Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.
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Auteurs : Susan H. Eshleman [États-Unis] ; Sarah E. Hudelson ; Andrew D. Redd ; Ronald Swanstrom ; San-San Ou ; Xinyi Cindy Zhang ; Li-Hua Ping ; Estelle Piwowar-Manning ; Stephen F. Porcella ; Matthew F. Sievers ; Craig A. Martens ; Daniel Bruno ; Elena Dukhovlinova ; Marybeth Mccauley ; Theresa Gamble ; Jessica M. Fogel ; Devin Sabin ; Thomas C. Quinn ; Laurence Gunde ; Madalitso Maliwichi ; Nehemiah Nhando ; Victor Akelo ; Sikhulile Moyo ; Ravindre Panchia ; Nagalingeswaran Kumarasamy ; Nuntisa Chotirosniramit ; Marineide Gonçalves De Melo ; Jose Pilotto ; Beatriz Grinsztejn ; Kenneth Mayer ; Ying Q. Chen ; James P. Hughes ; Myron S. CohenSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2017.
Abstract
HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.
DOI: 10.1097/QAI.0000000000001158
PubMed: 27532476
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.</title><author><name sortKey="Eshleman, Susan H" sort="Eshleman, Susan H" uniqKey="Eshleman S" first="Susan H" last="Eshleman">Susan H. Eshleman</name><affiliation wicri:level="2"><nlm:affiliation>*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Hudelson, Sarah E" sort="Hudelson, Sarah E" uniqKey="Hudelson S" first="Sarah E" last="Hudelson">Sarah E. 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Porcella</name></author><author><name sortKey="Sievers, Matthew F" sort="Sievers, Matthew F" uniqKey="Sievers M" first="Matthew F" last="Sievers">Matthew F. Sievers</name></author><author><name sortKey="Martens, Craig A" sort="Martens, Craig A" uniqKey="Martens C" first="Craig A" last="Martens">Craig A. 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Quinn</name></author><author><name sortKey="Gunde, Laurence" sort="Gunde, Laurence" uniqKey="Gunde L" first="Laurence" last="Gunde">Laurence Gunde</name></author><author><name sortKey="Maliwichi, Madalitso" sort="Maliwichi, Madalitso" uniqKey="Maliwichi M" first="Madalitso" last="Maliwichi">Madalitso Maliwichi</name></author><author><name sortKey="Nhando, Nehemiah" sort="Nhando, Nehemiah" uniqKey="Nhando N" first="Nehemiah" last="Nhando">Nehemiah Nhando</name></author><author><name sortKey="Akelo, Victor" sort="Akelo, Victor" uniqKey="Akelo V" first="Victor" last="Akelo">Victor Akelo</name></author><author><name sortKey="Moyo, Sikhulile" sort="Moyo, Sikhulile" uniqKey="Moyo S" first="Sikhulile" last="Moyo">Sikhulile Moyo</name></author><author><name sortKey="Panchia, Ravindre" sort="Panchia, Ravindre" uniqKey="Panchia R" first="Ravindre" last="Panchia">Ravindre Panchia</name></author><author><name sortKey="Kumarasamy, Nagalingeswaran" sort="Kumarasamy, Nagalingeswaran" uniqKey="Kumarasamy N" first="Nagalingeswaran" last="Kumarasamy">Nagalingeswaran Kumarasamy</name></author><author><name sortKey="Chotirosniramit, Nuntisa" sort="Chotirosniramit, Nuntisa" uniqKey="Chotirosniramit N" first="Nuntisa" last="Chotirosniramit">Nuntisa Chotirosniramit</name></author><author><name sortKey="Melo, Marineide Goncalves De" sort="Melo, Marineide Goncalves De" uniqKey="Melo M" first="Marineide Gonçalves De" last="Melo">Marineide Gonçalves De Melo</name></author><author><name sortKey="Pilotto, Jose" sort="Pilotto, Jose" uniqKey="Pilotto J" first="Jose" last="Pilotto">Jose Pilotto</name></author><author><name sortKey="Grinsztejn, Beatriz" sort="Grinsztejn, Beatriz" uniqKey="Grinsztejn B" first="Beatriz" last="Grinsztejn">Beatriz Grinsztejn</name></author><author><name sortKey="Mayer, Kenneth" sort="Mayer, Kenneth" uniqKey="Mayer K" first="Kenneth" last="Mayer">Kenneth Mayer</name></author><author><name sortKey="Chen, Ying Q" sort="Chen, Ying Q" uniqKey="Chen Y" first="Ying Q" last="Chen">Ying Q. Chen</name></author><author><name sortKey="Hughes, James P" sort="Hughes, James P" uniqKey="Hughes J" first="James P" last="Hughes">James P. Hughes</name></author><author><name sortKey="Cohen, Myron S" sort="Cohen, Myron S" uniqKey="Cohen M" first="Myron S" last="Cohen">Myron S. Cohen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27532476</idno><idno type="pmid">27532476</idno><idno type="doi">10.1097/QAI.0000000000001158</idno><idno type="wicri:Area/PubMed/Corpus">000E24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E24</idno><idno type="wicri:Area/PubMed/Curation">000E24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.