A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial.
Identifieur interne : 000948 ( PubMed/Checkpoint ); précédent : 000947; suivant : 000949A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial.
Auteurs : Richard Hayes [Royaume-Uni] ; Sian Floyd [Royaume-Uni] ; Ab Schaap [Royaume-Uni] ; Kwame Shanaube [Zambie] ; Peter Bock [Afrique du Sud] ; Kalpana Sabapathy [Royaume-Uni] ; Sam Griffith [États-Unis] ; Deborah Donnell [États-Unis] ; Estelle Piwowar-Manning [États-Unis] ; Wafaa El-Sadr [États-Unis] ; Nulda Beyers [Afrique du Sud] ; Helen Ayles [Zambie] ; Sarah Fidler [Royaume-Uni]Source :
- PLoS medicine [ 1549-1676 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Antirétroviraux (usage thérapeutique), Dépistage systématique, Femelle, Humains, Incidence, Infections à VIH (), Infections à VIH (diagnostic), Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Jeune adulte, Mâle, Zambie (épidémiologie), Études de cohortes.
- MESH :
- diagnostic : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- épidémiologie : Infections à VIH, Zambie.
- Adolescent, Adulte, Dépistage systématique, Femelle, Humains, Incidence, Infections à VIH, Jeune adulte, Mâle, Études de cohortes.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-Retroviral Agents.
- diagnosis : HIV Infections.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections, Zambia.
- prevention & control : HIV Infections.
- Adolescent, Adult, Cohort Studies, Female, Humans, Incidence, Male, Mass Screening, Young Adult.
Abstract
The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained antiretroviral therapy (ART), and 90% of individuals on ART have durable viral suppression. The HPTN 071 (PopART) trial is measuring the impact of a universal testing and treatment intervention on population-level HIV incidence in 21 urban communities in Zambia and South Africa. We report observational data from four communities in Zambia to assess progress towards the UNAIDS targets after 1 y of the PopART intervention.
DOI: 10.1371/journal.pmed.1002292
PubMed: 28464041
Affiliations:
- Afrique du Sud, Royaume-Uni, Zambie, États-Unis
- Angleterre, Caroline du Nord, Grand Londres, Maryland, Washington (État), État de New York
- Londres, New York
- Université Columbia
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sortKey="Griffith, Sam" sort="Griffith, Sam" uniqKey="Griffith S" first="Sam" last="Griffith">Sam Griffith</name><affiliation wicri:level="2"><nlm:affiliation>FHI 360, HIV Prevention Trials Network, Durham, North Carolina, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>FHI 360, HIV Prevention Trials Network, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Donnell, Deborah" sort="Donnell, Deborah" uniqKey="Donnell D" first="Deborah" last="Donnell">Deborah Donnell</name><affiliation wicri:level="2"><nlm:affiliation>HIV Prevention Trials Network Statistical and Data Management Center, Statistical Center for HIV/AIDS Research and Prevention, Seattle, Washington, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>HIV Prevention Trials Network Statistical and Data Management 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wicri:level="4"><nlm:affiliation>Mailman School of Public Health, Columbia University, New York, New York, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Beyers, Nulda" sort="Beyers, Nulda" uniqKey="Beyers N" first="Nulda" last="Beyers">Nulda Beyers</name><affiliation wicri:level="1"><nlm:affiliation>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, 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intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial.</title><author><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Floyd, Sian" sort="Floyd, Sian" uniqKey="Floyd S" first="Sian" last="Floyd">Sian Floyd</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schaap, Ab" sort="Schaap, Ab" uniqKey="Schaap A" first="Ab" last="Schaap">Ab Schaap</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Shanaube, Kwame" sort="Shanaube, Kwame" uniqKey="Shanaube K" first="Kwame" last="Shanaube">Kwame Shanaube</name><affiliation wicri:level="1"><nlm:affiliation>Zambart, University of Zambia School of Medicine, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>Zambart, University of Zambia School of Medicine, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Bock, Peter" sort="Bock, Peter" uniqKey="Bock P" first="Peter" last="Bock">Peter Bock</name><affiliation wicri:level="1"><nlm:affiliation>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch</wicri:regionArea><wicri:noRegion>Stellenbosch</wicri:noRegion></affiliation></author><author><name sortKey="Sabapathy, Kalpana" sort="Sabapathy, Kalpana" uniqKey="Sabapathy K" first="Kalpana" last="Sabapathy">Kalpana Sabapathy</name><affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Griffith, Sam" sort="Griffith, Sam" uniqKey="Griffith S" first="Sam" last="Griffith">Sam Griffith</name><affiliation wicri:level="2"><nlm:affiliation>FHI 360, HIV Prevention Trials Network, Durham, North Carolina, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>FHI 360, HIV Prevention Trials Network, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Donnell, Deborah" sort="Donnell, Deborah" uniqKey="Donnell D" first="Deborah" last="Donnell">Deborah Donnell</name><affiliation wicri:level="2"><nlm:affiliation>HIV Prevention Trials Network Statistical and Data Management Center, Statistical Center for HIV/AIDS Research and Prevention, Seattle, Washington, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>HIV Prevention Trials Network Statistical and Data Management Center, Statistical Center for HIV/AIDS Research and Prevention, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Piwowar Manning, Estelle" sort="Piwowar Manning, Estelle" uniqKey="Piwowar Manning E" first="Estelle" last="Piwowar-Manning">Estelle Piwowar-Manning</name><affiliation wicri:level="2"><nlm:affiliation>HIV Prevention Trials Network Laboratory Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>HIV Prevention Trials Network Laboratory Center, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation wicri:level="4"><nlm:affiliation>Mailman School of Public Health, Columbia University, New York, New York, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mailman