Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Identifieur interne : 000041 ( Hal/Curation ); précédent : 000040; suivant : 000042Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Auteurs : Jean-Paul Armache [Allemagne] ; Alexander Jarasch [Allemagne] ; Andreas M. Anger [Allemagne] ; Elizabeth Villa [Allemagne] ; Thomas Becker [Allemagne] ; Shashi Bhushan [Allemagne] ; Fabrice Jossinet [France] ; Michael Habeck [France] ; Gülcin Dindar [Allemagne] ; Sibylle Franckenberg [Allemagne] ; Viter Marquez [Allemagne] ; Thorsten Mielke [Allemagne] ; Michael Thomm [Allemagne] ; Otto Berninghausen [Allemagne] ; Birgitta Beatrix [Allemagne] ; Johannes Söding [Allemagne] ; Eric Westhof [France] ; Daniel N. Wilson [Allemagne] ; Roland Beckmann [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2010-10-27.
Abstract
Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.
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DOI: 10.1073/pnas.1009999107
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</org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-00530586</idno><idno type="halId">hal-00530586</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00530586</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-00530586</idno><idno type="doi">10.1073/pnas.1009999107</idno><date when="2010-10-27">2010-10-27</date><idno type="wicri:Area/Hal/Corpus">000041</idno><idno type="wicri:Area/Hal/Curation">000041</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.</title><author><name sortKey="Armache, Jean Paul" sort="Armache, Jean Paul" uniqKey="Armache J" first="Jean-Paul" last="Armache">Jean-Paul Armache</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-460216" status="VALID"> 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last="Wilson">Daniel N. Wilson</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-460216" status="VALID"> <orgName>Max Von Pettenkofer Institute</orgName> <orgName type="acronym">MVP</orgName> <desc> <address> <addrLine>Pettenkoferstraße 9a, 80336 Munich, Germany</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.mvp.uni-muenchen.de/en/home/</ref> </desc> <listRelation> <relation active="#struct-301945" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301945" type="direct"><org type="institution" xml:id="struct-301945" status="VALID"> <orgName>Ludwig-Maximilians-Universität München</orgName> <orgName type="acronym">LMU</orgName> <desc> <address> <addrLine>Geschwister-Scholl-Platz 1, 80539 München</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-muenchen.de</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Beckmann, Roland" sort="Beckmann, Roland" uniqKey="Beckmann R" first="Roland" last="Beckmann">Roland Beckmann</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-460216" status="VALID"> <orgName>Max Von Pettenkofer Institute</orgName> <orgName type="acronym">MVP</orgName> <desc> <address> <addrLine>Pettenkoferstraße 9a, 80336 Munich, Germany</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.mvp.uni-muenchen.de/en/home/</ref> </desc> <listRelation> <relation active="#struct-301945" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301945" type="direct"><org type="institution" xml:id="struct-301945" status="VALID"> <orgName>Ludwig-Maximilians-Universität München</orgName> <orgName type="acronym">LMU</orgName> <desc> <address> <addrLine>Geschwister-Scholl-Platz 1, 80539 München</addrLine> <country key="DE"></country> </address> <ref type="url">http://www.uni-muenchen.de</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author></analytic><idno type="DOI">10.1073/pnas.1009999107</idno><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America </title><idno type="ISSN">0027-8424</idno><imprint><date type="datePub">2010-10-27</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.</title> <author role="aut"> <persName> <forename type="first">Jean-Paul</forename> <surname>Armache</surname> </persName> <idno type="halauthorid">482490</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alexander</forename> <surname>Jarasch</surname> </persName> <idno type="halauthorid">482489</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Andreas M</forename> <surname>Anger</surname> </persName> <idno type="halauthorid">538127</idno> <affiliation 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<seriesStmt> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno> <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.</title> <author role="aut"> <persName> <forename type="first">Jean-Paul</forename> <surname>Armache</surname> </persName> <idno type="halauthorid">482490</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alexander</forename> <surname>Jarasch</surname> 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<idno type="halauthorid">538131</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thorsten</forename> <surname>Mielke</surname> </persName> <idno type="halauthorid">152230</idno> <affiliation ref="#struct-333449"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Michael</forename> <surname>Thomm</surname> </persName> <idno type="halauthorid">538132</idno> <affiliation ref="#struct-131269"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Otto</forename> <surname>Berninghausen</surname> </persName> <idno type="halauthorid">482492</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Birgitta</forename> <surname>Beatrix</surname> </persName> <idno type="halauthorid">538133</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Johannes</forename> <surname>Söding</surname> </persName> <idno type="halauthorid">538134</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Westhof</surname> </persName> <idno type="halauthorid">122890</idno> <affiliation ref="#struct-93780"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Daniel N</forename> <surname>Wilson</surname> </persName> <idno type="halauthorid">538135</idno> <affiliation ref="#struct-460216"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Roland</forename> <surname>Beckmann</surname> </persName> <idno type="halauthorid">482496</idno> <affiliation ref="#struct-460216"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">7969</idno> <idno type="issn">0027-8424</idno> <idno type="eissn">1091-6490</idno> <title level="j">Proceedings of the National Academy of Sciences of the United States of America </title> <imprint> <publisher>National Academy of Sciences</publisher> <biblScope unit="pp">epub ahead of print</biblScope> <date type="datePub">2010-10-27</date> <date type="dateEpub">2010-10-27</date> </imprint> </monogr> <idno type="doi">10.1073/pnas.1009999107</idno> <idno type="pubmed">20980660</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv.bbm">Life Sciences [q-bio]/Biochemistry, Molecular Biology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES-ES and r-protein-ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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