From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa.
Identifieur interne : 000905 ( PubMed/Corpus ); précédent : 000904; suivant : 000906From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa.
Auteurs : Noah Haber ; Frank Tanser ; Jacob Bor ; Kevindra Naidu ; Tinofa Mutevedzi ; Kobus Herbst ; Kholoud Porter ; Deenan Pillay ; Till B RnighausenSource :
- The lancet. HIV [ 2352-3018 ] ; 2017.
Abstract
Standard approaches to estimation of losses in the HIV cascade of care are typically cross-sectional and do not include the population stages before linkage to clinical care. We used indiviual-level longitudinal cascade data, transition by transition, including population stages, both to identify the health-system losses in the cascade and to show the differences in inference between standard methods and the longitudinal approach.
DOI: 10.1016/S2352-3018(16)30224-7
PubMed: 28153470
Links to Exploration step
pubmed:28153470Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa.</title>
<author><name sortKey="Haber, Noah" sort="Haber, Noah" uniqKey="Haber N" first="Noah" last="Haber">Noah Haber</name>
<affiliation><nlm:affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa. Electronic address: nhaber@mail.harvard.edu.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanser, Frank" sort="Tanser, Frank" uniqKey="Tanser F" first="Frank" last="Tanser">Frank Tanser</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa-CAPRISA, University of KwaZulu-Natal, Congella, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bor, Jacob" sort="Bor, Jacob" uniqKey="Bor J" first="Jacob" last="Bor">Jacob Bor</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Department of Global Health, Boston University School of Public Health, Boston, MA, USA; Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Naidu, Kevindra" sort="Naidu, Kevindra" uniqKey="Naidu K" first="Kevindra" last="Naidu">Kevindra Naidu</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; MatCH (Maternal Adolescent and Child Health Systems), School of Public Health, University of the Witwatersrand, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mutevedzi, Tinofa" sort="Mutevedzi, Tinofa" uniqKey="Mutevedzi T" first="Tinofa" last="Mutevedzi">Tinofa Mutevedzi</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herbst, Kobus" sort="Herbst, Kobus" uniqKey="Herbst K" first="Kobus" last="Herbst">Kobus Herbst</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Porter, Kholoud" sort="Porter, Kholoud" uniqKey="Porter K" first="Kholoud" last="Porter">Kholoud Porter</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pillay, Deenan" sort="Pillay, Deenan" uniqKey="Pillay D" first="Deenan" last="Pillay">Deenan Pillay</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="B Rnighausen, Till" sort="B Rnighausen, Till" uniqKey="B Rnighausen T" first="Till" last="B Rnighausen">Till B Rnighausen</name>
<affiliation><nlm:affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa; Institute of Public Health, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28153470</idno>
<idno type="pmid">28153470</idno>
<idno type="doi">10.1016/S2352-3018(16)30224-7</idno>
<idno type="wicri:Area/PubMed/Corpus">000905</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000905</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa.</title>
<author><name sortKey="Haber, Noah" sort="Haber, Noah" uniqKey="Haber N" first="Noah" last="Haber">Noah Haber</name>
<affiliation><nlm:affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa. Electronic address: nhaber@mail.harvard.edu.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanser, Frank" sort="Tanser, Frank" uniqKey="Tanser F" first="Frank" last="Tanser">Frank Tanser</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa-CAPRISA, University of KwaZulu-Natal, Congella, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bor, Jacob" sort="Bor, Jacob" uniqKey="Bor J" first="Jacob" last="Bor">Jacob Bor</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Department of Global Health, Boston University School of Public Health, Boston, MA, USA; Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Naidu, Kevindra" sort="Naidu, Kevindra" uniqKey="Naidu K" first="Kevindra" last="Naidu">Kevindra Naidu</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; MatCH (Maternal Adolescent and Child Health Systems), School of Public Health, University of the Witwatersrand, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mutevedzi, Tinofa" sort="Mutevedzi, Tinofa" uniqKey="Mutevedzi T" first="Tinofa" last="Mutevedzi">Tinofa Mutevedzi</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herbst, Kobus" sort="Herbst, Kobus" uniqKey="Herbst K" first="Kobus" last="Herbst">Kobus Herbst</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Porter, Kholoud" sort="Porter, Kholoud" uniqKey="Porter K" first="Kholoud" last="Porter">Kholoud Porter</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Research Department of Infection and Population Health, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pillay, Deenan" sort="Pillay, Deenan" uniqKey="Pillay D" first="Deenan" last="Pillay">Deenan Pillay</name>
<affiliation><nlm:affiliation>Africa Health Research Institute, Somkhele, South Africa; Division of Infection and Immunity, University College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="B Rnighausen, Till" sort="B Rnighausen, Till" uniqKey="B Rnighausen T" first="Till" last="B Rnighausen">Till B Rnighausen</name>
<affiliation><nlm:affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa; Institute of Public Health, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">The lancet. HIV</title>
<idno type="eISSN">2352-3018</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Standard approaches to estimation of losses in the HIV cascade of care are typically cross-sectional and do not include the population stages before linkage to clinical care. We used indiviual-level longitudinal cascade data, transition by transition, including population stages, both to identify the health-system losses in the cascade and to show the differences in inference between standard methods and the longitudinal approach.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28153470</PMID>
<DateCreated><Year>2017</Year>
<Month>02</Month>
<Day>03</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2352-3018</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>4</Volume>