School of Public Health, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Beyers, Nulda" sort="Beyers, Nulda" uniqKey="Beyers N" first="Nulda" last="Beyers">Nulda Beyers</name><affiliation wicri:level="1"><nlm:affiliation>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch</wicri:regionArea><wicri:noRegion>Stellenbosch</wicri:noRegion></affiliation></author><author><name sortKey="Ayles, Helen" sort="Ayles, Helen" uniqKey="Ayles H" first="Helen" last="Ayles">Helen Ayles</name><affiliation wicri:level="1"><nlm:affiliation>Zambart, University of Zambia School of Medicine, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>Zambart, University of Zambia School of Medicine, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Fidler, Sarah" sort="Fidler, Sarah" uniqKey="Fidler S" first="Sarah" last="Fidler">Sarah Fidler</name><affiliation wicri:level="3"><nlm:affiliation>HIV Clinical Trials Unit, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>HIV Clinical Trials Unit, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">PLoS medicine</title><idno type="eISSN">1549-1676</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>Cohort Studies</term><term>Female</term><term>HIV Infections (diagnosis)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (prevention & control)</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mass Screening</term><term>Young Adult</term><term>Zambia (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Antirétroviraux (usage thérapeutique)</term><term>Dépistage systématique</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Infections à VIH ()</term><term>Infections à VIH (diagnostic)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Zambie (épidémiologie)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>Zambia</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à VIH</term><term>Zambie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Mass Screening</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Dépistage systématique</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Infections à VIH</term><term>Jeune adulte</term><term>Mâle</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained antiretroviral therapy (ART), and 90% of individuals on ART have durable viral suppression. The HPTN 071 (PopART) trial is measuring the impact of a universal testing and treatment intervention on population-level HIV incidence in 21 urban communities in Zambia and South Africa. We report observational data from four communities in Zambia to assess progress towards the UNAIDS targets after 1 y of the PopART intervention.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28464041</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>02</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>21</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1549-1676</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month></PubDate></JournalIssue><Title>PLoS medicine</Title><ISOAbbreviation>PLoS Med.</ISOAbbreviation></Journal><ArticleTitle>A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial.</ArticleTitle><Pagination><MedlinePgn>e1002292</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pmed.1002292</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets require that, by 2020, 90% of those living with HIV know their status, 90% of known HIV-positive individuals receive sustained antiretroviral therapy (ART), and 90% of individuals on ART have durable viral suppression. The HPTN 071 (PopART) trial is measuring the impact of a universal testing and treatment intervention on population-level HIV incidence in 21 urban communities in Zambia and South Africa. We report observational data from four communities in Zambia to assess progress towards the UNAIDS targets after 1 y of the PopART intervention.</AbstractText><AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">The PopART intervention comprises annual rounds of home-based HIV testing delivered by community HIV-care providers (CHiPs) who also support linkage to care, ART retention, and other services. Data from four communities in Zambia receiving the full intervention (including immediate ART for all individuals with HIV) were used to determine proportions of participants who knew their HIV status after the CHiP visit; proportions linking to care and initiating ART following referral; and overall proportions of HIV-infected individuals who knew their status (first 90 target) and the proportion of these on ART (second 90 target), pre- and post-intervention. We are not able to assess progress towards the third 90 target at this stage of the study. Overall, 121,130 adults (59,283 men and 61,847 women) were enumerated in 46,714 households during the first annual round (December 2013 to June 2015). Of the 45,399 (77%) men and 55,703 (90%) women consenting to the intervention, 80% of men and 85% of women knew their HIV status after the CHiP visit. Of 6,197 HIV-positive adults referred by CHiPs, 42% (95% CI: 40%-43%) initiated ART within 6 mo and 53% (95% CI: 52%-55%) within 12 mo. In the entire population, the estimated proportion of HIV-positive adults who knew their status increased from 52% to 78% for men and from 56% to 87% for women. The estimated proportion of known HIV-positive individuals on ART increased overall from 54% after the CHiP visit to 74% by the end of the round for men and from 53% to 73% for women. The estimated overall proportion of HIV-positive adults on ART, irrespective of whether they knew their status, increased from 44% to 61%, compared with the 81% target (the product of the first two 90 targets). Coverage was lower among young men and women than in older age groups. The main limitation of the study was the need for assumptions concerning knowledge of HIV status and ART coverage among adults not consenting to the intervention or HIV testing, although our conclusions were robust in sensitivity analyses.