CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.
Identifieur interne : 000842 ( PubMed/Checkpoint ); précédent : 000841; suivant : 000843CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.
Auteurs : Robert Gross [États-Unis] ; Scarlett L. Bellamy ; Bakgaki Ratshaa ; Xiaoyan Han ; Marijana Vujkovic ; Richard Aplenc ; Andrew P. Steenhoff ; Mosepele Mosepele ; Ganesh Moorthy ; Athena F. Zuppa ; Brian L. Strom ; Gregory P. BissonSource :
- AIDS (London, England) [ 1473-5571 ] ; 2017.
Abstract
To determine the association between cytochrome p450 2B6 genotypes and efavirenz-based HIV treatment outcomes.
DOI: 10.1097/QAD.0000000000001593
PubMed: 28692529
Affiliations:
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Bellamy</name></author><author><name sortKey="Ratshaa, Bakgaki" sort="Ratshaa, Bakgaki" uniqKey="Ratshaa B" first="Bakgaki" last="Ratshaa">Bakgaki Ratshaa</name></author><author><name sortKey="Han, Xiaoyan" sort="Han, Xiaoyan" uniqKey="Han X" first="Xiaoyan" last="Han">Xiaoyan Han</name></author><author><name sortKey="Vujkovic, Marijana" sort="Vujkovic, Marijana" uniqKey="Vujkovic M" first="Marijana" last="Vujkovic">Marijana Vujkovic</name></author><author><name sortKey="Aplenc, Richard" sort="Aplenc, Richard" uniqKey="Aplenc R" first="Richard" last="Aplenc">Richard Aplenc</name></author><author><name sortKey="Steenhoff, Andrew P" sort="Steenhoff, Andrew P" uniqKey="Steenhoff A" first="Andrew P" last="Steenhoff">Andrew P. Steenhoff</name></author><author><name sortKey="Mosepele, Mosepele" sort="Mosepele, Mosepele" uniqKey="Mosepele M" first="Mosepele" last="Mosepele">Mosepele Mosepele</name></author><author><name sortKey="Moorthy, Ganesh" sort="Moorthy, Ganesh" uniqKey="Moorthy G" first="Ganesh" last="Moorthy">Ganesh Moorthy</name></author><author><name sortKey="Zuppa, Athena F" sort="Zuppa, Athena F" uniqKey="Zuppa A" first="Athena F" last="Zuppa">Athena F. Zuppa</name></author><author><name sortKey="Strom, Brian L" sort="Strom, Brian L" uniqKey="Strom B" first="Brian L" last="Strom">Brian L. Strom</name></author><author><name sortKey="Bisson, Gregory P" sort="Bisson, Gregory P" uniqKey="Bisson G" first="Gregory P" last="Bisson">Gregory P. Bisson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28692529</idno><idno type="pmid">28692529</idno><idno type="doi">10.1097/QAD.0000000000001593</idno><idno type="wicri:Area/PubMed/Corpus">000A03</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A03</idno><idno type="wicri:Area/PubMed/Curation">000A03</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A03</idno><idno type="wicri:Area/PubMed/Checkpoint">000A03</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.</title><author><name sortKey="Gross, Robert" sort="Gross, Robert" uniqKey="Gross R" first="Robert" last="Gross">Robert Gross</name><affiliation wicri:level="2"><nlm:affiliation>aDepartments of Medicine (Infectious Diseases) bEpidemiology cCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia dDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania eBotswana -UPenn Partnership, Gaborone, Botswana fDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania gFaculty of Medicine, University of Botswana, Gaborone, Botswana hOffice of the Chancellor, Rutgers Biomedical and Health Sciences, Rutgers University New Brunswick, New Jersey, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>aDepartments of Medicine (Infectious Diseases) bEpidemiology cCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia dDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania eBotswana -UPenn Partnership, Gaborone, Botswana fDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania gFaculty of Medicine, University of Botswana, Gaborone, Botswana hOffice of the Chancellor, Rutgers Biomedical and Health Sciences, Rutgers University New Brunswick, New Jersey</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Bellamy, Scarlett L" sort="Bellamy, Scarlett L" uniqKey="Bellamy S" first="Scarlett L" last="Bellamy">Scarlett L. Bellamy</name></author><author><name sortKey="Ratshaa, Bakgaki" sort="Ratshaa, Bakgaki" uniqKey="Ratshaa B" first="Bakgaki" last="Ratshaa">Bakgaki Ratshaa</name></author><author><name sortKey="Han, Xiaoyan" sort="Han, Xiaoyan" uniqKey="Han X" first="Xiaoyan" last="Han">Xiaoyan Han</name></author><author><name sortKey="Vujkovic, Marijana" sort="Vujkovic, Marijana" uniqKey="Vujkovic M" first="Marijana" last="Vujkovic">Marijana Vujkovic</name></author><author><name sortKey="Aplenc, Richard" sort="Aplenc, Richard" uniqKey="Aplenc R" first="Richard" last="Aplenc">Richard Aplenc</name></author><author><name sortKey="Steenhoff, Andrew P" sort="Steenhoff, Andrew P" uniqKey="Steenhoff A" first="Andrew P" last="Steenhoff">Andrew P. Steenhoff</name></author><author><name sortKey="Mosepele, Mosepele" sort="Mosepele, Mosepele" uniqKey="Mosepele M" first="Mosepele" last="Mosepele">Mosepele Mosepele</name></author><author><name sortKey="Moorthy, Ganesh" sort="Moorthy, Ganesh" uniqKey="Moorthy G" first="Ganesh" last="Moorthy">Ganesh Moorthy</name></author><author><name sortKey="Zuppa, Athena F" sort="Zuppa, Athena F" uniqKey="Zuppa A" first="Athena F" last="Zuppa">Athena F. Zuppa</name></author><author><name sortKey="Strom, Brian L" sort="Strom, Brian L" uniqKey="Strom B" first="Brian L" last="Strom">Brian L. Strom</name></author><author><name sortKey="Bisson, Gregory P" sort="Bisson, Gregory P" uniqKey="Bisson G" first="Gregory P" last="Bisson">Gregory P. Bisson</name></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="eISSN">1473-5571</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the association between cytochrome p450 2B6 genotypes and efavirenz-based HIV treatment outcomes.