Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine.
Identifieur interne : 001245 ( PubMed/Curation ); précédent : 001244; suivant : 001246Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine.
Auteurs : Christopher Zamani [États-Unis] ; Jared D. Elzey ; James Ek HildrethSource :
- HIV/AIDS (Auckland, N.Z.) [ 1179-1373 ] ; 2013.
Abstract
After decades of research, AIDS continues to be a major pandemic and to date, adaptive immunity vaccine designs have had little to no success. Data indicate the alloimmune response is a potent mitigator of human immunodeficiency virus (HIV) infection, for which experiments of nature should be demonstrable to justify pursuit of an alloimmune vaccine strategy. We sought to determine if large-scale alloimmune diversity correlates with lower HIV infection rates.
DOI: 10.2147/HIV.S38922
PubMed: 23610530
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<author><name sortKey="Zamani, Christopher" sort="Zamani, Christopher" uniqKey="Zamani C" first="Christopher" last="Zamani">Christopher Zamani</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for AIDS Health Disparities Research at Meharry Medical College, Nashville, Tennessee, USA.</nlm:affiliation>
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<author><name sortKey="Zamani, Christopher" sort="Zamani, Christopher" uniqKey="Zamani C" first="Christopher" last="Zamani">Christopher Zamani</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for AIDS Health Disparities Research at Meharry Medical College, Nashville, Tennessee, USA.</nlm:affiliation>
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<series><title level="j">HIV/AIDS (Auckland, N.Z.)</title>
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<front><div type="abstract" xml:lang="en">After decades of research, AIDS continues to be a major pandemic and to date, adaptive immunity vaccine designs have had little to no success. Data indicate the alloimmune response is a potent mitigator of human immunodeficiency virus (HIV) infection, for which experiments of nature should be demonstrable to justify pursuit of an alloimmune vaccine strategy. We sought to determine if large-scale alloimmune diversity correlates with lower HIV infection rates.</div>
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<Title>HIV/AIDS (Auckland, N.Z.)</Title>
<ISOAbbreviation>HIV AIDS (Auckl)</ISOAbbreviation>
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<ArticleTitle>Greater ethnic diversity correlates with lower HIV prevalence in Africa: justification for an alloimmunity vaccine.</ArticleTitle>
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<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">After decades of research, AIDS continues to be a major pandemic and to date, adaptive immunity vaccine designs have had little to no success. Data indicate the alloimmune response is a potent mitigator of human immunodeficiency virus (HIV) infection, for which experiments of nature should be demonstrable to justify pursuit of an alloimmune vaccine strategy. We sought to determine if large-scale alloimmune diversity correlates with lower HIV infection rates.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using published data of African linguistic groups to determine sub-Saharan country ethnicity profiles as a proxy for human leukocyte antigen (HLA) diversity, a correlation analysis was performed against respective sub-Saharan country HIV infection rates. Ethnicity data from 37 sub-Saharan nations in 2003 and from 38 nations in 2005 were used to calculate the Meyers-Macintosh ethnic diversity score for each nation as the independent variable. World Health Organization data on HIV infection rates for the same countries were used as the dependent variable. The main outcome measure was the correlation coefficient of ethnic diversity versus HIV infection rate.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A SIGNIFICANT NEGATIVE CORRELATION WAS SHOWN BETWEEN ETHNIC DIVERSITY AND HIV INFECTION: for 2003 data, -0.4586 (two-tailed P-value of 0.0043); and, for 2005 data, -0.3866 (two-tailed P-value of 0.0165).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In conjunction with substantial evidence that alloimmunity confers protection against HIV transmission and recent work identifying specific anti-HIV mechanisms, this analysis strongly justifies an HLA-based alloimmune vaccine strategy against HIV.</AbstractText>
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<Author ValidYN="Y"><LastName>Hildreth</LastName>
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<Acronym>RR</Acronym>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Virol. 2007 Dec;81(24):13346-53</RefSource>
<PMID Version="1">17928335</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 1992 Dec 18;258(5090):1935-8</RefSource>
<PMID Version="1">1470916</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunology. 1994 Oct;83(2):213-20</RefSource>
<PMID Version="1">7835937</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2003 Nov;19(11):957-65</RefSource>
<PMID Version="1">14678602</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Allergy Clin Immunol. 2007 Dec;120(6):1418-24</RefSource>
<PMID Version="1">17868797</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Biol. 1991 Jun;63(3):273-307</RefSource>
<PMID Version="1">1905266</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2005 Jan 26;15(2):166-70</RefSource>
<PMID Version="1">15668174</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Acquir Immune Defic Syndr. 2001 Jul 1;27(3):277-80</RefSource>
<PMID Version="1">11464148</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2004 Aug 13;279(33):34083-6</RefSource>
<PMID Version="1">15215254</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Exp Immunol. 2002 Sep;129(3):493-501</RefSource>
<PMID Version="1">12197891</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2009 Mar 19;113(12):2673-83</RefSource>
<PMID Version="1">19176319</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2007 Aug 1;179(3):1969-78</RefSource>
<PMID Version="1">17641064</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biochem. 2006 Jul;140(1):13-21</RefSource>
<PMID Version="1">16877764</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Retrovirology. 2005 May 29;2:37</RefSource>
<PMID Version="1">15921532</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Feb 14;363(9408):503-4</RefSource>
<PMID Version="1">14975608</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1991 Oct 3;353(6343):393</RefSource>
<PMID Version="1">1815549</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2006 Nov 15;177(10 ):6588-92</RefSource>
<PMID Version="1">17082569</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2000 Mar 1;16(4):309-13</RefSource>
<PMID Version="1">10716368</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2008 May;38(5):1423-34</RefSource>
<PMID Version="1">18425730</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Immunol. 2001 Sep;62(9):937-48</RefSource>
<PMID Version="1">11543896</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10592-7</RefSource>
<PMID Version="1">12947040</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2002 Jul 20;18(11):741-6</RefSource>
<PMID Version="1">12167265</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2005 May 5;435(7038):108-14</RefSource>
<PMID Version="1">15829920</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 2005 Jan 27;433(7024):430-3</RefSource>
<PMID Version="1">15674295</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Jun 26;363(9427):2137-9</RefSource>
<PMID Version="1">15220037</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Reprod. 2006 Feb;21(2):429-35</RefSource>
<PMID Version="1">16210388</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Gen Virol. 2005 Aug;86(Pt 8):2231-8</RefSource>
<PMID Version="1">16033970</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1999 Sep;5(9):1004-9</RefSource>
<PMID Version="1">10470076</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunol Today. 1999 Feb;20(2):66-71</RefSource>
<PMID Version="1">10098324</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Virol. 2009 Jan;83(2):512-21</RefSource>
<PMID Version="1">18987139</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2006 Dec 25;203(13):2887-93</RefSource>
<PMID Version="1">17145955</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Feb 14;363(9408):518-24</RefSource>
<PMID Version="1">14975614</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2009 Dec 3;361(23):2209-20</RefSource>
<PMID Version="1">19843557</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2008 Nov 29;372(9653):1881-93</RefSource>
<PMID Version="1">19012954</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Biol. 2003 Feb 18;13(4):R134-6</RefSource>
<PMID Version="1">12593814</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 1990 Feb;46(2):383-92</RefSource>
<PMID Version="1">2105642</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Exp Immunol. 2006 Mar;143(3):435-44</RefSource>
<PMID Version="1">16487242</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 2009 Jul;39(7):1956-65</RefSource>
<PMID Version="1">19585516</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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