Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.
Identifieur interne : 001152 ( PubMed/Corpus ); précédent : 001151; suivant : 001153Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.
Auteurs : Benjamin H. Chi ; Jeffrey S A. Stringer ; Dhayendre MoodleySource :
- Current HIV/AIDS reports [ 1548-3576 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Africa South of the Sahara (epidemiology), Anti-HIV Agents, Breast Feeding, Child, Child, Preschool, Female, HIV Infections (prevention & control), HIV Infections (transmission), Health Policy, Humans, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical (prevention & control), Infectious Disease Transmission, Vertical (statistics & numerical data), Male, Maternal-Child Health Centers (organization & administration), Mothers, Policy Making, Pregnancy, Pregnancy Complications, Infectious (epidemiology), Pregnancy Complications, Infectious (prevention & control), Program Evaluation.
- MESH :
- chemical : Anti-HIV Agents.
- geographic , epidemiology : Africa South of the Sahara.
- epidemiology : Pregnancy Complications, Infectious.
- organization & administration : Maternal-Child Health Centers.
- prevention & control : HIV Infections, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious.
- statistics & numerical data : Infectious Disease Transmission, Vertical.
- transmission : HIV Infections.
- Adult, Breast Feeding, Child, Child, Preschool, Female, Health Policy, Humans, Infant, Infant, Newborn, Male, Mothers, Policy Making, Pregnancy, Program Evaluation.
Abstract
Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to "virtually eliminate" pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges--and opportunities--of improving health services for HIV-infected mothers and their children across the region.
DOI: 10.1007/s11904-013-0154-z
PubMed: 23440538
Links to Exploration step
pubmed:23440538Le document en format XML
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Stringer</name></author><author><name sortKey="Moodley, Dhayendre" sort="Moodley, Dhayendre" uniqKey="Moodley D" first="Dhayendre" last="Moodley">Dhayendre Moodley</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23440538</idno><idno type="pmid">23440538</idno><idno type="doi">10.1007/s11904-013-0154-z</idno><idno type="wicri:Area/PubMed/Corpus">001152</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001152</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.</title><author><name sortKey="Chi, Benjamin H" sort="Chi, Benjamin H" uniqKey="Chi B" first="Benjamin H" last="Chi">Benjamin H. Chi</name><affiliation><nlm:affiliation>Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. bchi@cidrz.org</nlm:affiliation></affiliation></author><author><name sortKey="Stringer, Jeffrey S A" sort="Stringer, Jeffrey S A" uniqKey="Stringer J" first="Jeffrey S A" last="Stringer">Jeffrey S A. Stringer</name></author><author><name sortKey="Moodley, Dhayendre" sort="Moodley, Dhayendre" uniqKey="Moodley D" first="Dhayendre" last="Moodley">Dhayendre Moodley</name></author></analytic><series><title level="j">Current HIV/AIDS reports</title><idno type="eISSN">1548-3576</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Africa South of the Sahara (epidemiology)</term><term>Anti-HIV Agents</term><term>Breast Feeding</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>HIV Infections (prevention & control)</term><term>HIV Infections (transmission)</term><term>Health Policy</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Infectious Disease Transmission, Vertical (prevention & control)</term><term>Infectious Disease Transmission, Vertical (statistics & numerical data)</term><term>Male</term><term>Maternal-Child Health Centers (organization & administration)</term><term>Mothers</term><term>Policy Making</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (epidemiology)</term><term>Pregnancy Complications, Infectious (prevention & control)</term><term>Program Evaluation</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Africa South of the Sahara</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Maternal-Child Health Centers</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term><term>Infectious Disease Transmission, Vertical</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Infectious Disease Transmission, Vertical</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Breast Feeding</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Health Policy</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Mothers</term><term>Policy Making</term><term>Pregnancy</term><term>Program Evaluation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to "virtually eliminate" pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges--and opportunities--of improving health services for HIV-infected mothers and their children across the region.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23440538</PMID><DateCreated><Year>2013</Year><Month>05</Month><Day>03</Day></DateCreated><DateCompleted><Year>2013</Year><Month>12</Month><Day>10</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1548-3576</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Current HIV/AIDS reports</Title><ISOAbbreviation>Curr HIV/AIDS Rep</ISOAbbreviation></Journal><ArticleTitle>Antiretroviral drug regimens to prevent mother-to-child transmission of HIV: a review of scientific, program, and policy advances for sub-Saharan Africa.</ArticleTitle><Pagination><MedlinePgn>124-33</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11904-013-0154-z</ELocationID><Abstract><AbstractText>Considerable advances have been made in the effort to prevent mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Clinical trials have demonstrated the efficacy of antiretroviral regimens to interrupt HIV transmission through the antenatal, intrapartum, and postnatal periods. Scientific discoveries have been rapidly translated into health policy, bolstered by substantial investment in health infrastructure capable of delivering increasingly complex services. A new scientific agenda is also emerging, one that is focused on the challenges of effective and sustainable program implementation. Finally, global campaigns to "virtually eliminate" pediatric HIV and dramatically reduce HIV-related maternal mortality have mobilized new resources and renewed political will. Each of these developments marks a major step in regional PMTCT efforts; their convergence signals a time of rapid progress in the field, characterized by an increased interdependency between clinical research, program implementation, and policy. In this review, we take stock of recent advances across each of these areas, highlighting the challenges--and opportunities--of improving health services for HIV-infected mothers and their children across the region.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chi</LastName><ForeName>Benjamin H</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. bchi@cidrz.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stringer</LastName><ForeName>Jeffrey S A</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Moodley</LastName><ForeName>Dhayendre</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HD075131</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Curr HIV/AIDS Rep</MedlineTA><NlmUniqueID>101235661</NlmUniqueID><ISSNLinking>1548-3568</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Clin Infect Dis. 2011 Apr 15;52(8):1069-76</RefSource><PMID Version="1">21460326</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2011 Mar;8(3):e1001015</RefSource><PMID Version="1">21468300</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2011 Mar;8(3):e1000430</RefSource><PMID Version="1">21468304</PMID></CommentsCorrections><CommentsCorrections 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Version="1">21237718</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>AIDS. 2011 Mar 27;25(6):767-76</RefSource><PMID Version="1">21330912</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017954" MajorTopicYN="N" Type="Geographic">Africa South of the Sahara</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001942" MajorTopicYN="N">Breast Feeding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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