Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.
Identifieur interne : 000983 ( PubMed/Corpus ); précédent : 000982; suivant : 000984Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.
Auteurs : Nectarios Sophocles Papavarnavas ; Kathryn Manning ; Fahd Conrad ; Milah Govender ; Gary MaartensSource :
- AIDS research and therapy [ 1742-6405 ] ; 2017.
Abstract
There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.
DOI: 10.1186/s12981-017-0149-8
PubMed: 28431556
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.</title><author><name sortKey="Papavarnavas, Nectarios Sophocles" sort="Papavarnavas, Nectarios Sophocles" uniqKey="Papavarnavas N" first="Nectarios Sophocles" last="Papavarnavas">Nectarios Sophocles Papavarnavas</name><affiliation><nlm:affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Manning, Kathryn" sort="Manning, Kathryn" uniqKey="Manning K" first="Kathryn" last="Manning">Kathryn Manning</name><affiliation><nlm:affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Conrad, Fahd" sort="Conrad, Fahd" uniqKey="Conrad F" first="Fahd" last="Conrad">Fahd Conrad</name><affiliation><nlm:affiliation>Trauma and Emergency Unit, Floor E11A, Management Suite, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Govender, Milah" sort="Govender, Milah" uniqKey="Govender M" first="Milah" last="Govender">Milah Govender</name><affiliation><nlm:affiliation>Quality and Safety Unit, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 7925, South Africa. gary.maartens@uct.ac.za.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28431556</idno><idno type="pmid">28431556</idno><idno type="doi">10.1186/s12981-017-0149-8</idno><idno type="wicri:Area/PubMed/Corpus">000983</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000983</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.</title><author><name sortKey="Papavarnavas, Nectarios Sophocles" sort="Papavarnavas, Nectarios Sophocles" uniqKey="Papavarnavas N" first="Nectarios Sophocles" last="Papavarnavas">Nectarios Sophocles Papavarnavas</name><affiliation><nlm:affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Manning, Kathryn" sort="Manning, Kathryn" uniqKey="Manning K" first="Kathryn" last="Manning">Kathryn Manning</name><affiliation><nlm:affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Conrad, Fahd" sort="Conrad, Fahd" uniqKey="Conrad F" first="Fahd" last="Conrad">Fahd Conrad</name><affiliation><nlm:affiliation>Trauma and Emergency Unit, Floor E11A, Management Suite, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Govender, Milah" sort="Govender, Milah" uniqKey="Govender M" first="Milah" last="Govender">Milah Govender</name><affiliation><nlm:affiliation>Quality and Safety Unit, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 7925, South Africa. gary.maartens@uct.ac.za.</nlm:affiliation></affiliation></author></analytic><series><title level="j">AIDS research and therapy</title><idno type="eISSN">1742-6405</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28431556</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>22</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1742-6405</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Apr</Month><Day>21</Day></PubDate></JournalIssue><Title>AIDS research and therapy</Title><ISOAbbreviation>AIDS Res Ther</ISOAbbreviation></Journal><ArticleTitle>Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.</ArticleTitle><Pagination><MedlinePgn>23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12981-017-0149-8</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective cohort study was conducted of HCWs attending a referral hospital's Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Two hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5-0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3-5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3-26.9]).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We identified factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Papavarnavas</LastName><ForeName>Nectarios Sophocles</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manning</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conrad</LastName><ForeName>Fahd</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Trauma and Emergency Unit, Floor E11A, Management Suite, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Govender</LastName><ForeName>Milah</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Quality and Safety Unit, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maartens</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 7925, South Africa. gary.maartens@uct.ac.za.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>AIDS Res Ther</MedlineTA><NlmUniqueID>101237921</NlmUniqueID><ISSNLinking>1742-6405</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am Psychol. 2000 May;55(5):469-80</RefSource><PMID Version="1">10842426</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J STD AIDS. 1998 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