Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation.
Identifieur interne : 000067 ( Hal/Corpus ); précédent : 000066; suivant : 000068Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation.
Auteurs : Stefanie Topp ; Christian Stigloher ; Anna Z. Komisarczuk ; Birgit Adolf ; Thomas S. Becker ; Laure Bally-CuifSource :
- Journal of Comparative Neurology [ 0092-7317 ] ; 2008-10-01.
Abstract
The zebrafish adult brain contains numerous neural progenitors and is a good model to approach the general mechanisms of adult neural stem cell maintenance and neurogenesis. Here we use this model to test for a correlation between Fgf signaling and cell proliferation in adult progenitor zones. We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 synexpression group acquire strikingly divergent patterns in the adult brain. We further document the specific expression of fgf3, fgfr1-3, dusp6, and P-ERK in ventricular zones, which contain neural progenitors. In these locations, however, a comparison at the single-cell level of fgfr/P-ERK expression with bromo-deoxy-uridine (BrdU) incorporation and the proliferation marker MCM5 indicates that Fgf signaling is not specifically associated with proliferating progenitors. Rather, it correlates with the ventricular radial glia state, some of which only are progenitors. Together these results stress the importance of Fgf signaling in the adult brain and establish the basis to study its function in zebrafish, in particular in relation to adult neurogenesis.
Url:
DOI: 10.1002/cne.21802
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Hal:hal-01055260Le document en format XML
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<front><div type="abstract" xml:lang="en"> <p>The zebrafish adult brain contains numerous neural progenitors and is a good model to approach the general mechanisms of adult neural stem cell maintenance and neurogenesis. Here we use this model to test for a correlation between Fgf signaling and cell proliferation in adult progenitor zones. We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 synexpression group acquire strikingly divergent patterns in the adult brain. We further document the specific expression of fgf3, fgfr1-3, dusp6, and P-ERK in ventricular zones, which contain neural progenitors. In these locations, however, a comparison at the single-cell level of fgfr/P-ERK expression with bromo-deoxy-uridine (BrdU) incorporation and the proliferation marker MCM5 indicates that Fgf signaling is not specifically associated with proliferating progenitors. Rather, it correlates with the ventricular radial glia state, some of which only are progenitors. Together these results stress the importance of Fgf signaling in the adult brain and establish the basis to study its function in zebrafish, in particular in relation to adult neurogenesis.</p>
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<author role="aut"> <persName> <forename type="first">Thomas S</forename>
<surname>Becker</surname>
</persName>
<idno type="halauthorid">228930</idno>
<affiliation ref="#struct-51800"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Laure</forename>
<surname>Bally-Cuif</surname>
</persName>
<idno type="halauthorid">395856</idno>
<affiliation ref="#struct-90936"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">15260</idno>
<idno type="issn">0092-7317</idno>
<idno type="eissn">1550-7130</idno>
<title level="j">Journal of Comparative Neurology</title>
<imprint> <publisher>John Wiley & Sons</publisher>
<biblScope unit="volume">510</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="pp">422-39</biblScope>
<date type="datePub">2008-10-01</date>
</imprint>
</monogr>
<idno type="doi">10.1002/cne.21802</idno>
<idno type="pubmed">18666124</idno>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="mesh">Animals</classCode>
<classCode scheme="mesh">Animals, Genetically Modified</classCode>
<classCode scheme="mesh">Immunohistochemistry</classCode>
<classCode scheme="mesh">In Situ Hybridization</classCode>
<classCode scheme="mesh">Mesencephalon</classCode>
<classCode scheme="mesh">Receptors, Fibroblast Growth Factor</classCode>
<classCode scheme="mesh">Rhombencephalon</classCode>
<classCode scheme="mesh">Signal Transduction</classCode>
<classCode scheme="mesh">Zebrafish</classCode>
<classCode scheme="mesh">Brain</classCode>
<classCode scheme="mesh">Cell Division</classCode>
<classCode scheme="mesh">Cerebral Ventricles</classCode>
<classCode scheme="mesh">Fibroblast Growth Factors</classCode>
<classCode scheme="mesh">Genes, Reporter</classCode>
<classCode scheme="mesh">Glial Fibrillary Acidic Protein</classCode>
<classCode scheme="mesh">Green Fluorescent Proteins</classCode>
<classCode scheme="mesh">Hypothalamus</classCode>
<classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en"> <p>The zebrafish adult brain contains numerous neural progenitors and is a good model to approach the general mechanisms of adult neural stem cell maintenance and neurogenesis. Here we use this model to test for a correlation between Fgf signaling and cell proliferation in adult progenitor zones. We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 synexpression group acquire strikingly divergent patterns in the adult brain. We further document the specific expression of fgf3, fgfr1-3, dusp6, and P-ERK in ventricular zones, which contain neural progenitors. In these locations, however, a comparison at the single-cell level of fgfr/P-ERK expression with bromo-deoxy-uridine (BrdU) incorporation and the proliferation marker MCM5 indicates that Fgf signaling is not specifically associated with proliferating progenitors. Rather, it correlates with the ventricular radial glia state, some of which only are progenitors. Together these results stress the importance of Fgf signaling in the adult brain and establish the basis to study its function in zebrafish, in particular in relation to adult neurogenesis.</p>
</abstract>
</profileDesc>
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