The caspase family in urochordates: distinct evolutionary fates in ascidians and larvaceans
Identifieur interne : 000163 ( Hal/Curation ); précédent : 000162; suivant : 000164The caspase family in urochordates: distinct evolutionary fates in ascidians and larvaceans
Auteurs : Mylene Weill [France] ; Alexandre Philips [France] ; Daniel Chourrout [Norvège] ; Philippe Fort [France]Source :
- Biology of the Cell [ 0248-4900 ] ; 2005-11.
Abstract
Caspases are cysteine proteases that mediate apoptosis (programmed cell death) initiation and execution. Apoptosis is a conserved mechanism shared by all metazoans, although its physiological function and complexity show considerable taxon-dependent variations. To gain insight into the caspase repertoire of putative ancestors to vertebrates, we performed exhaustive genomic searches in urochordates, a sister taxon to vertebrates in which ascidians and appendicularians display chordate characters at early stages of their development.
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DOI: 10.1042/BC20050018
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<abstract xml:lang="en"> <p>Caspases are cysteine proteases that mediate apoptosis (programmed cell death) initiation and execution. Apoptosis is a conserved mechanism shared by all metazoans, although its physiological function and complexity show considerable taxon-dependent variations. To gain insight into the caspase repertoire of putative ancestors to vertebrates, we performed exhaustive genomic searches in urochordates, a sister taxon to vertebrates in which ascidians and appendicularians display chordate characters at early stages of their development.</p>
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