</title><author><name sortKey="Eshleman, Susan H" sort="Eshleman, Susan H" uniqKey="Eshleman S" first="Susan H" last="Eshleman">Susan H. Eshleman</name><affiliation wicri:level="2"><nlm:affiliation>*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Hudelson, Sarah E" sort="Hudelson, Sarah E" uniqKey="Hudelson S" first="Sarah E" last="Hudelson">Sarah E. Hudelson</name></author><author><name sortKey="Redd, Andrew D" sort="Redd, Andrew D" uniqKey="Redd A" first="Andrew D" last="Redd">Andrew D. Redd</name></author><author><name sortKey="Swanstrom, Ronald" sort="Swanstrom, Ronald" uniqKey="Swanstrom R" first="Ronald" last="Swanstrom">Ronald Swanstrom</name></author><author><name sortKey="Ou, San San" sort="Ou, San San" uniqKey="Ou S" first="San-San" last="Ou">San-San Ou</name></author><author><name sortKey="Zhang, Xinyi Cindy" sort="Zhang, Xinyi Cindy" uniqKey="Zhang X" first="Xinyi Cindy" last="Zhang">Xinyi Cindy Zhang</name></author><author><name sortKey="Ping, Li Hua" sort="Ping, Li Hua" uniqKey="Ping L" first="Li-Hua" last="Ping">Li-Hua Ping</name></author><author><name sortKey="Piwowar Manning, Estelle" sort="Piwowar Manning, Estelle" uniqKey="Piwowar Manning E" first="Estelle" last="Piwowar-Manning">Estelle Piwowar-Manning</name></author><author><name sortKey="Porcella, Stephen F" sort="Porcella, Stephen F" uniqKey="Porcella S" first="Stephen F" last="Porcella">Stephen F. Porcella</name></author><author><name sortKey="Sievers, Matthew F" sort="Sievers, Matthew F" uniqKey="Sievers M" first="Matthew F" last="Sievers">Matthew F. Sievers</name></author><author><name sortKey="Martens, Craig A" sort="Martens, Craig A" uniqKey="Martens C" first="Craig A" last="Martens">Craig A. Martens</name></author><author><name sortKey="Bruno, Daniel" sort="Bruno, Daniel" uniqKey="Bruno D" first="Daniel" last="Bruno">Daniel Bruno</name></author><author><name sortKey="Dukhovlinova, Elena" sort="Dukhovlinova, Elena" uniqKey="Dukhovlinova E" first="Elena" last="Dukhovlinova">Elena Dukhovlinova</name></author><author><name sortKey="Mccauley, Marybeth" sort="Mccauley, Marybeth" uniqKey="Mccauley M" first="Marybeth" last="Mccauley">Marybeth Mccauley</name></author><author><name sortKey="Gamble, Theresa" sort="Gamble, Theresa" uniqKey="Gamble T" first="Theresa" last="Gamble">Theresa Gamble</name></author><author><name sortKey="Fogel, Jessica M" sort="Fogel, Jessica M" uniqKey="Fogel J" first="Jessica M" last="Fogel">Jessica M. Fogel</name></author><author><name sortKey="Sabin, Devin" sort="Sabin, Devin" uniqKey="Sabin D" first="Devin" last="Sabin">Devin Sabin</name></author><author><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C" last="Quinn">Thomas C. Quinn</name></author><author><name sortKey="Gunde, Laurence" sort="Gunde, Laurence" uniqKey="Gunde L" first="Laurence" last="Gunde">Laurence Gunde</name></author><author><name sortKey="Maliwichi, Madalitso" sort="Maliwichi, Madalitso" uniqKey="Maliwichi M" first="Madalitso" last="Maliwichi">Madalitso Maliwichi</name></author><author><name sortKey="Nhando, Nehemiah" sort="Nhando, Nehemiah" uniqKey="Nhando N" first="Nehemiah" last="Nhando">Nehemiah Nhando</name></author><author><name sortKey="Akelo, Victor" sort="Akelo, Victor" uniqKey="Akelo V" first="Victor" last="Akelo">Victor Akelo</name></author><author><name sortKey="Moyo, Sikhulile" sort="Moyo, Sikhulile" uniqKey="Moyo S" first="Sikhulile" last="Moyo">Sikhulile Moyo</name></author><author><name sortKey="Panchia, Ravindre" sort="Panchia, Ravindre" uniqKey="Panchia R" first="Ravindre" last="Panchia">Ravindre Panchia</name></author><author><name sortKey="Kumarasamy, Nagalingeswaran" sort="Kumarasamy, Nagalingeswaran" uniqKey="Kumarasamy N" first="Nagalingeswaran" last="Kumarasamy">Nagalingeswaran Kumarasamy</name></author><author><name sortKey="Chotirosniramit, Nuntisa" sort="Chotirosniramit, Nuntisa" uniqKey="Chotirosniramit N" first="Nuntisa" last="Chotirosniramit">Nuntisa