Looking for fungi in all the right places: screening for cryptococcal disease and other AIDS-related mycoses among patients with advanced HIV disease.
Identifieur interne : 000446 ( PubMed/Checkpoint ); précédent : 000445; suivant : 000447Looking for fungi in all the right places: screening for cryptococcal disease and other AIDS-related mycoses among patients with advanced HIV disease.
Auteurs : Greg Greene [Afrique du Sud] ; Charlotte Sriruttan ; Thuy Le ; Tom Chiller ; Nelesh P. GovenderSource :
- Current opinion in HIV and AIDS [ 1746-6318 ] ; 2017.
Descripteurs français
- KwdFr :
- Champignons (), Champignons (isolement et purification), Co-infection (diagnostic), Dépistage systématique (), Dépistage systématique (tendances), Humains, Infections fongiques invasives (), Infections fongiques invasives (diagnostic), Infections opportunistes liées au SIDA (diagnostic), Infections à VIH (), Tests diagnostiques courants (), Tests diagnostiques courants (tendances).
- MESH :
- diagnostic : Co-infection, Infections fongiques invasives, Infections opportunistes liées au SIDA.
- isolement et purification : Champignons.
- tendances : Dépistage systématique, Tests diagnostiques courants.
- Champignons, Dépistage systématique, Humains, Infections fongiques invasives, Infections à VIH, Tests diagnostiques courants.
English descriptors
- KwdEn :
- AIDS-Related Opportunistic Infections (diagnosis), Coinfection (diagnosis), Diagnostic Tests, Routine (methods), Diagnostic Tests, Routine (trends), Fungi (drug effects), Fungi (isolation & purification), HIV Infections (complications), Humans, Invasive Fungal Infections (diagnosis), Invasive Fungal Infections (prevention & control), Mass Screening (methods), Mass Screening (trends).
- MESH :
- complications : HIV Infections.
- diagnosis : AIDS-Related Opportunistic Infections, Coinfection, Invasive Fungal Infections.
- drug effects : Fungi.
- isolation & purification : Fungi.
- methods : Diagnostic Tests, Routine, Mass Screening.
- prevention & control : Invasive Fungal Infections.
- trends : Diagnostic Tests, Routine, Mass Screening.
- Humans.
Abstract
As HIV treatment programmes scale up to meet the UNAIDS 90-90-90 goals, care must be taken to start antiretroviral treatment safely in patients with advanced disease (CD4 counts <200 cells/μl) who are simultaneously at risk for opportunistic infections and immune reconstitution inflammatory syndrome. Invasive fungal diseases pose a great threat at this critical time point, though the development of inexpensive and highly accurate rapid diagnostic tests has changed the approach HIV programmes are taking to reduce the high mortality associated with these opportunistic infections. This article summarizes recent advances and findings in fungal opportunistic infection diagnostics with a focus on screening to prevent cryptococcal meningitis.
DOI: 10.1097/COH.0000000000000347
PubMed: 28134711
Affiliations:
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Govender</name></author></analytic><series><title level="j">Current opinion in HIV and AIDS</title><idno type="eISSN">1746-6318</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS-Related Opportunistic Infections (diagnosis)</term><term>Coinfection (diagnosis)</term><term>Diagnostic Tests, Routine (methods)</term><term>Diagnostic Tests, Routine (trends)</term><term>Fungi (drug effects)</term><term>Fungi (isolation & purification)</term><term>HIV Infections (complications)</term><term>Humans</term><term>Invasive Fungal Infections (diagnosis)</term><term>Invasive Fungal Infections (prevention & control)</term><term>Mass Screening (methods)</term><term>Mass Screening (trends)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Champignons ()</term><term>Champignons (isolement et purification)</term><term>Co-infection (diagnostic)</term><term>Dépistage systématique ()</term><term>Dépistage systématique (tendances)</term><term>Humains</term><term>Infections fongiques invasives ()</term><term>Infections fongiques invasives (diagnostic)</term><term>Infections opportunistes liées au SIDA (diagnostic)</term><term>Infections à VIH ()</term><term>Tests diagnostiques courants ()</term><term>Tests diagnostiques courants (tendances)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>AIDS-Related Opportunistic Infections</term><term>Coinfection</term><term>Invasive Fungal Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Co-infection</term><term>Infections fongiques invasives</term><term>Infections opportunistes liées au SIDA</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Champignons</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Tests, Routine</term><term>Mass Screening</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Invasive Fungal Infections</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Dépistage systématique</term><term>Tests diagnostiques courants</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Diagnostic Tests, Routine</term><term>Mass Screening</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Champignons</term><term>Dépistage systématique</term><term>Humains</term><term>Infections fongiques invasives</term><term>Infections à VIH</term><term>Tests diagnostiques courants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As HIV treatment programmes scale up to meet the UNAIDS 90-90-90 goals, care must be taken to start antiretroviral treatment safely in patients with advanced disease (CD4 counts <200 cells/μl) who are simultaneously at risk for opportunistic infections and immune reconstitution inflammatory syndrome. Invasive fungal diseases pose a great threat at this critical time point, though the development of inexpensive and highly accurate rapid diagnostic tests has changed the approach HIV programmes are taking to reduce the high mortality associated with these opportunistic infections. This article summarizes recent advances and findings in fungal opportunistic infection diagnostics with a focus on screening to prevent cryptococcal meningitis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28134711</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1746-6318</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Current opinion in HIV and AIDS</Title><ISOAbbreviation>Curr Opin HIV AIDS</ISOAbbreviation></Journal><ArticleTitle>Looking for fungi in all the right places: screening for cryptococcal disease and other AIDS-related mycoses among patients with advanced HIV disease.