Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.
Identifieur interne : 000983 ( PubMed/Corpus ); précédent : 000982; suivant : 000984Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.
Auteurs : Nectarios Sophocles Papavarnavas ; Kathryn Manning ; Fahd Conrad ; Milah Govender ; Gary MaartensSource :
- AIDS research and therapy [ 1742-6405 ] ; 2017.
Abstract
There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.
DOI: 10.1186/s12981-017-0149-8
PubMed: 28431556
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<author><name sortKey="Papavarnavas, Nectarios Sophocles" sort="Papavarnavas, Nectarios Sophocles" uniqKey="Papavarnavas N" first="Nectarios Sophocles" last="Papavarnavas">Nectarios Sophocles Papavarnavas</name>
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<author><name sortKey="Manning, Kathryn" sort="Manning, Kathryn" uniqKey="Manning K" first="Kathryn" last="Manning">Kathryn Manning</name>
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<author><name sortKey="Conrad, Fahd" sort="Conrad, Fahd" uniqKey="Conrad F" first="Fahd" last="Conrad">Fahd Conrad</name>
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<author><name sortKey="Govender, Milah" sort="Govender, Milah" uniqKey="Govender M" first="Milah" last="Govender">Milah Govender</name>
<affiliation><nlm:affiliation>Quality and Safety Unit, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</nlm:affiliation>
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<author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.</title>
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<author><name sortKey="Govender, Milah" sort="Govender, Milah" uniqKey="Govender M" first="Milah" last="Govender">Milah Govender</name>
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<series><title level="j">AIDS research and therapy</title>
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<front><div type="abstract" xml:lang="en">There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.</div>
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<DateCreated><Year>2017</Year>
<Month>04</Month>
<Day>22</Day>
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<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>25</Day>
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<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1742-6405</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>Apr</Month>
<Day>21</Day>
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<Title>AIDS research and therapy</Title>
<ISOAbbreviation>AIDS Res Ther</ISOAbbreviation>
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<ArticleTitle>Factors associated with loss to follow-up after occupational HIV exposure in Cape Town, South Africa: a retrospective cohort study.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A retrospective cohort study was conducted of HCWs attending a referral hospital's Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available. Our primary outcome was LTFU at the 3-month visit. We selected seven variables a priori for our logistic regression model and ensured there were at least 10 outcome events per variable to minimize bias.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Two hundred and ninety-three folders were evaluated for descriptive analysis. LTFU worsened with successive visits: 36% at 6 weeks, 60% at 3 months, and 72% at 6 months. In multivariate analysis at the 3-month visit LTFU was associated with age (adjusted odds ratio (aOR), 0.6 per 10-year increase [95% CI, 0.5-0.9]), HCW category of doctor (aOR 2.7 [95% CI, 1.3-5.5]), and time from exposure to receiving PEP of more than 24 h (aOR 5.9 [95% CI, 1.3-26.9]).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We identified factors associated with LTFU of HCWs after occupational HIV exposure, which could be used to target interventions to improve follow-up.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Papavarnavas</LastName>
<ForeName>Nectarios Sophocles</ForeName>
<Initials>NS</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</Affiliation>
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<Author ValidYN="Y"><LastName>Manning</LastName>
<ForeName>Kathryn</ForeName>
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<AffiliationInfo><Affiliation>Department of Medicine, Old Main Building, J-Floor, Groote Schuur Hospital, University of Cape Town, Observatory, Cape Town, 7925, South Africa.</Affiliation>
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<Author ValidYN="Y"><LastName>Conrad</LastName>
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<AffiliationInfo><Affiliation>Trauma and Emergency Unit, Floor E11A, Management Suite, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</Affiliation>
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<Author ValidYN="Y"><LastName>Govender</LastName>
<ForeName>Milah</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Quality and Safety Unit, Groote Schuur Hospital, Main Road, Observatory, Cape Town, 7925, South Africa.</Affiliation>
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<Author ValidYN="Y"><LastName>Maartens</LastName>
<ForeName>Gary</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, 7925, South Africa. gary.maartens@uct.ac.za.</Affiliation>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">HIV</Keyword>
<Keyword MajorTopicYN="N">Health care workers</Keyword>
<Keyword MajorTopicYN="N">Loss to follow-up</Keyword>
<Keyword MajorTopicYN="N">Post exposure prophylaxis</Keyword>
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