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Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.

Identifieur interne : 000D20 ( PubMed/Corpus ); précédent : 000D19; suivant : 000D21

Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.

Auteurs : S. Janssen ; K. Osbak ; R. Holman ; S. Hermans ; A. Moekotte ; M. Knap ; E. Rossatanga ; M. Massinga-Loembe ; A. Alabi ; A. Adegnika ; C. Meenken ; M. Van Vugt ; P G Kremsner ; G. Meintjes ; T. Van Der Poll ; M P Grobusch

Source :

RBID : pubmed:28349491

Abstract

There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.

DOI: 10.1007/s15010-017-1000-9
PubMed: 28349491

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pubmed:28349491

Le document en format XML

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<div type="abstract" xml:lang="en">There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.</div>
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