Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.
Identifieur interne : 001286 ( PubMed/Corpus ); précédent : 001285; suivant : 001287Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.
Auteurs : Helen Van Der Plas ; Graeme Meintjes ; Charlotte Schutz ; Rene Goliath ; Landon Myer ; Dorothea Baatjie ; Robert J. Wilkinson ; Gary Maartens ; Marc MendelsonSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Anti-HIV Agents.
- geographic : South Africa.
- complications : Tuberculosis.
- drug therapy : AIDS-Related Opportunistic Infections.
- chemical , therapeutic use : Anti-HIV Agents.
- Adult, Cohort Studies, Female, Humans, Male, Prospective Studies.
Abstract
HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral therapy initiation may be required. The aim of this study was to document the causes of clinical deterioration of hospitalised patients with HIV-associated tuberculosis starting antiretroviral therapy in order to inform healthcare practice in low- to middle-income countries.
DOI: 10.1371/journal.pone.0054145
PubMed: 23408935
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pubmed:23408935Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.</title><author><name sortKey="Van Der Plas, Helen" sort="Van Der Plas, Helen" uniqKey="Van Der Plas H" first="Helen" last="Van Der Plas">Helen Van Der Plas</name><affiliation><nlm:affiliation>Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa. Helenvanderplas@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Meintjes, Graeme" sort="Meintjes, Graeme" uniqKey="Meintjes G" first="Graeme" last="Meintjes">Graeme Meintjes</name></author><author><name sortKey="Schutz, Charlotte" sort="Schutz, Charlotte" uniqKey="Schutz C" first="Charlotte" last="Schutz">Charlotte Schutz</name></author><author><name sortKey="Goliath, Rene" sort="Goliath, Rene" uniqKey="Goliath R" first="Rene" last="Goliath">Rene Goliath</name></author><author><name sortKey="Myer, Landon" sort="Myer, Landon" uniqKey="Myer L" first="Landon" last="Myer">Landon Myer</name></author><author><name sortKey="Baatjie, Dorothea" sort="Baatjie, Dorothea" uniqKey="Baatjie D" first="Dorothea" last="Baatjie">Dorothea Baatjie</name></author><author><name sortKey="Wilkinson, Robert J" sort="Wilkinson, Robert J" uniqKey="Wilkinson R" first="Robert J" last="Wilkinson">Robert J. Wilkinson</name></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name></author><author><name sortKey="Mendelson, Marc" sort="Mendelson, Marc" uniqKey="Mendelson M" first="Marc" last="Mendelson">Marc Mendelson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23408935</idno><idno type="pmid">23408935</idno><idno type="doi">10.1371/journal.pone.0054145</idno><idno type="wicri:Area/PubMed/Corpus">001286</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001286</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.</title><author><name sortKey="Van Der Plas, Helen" sort="Van Der Plas, Helen" uniqKey="Van Der Plas H" first="Helen" last="Van Der Plas">Helen Van Der Plas</name><affiliation><nlm:affiliation>Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa. Helenvanderplas@gmail.com</nlm:affiliation></affiliation></author><author><name sortKey="Meintjes, Graeme" sort="Meintjes, Graeme" uniqKey="Meintjes G" first="Graeme" last="Meintjes">Graeme Meintjes</name></author><author><name sortKey="Schutz, Charlotte" sort="Schutz, Charlotte" uniqKey="Schutz C" first="Charlotte" last="Schutz">Charlotte Schutz</name></author><author><name sortKey="Goliath, Rene" sort="Goliath, Rene" uniqKey="Goliath R" first="Rene" last="Goliath">Rene Goliath</name></author><author><name sortKey="Myer, Landon" sort="Myer, Landon" uniqKey="Myer L" first="Landon" last="Myer">Landon Myer</name></author><author><name sortKey="Baatjie, Dorothea" sort="Baatjie, Dorothea" uniqKey="Baatjie D" first="Dorothea" last="Baatjie">Dorothea Baatjie</name></author><author><name sortKey="Wilkinson, Robert J" sort="Wilkinson, Robert J" uniqKey="Wilkinson R" first="Robert J" last="Wilkinson">Robert J. Wilkinson</name></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name></author><author><name sortKey="Mendelson, Marc" sort="Mendelson, Marc" uniqKey="Mendelson M" first="Marc" last="Mendelson">Marc Mendelson</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS-Related Opportunistic Infections (drug therapy)</term><term>Adult</term><term>Anti-HIV Agents (adverse effects)</term><term>Anti-HIV Agents (therapeutic use)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Prospective Studies</term><term>South Africa</term><term>Tuberculosis (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>AIDS-Related Opportunistic Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral therapy initiation may be required. The aim of this study was to document the causes of clinical deterioration of hospitalised patients with HIV-associated tuberculosis starting antiretroviral therapy in order to inform healthcare practice in low- to middle-income countries.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23408935</PMID><DateCreated><Year>2013</Year><Month>02</Month><Day>14</Day></DateCreated><DateCompleted><Year>2013</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>2</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.