</ArticleTitle><Pagination><MedlinePgn>139-147</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/COH.0000000000000347</ELocationID><Abstract><AbstractText Label="PURPOSE OF REVIEW" NlmCategory="OBJECTIVE">As HIV treatment programmes scale up to meet the UNAIDS 90-90-90 goals, care must be taken to start antiretroviral treatment safely in patients with advanced disease (CD4 counts <200 cells/μl) who are simultaneously at risk for opportunistic infections and immune reconstitution inflammatory syndrome. Invasive fungal diseases pose a great threat at this critical time point, though the development of inexpensive and highly accurate rapid diagnostic tests has changed the approach HIV programmes are taking to reduce the high mortality associated with these opportunistic infections. This article summarizes recent advances and findings in fungal opportunistic infection diagnostics with a focus on screening to prevent cryptococcal meningitis.</AbstractText><AbstractText Label="RECENT FINDINGS" NlmCategory="RESULTS">Cryptococcal antigen (CrAg) screening using a lateral flow assay platform is cost-effective and feasible to implement as either a laboratory reflex or point-of-care test. Recent CrAg screening pilots have elucidated the varying prevalence of cryptococcal antigenemia across geographic regions, which may aid programme planning. Evidence from recently completed clinical trials provides a strong motivation for the use of CrAg titer to refine treatment options for patients with subclinical cryptococcal disease.</AbstractText><AbstractText Label="SUMMARY" NlmCategory="CONCLUSIONS">Although several operational barriers to programme effectiveness still need to be addressed, the utility of CrAg screening using inexpensive and accurate antigen assays has been demonstrated in real-world HIV programmes, paving the way for development and testing of other fungal opportunistic infection screening strategies and for an integrated advanced HIV disease testing package to reduce AIDS mortality and ensure safe antiretroviral treatment initiation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Greene</LastName><ForeName>Greg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>aMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA bNational Institute for Communicable Diseases - Centre for Opportunistic, Tropical and Hospital Infections cClinical Microbiology and Infectious Diseases Department, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa dOxford University Clinical Research Unit, Ho Chi Minh City, Vietnam eCentre for Tropical Medicine and Global Health, Oxford University, Oxford, UK fHawaii Center for AIDS, University of Hawaii at Manoa, Honolulu, Hawaii, USA gDivision of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sriruttan</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Le</LastName><ForeName>Thuy</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Chiller</LastName><ForeName>Tom</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Govender</LastName><ForeName>Nelesh P</ForeName><Initials>NP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1100682</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Curr Opin HIV AIDS</MedlineTA><NlmUniqueID>101264945</NlmUniqueID><ISSNLinking>1746-630X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CitationSubset>X</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D017088" MajorTopicYN="N">AIDS-Related Opportunistic Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003955" MajorTopicYN="N">Diagnostic Tests, Routine</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000072742" MajorTopicYN="N">Invasive Fungal Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008403" MajorTopicYN="N">Mass Screening</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28134711</ArticleId><ArticleId IdType="doi">10.1097/COH.0000000000000347</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Afrique du Sud</li></country><region><li>Gauteng</li></region><settlement><li>Johannesbourg</li></settlement><orgName><li>Université du Witwatersrand</li></orgName></list><tree><noCountry><name sortKey="Chiller, Tom" sort="Chiller, Tom" uniqKey="Chiller T" first="Tom" last="Chiller">Tom Chiller</name><name sortKey="Govender, Nelesh P" sort="Govender, Nelesh P" uniqKey="Govender N" first="Nelesh P" last="Govender">Nelesh P. Govender</name><name sortKey="Le, Thuy" sort="Le, Thuy" uniqKey="Le T" first="Thuy" last="Le">Thuy Le</name><name sortKey="Sriruttan, Charlotte" sort="Sriruttan, Charlotte" uniqKey="Sriruttan C" first="Charlotte" last="Sriruttan">Charlotte Sriruttan</name></noCountry><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Greene, Greg" sort="Greene, Greg" uniqKey="Greene G" first="Greg" last="Greene">Greg Greene</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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