Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
Identifieur interne : 000315 ( 2020/Analysis ); précédent : 000314; suivant : 000316Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence
Auteurs : Yu-Chen Cao [République populaire de Chine] ; Qi-Xin Deng [République populaire de Chine] ; Shi-Xue Dai [République populaire de Chine]Source :
- Travel Medicine and Infectious Disease [ 1477-8939 ] ; 2020.
Abstract
The novel coronavirus infection that initially found at the end of 2019 has attracted great attention. So far, the number of infectious cases has increased globally to more than 100 thousand and the outbreak has been defined as a pandemic situation, but there are still no “specific drug” available. Relevant reports have pointed out the novel coronavirus has 80% homology with SARS. In the difficulty where new synthesized drug cannot be applied immediately to patients, “conventional drug in new use” becomes a feasible solution. The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). We started from the structure, immunogenicity, and pathogenesis of coronavirus infections of the novel coronavirus. Further, we analyzed the pharmacological actions and previous trials of remdesivir to identify the feasibility of conducting experiments on COVID-19.
Url:
DOI: 10.1016/j.tmaid.2020.101647
PubMed: 32247927
PubMed Central: 7151266
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001895
- to stream Pmc, to step Curation: 001895
- to stream Pmc, to step Checkpoint: 000104
- to stream PubMed, to step Corpus: 000350
- to stream PubMed, to step Curation: 000350
- to stream PubMed, to step Checkpoint: 000263
- to stream Ncbi, to step Merge: 003748
- to stream Ncbi, to step Curation: 003748
- to stream Ncbi, to step Checkpoint: 003748
- to stream Main, to step Merge: 000315
- to stream Main, to step Curation: 000315
- to stream Main, to step Exploration: 000315
- to stream 2020, to step Extraction: 000315
Links to Exploration step
PMC:7151266Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence</title>
<author><name sortKey="Cao, Yu Chen" sort="Cao, Yu Chen" uniqKey="Cao Y" first="Yu-Chen" last="Cao">Yu-Chen Cao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deng, Qi Xin" sort="Deng, Qi Xin" uniqKey="Deng Q" first="Qi-Xin" last="Deng">Qi-Xin Deng</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dai, Shi Xue" sort="Dai, Shi Xue" uniqKey="Dai S" first="Shi-Xue" last="Dai">Shi-Xue Dai</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32247927</idno>
<idno type="pmc">7151266</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151266</idno>
<idno type="RBID">PMC:7151266</idno>
<idno type="doi">10.1016/j.tmaid.2020.101647</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">001895</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001895</idno>
<idno type="wicri:Area/Pmc/Curation">001895</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001895</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000104</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000104</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:32247927</idno>
<idno type="wicri:Area/PubMed/Corpus">000350</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000350</idno>
<idno type="wicri:Area/PubMed/Curation">000350</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000350</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000263</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000263</idno>
<idno type="wicri:Area/Ncbi/Merge">003748</idno>
<idno type="wicri:Area/Ncbi/Curation">003748</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003748</idno>
<idno type="wicri:doubleKey">1477-8939:2020:Cao Y:remdesivir:for:severe</idno>
<idno type="wicri:Area/Main/Merge">000315</idno>
<idno type="wicri:Area/Main/Curation">000315</idno>
<idno type="wicri:Area/Main/Exploration">000315</idno>
<idno type="wicri:Area/2020/Extraction">000315</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence</title>
<author><name sortKey="Cao, Yu Chen" sort="Cao, Yu Chen" uniqKey="Cao Y" first="Yu-Chen" last="Cao">Yu-Chen Cao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deng, Qi Xin" sort="Deng, Qi Xin" uniqKey="Deng Q" first="Qi-Xin" last="Deng">Qi-Xin Deng</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dai, Shi Xue" sort="Dai, Shi Xue" uniqKey="Dai S" first="Shi-Xue" last="Dai">Shi-Xue Dai</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong</wicri:regionArea>