Chotirosniramit</name></author><author><name sortKey="Melo, Marineide Goncalves De" sort="Melo, Marineide Goncalves De" uniqKey="Melo M" first="Marineide Gonçalves De" last="Melo">Marineide Gonçalves De Melo</name></author><author><name sortKey="Pilotto, Jose" sort="Pilotto, Jose" uniqKey="Pilotto J" first="Jose" last="Pilotto">Jose Pilotto</name></author><author><name sortKey="Grinsztejn, Beatriz" sort="Grinsztejn, Beatriz" uniqKey="Grinsztejn B" first="Beatriz" last="Grinsztejn">Beatriz Grinsztejn</name></author><author><name sortKey="Mayer, Kenneth" sort="Mayer, Kenneth" uniqKey="Mayer K" first="Kenneth" last="Mayer">Kenneth Mayer</name></author><author><name sortKey="Chen, Ying Q" sort="Chen, Ying Q" uniqKey="Chen Y" first="Ying Q" last="Chen">Ying Q. Chen</name></author><author><name sortKey="Hughes, James P" sort="Hughes, James P" uniqKey="Hughes J" first="James P" last="Hughes">James P. Hughes</name></author><author><name sortKey="Cohen, Myron S" sort="Cohen, Myron S" uniqKey="Cohen M" first="Myron S" last="Cohen">Myron S. Cohen</name></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="eISSN">1944-7884</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27532476</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1944-7884</ISSN><JournalIssue CitedMedium="Internet"><Volume>74</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of acquired immune deficiency syndromes (1999)</Title><ISOAbbreviation>J. Acquir. Immune Defic. Syndr.</ISOAbbreviation></Journal><ArticleTitle>Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial.</ArticleTitle><Pagination><MedlinePgn>112-116</MedlinePgn></Pagination><Abstract><AbstractText>HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eshleman</LastName><ForeName>Susan H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Laboratory of Immunoregulation, NIAID, NIH, Baltimore, MD; ‡Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC; §Vaccine and Infectious Disease Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‖Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; ¶Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, DIR, NIAID, NIH, Hamilton, MT; #Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; **Science Facilitation Department, FHI360, Washington, DC; ††Science Facilitation Department, FHI360, Durham, NC; ‡‡College of Medicine-Johns Hopkins Project, Blantyre, Malawi; §§UNC Project, Lilongwe, Malawi; ‖‖Department of Medicine, University of Zimbabwe, Harare, Zimbabwe; ¶¶HIV Research Branch, Center for Global Health, Kenya Medical Research Institute (KEMRI)-Centers for Disease Control (CDC), Kisumu, Kenya; ##BHHRL & Clinical Trials Unit, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; ***Soweto HPTN CRS, Chris Hani Baragwanath Hospital, Soweto, South Africa; †††YRGCARE Medical Centre, Chennai, India; ‡‡‡Center for AIDS and STDs, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; §§§Hospital Nossa Senhora da Conceição, Serviço de Infectologia, Porto Alegre, Brazil; ‖‖‖Hospital Geral de Nova Iguaçu and Laboratorio de AIDS e Imunologia Molecular (IOC/Fiocruz), Rio de Janeiro, Brazil; ¶¶¶Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro, Brazil; ###Fenway Health and Infectious Disease Division, The Fenway Institute, Boston, MA; ****Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA; ††††Vaccine and Infectious Disease Division and Public Health Science Division, Fred Hutchinson Cancer Research Institute, Seattle, WA; ‡‡‡‡Department of Biostatistics, University of Washington, Seattle, WA; and §§§§Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudelson</LastName><ForeName>Sarah E</ForeName><Initials>SE</Initials></Author><Author ValidYN="Y"><LastName>Redd</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Swanstrom</LastName><ForeName>Ronald</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Ou</LastName><ForeName>San-San</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xinyi Cindy</ForeName><Initials>XC</Initials></Author><Author ValidYN="Y"><LastName>Ping</LastName><ForeName>Li-Hua</ForeName><Initials>LH</Initials></Author><Author