Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants.
Identifieur interne : 000D23 ( PubMed/Corpus ); précédent : 000D22; suivant : 000D24Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants.
Auteurs : Alexander C. Ewing ; Caroline C. King ; Jeffrey B. Wiener ; Charles S. Chasela ; Michael G. Hudgens ; Debbie Kamwendo ; Gerald Tegha ; Mina C. Hosseinipour ; Denise J. Jamieson ; Charles Van Der Horst ; Athena P. KourtisSource :
- AIDS (London, England) [ 1473-5571 ] ; 2017.
Abstract
Given the potential of cotrimoxazole preventive therapy (CPT) to prevent bacterial and malarial infections in HIV-exposed, uninfected (HEU) infants, it is important to evaluate the effects of its concurrent use with antiretroviral agents that have overlapping toxicity profiles.
DOI: 10.1097/QAD.0000000000001641
PubMed: 28926409
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants.</title><author><name sortKey="Ewing, Alexander C" sort="Ewing, Alexander C" uniqKey="Ewing A" first="Alexander C" last="Ewing">Alexander C. Ewing</name><affiliation><nlm:affiliation>aCenters for Disease Control and Prevention, Atlanta, Georgia, USA bDepartment of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa cUniversity of North Carolina, Chapel Hill, North Carolina, USA dUNC Project, Lilongwe, Malawi.</nlm:affiliation></affiliation></author><author><name sortKey="King, Caroline C" sort="King, Caroline C" uniqKey="King C" first="Caroline C" last="King">Caroline C. King</name></author><author><name sortKey="Wiener, Jeffrey B" sort="Wiener, Jeffrey B" uniqKey="Wiener J" first="Jeffrey B" last="Wiener">Jeffrey B. Wiener</name></author><author><name sortKey="Chasela, Charles S" sort="Chasela, Charles S" uniqKey="Chasela C" first="Charles S" last="Chasela">Charles S. Chasela</name></author><author><name sortKey="Hudgens, Michael G" sort="Hudgens, Michael G" uniqKey="Hudgens M" first="Michael G" last="Hudgens">Michael G. Hudgens</name></author><author><name sortKey="Kamwendo, Debbie" sort="Kamwendo, Debbie" uniqKey="Kamwendo D" first="Debbie" last="Kamwendo">Debbie Kamwendo</name></author><author><name sortKey="Tegha, Gerald" sort="Tegha, Gerald" uniqKey="Tegha G" first="Gerald" last="Tegha">Gerald Tegha</name></author><author><name sortKey="Hosseinipour, Mina C" sort="Hosseinipour, Mina C" uniqKey="Hosseinipour M" first="Mina C" last="Hosseinipour">Mina C. Hosseinipour</name></author><author><name sortKey="Jamieson, Denise J" sort="Jamieson, Denise J" uniqKey="Jamieson D" first="Denise J" last="Jamieson">Denise J. Jamieson</name></author><author><name sortKey="Van Der Horst, Charles" sort="Van Der Horst, Charles" uniqKey="Van Der Horst C" first="Charles" last="Van Der Horst">Charles Van Der Horst</name></author><author><name sortKey="Kourtis, Athena P" sort="Kourtis, Athena P" uniqKey="Kourtis A" first="Athena P" last="Kourtis">Athena P. Kourtis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28926409</idno><idno type="pmid">28926409</idno><idno type="doi">10.1097/QAD.0000000000001641</idno><idno type="wicri:Area/PubMed/Corpus">000D23</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D23</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants.</title><author><name sortKey="Ewing, Alexander C" sort="Ewing, Alexander C" uniqKey="Ewing A" first="Alexander C" last="Ewing">Alexander C. Ewing</name><affiliation><nlm:affiliation>aCenters for Disease Control and Prevention, Atlanta, Georgia, USA bDepartment of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa cUniversity of North Carolina, Chapel Hill, North Carolina, USA dUNC Project, Lilongwe, Malawi.</nlm:affiliation></affiliation></author><author><name sortKey="King, Caroline C" sort="King, Caroline C" uniqKey="King C" first="Caroline C" last="King">Caroline C. King</name></author><author><name sortKey="Wiener, Jeffrey B" sort="Wiener, Jeffrey B" uniqKey="Wiener J" first="Jeffrey B" last="Wiener">Jeffrey B. Wiener</name></author><author><name sortKey="Chasela, Charles S" sort="Chasela, Charles S" uniqKey="Chasela C" first="Charles S" last="Chasela">Charles S. Chasela</name></author><author><name sortKey="Hudgens, Michael G" sort="Hudgens, Michael G" uniqKey="Hudgens M" first="Michael G" last="Hudgens">Michael G. Hudgens</name></author><author><name sortKey="Kamwendo, Debbie" sort="Kamwendo, Debbie" uniqKey="Kamwendo D" first="Debbie" last="Kamwendo">Debbie Kamwendo</name></author><author><name sortKey="Tegha, Gerald" sort="Tegha, Gerald" uniqKey="Tegha G" first="Gerald" last="Tegha">Gerald Tegha</name></author><author><name sortKey="Hosseinipour, Mina C" sort="Hosseinipour, Mina C" uniqKey="Hosseinipour M" first="Mina C" last="Hosseinipour">Mina C. Hosseinipour</name></author><author><name sortKey="Jamieson, Denise J" sort="Jamieson, Denise J" uniqKey="Jamieson D" first="Denise J" last="Jamieson">Denise J. Jamieson</name></author><author><name sortKey="Van Der Horst, Charles" sort="Van Der Horst, Charles" uniqKey="Van Der Horst C" first="Charles" last="Van Der Horst">Charles Van Der Horst</name></author><author><name sortKey="Kourtis, Athena P" sort="Kourtis, Athena P" uniqKey="Kourtis A" first="Athena P" last="Kourtis">Athena P. Kourtis</name></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="eISSN">1473-5571</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Given the potential of cotrimoxazole preventive therapy (CPT) to prevent bacterial and malarial infections in HIV-exposed, uninfected (HEU) infants, it is important to evaluate the effects of its concurrent use with antiretroviral agents that have overlapping toxicity profiles.