A steady state of CD4+ T cell memory maturation and activation is established during primary subtype C HIV-1 infection.
Identifieur interne : 001980 ( PubMed/Checkpoint ); précédent : 001979; suivant : 001981A steady state of CD4+ T cell memory maturation and activation is established during primary subtype C HIV-1 infection.
Auteurs : Pholo Maenetje [Afrique du Sud] ; Catherine Riou ; Joseph P. Casazza ; David Ambrozak ; Brenna Hill ; Glenda Gray ; Richard A. Koup ; Guy De Bruyn ; Clive M. GraySource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2010.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Charge virale (immunologie), Humains, Infections à VIH (anatomopathologie), Infections à VIH (immunologie), Infections à VIH (virologie), Infections à cytomégalovirus (anatomopathologie), Infections à cytomégalovirus (immunologie), Infections à cytomégalovirus (virologie), Lymphocytes T CD4+ (cytologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD4+ (virologie), Mémoire immunologique, Produits du gène gag du virus de l'immunodéficience humaine (immunologie), Réplication virale (immunologie), Séquence consensus (immunologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Virémie (anatomopathologie), Virémie (immunologie), Études de cohortes, Études prospectives.
- MESH :
- anatomopathologie : Infections à VIH, Infections à cytomégalovirus, Virémie.
- cytologie : Lymphocytes T CD4+.
- immunologie : Activation des lymphocytes, Charge virale, Infections à VIH, Infections à cytomégalovirus, Lymphocytes T CD4+, Produits du gène gag du virus de l'immunodéficience humaine, Réplication virale, Séquence consensus, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virémie.
- virologie : Infections à VIH, Infections à cytomégalovirus, Lymphocytes T CD4+.
- Humains, Mémoire immunologique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études de cohortes, Études prospectives.
English descriptors
- KwdEn :
- CD4-Positive T-Lymphocytes (cytology), CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (virology), Cohort Studies, Consensus Sequence (immunology), Cytomegalovirus Infections (immunology), Cytomegalovirus Infections (pathology), Cytomegalovirus Infections (virology), HIV Infections (immunology), HIV Infections (pathology), HIV Infections (virology), HIV-1 (classification), HIV-1 (immunology), Humans, Immunologic Memory, Lymphocyte Activation (immunology), Prospective Studies, Viral Load (immunology), Viremia (immunology), Viremia (pathology), Virus Replication (immunology), gag Gene Products, Human Immunodeficiency Virus (immunology).
- MESH :
- chemical , immunology : gag Gene Products, Human Immunodeficiency Virus.
- classification : HIV-1.
- cytology : CD4-Positive T-Lymphocytes.
- immunology : CD4-Positive T-Lymphocytes, Consensus Sequence, Cytomegalovirus Infections, HIV Infections, HIV-1, Lymphocyte Activation, Viral Load, Viremia, Virus Replication.
- pathology : Cytomegalovirus Infections, HIV Infections, Viremia.
- virology : CD4-Positive T-Lymphocytes, Cytomegalovirus Infections, HIV Infections.
- Cohort Studies, Humans, Immunologic Memory, Prospective Studies.
Abstract
The functional integrity of CD4(+) T cells is crucial for well-orchestrated immunity and control of HIV-1 infection, but their selective depletion during infection creates a paradox for understanding a protective response. We used multiparameter flow cytometry to measure activation, memory maturation, and multiple functions of total and Ag-specific CD4(+) T cells in 14 HIV-1- and CMV- coinfected individuals at 3 and 12 mo post HIV-1 infection. Primary HIV-1 infection was characterized by elevated levels of CD38, HLA-DR, and Ki67 in total memory and Gag-specific CD4(+) and CD8(+) T cells. In both HIV-infected and 15 uninfected controls, the frequency of activated cells was uniformly distributed among early differentiated (ED; CD45RO(+)CD27(+)), late differentiated (CD45RO(+)CD27(-)), and fully differentiated effector (CD45RO(-)CD27(-)) memory CD4(+) T cells. In HIV-1-infected individuals, activated CD4(+) T cells significantly correlated with viremia at 3 mo postinfection (r = 0.79, p = 0.0007) and also harbored more gag provirus DNA copies than nonactivated cells (p = 0.04). Moreover, Gag-specific ED CD4(+) T cells inversely associated with plasma viral load (r = -0.87, p < 0.0001). Overall, we show that low copy numbers of gag provirus and plasma RNA copies associated with low CD4 activation as well as accumulation of ED HIV-specific CD4(+) memory. Significant positive correlations between 3 and 12 mo activation and memory events highlighted that a steady state of CD4(+) T cell activation and memory maturation was established during primary infection and that these cells were unlikely to be involved in influencing the course of viremia in the first 12 mo of HIV-1 infection.
