Brief Report: Recovery of Bone Mineral Density After Discontinuation of Tenofovir-Based HIV Pre-exposure Prophylaxis.
Identifieur interne : 000D09 ( PubMed/Corpus ); précédent : 000D08; suivant : 000D10Brief Report: Recovery of Bone Mineral Density After Discontinuation of Tenofovir-Based HIV Pre-exposure Prophylaxis.
Auteurs : David V. Glidden ; Kathleen Mulligan ; Vanessa Mcmahan ; Peter L. Anderson ; Juan Guanira ; Suwat Chariyalertsak ; Susan P. Buchbinder ; Linda Gail Bekker ; Mauro Schechter ; Beatriz Grinsztejn ; Robert M. GrantSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1944-7884 ] ; 2017.
English descriptors
- KwdEn :
- Absorptiometry, Photon, Adult, Anti-HIV Agents (administration & dosage), Anti-HIV Agents (adverse effects), Bone Density (drug effects), Bone Diseases (chemically induced), Bone Diseases (therapy), Emtricitabine (administration & dosage), Female, Follow-Up Studies, HIV Infections (complications), HIV Infections (drug therapy), HIV Infections (prevention & control), Homosexuality, Male, Humans, Male, Patient Compliance, Pre-Exposure Prophylaxis, Tenofovir (administration & dosage), Tenofovir (adverse effects).
- MESH :
- chemical , administration & dosage : Anti-HIV Agents, Emtricitabine, Tenofovir.
- chemical , adverse effects : Anti-HIV Agents, Tenofovir.
- chemically induced : Bone Diseases.
- complications : HIV Infections.
- drug effects : Bone Density.
- drug therapy : HIV Infections.
- prevention & control : HIV Infections.
- therapy : Bone Diseases.
- Absorptiometry, Photon, Adult, Female, Follow-Up Studies, Homosexuality, Male, Humans, Male, Patient Compliance, Pre-Exposure Prophylaxis.
Abstract
Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF.
DOI: 10.1097/QAI.0000000000001475
PubMed: 28639995
Links to Exploration step
pubmed:28639995Le document en format XML
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<front><div type="abstract" xml:lang="en">Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF.</div>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Oral tenofovir disoproxil fumarate (TDF) for HIV prevention and treatment is associated with decreases in bone mineral density (BMD). Previous reports suggest that these changes may be reversible after discontinuation of TDF.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">A metabolic substudy of 498 participants in a randomized, placebo-controlled HIV prevention trial of oral coformulated TDF with emtricitabine (TDF/FTC, Truvada) for HIV pre-exposure prophylaxis (PrEP) enrolling a global sample of men who have sex with men and trans women.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Participants underwent dual X-ray absorptiometry to quantify bone mineral density (BMD) in the hip and spine during PrEP and at 2 visits after stopping (median of 23 and 79 weeks post-PrEP, respectively). Results are stratified by pharmacologic measure of TDF/FTC adherence.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">There was no significant difference in change in hip/spine BMD at any time point between placebo and those with low adherence. Adherent participants had a mean (standard error) BMD change at TDF/FTC discontinuation of -1.02% (0.24) in the hip and -1.84% (0.36) in the spine. After stop, annualized BMD increases of 1.13% per year (0.27) in hip and 1.81% per year (0.36) in spine BMD were observed in adherent participants compared with 0.19% (0.16) and 0.74% (0.21) in the placebo group, respectively (P = 0.003, both comparisons). On average, BMD returned to baseline levels by 1 year after PrEP stop. Recovery was consistent across age, baseline BMD z-score, and treatment duration.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Mean BMD returns to baseline levels within 12-18 months after TDF-based PrEP discontinuation in both hip and spine with consistency across participant subgroups.</AbstractText>
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