The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection.
Identifieur interne : 000C61 ( PubMed/Checkpoint ); précédent : 000C60; suivant : 000C62The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection.
Auteurs : Naadira Vanker [Afrique du Sud] ; Hayley IppSource :
- South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde [ 0256-9574 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Antigènes CD38.
- immunologie : Infections à VIH, Lymphocytes T CD8+.
- Adulte, Cytométrie en flux, Femelle, Humains, Mâle, Numération des leucocytes, Numération des lymphocytes CD4, Études transversales.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Antigens, CD38.
- immunology : CD8-Positive T-Lymphocytes, HIV Infections.
- Adult, CD4 Lymphocyte Count, Cross-Sectional Studies, Female, Flow Cytometry, Humans, Leukocyte Count, Male.
Abstract
A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested in HIV infection. However, the full blood count (FBC) is a commonly performed test.
PubMed: 24388088
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection.</title><author><name sortKey="Vanker, Naadira" sort="Vanker, Naadira" uniqKey="Vanker N" first="Naadira" last="Vanker">Naadira Vanker</name><affiliation wicri:level="1"><nlm:affiliation>Division of Haematopathology, National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa. naadira.vanker@nhls.ac.za.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Haematopathology, National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Ipp, Hayley" sort="Ipp, Hayley" uniqKey="Ipp H" first="Hayley" last="Ipp">Hayley Ipp</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:24388088</idno><idno type="pmid">24388088</idno><idno type="wicri:Area/PubMed/Corpus">001595</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001595</idno><idno type="wicri:Area/PubMed/Curation">001595</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001595</idno><idno type="wicri:Area/PubMed/Checkpoint">001595</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001595</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection.</title><author><name sortKey="Vanker, Naadira" sort="Vanker, Naadira" uniqKey="Vanker N" first="Naadira" last="Vanker">Naadira Vanker</name><affiliation wicri:level="1"><nlm:affiliation>Division of Haematopathology, National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa. naadira.vanker@nhls.ac.za.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Haematopathology, National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Ipp, Hayley" sort="Ipp, Hayley" uniqKey="Ipp H" first="Hayley" last="Ipp">Hayley Ipp</name></author></analytic><series><title level="j">South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde</title><idno type="ISSN">0256-9574</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, CD38 (analysis)</term><term>CD4 Lymphocyte Count</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Flow Cytometry</term><term>HIV Infections (immunology)</term><term>Humans</term><term>Leukocyte Count</term><term>Male</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antigènes CD38 (analyse)</term><term>Cytométrie en flux</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Mâle</term><term>Numération des leucocytes</term><term>Numération des lymphocytes CD4</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD38</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD38</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term><term>Lymphocytes T CD8+</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>CD4 Lymphocyte Count</term><term>Cross-Sectional Studies</term><term>Female</term><term>Flow Cytometry</term><term>Humans</term><term>Leukocyte Count</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Cytométrie en flux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Numération des leucocytes</term><term>Numération des lymphocytes CD4</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested in HIV infection. However, the full blood count (FBC) is a commonly performed test.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24388088</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>06</Day></DateCreated><DateCompleted><Year>2014</Year><Month>03</Month><Day>20</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>12</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">0256-9574</ISSN><JournalIssue CitedMedium="Print"><Volume>104</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Oct</Month><Day>11</Day></PubDate></JournalIssue><Title>South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde</Title><ISOAbbreviation>S. Afr. Med. J.</ISOAbbreviation></Journal><ArticleTitle>The use of the full blood count and differential parameters to assess immune activation levels in asymptomatic, untreated HIV infection.</ArticleTitle><Pagination><MedlinePgn>45-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.7196/samj.6983</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A feature of HIV/AIDS is chronic immune activation, which results in a number of complications including inflammation-related disorders and blood cytopaenias. Immune activation status is not routinely tested in HIV infection. However, the full blood count (FBC) is a commonly performed test.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We hypothesised that FBC parameters would be significantly different in HIV-infected v. -uninfected individuals, and that some of these parameters would correlate with markers of immune activation (i.e. percentage CD38 expression on CD8(+) T cells (%CD38onCD8)) and disease progression (i.e. CD4(+) counts) in HIV infection.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This was a cross-sectional study with 83 HIV-infected adults who were antiretroviral therapy-naive and clinically well, and 51 HIV-uninfected adults. The %CD38onCD8 and CD4(+) counts were determined by flow cytometry and the FBC was performed on a Siemens ADVIA 2120 system. FBC parameters investigated were total white cell count (WCC), haemoglobin (Hb) concentration, platelet count, absolute neutrophil count, absolute lymphocyte count, and percentage of large unstained cells (%LUCs).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Significant differences were found between the HIV-infected and -uninfected groups for total WCC, Hb, neutrophil count, lymphocyte count and %LUCs. The mean ± standard deviation (SD) for the total WCC (5.3±1.3 v. 6.9±2.2; p≤0.001) and the %LUCs (2.5±0.9 v. 2.0±0.9; p=0.001) both showed correlations with CD4(+) counts and %CD38onCD8.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The total WCC and %LUCs showed significant differences in HIV-infected individuals and correlated with markers of immune activation and disease progression. This suggests the potential use of these parameters as markers of immune activation in HIV infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vanker</LastName><ForeName>Naadira</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Haematopathology, National Health Laboratory Service and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa. naadira.vanker@nhls.ac.za.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ipp</LastName><ForeName>Hayley</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>South Africa</Country><MedlineTA>S Afr Med J</MedlineTA><NlmUniqueID>0404520</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.2.2.5</RegistryNumber><NameOfSubstance UI="D051997">Antigens, CD38</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051997" MajorTopicYN="N">Antigens, CD38</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007958" MajorTopicYN="Y">Leukocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>04</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24388088</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li></country></list><tree><noCountry><name sortKey="Ipp, Hayley" sort="Ipp, Hayley" uniqKey="Ipp H" first="Hayley" last="Ipp">Hayley Ipp</name></noCountry><country name="Afrique du Sud"><noRegion><name sortKey="Vanker, Naadira" sort="Vanker, Naadira" uniqKey="Vanker N" first="Naadira" last="Vanker">Naadira Vanker</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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