<Issue>5</Issue>
<PubDate><Year>2017</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>The lancet. HIV</Title>
<ISOAbbreviation>Lancet HIV</ISOAbbreviation>
</Journal>
<ArticleTitle>From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa.</ArticleTitle>
<Pagination><MedlinePgn>e223-e230</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S2352-3018(16)30224-7</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S2352-3018(16)30224-7</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Standard approaches to estimation of losses in the HIV cascade of care are typically cross-sectional and do not include the population stages before linkage to clinical care. We used indiviual-level longitudinal cascade data, transition by transition, including population stages, both to identify the health-system losses in the cascade and to show the differences in inference between standard methods and the longitudinal approach.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used non-parametric survival analysis to estimate a longitudinal HIV care cascade for a large population of people with HIV residing in rural KwaZulu-Natal, South Africa. We linked data from a longitudinal population health surveillance (which is maintained by the Africa Health Research Institute) with patient records from the local public-sector HIV treatment programme (contained in an electronic clinical HIV treatment and care database, ARTemis). We followed up all people who had been newly detected as having HIV between Jan 1, 2006, and Dec 31, 2011, across six cascade stages: three population stages (first positive HIV test, HIV status knowledge, and linkage to care) and three clinical stages (eligibility for antiretroviral therapy [ART], initiation of ART, and therapeutic response). We compared our estimates to cross-sectional cascades in the same population. We estimated the cumulative incidence of reaching a particular cascade stage at a specific time with Kaplan-Meier survival analysis.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">Our population consisted of 5205 individuals with HIV who were followed up for 24 031 person-years. We recorded 598 deaths. 4539 individuals gained knowledge of their positive HIV status, 2818 were linked to care, 2151 became eligible for ART, 1839 began ART, and 1456 had successful responses to therapy. We used Kaplan-Meier survival analysis to adjust for censorship due to the end of data collection, and found that 8 years after testing positive in the population health surveillance, 16% had died. Among living patients, 82% knew their HIV status, 45% were linked to care, 39% were eligible for ART, 35% initiated ART, and 33% had reached therapeutic response. Median times to transition for these cascade stages were 52 months, 52 months, 20 months, 3 months, and 9 months, respectively. Compared with the population stages in the cascade, the transitions across the clinical stages were fast. Over calendar time, rates of linkage to care have decreased and patients presenting for the first time for care were, on average, healthier.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">HIV programmes should focus on linkage to care as the most important bottleneck in the cascade. Cascade estimation should be longitudinal rather than cross-sectional and start with the population stages preceding clinical care.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Wellcome Trust, PEPFAR.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Haber</LastName>
<ForeName>Noah</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa. Electronic address: nhaber@mail.harvard.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tanser</LastName>
<ForeName>Frank</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa; School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa-CAPRISA, University of KwaZulu-Natal, Congella, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bor</LastName>
<ForeName>Jacob</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa; Department of Global Health, Boston University School of Public Health, Boston, MA, USA; Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Naidu</LastName>
<ForeName>Kevindra</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa; MatCH (Maternal Adolescent and Child Health Systems), School of Public Health, University of the Witwatersrand, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mutevedzi</LastName>
<ForeName>Tinofa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herbst</LastName>
<ForeName>Kobus</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Porter</LastName>
<ForeName>Kholoud</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa; Research Department of Infection and Population Health, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pillay</LastName>
<ForeName>Deenan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Africa Health Research Institute, Somkhele, South Africa; Division of Infection and Immunity, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bärnighausen</LastName>
<ForeName>Till</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Africa Health Research Institute, Somkhele, South Africa; Institute of Public Health, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MC_UU_12023/15</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>01</Month>
<Day>31</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Lancet HIV</MedlineTA>
<NlmUniqueID>101645355</NlmUniqueID>
<ISSNLinking>2352-3018</ISSNLinking>
</MedlineJournalInfo>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>06</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>11</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>11</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>2</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28153470</ArticleId>
<ArticleId IdType="pii">S2352-3018(16)30224-7</ArticleId>
<ArticleId IdType="doi">10.1016/S2352-3018(16)30224-7</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000905 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000905 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:28153470 |texte= From HIV infection to therapeutic response: a population-based longitudinal HIV cascade-of-care study in KwaZulu-Natal, South Africa. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28153470" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |