Micronutrient supplementation in children and adults with HIV infection.
Identifieur interne : 000485 ( PubMed/Corpus ); précédent : 000484; suivant : 000486Micronutrient supplementation in children and adults with HIV infection.
Auteurs : James H. Irlam ; Marianne Me Visser ; Nigel N. Rollins ; Nandi SiegfriedSource :
- The Cochrane database of systematic reviews [ 1469-493X ] ; 2010.
English descriptors
- KwdEn :
- Adult, Child, Dietary Supplements, Female, HIV Infections (complications), HIV Infections (mortality), HIV-1, HIV-2, Humans, Micronutrients (administration & dosage), Micronutrients (deficiency), Pregnancy, Pregnancy Complications, Infectious (mortality), Randomized Controlled Trials as Topic, Selenium (administration & dosage), Vitamin A (administration & dosage), Vitamin D (administration & dosage), Vitamins (administration & dosage), Zinc (administration & dosage), beta Carotene (administration & dosage).
- MESH :
- chemical , administration & dosage : Micronutrients, Selenium, Vitamin A, Vitamin D, Vitamins, Zinc, beta Carotene.
- complications : HIV Infections.
- chemical , deficiency : Micronutrients.
- mortality : HIV Infections, Pregnancy Complications, Infectious.
- Adult, Child, Dietary Supplements, Female, HIV-1, HIV-2, Humans, Pregnancy, Randomized Controlled Trials as Topic.
Abstract
Micronutrient deficiencies are widespread and compound the effects of HIV disease; micronutrient supplements may be effective and safe in reducing this burden.
DOI: 10.1002/14651858.CD003650.pub3
PubMed: 21154354
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pubmed:21154354Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Micronutrient supplementation in children and adults with HIV infection.</title><author><name sortKey="Irlam, James H" sort="Irlam, James H" uniqKey="Irlam J" first="James H" last="Irlam">James H. Irlam</name><affiliation><nlm:affiliation>Primary Health Care Directorate, University of Cape Town, E47 OMB, Groote Schuur Hospital, Cape Town, Western Cape, South Africa, 7925.</nlm:affiliation></affiliation></author><author><name sortKey="Visser, Marianne Me" sort="Visser, Marianne Me" uniqKey="Visser M" first="Marianne Me" last="Visser">Marianne Me Visser</name></author><author><name sortKey="Rollins, Nigel N" sort="Rollins, Nigel N" uniqKey="Rollins N" first="Nigel N" last="Rollins">Nigel N. Rollins</name></author><author><name sortKey="Siegfried, Nandi" sort="Siegfried, Nandi" uniqKey="Siegfried N" first="Nandi" last="Siegfried">Nandi Siegfried</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21154354</idno><idno type="pmid">21154354</idno><idno type="doi">10.1002/14651858.CD003650.pub3</idno><idno type="wicri:Area/PubMed/Corpus">000485</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000485</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Micronutrient supplementation in children and adults with HIV infection.</title><author><name sortKey="Irlam, James H" sort="Irlam, James H" uniqKey="Irlam J" first="James H" last="Irlam">James H. Irlam</name><affiliation><nlm:affiliation>Primary Health Care Directorate, University of Cape Town, E47 OMB, Groote Schuur Hospital, Cape Town, Western Cape, South Africa, 7925.</nlm:affiliation></affiliation></author><author><name sortKey="Visser, Marianne Me" sort="Visser, Marianne Me" uniqKey="Visser M" first="Marianne Me" last="Visser">Marianne Me Visser</name></author><author><name sortKey="Rollins, Nigel N" sort="Rollins, Nigel N" uniqKey="Rollins N" first="Nigel N" last="Rollins">Nigel N. Rollins</name></author><author><name sortKey="Siegfried, Nandi" sort="Siegfried, Nandi" uniqKey="Siegfried N" first="Nandi" last="Siegfried">Nandi Siegfried</name></author></analytic><series><title level="j">The Cochrane database of systematic reviews</title><idno type="eISSN">1469-493X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Child</term><term>Dietary Supplements</term><term>Female</term><term>HIV Infections (complications)</term><term>HIV Infections (mortality)</term><term>HIV-1</term><term>HIV-2</term><term>Humans</term><term>Micronutrients (administration & dosage)</term><term>Micronutrients (deficiency)</term><term>Pregnancy</term><term>Pregnancy Complications, Infectious (mortality)</term><term>Randomized Controlled Trials as