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28692529</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>10</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>15</Issue><PubDate><Year>2017</Year><Month>Sep</Month><Day>24</Day></PubDate></JournalIssue><Title>AIDS (London, England)</Title><ISOAbbreviation>AIDS</ISOAbbreviation></Journal><ArticleTitle>CYP2B6 genotypes and early efavirenz-based HIV treatment outcomes in Botswana.</ArticleTitle><Pagination><MedlinePgn>2107-2113</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0000000000001593</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To determine the association between cytochrome p450 2B6 genotypes and efavirenz-based HIV treatment outcomes.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Observational cohort study of HIV-infected adults initiating efavirenz-based regimens in Botswana.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The primary endpoint was a composite of death or loss to care or HIV RNA more than 25 copies/ml at 6 months. CYP2B6 516G>T and 983T>C genotyping was done with Taqman Open Array platform. Adverse experiences were measured by using the Subject Experience Questionnaire. Metabolism alleles were included in logistic regression models of the composite endpoint.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 801 individuals included 406 (51%) men, median age 37 years, median baseline CD4 cell count 195 cells/μl, and plasma HIV RNA 4.9 log10 copies/ml. 288 (36%) reached the endpoint, including 34 (4%) deaths, 151 (19%) lost to care, 11 (1%) lost to the study, but alive and in care, and 92 (11%) with plasma HIV RNA more than 25 copies/ml. Metabolism variant alleles were common with 396 (49%) intermediate and 192 (24%) slow metabolizers. There were no statistically significant associations between metabolism and treatment endpoints. However, slower metabolism was associated with fewer adverse experiences.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Slow metabolism alleles were associated with lower efavirenz clearance but not any of the treatment endpoints. Slow efavirenz metabolism did not exacerbate central nervous system toxicity. These results should allay concern that slow efavirenz metabolism adversely impacts individuals in sub-Saharan African settings in which these alleles are common.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>aDepartments of Medicine (Infectious Diseases) bEpidemiology cCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia dDepartment of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania eBotswana -UPenn Partnership, Gaborone, Botswana fDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania gFaculty of Medicine, University of Botswana, Gaborone, Botswana hOffice of the Chancellor, Rutgers Biomedical and Health Sciences, Rutgers University New Brunswick, New Jersey, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellamy</LastName><ForeName>Scarlett L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Ratshaa</LastName><ForeName>Bakgaki</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Xiaoyan</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Vujkovic</LastName><ForeName>Marijana</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Aplenc</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Steenhoff</LastName><ForeName>Andrew P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Mosepele</LastName><ForeName>Mosepele</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Moorthy</LastName><ForeName>Ganesh</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Zuppa</LastName><ForeName>Athena F</ForeName><Initials>AF</Initials></Author><Author ValidYN="Y"><LastName>Strom</LastName><ForeName>Brian L</ForeName><Initials>BL</Initials></Author><Author ValidYN="Y"><LastName>Bisson</LastName><ForeName>Gregory P</ForeName><Initials>GP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>D43 TW009781</GrantID><Acronym>TW</Acronym><Agency>FIC NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AI045008</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 MH097488</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH080701</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal 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Bellamy</name><name sortKey="Bisson, Gregory P" sort="Bisson, Gregory P" uniqKey="Bisson G" first="Gregory P" last="Bisson">Gregory P. Bisson</name><name sortKey="Han, Xiaoyan" sort="Han, Xiaoyan" uniqKey="Han X" first="Xiaoyan" last="Han">Xiaoyan Han</name><name sortKey="Moorthy, Ganesh" sort="Moorthy, Ganesh" uniqKey="Moorthy G" first="Ganesh" last="Moorthy">Ganesh Moorthy</name><name sortKey="Mosepele, Mosepele" sort="Mosepele, Mosepele" uniqKey="Mosepele M" first="Mosepele" last="Mosepele">Mosepele Mosepele</name><name sortKey="Ratshaa, Bakgaki" sort="Ratshaa, Bakgaki" uniqKey="Ratshaa B" first="Bakgaki" last="Ratshaa">Bakgaki Ratshaa</name><name sortKey="Steenhoff, Andrew P" sort="Steenhoff, Andrew P" uniqKey="Steenhoff A" first="Andrew P" last="Steenhoff">Andrew P. Steenhoff</name><name sortKey="Strom, Brian L" sort="Strom, Brian L" uniqKey="Strom B" first="Brian L" last="Strom">Brian L. Strom</name><name sortKey="Vujkovic, Marijana" sort="Vujkovic, Marijana" uniqKey="Vujkovic M" first="Marijana" last="Vujkovic">Marijana Vujkovic</name><name sortKey="Zuppa, Athena F" sort="Zuppa, Athena F" uniqKey="Zuppa A" first="Athena F" last="Zuppa">Athena F. Zuppa</name></noCountry><country name="États-Unis"><region name="New Jersey"><name sortKey="Gross, Robert" sort="Gross, Robert" uniqKey="Gross R" first="Robert" last="Gross">Robert Gross</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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