<wicri:noRegion>Guangdong</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Travel Medicine and Infectious Disease</title>
<idno type="ISSN">1477-8939</idno>
<idno type="eISSN">1873-0442</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The novel coronavirus infection that initially found at the end of 2019 has attracted great attention. So far, the number of infectious cases has increased globally to more than 100 thousand and the outbreak has been defined as a pandemic situation, but there are still no “specific drug” available. Relevant reports have pointed out the novel coronavirus has 80% homology with SARS. In the difficulty where new synthesized drug cannot be applied immediately to patients, “conventional drug in new use” becomes a feasible solution. The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). We started from the structure, immunogenicity, and pathogenesis of coronavirus infections of the novel coronavirus. Further, we analyzed the pharmacological actions and previous trials of remdesivir to identify the feasibility of conducting experiments on COVID-19.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name>
</author>
<author><name sortKey="Morse, J S" uniqKey="Morse J">J.S. Morse</name>
</author>
<author><name sortKey="Lalonde, T" uniqKey="Lalonde T">T. Lalonde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="W, M" uniqKey="W M">M. W</name>
</author>
<author><name sortKey="C, R" uniqKey="C R">R. C</name>
</author>
<author><name sortKey="Z, L" uniqKey="Z L">L. Z</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="L, H" uniqKey="L H">H. L</name>
</author>
<author><name sortKey="W, Ym" uniqKey="W Y">Ym W</name>
</author>
<author><name sortKey="X, Jy" uniqKey="X J">Jy X</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name>
</author>
<author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name>
</author>
<author><name sortKey="He, Y" uniqKey="He Y">Y. He</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, P" uniqKey="Zhou P">P. Zhou</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qiu, T" uniqKey="Qiu T">T. Qiu</name>
</author>
<author><name sortKey="Mao, T" uniqKey="Mao T">T. Mao</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, M" uniqKey="Hoffmann M">M. Hoffmann</name>
</author>
<author><name sortKey="Kleine Weber, H" uniqKey="Kleine Weber H">H. Kleine-Weber</name>
</author>
<author><name sortKey="Kruger, N" uniqKey="Kruger N">N. Krüger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name>
</author>
<author><name sortKey="Chen, P" uniqKey="Chen P">P. Chen</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, P" uniqKey="Zhou P">P. Zhou</name>
</author>
<author><name sortKey="Yang, X L" uniqKey="Yang X">X.L. Yang</name>
</author>
<author><name sortKey="Wang, X G" uniqKey="Wang X">X.G. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wrapp, D" uniqKey="Wrapp D">D. Wrapp</name>
</author>
<author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name>
</author>
<author><name sortKey="Corbett, K S" uniqKey="Corbett K">K.S. Corbett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name>
</author>
<author><name sortKey="Yuan, S" uniqKey="Yuan S">S. Yuan</name>
</author>
<author><name sortKey="Kok, K" uniqKey="Kok K">K. Kok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fan, C" uniqKey="Fan C">C. Fan</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K. Li</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
<author><name sortKey="Kang, Z" uniqKey="Kang Z">Z. Kang</name>
</author>
<author><name sortKey="Gong, H" uniqKey="Gong H">H. Gong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, C K" uniqKey="Wong C">C.K. Wong</name>
</author>
<author><name sortKey="Lam, C W K" uniqKey="Lam C">C.W.K. Lam</name>
</author>
<author><name sortKey="Wu, A K L" uniqKey="Wu A">A.K.L. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahallawi, W H" uniqKey="Mahallawi W">W.H. Mahallawi</name>
</author>
<author><name sortKey="Khabour, O F" uniqKey="Khabour O">O.F. Khabour</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z. Xu</name>
