SrasV1, Hal, Checkpoint, bibRecord, 000181

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Identifieur interne : 000181 ( Hal/Checkpoint ); précédent : 000180; suivant : 000182

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Auteurs : Christophe Biot [France] ; Wassim Daher [France] ; Natascha Chavain [France] ; Thierry Fandeur [France] ; Jamal Khalife [France] ; Daniel Dive [France] ; Erik De Clercq [Belgique]

Source :

Journal of Medicinal Chemistry [ 0022-2623 ] ; 2006.

RBID : Hal:hal-00099876

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Url:

https://hal.archives-ouvertes.fr/hal-00099876

DOI: 10.1021/jm0601856

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000043
to stream Hal, to step Curation: 000043

Links to Exploration step

Hal:hal-00099876

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities</title>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20673" status="OLD">          <orgName>Immunologie parasitaire</orgName>
          <orgName type="acronym">TOURS UMR IMMUNOLOGIE PARASIT</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculte des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont, 37200 Tours</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-307326" type="direct"></relation>
            <relation name="UR" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-307326" type="direct"><org type="institution" xml:id="struct-307326" status="INCOMING">          <orgName>Faculte des Sciences Pharmaceutiques</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UR" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20675" status="INCOMING">          <orgName>Rega Institute for Medical Research</orgName>
          <desc>            <address>              <addrLine>K.U.Leuven, B-3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300832" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300832" type="direct"><org type="institution" xml:id="struct-300832" status="VALID">          <orgName>Facultés Universitaires Notre Dame de la Paix (FUNDP) - Namur</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00099876</idno>
<idno type="halId">hal-00099876</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00099876</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00099876</idno>
<idno type="doi">10.1021/jm0601856</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Hal/Corpus">000043</idno>
<idno type="wicri:Area/Hal/Curation">000043</idno>
<idno type="wicri:Area/Hal/Checkpoint">000181</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000181</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities</title>
<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3209" status="VALID">          <idno type="IdRef">161608809</idno>
          <idno type="ISNI">0000 0004 0368 3038</idno>
          <idno type="RNSR">200612828X</idno>
          <orgName>Unité de Catalyse et de Chimie du Solide - UMR 8181</orgName>
          <orgName type="acronym">UCCS</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - Bâtiment C3 59655 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-56711" type="direct"></relation>
            <relation active="#struct-120930" type="direct"></relation>
            <relation active="#struct-300369" type="direct"></relation>
            <relation active="#struct-374570" type="direct"></relation>
            <relation name="UMR8181" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-56711" type="direct"><org type="institution" xml:id="struct-56711" status="VALID">          <orgName>Université d'Artois</orgName>
          <orgName type="acronym">UA</orgName>
          <desc>            <address>              <addrLine>9 rue du Temple - BP 10665 - 62030 Arras cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-artois.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID">          <orgName>Ecole Centrale de Lille</orgName>
          <desc>            <address>              <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ec-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-300369" type="direct"><org type="institution" xml:id="struct-300369" status="VALID">          <orgName>Ecole Nationale Supérieure de Chimie de Lille</orgName>
          <orgName type="acronym">ENSCL</orgName>
          <desc>            <address>              <addrLine>Cité ScientifiqueBât. C7Avenue MendeleïevCS 9010859652 VILLENEUVE D’ASCQ CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ensc-lille.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID">          <idno type="IdRef">223446556</idno>
          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.univ-lille.fr/</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR8181" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20673" status="OLD">          <orgName>Immunologie parasitaire</orgName>
          <orgName type="acronym">TOURS UMR IMMUNOLOGIE PARASIT</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Faculte des Sciences Pharmaceutiques, 31, avenue Monge, Parc Grandmont, 37200 Tours</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-307326" type="direct"></relation>
            <relation name="UR" active="#struct-92114" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-307326" type="direct"><org type="institution" xml:id="struct-307326" status="INCOMING">          <orgName>Faculte des Sciences Pharmaceutiques</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="UR" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2906" status="VALID">          <orgName>Schistosomiase, paludisme et inflammation</orgName>
          <desc>            <address>              <addrLine>Institut Pasteur 1, Rue du Professeur Calmette 59019 LILLE CEDEX</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300166" type="direct"></relation>
            <relation active="#struct-301247" type="indirect"></relation>
            <relation name="U547" active="#struct-303623" type="direct"></relation>
            <relation active="#struct-361611" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300166" type="direct"><org type="institution" xml:id="struct-300166" status="VALID">          <orgName>Institut Pasteur de Lille</orgName>
          <date type="start">1894</date>
          <desc>            <address>              <addrLine>1 Rue du Professeur Calmette - Lille Cedex - 59019</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur-lille.fr/accueil/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="U547" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle active="#struct-361611" type="direct"><org type="institution" xml:id="struct-361611" status="OLD">          <idno type="ISNI">0000000120977060</idno>
          <idno type="IdRef">026404389</idno>
          <orgName>Université de Lille, Droit et Santé</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lille2.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20675" status="INCOMING">          <orgName>Rega Institute for Medical Research</orgName>
          <desc>            <address>              <addrLine>K.U.Leuven, B-3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-300832" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-300832" type="direct"><org type="institution" xml:id="struct-300832" status="VALID">          <orgName>Facultés Universitaires Notre Dame de la Paix (FUNDP) - Namur</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1021/jm0601856</idno>
<series><title level="j">Journal of Medicinal Chemistry</title>
