Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women.
Identifieur interne : 000355 ( PubMed/Corpus ); précédent : 000354; suivant : 000356Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women.
Auteurs : Louise Kuhn ; Chunhui Wang ; Wei-Yann Tsai ; Thomas C. Wright ; Lynette DennySource :
- AIDS (London, England) [ 1473-5571 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Cervical Intraepithelial Neoplasia (diagnosis), Cervical Intraepithelial Neoplasia (epidemiology), Cervical Intraepithelial Neoplasia (prevention & control), Colposcopy (economics), Cryotherapy (economics), DNA, Viral (analysis), Female, HIV Infections (complications), HIV Infections (diagnosis), HIV Infections (epidemiology), Health Services Accessibility (economics), Humans, Mass Screening (economics), Middle Aged, Papillomaviridae (isolation & purification), Papillomavirus Infections (diagnosis), Prevalence, South Africa (epidemiology), Uterine Cervical Neoplasms (diagnosis), Uterine Cervical Neoplasms (epidemiology), Uterine Cervical Neoplasms (prevention & control).
- MESH :
- chemical , analysis : DNA, Viral.
- geographic , epidemiology : South Africa.
- complications : HIV Infections.
- diagnosis : Cervical Intraepithelial Neoplasia, HIV Infections, Papillomavirus Infections, Uterine Cervical Neoplasms.
- economics : Colposcopy, Cryotherapy, Health Services Accessibility, Mass Screening.
- epidemiology : Cervical Intraepithelial Neoplasia, HIV Infections, Uterine Cervical Neoplasms.
- isolation & purification : Papillomaviridae.
- prevention & control : Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms.
- Adult, Aged, Female, Humans, Middle Aged, Prevalence.
Abstract
Cervical cancer prevention should be provided as part of primary healthcare services for HIV-infected women but conventional screening programs are difficult to implement in low-resource settings. Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy.
DOI: 10.1097/QAD.0b013e32833e163e
PubMed: 20706107
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Wright</name></author><author><name sortKey="Denny, Lynette" sort="Denny, Lynette" uniqKey="Denny L" first="Lynette" last="Denny">Lynette Denny</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20706107</idno><idno type="pmid">20706107</idno><idno type="doi">10.1097/QAD.0b013e32833e163e</idno><idno type="wicri:Area/PubMed/Corpus">000355</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000355</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women.</title><author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name><affiliation><nlm:affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. lk24@columbia.edu</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Chunhui" sort="Wang, Chunhui" uniqKey="Wang C" first="Chunhui" last="Wang">Chunhui Wang</name></author><author><name sortKey="Tsai, Wei Yann" sort="Tsai, Wei Yann" uniqKey="Tsai W" first="Wei-Yann" last="Tsai">Wei-Yann Tsai</name></author><author><name sortKey="Wright, Thomas C" sort="Wright, Thomas C" uniqKey="Wright T" first="Thomas C" last="Wright">Thomas C. Wright</name></author><author><name sortKey="Denny, Lynette" sort="Denny, Lynette" uniqKey="Denny L" first="Lynette" last="Denny">Lynette Denny</name></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="eISSN">1473-5571</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cervical Intraepithelial Neoplasia (diagnosis)</term><term>Cervical Intraepithelial Neoplasia (epidemiology)</term><term>Cervical Intraepithelial Neoplasia (prevention & control)</term><term>Colposcopy (economics)</term><term>Cryotherapy (economics)</term><term>DNA, Viral (analysis)</term><term>Female</term><term>HIV Infections (complications)</term><term>HIV Infections (diagnosis)</term><term>HIV Infections (epidemiology)</term><term>Health Services Accessibility (economics)</term><term>Humans</term><term>Mass Screening (economics)</term><term>Middle Aged</term><term>Papillomaviridae (isolation & purification)</term><term>Papillomavirus Infections (diagnosis)</term><term>Prevalence</term><term>South Africa (epidemiology)</term><term>Uterine Cervical Neoplasms (diagnosis)</term><term>Uterine Cervical Neoplasms (epidemiology)</term><term>Uterine Cervical Neoplasms (prevention & control)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cervical Intraepithelial Neoplasia</term><term>HIV Infections</term><term>Papillomavirus Infections</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Colposcopy</term><term>Cryotherapy</term><term>Health Services Accessibility</term><term>Mass Screening</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cervical Intraepithelial Neoplasia</term><term>HIV Infections</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Papillomaviridae</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cervical Intraepithelial Neoplasia</term><term>Uterine Cervical Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Prevalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cervical cancer prevention should be provided as part of primary healthcare services for HIV-infected women but conventional screening programs are difficult to implement in low-resource settings. Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20706107</PMID><DateCreated><Year>2010</Year><Month>10</Month><Day>13</Day></DateCreated><DateCompleted><Year>2011</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2010</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>16</Issue><PubDate><Year>2010</Year><Month>Oct</Month><Day>23</Day></PubDate></JournalIssue><Title>AIDS (London, England)</Title><ISOAbbreviation>AIDS</ISOAbbreviation></Journal><ArticleTitle>Efficacy of human papillomavirus-based screen-and-treat for cervical cancer prevention among HIV-infected women.</ArticleTitle><Pagination><MedlinePgn>2553-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0b013e32833e163e</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Cervical cancer prevention should be provided as part of primary healthcare services for HIV-infected women but conventional screening programs are difficult to implement in low-resource settings. Here, we evaluate the efficacy among HIV-infected women of a simpler, screen-and-treat strategy in which all women with a positive screening test are treated with cryotherapy.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a randomized clinical trial of two screen-and-treat strategies among 6555 women in Cape Town, South Africa, among whom 956 were HIV-positive. Women were randomized to screen-and-treat utilizing either human papillomavirus DNA testing or visual inspection with acetic acid as the screening method or to a control group. Women were followed for up to 36 months after randomization with colposcopy and biopsy to determine the study endpoint of cervical intraepithelial neoplasia grade 2 or higher.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the control group, HIV-positive women had higher rates of cervical intraepithelial neoplasia grade 2 or higher detected by 36 months (14.9%) than HIV-negative women (4.6%) (P = 0.0006). Screen-and-treat utilizing human papillomavirus DNA testing significantly reduced cervical intraepithelial neoplasia grade 2 or higher through 36 months in both HIV-positive (relative risk = 0.20, 95% confidence interval 0.06-0.69) and HIV-negative women (relative risk = 0.31, 95% confidence interval 0.20-0.50). Reductions in the visual inspection with acetic acid-and-treat group were less marked. Complications of cryotherapy were mostly minor and did not differ in frequency between HIV-positive and HIV-negative women.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Screen-and-treat using human papillomavirus testing is a simple and effective method to reduce high-grade cervical cancer precursors in HIV-infected women.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kuhn</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. lk24@columbia.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Chunhui</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Wei-Yann</ForeName><Initials>WY</Initials></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Thomas C</ForeName><Initials>TC</Initials></Author><Author ValidYN="Y"><LastName>Denny</LastName><ForeName>Lynette</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00233727</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>AIDS</MedlineTA><NlmUniqueID>8710219</NlmUniqueID><ISSNLinking>0269-9370</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018290" MajorTopicYN="N">Cervical Intraepithelial Neoplasia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003127" MajorTopicYN="N">Colposcopy</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017679" MajorTopicYN="N">Cryotherapy</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004279" MajorTopicYN="N">DNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006297" MajorTopicYN="N">Health Services Accessibility</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008403" MajorTopicYN="N">Mass Screening</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027383" MajorTopicYN="N">Papillomaviridae</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030361" MajorTopicYN="N">Papillomavirus Infections</DescriptorName><QualifierName UI="Q000175" 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