SrasV1, France, Analysis, bibRecord, 000403

Effects of GSM-900 microwaves on DMBA-induced mammary gland tumors in female Sprague Dawley rats

Identifieur interne : 000403 ( France/Analysis ); précédent : 000402; suivant : 000404

Effects of GSM-900 microwaves on DMBA-induced mammary gland tumors in female Sprague Dawley rats

Auteurs : R. Anane [France] ; P. E. Dulou [France] ; M. Taxile [France] ; M. Geffard [France] ; F. L. Crespeau ; B. Veyret [France]

Source :

RBID : Hal:hal-00337462

Abstract

The aim of this investigation was to test the hypothesis that sub-chronic whole-body exposure to GSM-900 microwaves had an effect on tumor promotion and progression. Mammary tumors were induced by ingestion of a single 10-mg dose of 7,12-dimethylbenz(a)anthracene (DMBA) in female Sprague-Dawley rats (Ico:OFA-SD; IOPS Caw). In two independent experiments, DMBA-treated animals were divided into four groups: sham-exposed (16) and exposed (three groups of 16 animals). The specific absorption rates (SARs), averaged over the whole body, were 3.5, 2.2 and 1.4 W/kg in the first experiment (May-July) and 1.4, 0.7 and 0.1 W/kg in the second experiment (September-November). Exposure started 10 days after DMBA treatment and lasted 2 h/day, 5 days/week for 9 weeks. Animals were exposed to plane waves with the electric field parallel to the long axis of the animals. Body weight and the number, location and size of the tumors were recorded at regular intervals. Rats were killed humanely 3 weeks after the end of exposure. The results are negative in terms of latency, multiplicity and tumor volume. With regard to tumor incidence, in the first experiment there was an increase in the rate of incidence at 1.4 W/kg but less at 2.2 W/kg and none at 3.5 W/kg. Overall, these results, which are rather inconsistent, do not bring new evidence of a co-promoting effect of exposure to GSM-900 signals using the DMBA rat model

Url:

https://hal.archives-ouvertes.fr/hal-00337462

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000051
to stream Hal, to step Curation: 000051
to stream Hal, to step Checkpoint: 000196
to stream Main, to step Merge: 006935
to stream Main, to step Curation: 006423
to stream Main, to step Exploration: 006423
to stream France, to step Extraction: 000403

Links to Exploration step

Hal:hal-00337462

Le document en format XML

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</author>
<author><name sortKey="Veyret, B" sort="Veyret, B" uniqKey="Veyret B" first="B." last="Veyret">B. Veyret</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-689" status="OLD">          <orgName>Laboratoire de physique des interactions ondes matières</orgName>
          <orgName type="acronym">LPIOM</orgName>
          <desc>            <address>              <addrLine>16 Avenue Pey Berland 33607 PESSAC CEDEX</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.piom.u-bordeaux.fr</ref>
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          <desc>            <address>              <addrLine>351 cours de la Libération - 33405 Talence cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-bordeaux1.fr</ref>
          </desc>
        </org>
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<tutelle active="#struct-300061" type="direct"><org type="institution" xml:id="struct-300061" status="VALID">          <orgName>ENSCPB</orgName>
          <desc>            <address>              <country key="FR"></country>
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<tutelle name="UMR5501" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
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<country>France</country>
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<front><div type="abstract" xml:lang="en">              <p>The aim of this investigation was to test the hypothesis that sub-chronic whole-body exposure to GSM-900 microwaves had an effect on tumor promotion and progression. Mammary tumors were induced by ingestion of a single 10-mg dose of 7,12-dimethylbenz(a)anthracene (DMBA) in female Sprague-Dawley rats (Ico:OFA-SD; IOPS Caw). In two independent experiments, DMBA-treated animals were divided into four groups: sham-exposed (16) and exposed (three groups of 16 animals). The specific absorption rates (SARs), averaged over the whole body, were 3.5, 2.2 and 1.4 W/kg in the first experiment (May-July) and 1.4, 0.7 and 0.1 W/kg in the second experiment (September-November). Exposure started 10 days after DMBA treatment and lasted 2 h/day, 5 days/week for 9 weeks. Animals were exposed to plane waves with the electric field parallel to the long axis of the animals. Body weight and the number, location and size of the tumors were recorded at regular intervals. Rats were killed humanely 3 weeks after the end of exposure. The results are negative in terms of latency, multiplicity and tumor volume. With regard to tumor incidence, in the first experiment there was an increase in the rate of incidence at 1.4 W/kg but less at 2.2 W/kg and none at 3.5 W/kg. Overall, these results, which are rather inconsistent, do not bring new evidence of a co-promoting effect of exposure to GSM-900 signals using the DMBA rat model</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Crespeau, F L" sort="Crespeau, F L" uniqKey="Crespeau F" first="F. L." last="Crespeau">F. L. Crespeau</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Anane, R" sort="Anane, R" uniqKey="Anane R" first="R." last="Anane">R. Anane</name>
</noRegion>
<name sortKey="Dulou, P E" sort="Dulou, P E" uniqKey="Dulou P" first="P. E." last="Dulou">P. E. Dulou</name>
<name sortKey="Geffard, M" sort="Geffard, M" uniqKey="Geffard M" first="M." last="Geffard">M. Geffard</name>
<name sortKey="Taxile, M" sort="Taxile, M" uniqKey="Taxile M" first="M." last="Taxile">M. Taxile</name>
<name sortKey="Veyret, B" sort="Veyret, B" uniqKey="Veyret B" first="B." last="Veyret">B. Veyret</name>
</country>
</tree>
</affiliations>
</record>

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Effects of GSM-900 microwaves on DMBA-induced mammary gland tumors in female Sprague Dawley rats

Effects of GSM-900 microwaves on DMBA-induced mammary gland tumors in female Sprague Dawley rats

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