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this analysis, acceptance of HIV testing among those consenting to the intervention was high, although linkage to care and ART initiation took longer than expected. Knowledge of HIV-positive status increased steeply after 1 y, almost attaining the first 90 target in women and approaching it in men. The second 90 target was more challenging, with approximately three-quarters of known HIV-positive individuals on ART by the end of the annual round. Achieving higher test uptake in men and more rapid linkage to care will be key objectives during the second annual round of the intervention.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov NCT01900977.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hayes</LastName><ForeName>Richard</ForeName><Initials>R</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1729-9892</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Floyd</LastName><ForeName>Sian</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8615-7601</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaap</LastName><ForeName>Ab</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5959-526X</Identifier><AffiliationInfo><Affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Zambart, University of Zambia School of Medicine, Lusaka, Zambia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shanaube</LastName><ForeName>Kwame</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Zambart, University of Zambia School of Medicine, Lusaka, Zambia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bock</LastName><ForeName>Peter</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-3211-6078</Identifier><AffiliationInfo><Affiliation>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabapathy</LastName><ForeName>Kalpana</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griffith</LastName><ForeName>Sam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>FHI 360, HIV Prevention Trials Network, Durham, North Carolina, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donnell</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0587-7480</Identifier><AffiliationInfo><Affiliation>HIV Prevention Trials Network Statistical and Data Management Center, Statistical Center for HIV/AIDS Research and Prevention, Seattle, Washington, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piwowar-Manning</LastName><ForeName>Estelle</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6501-0440</Identifier><AffiliationInfo><Affiliation>HIV Prevention Trials Network Laboratory Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>El-Sadr</LastName><ForeName>Wafaa</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Mailman School of Public Health, Columbia University, New York, New York, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beyers</LastName><ForeName>Nulda</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Desmond Tutu TB Centre, Department of Paediatrics and Child Health, University of Stellenbosch, Stellenbosch, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ayles</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Zambart, University of Zambia School of Medicine, Lusaka, Zambia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fidler</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>HIV Clinical Trials Unit, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>HPTN 071 (PopART) Study Team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>05</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS Med</MedlineTA><NlmUniqueID>101231360</NlmUniqueID><ISSNLinking>1549-1277</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Jul 06;10(7):e0131353</RefSource><PMID Version="1">26147987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2005 May 1;191(9):1403-9</RefSource><PMID Version="1">15809897</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet HIV. 2016 May;3(5):e193-4</RefSource><PMID 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Version="1">28464003</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044966" MajorTopicYN="N">Anti-Retroviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008403" MajorTopicYN="N">Mass Screening</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015024" MajorTopicYN="N">Zambia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28464041</ArticleId><ArticleId IdType="doi">10.1371/journal.pmed.1002292</ArticleId><ArticleId IdType="pii">PMEDICINE-D-16-03697</ArticleId><ArticleId IdType="pmc">PMC5412988</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li><li>Royaume-Uni</li><li>Zambie</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Nord</li><li>Grand Londres</li><li>Maryland</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Londres</li><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hayes, Richard" sort="Hayes, Richard" uniqKey="Hayes R" first="Richard" last="Hayes">Richard Hayes</name></region><name sortKey="Fidler, Sarah" sort="Fidler, Sarah" uniqKey="Fidler S" first="Sarah" last="Fidler">Sarah Fidler</name><name sortKey="Floyd, Sian" sort="Floyd, Sian" uniqKey="Floyd S" first="Sian" last="Floyd">Sian Floyd</name><name sortKey="Sabapathy, Kalpana" sort="Sabapathy, Kalpana" uniqKey="Sabapathy K" first="Kalpana" last="Sabapathy">Kalpana Sabapathy</name><name sortKey="Schaap, Ab" sort="Schaap, Ab" uniqKey="Schaap A" first="Ab" last="Schaap">Ab Schaap</name></country><country name="Zambie"><noRegion><name sortKey="Shanaube, Kwame" sort="Shanaube, Kwame" uniqKey="Shanaube K" first="Kwame" last="Shanaube">Kwame Shanaube</name></noRegion><name sortKey="Ayles, Helen" sort="Ayles, Helen" uniqKey="Ayles H" first="Helen" last="Ayles">Helen Ayles</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Bock, Peter" sort="Bock, Peter" uniqKey="Bock P" first="Peter" last="Bock">Peter Bock</name></noRegion><name sortKey="Beyers, Nulda" sort="Beyers, Nulda" uniqKey="Beyers N" first="Nulda" last="Beyers">Nulda Beyers</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Griffith, Sam" sort="Griffith, Sam" uniqKey="Griffith S" first="Sam" last="Griffith">Sam Griffith</name></region><name sortKey="Donnell, Deborah" sort="Donnell, Deborah" uniqKey="Donnell D" first="Deborah" last="Donnell">Deborah Donnell</name><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><name sortKey="Piwowar Manning, Estelle" sort="Piwowar Manning, Estelle" uniqKey="Piwowar Manning E" first="Estelle" last="Piwowar-Manning">Estelle Piwowar-Manning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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