Master Regulator Analysis of the SARS-CoV-2/Human Interactome.
Identifieur interne : 000491 ( 2020/Analysis ); précédent : 000490; suivant : 000492Master Regulator Analysis of the SARS-CoV-2/Human Interactome.
Auteurs : Pietro H. Guzzi [Italie] ; Daniele Mercatelli [Italie] ; Carmine Ceraolo [Italie] ; Federico M. Giorgi [Italie]Source :
- Journal of clinical medicine [ 2077-0383 ] ; 2020.
Abstract
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.
DOI: 10.3390/jcm9040982
PubMed: 32244779
Affiliations:
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Guzzi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical and Medical Science, University of Catanzaro, 88100 Catanzaro</wicri:regionArea><wicri:noRegion>88100 Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Mercatelli, Daniele" sort="Mercatelli, Daniele" uniqKey="Mercatelli D" first="Daniele" last="Mercatelli">Daniele Mercatelli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna</wicri:regionArea><wicri:noRegion>40126 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ceraolo, Carmine" sort="Ceraolo, Carmine" uniqKey="Ceraolo C" first="Carmine" last="Ceraolo">Carmine Ceraolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna</wicri:regionArea><wicri:noRegion>40126 Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Giorgi, Federico M" sort="Giorgi, Federico M" uniqKey="Giorgi F" first="Federico M" last="Giorgi">Federico M. Giorgi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna</wicri:regionArea><wicri:noRegion>40126 Bologna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of clinical medicine</title><idno type="ISSN">2077-0383</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Guzzi, Pietro H" sort="Guzzi, Pietro H" uniqKey="Guzzi P" first="Pietro H" last="Guzzi">Pietro H. Guzzi</name></noRegion><name sortKey="Ceraolo, Carmine" sort="Ceraolo, Carmine" uniqKey="Ceraolo C" first="Carmine" last="Ceraolo">Carmine Ceraolo</name><name sortKey="Giorgi, Federico M" sort="Giorgi, Federico M" uniqKey="Giorgi F" first="Federico M" last="Giorgi">Federico M. Giorgi</name><name sortKey="Mercatelli, Daniele" sort="Mercatelli, Daniele" uniqKey="Mercatelli D" first="Daniele" last="Mercatelli">Daniele Mercatelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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