</ArticleTitle><Pagination><MedlinePgn>e54145</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0054145</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral therapy initiation may be required. The aim of this study was to document the causes of clinical deterioration of hospitalised patients with HIV-associated tuberculosis starting antiretroviral therapy in order to inform healthcare practice in low- to middle-income countries.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Prospective, observational cohort study of adult inpatients with HIV-associated tuberculosis starting antiretroviral therapy in a dedicated tuberculosis hospital in Cape Town, South Africa. Causes of clinical deterioration and outcome were recorded in the first 12 weeks of antiretroviral therapy. Patients with rifampicin-resistant tuberculosis were excluded.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Between May 2009 and November 2010, 112 patients (60% female), with a median age of 32 years were enrolled. At baseline the median CD4 count was 55 cells/mm3 (IQR 31-106) and HIV viral load 5.6 log copies/mL. All patients had significant comorbidity: 82% were bed-bound, 65% had disseminated tuberculosis and 27% had central nervous system tuberculosis. Seventy six patients (68%) developed 144 clinical events after starting antiretroviral therapy. TB-IRIS, hospital-acquired infections and significant drug toxicities occurred in 42%, 20.5% and 15% of patients respectively. A new opportunistic disease occurred in 15% of patients and a thromboembolic event in 8%. Mortality during the 12 week period was 10.6%.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">High rates of TB-IRIS, hospital-acquired infections and drug toxicities complicate the course of patients with HIV-associated tuberculosis starting antiretroviral therapy in hospital. Despite the high morbidity, mortality was relatively low. Careful clinical management and adequate resources are needed in hospitalised HIV-TB patients in the 1(st) three months following ART initiation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Plas</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa. Helenvanderplas@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meintjes</LastName><ForeName>Graeme</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Schutz</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Goliath</LastName><ForeName>Rene</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Myer</LastName><ForeName>Landon</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Baatjie</LastName><ForeName>Dorothea</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Wilkinson</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Maartens</LastName><ForeName>Gary</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Mendelson</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U2RTW007970/3</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1U2RTW007373-01A1</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U2RTW007373</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>088316</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U.1175.02.002.00014.01</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>081667</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>02</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2007 Aug 15;196 Suppl 1:S63-75</RefSource><PMID Version="1">17624828</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Infect Control. 2008 Jun;36(5):309-32</RefSource><PMID Version="1">18538699</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Infect Dis. 2008 Aug;8(8):516-23</RefSource><PMID Version="1">18652998</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2008 Oct 1;22(15):1897-908</RefSource><PMID Version="1">18784453</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2009;4(2):e4520</RefSource><PMID Version="1">19229341</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2010 Feb 25;362(8):697-706</RefSource><PMID Version="1">20181971</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2011 Oct 20;365(16):1482-91</RefSource><PMID Version="1">22010914</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Infect Dis. 2010;10:83</RefSource><PMID Version="1">20353569</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2011 Jun 1;25(9):1163-74</RefSource><PMID Version="1">21505297</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(6):e20755</RefSource><PMID Version="1">21738585</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2011 Aug 1;204(3):358-62</RefSource><PMID Version="1">21742833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>S Afr Med J. 2011 Aug;101(8):529-32</RefSource><PMID Version="1">21920125</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2011 Oct 20;365(16):1471-81</RefSource><PMID Version="1">22010913</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet Infect Dis. 2010 Apr;10(4):251-61</RefSource><PMID Version="1">20334848</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D017088" MajorTopicYN="N">AIDS-Related Opportunistic Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV 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