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28926409</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>19</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>18</Issue><PubDate><Year>2017</Year><Month>Nov</Month><Day>28</Day></PubDate></JournalIssue><Title>AIDS (London, England)</Title><ISOAbbreviation>AIDS</ISOAbbreviation></Journal><ArticleTitle>Effects of concurrent exposure to antiretrovirals and cotrimoxazole prophylaxis among HIV-exposed, uninfected infants.</ArticleTitle><Pagination><MedlinePgn>2455-2463</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0000000000001641</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Given the potential of cotrimoxazole preventive therapy (CPT) to prevent bacterial and malarial infections in HIV-exposed, uninfected (HEU) infants, it is important to evaluate the effects of its concurrent use with antiretroviral agents that have overlapping toxicity profiles.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used data from the Breastfeeding, Antiretrovirals, and Nutrition study (2004-2010) to evaluate the association of CPT and antiretrovirals with hematologic measures (hemoglobin, neutrophil, and alanine aminotransferase levels) from 6 to 48 weeks of age in 2006 HEU infants in Lilongwe, Malawi. Hazards of severe outcomes (anemia, neutropenia, and elevated alanine aminotransferase), as defined by the National Institutes of Health, were compared using Cox regression models, according to time-varying CPT (implemented June 2006), antiretroviral treatment arm (maternal triple antiretroviral, infant nevirapine, or none during 6 months of breastfeeding), and their interaction. The effects of these treatments on hemoglobin, neutrophil, and alanine aminotransferase levels were assessed using linear mixed models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In Cox models, CPT was associated with an increase in severe neutropenia [hazard ratio 1.97 (1.01, 3.86)] and a decrease in severe anemia (hazard ratio 0.65 (0.48, 0.88)]. Interactions between CPT and antiretroviral treatment were not significant. By 36 weeks, there was a significant association of CPT with increased hemoglobin levels regardless of antiretroviral drug exposure.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In addition to expected associations with increased hazard of severe neutropenia and decreased neutrophil count, CPT was associated with reduced hazard of severe anemia and higher infant blood hemoglobin. This provides further support for CPT use in HEU infants in malaria-endemic resource-limited settings where anemia is prevalent.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ewing</LastName><ForeName>Alexander C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>aCenters for Disease Control and Prevention, Atlanta, Georgia, USA bDepartment of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa cUniversity of North Carolina, Chapel Hill, North Carolina, USA dUNC Project, Lilongwe, Malawi.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Caroline C</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Wiener</LastName><ForeName>Jeffrey B</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Chasela</LastName><ForeName>Charles S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Hudgens</LastName><ForeName>Michael G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Kamwendo</LastName><ForeName>Debbie</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Tegha</LastName><ForeName>Gerald</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Hosseinipour</LastName><ForeName>Mina C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Jamieson</LastName><ForeName>Denise J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Van der Horst</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Kourtis</LastName><ForeName>Athena P</ForeName><Initials>AP</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>AIDS</MedlineTA><NlmUniqueID>8710219</NlmUniqueID><ISSNLinking>0269-9370</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28926409</ArticleId><ArticleId IdType="doi">10.1097/QAD.0000000000001641</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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