</author>
<author><name sortKey="Shi, L" uniqKey="Shi L">L. Shi</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, L" uniqKey="Zou L">L. Zou</name>
</author>
<author><name sortKey="Ruan, F" uniqKey="Ruan F">F. Ruan</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="L, Mk" uniqKey="L M">Mk L</name>
</author>
<author><name sortKey="F, F" uniqKey="F F">F. F</name>
</author>
<author><name sortKey="Jm, G" uniqKey="Jm G">G. Jm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cj, G" uniqKey="Cj G">G. Cj</name>
</author>
<author><name sortKey="Ep, T" uniqKey="Ep T">T. Ep</name>
</author>
<author><name sortKey="Jy, F" uniqKey="Jy F">F. Jy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tp, S" uniqKey="Tp S">S. Tp</name>
</author>
<author><name sortKey="Ac, S" uniqKey="Ac S">S. Ac</name>
</author>
<author><name sortKey="Sr, L" uniqKey="Sr L">L. Sr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F. Feldmann</name>
</author>
<author><name sortKey="Cronin, J" uniqKey="Cronin J">J. Cronin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warren, T" uniqKey="Warren T">T. Warren</name>
</author>
<author><name sortKey="Jordan, R" uniqKey="Jordan R">R. Jordan</name>
</author>
<author><name sortKey="Lo, M" uniqKey="Lo M">M. Lo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Appendix" uniqKey="Appendix">Appendix 4</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="M, S" uniqKey="M S">S. M</name>
</author>
<author><name sortKey="D, Le" uniqKey="D L">Le D</name>
</author>
<author><name sortKey="D, Rt" uniqKey="D R">Rt D</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="B, L" uniqKey="B L">L. B</name>
</author>
<author><name sortKey="C, Ds" uniqKey="C D">Ds C</name>
</author>
<author><name sortKey="J, Km" uniqKey="J K">Km J</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="W, Tk" uniqKey="W T">Tk W</name>
</author>
<author><name sortKey="J, R" uniqKey="J R">R. J</name>
</author>
<author><name sortKey="L, Mk" uniqKey="L M">Mk L</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jordan, P C" uniqKey="Jordan P">P.C. Jordan</name>
</author>
<author><name sortKey="Stevens, S K" uniqKey="Stevens S">S.K. Stevens</name>
</author>
<author><name sortKey="Deval, J" uniqKey="Deval J">J. Deval</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, J Y" uniqKey="Kim J">J.Y. Kim</name>
</author>
<author><name sortKey="Choe, P G" uniqKey="Choe P">P.G. Choe</name>
</author>
<author><name sortKey="Oh, Y" uniqKey="Oh Y">Y. Oh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Yang, W" uniqKey="Yang W">W. Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="A, Ja" uniqKey="A J">Ja A</name>
</author>
<author><name sortKey="A, Ah" uniqKey="A A">Ah A</name>
</author>
<author><name sortKey="M, Za" uniqKey="M Z">Za M</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pedersen, N C" uniqKey="Pedersen N">N.C. Pedersen</name>
</author>
<author><name sortKey="Perron, M" uniqKey="Perron M">M. Perron</name>
</author>
<author><name sortKey="Bannasch, M" uniqKey="Bannasch M">M. Bannasch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ml, A" uniqKey="Ml A">A. Ml</name>
</author>
<author><name sortKey="El, A" uniqKey="El A">A. El</name>
</author>
<author><name sortKey="Ac, S" uniqKey="Ac S">S. Ac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="C, A" uniqKey="C A">A. C</name>
</author>
<author><name sortKey="S, Ol" uniqKey="S O">Ol S</name>
</author>
<author><name sortKey="B, T" uniqKey="B T">T. B</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Cao, Yu Chen" sort="Cao, Yu Chen" uniqKey="Cao Y" first="Yu-Chen" last="Cao">Yu-Chen Cao</name>
</noRegion>
<name sortKey="Dai, Shi Xue" sort="Dai, Shi Xue" uniqKey="Dai S" first="Shi-Xue" last="Dai">Shi-Xue Dai</name>
<name sortKey="Deng, Qi Xin" sort="Deng, Qi Xin" uniqKey="Deng Q" first="Qi-Xin" last="Deng">Qi-Xin Deng</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000315 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd -nk 000315 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= 2020 |étape= Analysis |type= RBID |clé= PMC:7151266 |texte= Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/2020/Analysis/RBID.i -Sk "pubmed:32247927" \ | HfdSelect -Kh $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |