Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.
Identifieur interne : 000C95 ( PubMed/Corpus ); précédent : 000C94; suivant : 000C96Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.
Auteurs : Karl-Günter Technau ; Ahmad Haeri Mazanderani ; Louise Kuhn ; Lucia Hans ; Renate Strehlau ; Elaine J. Abrams ; Martie Conradie ; Ashraf Coovadia ; Ndileka Mbete ; Pamela M. Murnane ; Faeezah Patel ; Stephanie Shiau ; Caroline T. Tiemessen ; Gayle G. ShermanSource :
- Journal of the International AIDS Society [ 1758-2652 ] ; 2017.
Abstract
HIV-1 polymerase chain reaction (PCR) testing at birth aims to facilitate earlier initiation of antiretroviral therapy (ART) for HIV-infected neonates. Data from two years of universal birth testing implementation in a high-burden South African urban setting are presented to demonstrate the prevalence and outcomes of diagnostic challenges in this context.
DOI: 10.7448/IAS.20.7.21761
PubMed: 28872276
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Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hans, Lucia" sort="Hans, Lucia" uniqKey="Hans L" first="Lucia" last="Hans">Lucia Hans</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Strehlau, Renate" sort="Strehlau, Renate" uniqKey="Strehlau R" first="Renate" last="Strehlau">Renate Strehlau</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Abrams, Elaine J" sort="Abrams, Elaine J" uniqKey="Abrams E" first="Elaine J" last="Abrams">Elaine J. Abrams</name><affiliation><nlm:affiliation>ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conradie, Martie" sort="Conradie, Martie" uniqKey="Conradie M" first="Martie" last="Conradie">Martie Conradie</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Coovadia, Ashraf" sort="Coovadia, Ashraf" uniqKey="Coovadia A" first="Ashraf" last="Coovadia">Ashraf Coovadia</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mbete, Ndileka" sort="Mbete, Ndileka" uniqKey="Mbete N" first="Ndileka" last="Mbete">Ndileka Mbete</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Murnane, Pamela M" sort="Murnane, Pamela M" uniqKey="Murnane P" first="Pamela M" last="Murnane">Pamela M. Murnane</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Faeezah" sort="Patel, Faeezah" uniqKey="Patel F" first="Faeezah" last="Patel">Faeezah Patel</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Shiau, Stephanie" sort="Shiau, Stephanie" uniqKey="Shiau S" first="Stephanie" last="Shiau">Stephanie Shiau</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemessen, Caroline T" sort="Tiemessen, Caroline T" uniqKey="Tiemessen C" first="Caroline T" last="Tiemessen">Caroline T. Tiemessen</name><affiliation><nlm:affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Sherman, Gayle G" sort="Sherman, Gayle G" uniqKey="Sherman G" first="Gayle G" last="Sherman">Gayle G. Sherman</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28872276</idno><idno type="pmid">28872276</idno><idno type="doi">10.7448/IAS.20.7.21761</idno><idno type="wicri:Area/PubMed/Corpus">000C95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.</title><author><name sortKey="Technau, Karl Gunter" sort="Technau, Karl Gunter" uniqKey="Technau K" first="Karl-Günter" last="Technau">Karl-Günter Technau</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mazanderani, Ahmad Haeri" sort="Mazanderani, Ahmad Haeri" uniqKey="Mazanderani A" first="Ahmad Haeri" last="Mazanderani">Ahmad Haeri Mazanderani</name><affiliation><nlm:affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name><affiliation><nlm:affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hans, Lucia" sort="Hans, Lucia" uniqKey="Hans L" first="Lucia" last="Hans">Lucia Hans</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Strehlau, Renate" sort="Strehlau, Renate" uniqKey="Strehlau R" first="Renate" last="Strehlau">Renate Strehlau</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Abrams, Elaine J" sort="Abrams, Elaine J" uniqKey="Abrams E" first="Elaine J" last="Abrams">Elaine J. Abrams</name><affiliation><nlm:affiliation>ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conradie, Martie" sort="Conradie, Martie" uniqKey="Conradie M" first="Martie" last="Conradie">Martie Conradie</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Coovadia, Ashraf" sort="Coovadia, Ashraf" uniqKey="Coovadia A" first="Ashraf" last="Coovadia">Ashraf Coovadia</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Mbete, Ndileka" sort="Mbete, Ndileka" uniqKey="Mbete N" first="Ndileka" last="Mbete">Ndileka Mbete</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Murnane, Pamela M" sort="Murnane, Pamela M" uniqKey="Murnane P" first="Pamela M" last="Murnane">Pamela M. Murnane</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Faeezah" sort="Patel, Faeezah" uniqKey="Patel F" first="Faeezah" last="Patel">Faeezah Patel</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Shiau, Stephanie" sort="Shiau, Stephanie" uniqKey="Shiau S" first="Stephanie" last="Shiau">Stephanie Shiau</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Tiemessen, Caroline T" sort="Tiemessen, Caroline T" uniqKey="Tiemessen C" first="Caroline T" last="Tiemessen">Caroline T. Tiemessen</name><affiliation><nlm:affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Sherman, Gayle G" sort="Sherman, Gayle G" uniqKey="Sherman G" first="Gayle G" last="Sherman">Gayle G. Sherman</name><affiliation><nlm:affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the International AIDS Society</title><idno type="eISSN">1758-2652</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">HIV-1 polymerase chain reaction (PCR) testing at birth aims to facilitate earlier initiation of antiretroviral therapy (ART) for HIV-infected neonates. Data from two years of universal birth testing implementation in a high-burden South African urban setting are presented to demonstrate the prevalence and outcomes of diagnostic challenges in this context.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28872276</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>05</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1758-2652</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>Suppl 6</Issue><PubDate><Year>2017</Year><Month>08</Month><Day>29</Day></PubDate></JournalIssue><Title>Journal of the International AIDS Society</Title><ISOAbbreviation>J Int AIDS Soc</ISOAbbreviation></Journal><ArticleTitle>Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.</ArticleTitle><Pagination><MedlinePgn>21761</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7448/IAS.20.7.21761</ELocationID><Abstract><AbstractText Label="INTRODUCTION">HIV-1 polymerase chain reaction (PCR) testing at birth aims to facilitate earlier initiation of antiretroviral therapy (ART) for HIV-infected neonates. Data from two years of universal birth testing implementation in a high-burden South African urban setting are presented to demonstrate the prevalence and outcomes of diagnostic challenges in this context.</AbstractText><AbstractText Label="METHODS">HIV-exposed neonates born at Rahima Moosa Mother and Child Hospital between 5 June 2014 and 31 August 2016 were routinely screened at birth for HIV-1 on whole blood samples using the COBAS® AmpliPrep/COBAS® TaqMan (CAP/CTM) HIV-1 Qualitative Test, version 2.0 (Roche Molecular Systems, Inc., Branchburg, NJ, USA). Virological results were interpreted according to standard operating procedures with the South African National Health Laboratory Service. All neonates with non-negative results were actively followed-up and categorized according to HIV infection status as positive, negative, uncertain and lost to follow-up (LTFU).</AbstractText><AbstractText Label="RESULTS">104 (1.8%) of 5743 HIV-exposed neonates received a non-negative birth PCR result, for which laboratory data were available for 102 (98%) cases - 78 (76%) tested positive and 24 (24%) indeterminate. HIV infection status was confirmed positive in 83 (81%) infants, negative in 8 (8%), uncertain in 5 (5%) and LTFU in 6 (6%) cases. The positive predictive value (excluding cases of uncertain diagnosis and inadequate testing) following a non-negative HIV-1 PCR screening test at birth was 0.91 (83/91; 95% confidence interval: 0.85-0.96). Neonates testing positive at birth had significantly higher viral load (VL) results than those testing indeterminate at birth of 4.5 and 3.0 log copies/ml (p = 0.0007), respectively. Similarly, mothers of neonates with positive as compared to indeterminate birth test results had higher VLs of 4.5 and 2.7 log copies/ml (p = 0.0013), respectively. Half of neonates with an indeterminate birth test were shown to be HIV-infected on subsequent confirmatory testing, with time to final diagnosis 30 days longer for these neonates (p < 0.0001).</AbstractText><AbstractText Label="CONCLUSION">Indeterminate HIV-1 PCR results accounted for a quarter of non-negative results at birth and were associated with a high risk of infection in comparison to the risk of in utero transmission. Indeterminate birth results with positive HIV PCR results on repeat testing were associated with later final diagnosis. The HIV-1 status remains uncertain in a minority of cases because of repeatedly indeterminate results, highlighting the need for more sensitive and specific virological tests.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Technau</LastName><ForeName>Karl-Günter</ForeName><Initials>KG</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazanderani</LastName><ForeName>Ahmad Haeri</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Virology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuhn</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hans</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strehlau</LastName><ForeName>Renate</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abrams</LastName><ForeName>Elaine J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>ICAP, Mailman School of Public Health, and Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conradie</LastName><ForeName>Martie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coovadia</LastName><ForeName>Ashraf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mbete</LastName><ForeName>Ndileka</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murnane</LastName><ForeName>Pamela M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Faeezah</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shiau</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tiemessen</LastName><ForeName>Caroline T</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sherman</LastName><ForeName>Gayle G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Empilweni Services and Research Unit, Department of Paediatrics & Child Health, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01 HD080441</GrantID><Acronym>NH</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>J Int AIDS Soc</MedlineTA><NlmUniqueID>101478566</NlmUniqueID><ISSNLinking>1758-2652</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">HIV-1 PCR</Keyword><Keyword MajorTopicYN="Y">birth testing</Keyword><Keyword MajorTopicYN="Y">early infant diagnosis</Keyword><Keyword MajorTopicYN="Y">indeterminate</Keyword></KeywordList><CoiStatement>The authors have no conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28872276</ArticleId><ArticleId IdType="doi">10.7448/IAS.20.7.21761</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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