ValidYN="Y"><LastName>Piwowar-Manning</LastName><ForeName>Estelle</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Porcella</LastName><ForeName>Stephen F</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Sievers</LastName><ForeName>Matthew F</ForeName><Initials>MF</Initials></Author><Author ValidYN="Y"><LastName>Martens</LastName><ForeName>Craig A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Bruno</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Dukhovlinova</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>McCauley</LastName><ForeName>Marybeth</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Gamble</LastName><ForeName>Theresa</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Fogel</LastName><ForeName>Jessica M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Sabin</LastName><ForeName>Devin</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Quinn</LastName><ForeName>Thomas C</ForeName><Initials>TC</Initials></Author><Author ValidYN="Y"><LastName>Gunde</LastName><ForeName>Laurence</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Maliwichi</LastName><ForeName>Madalitso</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nhando</LastName><ForeName>Nehemiah</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Akelo</LastName><ForeName>Victor</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Moyo</LastName><ForeName>Sikhulile</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Panchia</LastName><ForeName>Ravindre</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Kumarasamy</LastName><ForeName>Nagalingeswaran</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Chotirosniramit</LastName><ForeName>Nuntisa</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Melo</LastName><ForeName>Marineide Gonçalves de</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Pilotto</LastName><ForeName>Jose</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Grinsztejn</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Mayer</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ying Q</ForeName><Initials>YQ</Initials></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>James P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Myron S</ForeName><Initials>MS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UM1 AI069423</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI069476</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI069424</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI069456</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AI044667</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI069453</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI068619</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI068613</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AI050410</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 AI068617</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Acquir Immune Defic Syndr</MedlineTA><NlmUniqueID>100892005</NlmUniqueID><ISSNLinking>1525-4135</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):125-33</RefSource><PMID 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Version="1">27070123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2007 Nov 12;21(17):2315-21</RefSource><PMID Version="1">18090280</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2011 Dec 15;204(12):1918-26</RefSource><PMID Version="1">21990420</PMID></CommentsCorrections></CommentsCorrectionsList><CoiStatement>Conflict of Interests None of the authors has a financial or personal relationship with other people or organizations that could inappropriately influence (bias) their work. The following relationship is noted: SHE has collaborated with Abbott Diagnostics (distributor of the ViroSeq HIV Genotyping System) on evaluation of HIV-related assays.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>01</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27532476</ArticleId><ArticleId IdType="doi">10.1097/QAI.0000000000001158</ArticleId><ArticleId IdType="pmc">PMC5140698</ArticleId><ArticleId IdType="mid">NIHMS808631</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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