DOI: 10.4049/jimmunol.0903771
PubMed: 20363974
Affiliations:
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Casazza</name></author><author><name sortKey="Ambrozak, David" sort="Ambrozak, David" uniqKey="Ambrozak D" first="David" last="Ambrozak">David Ambrozak</name></author><author><name sortKey="Hill, Brenna" sort="Hill, Brenna" uniqKey="Hill B" first="Brenna" last="Hill">Brenna Hill</name></author><author><name sortKey="Gray, Glenda" sort="Gray, Glenda" uniqKey="Gray G" first="Glenda" last="Gray">Glenda Gray</name></author><author><name sortKey="Koup, Richard A" sort="Koup, Richard A" uniqKey="Koup R" first="Richard A" last="Koup">Richard A. Koup</name></author><author><name sortKey="De Bruyn, Guy" sort="De Bruyn, Guy" uniqKey="De Bruyn G" first="Guy" last="De Bruyn">Guy De Bruyn</name></author><author><name sortKey="Gray, Clive M" sort="Gray, Clive M" uniqKey="Gray C" first="Clive M" last="Gray">Clive M. Gray</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="eISSN">1550-6606</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4-Positive T-Lymphocytes (cytology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD4-Positive T-Lymphocytes (virology)</term><term>Cohort Studies</term><term>Consensus Sequence (immunology)</term><term>Cytomegalovirus Infections (immunology)</term><term>Cytomegalovirus Infections (pathology)</term><term>Cytomegalovirus Infections (virology)</term><term>HIV Infections (immunology)</term><term>HIV Infections (pathology)</term><term>HIV Infections (virology)</term><term>HIV-1 (classification)</term><term>HIV-1 (immunology)</term><term>Humans</term><term>Immunologic Memory</term><term>Lymphocyte Activation (immunology)</term><term>Prospective Studies</term><term>Viral Load (immunology)</term><term>Viremia (immunology)</term><term>Viremia (pathology)</term><term>Virus Replication (immunology)</term><term>gag Gene Products, Human Immunodeficiency Virus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term><term>Charge virale (immunologie)</term><term>Humains</term><term>Infections à VIH (anatomopathologie)</term><term>Infections à VIH (immunologie)</term><term>Infections à VIH (virologie)</term><term>Infections à cytomégalovirus (anatomopathologie)</term><term>Infections à cytomégalovirus (immunologie)</term><term>Infections à cytomégalovirus (virologie)</term><term>Lymphocytes T CD4+ (cytologie)</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD4+ (virologie)</term><term>Mémoire immunologique</term><term>Produits du gène gag du virus de l'immunodéficience humaine (immunologie)</term><term>Réplication virale (immunologie)</term><term>Séquence consensus (immunologie)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>Virémie (anatomopathologie)</term><term>Virémie (immunologie)</term><term>Études de cohortes</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>gag Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à VIH</term><term>Infections à cytomégalovirus</term><term>Virémie</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes T CD4+</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term><term>Charge virale</term><term>Infections à VIH</term><term>Infections à cytomégalovirus</term><term>Lymphocytes T CD4+</term><term>Produits du gène gag du virus de l'immunodéficience humaine</term><term>Réplication virale</term><term>Séquence consensus</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Virémie</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Consensus Sequence</term><term>Cytomegalovirus Infections</term><term>HIV Infections</term><term>HIV-1</term><term>Lymphocyte Activation</term><term>Viral Load</term><term>Viremia</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cytomegalovirus Infections</term><term>HIV Infections</term><term>Viremia</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term><term>Infections à cytomégalovirus</term><term>Lymphocytes T CD4+</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Cytomegalovirus Infections</term><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term><term>Humans</term><term>Immunologic Memory</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Mémoire immunologique</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Études de cohortes</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The functional integrity of CD4(+) T cells is crucial for well-orchestrated immunity and control of HIV-1 infection, but their selective depletion during infection creates a paradox for understanding a protective response. We used multiparameter flow cytometry to measure activation, memory maturation, and multiple functions of total and Ag-specific CD4(+) T cells in 14 HIV-1- and CMV- coinfected individuals at 3 and 12 mo post HIV-1 infection. Primary HIV-1 infection was characterized by elevated levels of CD38, HLA-DR, and Ki67 in total memory and Gag-specific CD4(+) and CD8(+) T cells. In both HIV-infected and 15 uninfected controls, the frequency of activated cells was uniformly distributed among early differentiated (ED; CD45RO(+)CD27(+)), late differentiated (CD45RO(+)CD27(-)), and fully differentiated effector (CD45RO(-)CD27(-)) memory CD4(+) T cells. In HIV-1-infected individuals, activated CD4(+) T cells significantly correlated with viremia at 3 mo postinfection (r = 0.79, p = 0.0007) and also harbored more gag provirus DNA copies than nonactivated cells (p = 0.04). Moreover, Gag-specific ED CD4(+) T cells inversely associated with plasma viral load (r = -0.87, p < 0.0001). Overall, we show that low copy numbers of gag provirus and plasma RNA copies associated with low CD4 activation as well as accumulation of ED HIV-specific CD4(+) memory. Significant positive correlations between 3 and 12 mo activation and memory events highlighted that a steady state of CD4(+) T cell activation and memory maturation was established during primary infection and that these cells were unlikely to be involved in influencing the course of viremia in the first 12 mo of HIV-1 infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20363974</PMID><DateCreated><Year>2010</Year><Month>04</Month><Day>22</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>01</Day></DateCompleted><DateRevised><Year>2010</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN><JournalIssue CitedMedium="Internet"><Volume>184</Volume><Issue>9</Issue><PubDate><Year>2010</Year><Month>May</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>A steady state of CD4+ T cell memory maturation and activation is established during primary subtype C HIV-1 infection.