Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Chronology and evolution of the HIV-1 subtype C epidemic in Ethiopia.

Identifieur interne : 001893 ( PubMed/Checkpoint ); précédent : 001892; suivant : 001894

Chronology and evolution of the HIV-1 subtype C epidemic in Ethiopia.

Auteurs : Damien C. Tully [États-Unis] ; Charles Wood

Source :

RBID : pubmed:20539092

Descripteurs français

English descriptors

Abstract

To reconstruct the onset date and evolutionary history of the HIV-1 subtype C epidemic in Ethiopia - one of the earliest recorded subtype C epidemics in the world.

DOI: 10.1097/QAD.0b013e32833999e1
PubMed: 20539092


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:20539092

Le document en format XML

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<div type="abstract" xml:lang="en">To reconstruct the onset date and evolutionary history of the HIV-1 subtype C epidemic in Ethiopia - one of the earliest recorded subtype C epidemics in the world.</div>
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<AbstractText Label="DESIGN" NlmCategory="METHODS">HIV-1 C env sequences with a known sampling year isolated from HIV-1 positive patients from Ethiopia between 1984 and 2003.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Evolutionary parameters including origin and demographic growth patterns were estimated using a Bayesian coalescent-based approach under either strict or relaxed molecular clock models.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Bayesian evolutionary analysis indicated a most recent common ancestor date of 1965 with three distinct epidemic growth phases. Regression analysis of root-to-tip distances revealed a highly similar estimate for the origin of the clade. In addition, we reveal that the HIV-1C epidemic in Ethiopia has grown at a faster rate than the epidemic of subtype C in sub-Saharan Africa.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Reconstruction of the epidemic history in Ethiopia revealed that subtype C likely originated from either a single lineage or multiple descendents in the late 1960s or early 1970s where it grew exponentially throughout the mid-1970s and early 1980s, corresponding to a wave of urbanization and migration. In light of these findings, we suggest that subtype C strains were circulating at least a decade before previous estimates and the first recognition of symptomatic patients in Ethiopia. The timing of the Ethiopian epidemic is also in agreement with similar HIV-1 epidemics in sub-Saharan Africa.</AbstractText>
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