Topic</term><term>Selenium (administration & dosage)</term><term>Vitamin A (administration & dosage)</term><term>Vitamin D (administration & dosage)</term><term>Vitamins (administration & dosage)</term><term>Zinc (administration & dosage)</term><term>beta Carotene (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Micronutrients</term><term>Selenium</term><term>Vitamin A</term><term>Vitamin D</term><term>Vitamins</term><term>Zinc</term><term>beta Carotene</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Micronutrients</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>HIV Infections</term><term>Pregnancy Complications, Infectious</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Child</term><term>Dietary Supplements</term><term>Female</term><term>HIV-1</term><term>HIV-2</term><term>Humans</term><term>Pregnancy</term><term>Randomized Controlled Trials as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Micronutrient deficiencies are widespread and compound the effects of HIV disease; micronutrient supplements may be effective and safe in reducing this burden.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21154354</PMID><DateCreated><Year>2010</Year><Month>12</Month><Day>14</Day></DateCreated><DateCompleted><Year>2011</Year><Month>02</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1469-493X</ISSN><JournalIssue CitedMedium="Internet"><Issue>12</Issue><PubDate><Year>2010</Year><Month>Dec</Month><Day>08</Day></PubDate></JournalIssue><Title>The Cochrane database of systematic reviews</Title><ISOAbbreviation>Cochrane Database Syst Rev</ISOAbbreviation></Journal><ArticleTitle>Micronutrient supplementation in children and adults with HIV infection.</ArticleTitle><Pagination><MedlinePgn>CD003650</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/14651858.CD003650.pub3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Micronutrient deficiencies are widespread and compound the effects of HIV disease; micronutrient supplements may be effective and safe in reducing this burden.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To assess whether micronutrient supplements are effective and safe in reducing mortality and morbidity in adults and children with HIV infection.</AbstractText><AbstractText Label="SEARCH STRATEGY" NlmCategory="METHODS">The CENTRAL, EMBASE, PubMed, and GATEWAY databases were searched for randomised controlled trials of micronutrient supplements using the search methods of the Cochrane HIV/AIDS Group.</AbstractText><AbstractText Label="SELECTION CRITERIA" NlmCategory="METHODS">Randomised controlled trials were selected that compared the effects of micronutrient supplements (vitamins, trace elements, and combinations of these) with other supplements, placebo or no treatment on mortality, morbidity, pregnancy outcomes, immunologic indicators, and anthropometric measures in HIV-infected adults and children. Any adverse effects of supplementation were recorded.</AbstractText><AbstractText Label="DATA COLLECTION AND ANALYSIS" NlmCategory="METHODS">Two reviewers independently selected trials, appraised trial quality for risk of bias using standardised criteria, and extracted data using standardised forms.</AbstractText><AbstractText Label="MAIN RESULTS" NlmCategory="RESULTS">Sixteen additional trials are included in this update to the original Cochrane review (Irlam 2005). Overall, 30 trials involving 22 120 participants are reviewed: 20 trials of single supplements (vitamin A, vitamin D, zinc, selenium) and 10 of multiple micronutrients. Eight trials were undertaken in child populations.None of the six trials of vitamin A or beta-carotene supplementation in adults demonstrated any significant reduction in HIV disease progression. Vitamin A halved all-cause mortality in a meta-analysis of three trials in African children, had inconsistent impacts on diarrhoeal and respiratory morbidity, and improved short-term growth in one trial. No significant adverse effects of vitamin A in adults or children have been reported.Zinc supplements reduced diarrhoeal morbidity and had no adverse effects on disease progression in a single safety trial in South African children. No significant clinical benefits were found from zinc supplementation of pregnant Tanzanian women or Peruvian adults with persistent diarrhoea.Selenium reduced diarrhoeal morbidity in pregnant women in Tanzania, and reduced viral load in two separate small trials in American adults.Single trials of vitamin D supplements in adults, and in adolescents and children, demonstrated safety but no clinical benefits.Multiple micronutrient supplements conferred multiple clinical benefits to pregnant women and their offspring in a large Tanzanian trial. Supplementation in another Tanzanian trial reduced the recurrence of pulmonary TB and increased weight gain in co-infected patients. No significant adverse effects were reported.</AbstractText><AbstractText Label="AUTHORS' CONCLUSIONS" NlmCategory="CONCLUSIONS">Multiple micronutrient supplements reduced morbidity and mortality in HIV-infected pregnant women and their offspring and also improved early child growth in one large randomised controlled trial in Africa. Additional research is needed to determine if these are generalisable findings. Vitamin A supplementation is beneficial and safe in HIV-infected children, but further evidence is needed to establish if supplementation confers similar benefits in HIV-infected adults. Zinc is safe in HIV-infected adults and children. It may have similar benefits in HIV-infected children and adults, and uninfected children with diarrhoea, as it does in HIV-uninfected children.Further trials of single supplements (vitamin D, zinc, and selenium) are required to build the evidence base. The long-term clinical benefits, adverse effects, and optimal formulation of multiple micronutrient supplements require further investigation in individuals with diverse disease status. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Irlam</LastName><ForeName>James H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Primary Health Care Directorate, University of Cape Town, E47 OMB, Groote Schuur Hospital, Cape Town, Western Cape, South Africa, 7925.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Visser</LastName><ForeName>Marianne Me</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Rollins</LastName><ForeName>Nigel N</ForeName><Initials>NN</Initials></Author><Author ValidYN="Y"><LastName>Siegfried</LastName><ForeName>Nandi</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>12</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cochrane Database Syst Rev</MedlineTA><NlmUniqueID>100909747</NlmUniqueID><ISSNLinking>1361-6137</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018977">Micronutrients</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014815">Vitamins</NameOfSubstance></Chemical><Chemical><RegistryNumber>01YAE03M7J</RegistryNumber><NameOfSubstance UI="D019207">beta Carotene</NameOfSubstance></Chemical><Chemical><RegistryNumber>11103-57-4</RegistryNumber><NameOfSubstance UI="D014801">Vitamin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>1406-16-2</RegistryNumber><NameOfSubstance UI="D014807">Vitamin D</NameOfSubstance></Chemical><Chemical><RegistryNumber>H6241UJ22B</RegistryNumber><NameOfSubstance UI="D012643">Selenium</NameOfSubstance></Chemical><Chemical><RegistryNumber>J41CSQ7QDS</RegistryNumber><NameOfSubstance UI="D015032">Zinc</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="UpdateOf"><RefSource>Cochrane Database Syst Rev. 2005;(4):CD003650</RefSource><PMID Version="1">16235333</PMID></CommentsCorrections><CommentsCorrections RefType="UpdateIn"><RefSource>Cochrane Database Syst Rev. 2017 May 18;5:CD003650</RefSource><PMID Version="1">28518221</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="Y">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015498" MajorTopicYN="N">HIV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018977" MajorTopicYN="N">Micronutrients</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012643" MajorTopicYN="N">Selenium</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014801" MajorTopicYN="N">Vitamin A</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014807" MajorTopicYN="N">Vitamin D</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014815" MajorTopicYN="N">Vitamins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019207" MajorTopicYN="N">beta Carotene</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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