</ArticleTitle><Pagination><MedlinePgn>4926-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.0903771</ELocationID><Abstract><AbstractText>The functional integrity of CD4(+) T cells is crucial for well-orchestrated immunity and control of HIV-1 infection, but their selective depletion during infection creates a paradox for understanding a protective response. We used multiparameter flow cytometry to measure activation, memory maturation, and multiple functions of total and Ag-specific CD4(+) T cells in 14 HIV-1- and CMV- coinfected individuals at 3 and 12 mo post HIV-1 infection. Primary HIV-1 infection was characterized by elevated levels of CD38, HLA-DR, and Ki67 in total memory and Gag-specific CD4(+) and CD8(+) T cells. In both HIV-infected and 15 uninfected controls, the frequency of activated cells was uniformly distributed among early differentiated (ED; CD45RO(+)CD27(+)), late differentiated (CD45RO(+)CD27(-)), and fully differentiated effector (CD45RO(-)CD27(-)) memory CD4(+) T cells. In HIV-1-infected individuals, activated CD4(+) T cells significantly correlated with viremia at 3 mo postinfection (r = 0.79, p = 0.0007) and also harbored more gag provirus DNA copies than nonactivated cells (p = 0.04). Moreover, Gag-specific ED CD4(+) T cells inversely associated with plasma viral load (r = -0.87, p < 0.0001). Overall, we show that low copy numbers of gag provirus and plasma RNA copies associated with low CD4 activation as well as accumulation of ED HIV-specific CD4(+) memory. Significant positive correlations between 3 and 12 mo activation and memory events highlighted that a steady state of CD4(+) T cell activation and memory maturation was established during primary infection and that these cells were unlikely to be involved in influencing the course of viremia in the first 12 mo of HIV-1 infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maenetje</LastName><ForeName>Pholo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>AIDS Research Unit, National Institute for Communicable Diseases, Johannesburg, Gauteng, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riou</LastName><ForeName>Catherine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Casazza</LastName><ForeName>Joseph P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Ambrozak</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Brenna</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Gray</LastName><ForeName>Glenda</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Koup</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>de Bruyn</LastName><ForeName>Guy</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Gray</LastName><ForeName>Clive M</ForeName><Initials>CM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI070079</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>04</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Immunol</MedlineTA><NlmUniqueID>2985117R</NlmUniqueID><ISSNLinking>0022-1767</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054301">gag Gene Products, Human Immunodeficiency Virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016384" MajorTopicYN="N">Consensus Sequence</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003586" MajorTopicYN="N">Cytomegalovirus Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015497" MajorTopicYN="N">HIV-1</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007156" MajorTopicYN="Y">Immunologic Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014766" MajorTopicYN="N">Viremia</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054301" MajorTopicYN="N">gag Gene Products, Human Immunodeficiency Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>4</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>4</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>7</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20363974</ArticleId><ArticleId IdType="pii">jimmunol.0903771</ArticleId><ArticleId IdType="doi">10.4049/jimmunol.0903771</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><noCountry><name sortKey="Ambrozak, David" sort="Ambrozak, David" uniqKey="Ambrozak D" first="David" last="Ambrozak">David Ambrozak</name><name sortKey="Casazza, Joseph P" sort="Casazza, Joseph P" uniqKey="Casazza J" first="Joseph P" last="Casazza">Joseph P. Casazza</name><name sortKey="De Bruyn, Guy" sort="De Bruyn, Guy" uniqKey="De Bruyn G" first="Guy" last="De Bruyn">Guy De Bruyn</name><name sortKey="Gray, Clive M" sort="Gray, Clive M" uniqKey="Gray C" first="Clive M" last="Gray">Clive M. Gray</name><name sortKey="Gray, Glenda" sort="Gray, Glenda" uniqKey="Gray G" first="Glenda" last="Gray">Glenda Gray</name><name sortKey="Hill, Brenna" sort="Hill, Brenna" uniqKey="Hill B" first="Brenna" last="Hill">Brenna Hill</name><name sortKey="Koup, Richard A" sort="Koup, Richard A" uniqKey="Koup R" first="Richard A" last="Koup">Richard A. Koup</name><name sortKey="Riou, Catherine" sort="Riou, Catherine" uniqKey="Riou C" first="Catherine" last="Riou">Catherine Riou</name></noCountry><country name="Afrique du Sud"><noRegion><name sortKey="Maenetje, Pholo" sort="Maenetje, Pholo" uniqKey="Maenetje P" first="Pholo" last="Maenetje">Pholo Maenetje</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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