [ 0166-3542 ] ; 2020-02-10.

RBID : Hal:inserm-02517696

English descriptors

mix :
- 2019-nCoV, Antivirals, Furin, Maturation protease, SARS-CoV, Spike protein.

Abstract

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

Url:

https://www.hal.inserm.fr/inserm-02517696

DOI: 10.1016/j.antiviral.2020.104742

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000173

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Hal:inserm-02517696

Le document en format XML

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Serveur d'exploration SRAS

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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