<idno type="ISSN">0022-2623</idno>
<imprint><date type="datePub">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</p>
            </div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities</title>
            <author role="aut">              <persName>                <forename type="first">Christophe</forename>
                <surname>Biot</surname>
              </persName>
              <email type="md5">24d0649ab3920ff9444060dcdf04268d</email>
              <email type="domain">ensc-lille.fr</email>
              <idno type="halauthorid">129769</idno>
              <affiliation ref="#struct-3209"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Wassim</forename>
                <surname>Daher</surname>
              </persName>
              <idno type="halauthorid">113556</idno>
              <affiliation ref="#struct-2906"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Natascha</forename>
                <surname>Chavain</surname>
              </persName>
              <idno type="halauthorid">128614</idno>
              <affiliation ref="#struct-3209"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Thierry</forename>
                <surname>Fandeur</surname>
              </persName>
              <idno type="halauthorid">120623</idno>
              <affiliation ref="#struct-20673"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Jamal</forename>
                <surname>Khalife</surname>
              </persName>
              <idno type="halauthorid">113564</idno>
              <affiliation ref="#struct-2906"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Daniel</forename>
                <surname>Dive</surname>
              </persName>
              <idno type="halauthorid">113560</idno>
              <affiliation ref="#struct-2906"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Erik</forename>
                <surname>De Clercq</surname>
              </persName>
              <idno type="halauthorid">131131</idno>
              <affiliation ref="#struct-20675"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Christophe</forename>
                <surname>Biot</surname>
              </persName>
              <email type="md5">24d0649ab3920ff9444060dcdf04268d</email>
              <email type="domain">ensc-lille.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2006-09-26 13:50:57</date>
              <date type="whenModified">2020-03-17 02:26:31</date>
              <date type="whenReleased">2006-09-26 15:19:06</date>
              <date type="whenProduced">2006</date>
              <date type="whenEndEmbargoed">2006-09-26</date>
              <ref type="file" target="https://hal.archives-ouvertes.fr/hal-00099876/document">                <date notBefore="2006-09-26"></date>
              </ref>
              <ref type="file" n="1" target="https://hal.archives-ouvertes.fr/hal-00099876/file/Biot_BA-JMC-2006-revised-version.pdf">                <date notBefore="2006-09-26"></date>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-00099876/file/Biot_BA-JMC-2006-revised-version.pdf"></ref>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="113195">                <persName>                  <forename>Christophe</forename>
                  <surname>Biot</surname>
                </persName>
                <email type="md5">24d0649ab3920ff9444060dcdf04268d</email>
                <email type="domain">ensc-lille.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00099876</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00099876</idno>
            <idno type="halBibtex">biot:hal-00099876</idno>
            <idno type="halRefHtml">Journal of Medicinal Chemistry, American Chemical Society, 2006, 49, pp.2845. ⟨10.1021/jm0601856⟩</idno>
            <idno type="halRef">Journal of Medicinal Chemistry, American Chemical Society, 2006, 49, pp.2845. ⟨10.1021/jm0601856⟩</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="UCCS">Unité de Catalyse et de Chimie du Solide</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="EC-LILLE">Ecole Centrale de Lille</idno>
            <idno type="stamp" n="ENSC-LILLE">Ecole Nationale Supérieure de Chimie de Lille</idno>
            <idno type="stamp" n="RIIP_LILLE">Institut Pasteur de Lille</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIV-ARTOIS">Université d'Artois</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno>
            <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities</title>
                <author role="aut">                  <persName>                    <forename type="first">Christophe</forename>
                    <surname>Biot</surname>
                  </persName>
                  <email type="md5">24d0649ab3920ff9444060dcdf04268d</email>
                  <email type="domain">ensc-lille.fr</email>
                  <idno type="halauthorid">129769</idno>
                  <affiliation ref="#struct-3209"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Wassim</forename>
                    <surname>Daher</surname>
                  </persName>
                  <idno type="halauthorid">113556</idno>
                  <affiliation ref="#struct-2906"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Natascha</forename>
                    <surname>Chavain</surname>
                  </persName>
                  <idno type="halauthorid">128614</idno>
                  <affiliation ref="#struct-3209"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Thierry</forename>
                    <surname>Fandeur</surname>
                  </persName>
                  <idno type="halauthorid">120623</idno>
                  <affiliation ref="#struct-20673"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Jamal</forename>
                    <surname>Khalife</surname>
                  </persName>
                  <idno type="halauthorid">113564</idno>
                  <affiliation ref="#struct-2906"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Daniel</forename>
                    <surname>Dive</surname>
                  </persName>
                  <idno type="halauthorid">113560</idno>
                  <affiliation ref="#struct-2906"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Erik</forename>
                    <surname>De Clercq</surname>
                  </persName>
                  <idno type="halauthorid">131131</idno>
                  <affiliation ref="#struct-20675"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">15785</idno>
                <idno type="issn">0022-2623</idno>
                <idno type="eissn">1520-4804</idno>
                <title level="j">Journal of Medicinal Chemistry</title>
                <imprint>                  <publisher>American Chemical Society</publisher>
                  <biblScope unit="volume">49</biblScope>
                  <biblScope unit="pp">2845</biblScope>
                  <date type="datePub">2006</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1021/jm0601856</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="chim.ther">Chemical Sciences/Medicinal Chemistry</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Hal/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000181 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000181 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Hal
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Hal:hal-00099876
   |texte=   Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri