Initiation of antiretroviral therapy among pregnant women in resource-limited countries: CD4+ cell count response and program retention.
Identifieur interne : 000465 ( PubMed/Curation ); précédent : 000464; suivant : 000466Initiation of antiretroviral therapy among pregnant women in resource-limited countries: CD4+ cell count response and program retention.
Auteurs : Patricia L. Toro [États-Unis] ; Monica Katyal ; Rosalind J. Carter ; Landon Myer ; Wafaa M. El-Sadr ; Denis Nash ; Elaine J. AbramsSource :
- AIDS (London, England) [ 1473-5571 ] ; 2010.
Descripteurs français
- KwdFr :
- Accessibilité des services de santé (normes), Adulte, Afrique subsaharienne (épidémiologie), Antirétroviraux (usage thérapeutique), Calendrier d'administration des médicaments, Charge virale, Complications de la grossesse et maladies infectieuses (immunologie), Complications de la grossesse et maladies infectieuses (mortalité), Complications de la grossesse et maladies infectieuses (traitement médicamenteux), Femelle, Femmes enceintes, Grossesse, Humains, Infections à VIH (immunologie), Infections à VIH (mortalité), Infections à VIH (traitement médicamenteux), Mâle, Numération des lymphocytes CD4 (), Pays en voie de développement, Résultat thérapeutique, Sélection de patients, Thaïlande (épidémiologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
- MESH :
- immunologie : Complications de la grossesse et maladies infectieuses, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- mortalité : Complications de la grossesse et maladies infectieuses, Infections à VIH.
- normes : Accessibilité des services de santé.
- traitement médicamenteux : Complications de la grossesse et maladies infectieuses, Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- épidémiologie : Afrique subsaharienne, Thaïlande.
- Adulte, Calendrier d'administration des médicaments, Charge virale, Femelle, Femmes enceintes, Grossesse, Humains, Mâle, Numération des lymphocytes CD4, Pays en voie de développement, Résultat thérapeutique, Sélection de patients, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- Wicri :
- geographic : Thaïlande.
English descriptors
- KwdEn :
- Adult, Africa South of the Sahara (epidemiology), Anti-Retroviral Agents (therapeutic use), CD4 Lymphocyte Count (methods), Developing Countries, Drug Administration Schedule, Female, HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (mortality), HIV-1 (drug effects), HIV-1 (immunology), Health Services Accessibility (standards), Humans, Male, Patient Selection, Pregnancy, Pregnancy Complications, Infectious (drug therapy), Pregnancy Complications, Infectious (immunology), Pregnancy Complications, Infectious (mortality), Pregnant Women, Thailand (epidemiology), Treatment Outcome, Viral Load.
- MESH :
- chemical , therapeutic use : Anti-Retroviral Agents.
- geographic , epidemiology : Africa South of the Sahara, Thailand.
- drug effects : HIV-1.
- drug therapy : HIV Infections, Pregnancy Complications, Infectious.
- immunology : HIV Infections, HIV-1, Pregnancy Complications, Infectious.
- methods : CD4 Lymphocyte Count.
- mortality : HIV Infections, Pregnancy Complications, Infectious.
- standards : Health Services Accessibility.
- Adult, Developing Countries, Drug Administration Schedule, Female, Humans, Male, Patient Selection, Pregnancy, Pregnant Women, Treatment Outcome, Viral Load.
Abstract
Few data are available from resource-limited countries on long-term outcomes of HIV-infected women who initiate antiretroviral therapy (ART) during pregnancy.
DOI: 10.1097/QAD.0b013e3283350ecd
PubMed: 19996939
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pubmed:19996939Le document en format XML
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<term>Pregnancy Complications, Infectious</term>
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<term>Patient Selection</term>
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<term>Treatment Outcome</term>
<term>Viral Load</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Calendrier d'administration des médicaments</term>
<term>Charge virale</term>
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<front><div type="abstract" xml:lang="en">Few data are available from resource-limited countries on long-term outcomes of HIV-infected women who initiate antiretroviral therapy (ART) during pregnancy.</div>
</front>
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<Month>03</Month>
<Day>02</Day>
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<Month>01</Month>
<Day>20</Day>
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<Month>03</Month>
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<Issue>4</Issue>
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<Month>Feb</Month>
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<Title>AIDS (London, England)</Title>
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<ArticleTitle>Initiation of antiretroviral therapy among pregnant women in resource-limited countries: CD4+ cell count response and program retention.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE(S)" NlmCategory="OBJECTIVE">Few data are available from resource-limited countries on long-term outcomes of HIV-infected women who initiate antiretroviral therapy (ART) during pregnancy.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Analysis of data from adult patients enrolled in the MTCT-Plus Initiative who initiated ART between 2003 and 2006 in seven countries in Sub-Saharan Africa and Thailand.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Mean population changes were assessed and multivariable mixed linear regression modeling was used to examine covariate effects on differences in absolute CD4 cell count responses. Kaplan-Meier methods were used to examine program retention combining survival and losses to follow-up.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 2229 individuals initiating ART, 1688 were women, of which 605 were pregnant (median gestational age 7 months), 1083 were not pregnant, and 541 were men. The average CD4 response by 30 months on ART was 451 cells/microl among women who were pregnant at ART initiation as compared with 435 cells/microl among nonpregnant women (P = 0.53) and 349 cells/microl among men (P < 0.001). In multivariable analysis, lower CD4 cell increase was independently associated with male sex, older age, and lower CD4 cell count at initiation. After 30 months on ART retention was 0.85 with no retention differences between pregnant women, nonpregnant women, and men.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">HIV-infected women in resource-limited countries who start ART during pregnancy have similar or better long-term CD4 cell count responses as compared with other adults. These data support efforts to provide pregnant HIV-infected women with access to ART in resource-limited countries.</AbstractText>
</Abstract>
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<ForeName>Patricia L</ForeName>
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<AffiliationInfo><Affiliation>International Center for AIDS Care and Treatment Programs, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY 10032, USA. plt9@columbia.edu</Affiliation>
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<Author ValidYN="Y"><LastName>Katyal</LastName>
<ForeName>Monica</ForeName>
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<Author ValidYN="Y"><LastName>Carter</LastName>
<ForeName>Rosalind J</ForeName>
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<Author ValidYN="Y"><LastName>Myer</LastName>
<ForeName>Landon</ForeName>
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<Author ValidYN="Y"><LastName>El-Sadr</LastName>
<ForeName>Wafaa M</ForeName>
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<Author ValidYN="Y"><LastName>Nash</LastName>
<ForeName>Denis</ForeName>
<Initials>D</Initials>
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<Author ValidYN="Y"><LastName>Abrams</LastName>
<ForeName>Elaine J</ForeName>
<Initials>EJ</Initials>
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<Author ValidYN="Y"><CollectiveName>MTCT-Plus Initiative</CollectiveName>
</Author>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>AIDS</MedlineTA>
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