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Is smoking tobacco an independent risk factor for HIV infection and progression to AIDS? A systemic review

Identifieur interne : 000C16 ( Pmc/Curation ); précédent : 000C15; suivant : 000C17

Is smoking tobacco an independent risk factor for HIV infection and progression to AIDS? A systemic review

Auteurs : A S Furber ; R. Maheswaran ; J N Newell ; C. Carroll

Source :

RBID : PMC:2598585

Abstract

Objectives

To systematically review the evidence of the relation between smoking tobacco and HIV seroconversion and progression to AIDS.

Methods

A systematic review was undertaken of studies to look at tobacco smoking as a risk factor for either HIV seroconversion or progression to AIDS.

Results

Six studies were identified with HIV seroconversion as an outcome measure. Five of these indicated that smoking tobacco was an independent risk factor after adjusting for important confounders with adjusted odds ratios ranging from 1.6 to 3.5. 10 studies were identified using progression to AIDS as an end point of which nine found no relation with tobacco smoking.

Conclusions

Tobacco smoking may be an independent risk factor for HIV infection although residual confounding is another possible explanation. Smoking did not appear to be related to progression to AIDS although this finding may not be true in developing countries or with the longer life expectancies seen with highly active antiretroviral therapy.


Url:
DOI: 10.1136/sti.2005.019505
PubMed: 16923740
PubMed Central: 2598585

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PMC:2598585

Le document en format XML

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<title>Objectives</title>
<p>To systematically review the evidence of the relation between smoking tobacco and HIV seroconversion and progression to AIDS.</p>
</sec>
<sec>
<title>Methods</title>
<p>A systematic review was undertaken of studies to look at tobacco smoking as a risk factor for either HIV seroconversion or progression to AIDS.</p>
</sec>
<sec>
<title>Results</title>
<p>Six studies were identified with HIV seroconversion as an outcome measure. Five of these indicated that smoking tobacco was an independent risk factor after adjusting for important confounders with adjusted odds ratios ranging from 1.6 to 3.5. 10 studies were identified using progression to AIDS as an end point of which nine found no relation with tobacco smoking.</p>
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<sec>
<title>Conclusions</title>
<p>Tobacco smoking may be an independent risk factor for HIV infection although residual confounding is another possible explanation. Smoking did not appear to be related to progression to AIDS although this finding may not be true in developing countries or with the longer life expectancies seen with highly active antiretroviral therapy.</p>
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<article-title>Is smoking tobacco an independent risk factor for HIV infection and progression to AIDS? A systemic review</article-title>
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, South East Sheffield Primary Care Trust, 9 Orgreave Road, Sheffield S13 9LQ, UK</aff>
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<bold>R Maheswaran</bold>
, Public Health GIS Unit, School of Health and Related Research, University of Sheffield, Regents Court, 30 Regent Street, Sheffield S1 4DA, UK</aff>
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<bold>J N Newell</bold>
, Institute of Health Sciences and Public Health Research, 71‐75 Clarendon Road, University of Leeds, Leeds LS2 9PL, UK</aff>
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<bold>C Carroll</bold>
, School of Health and Related Research, University of Sheffield, Regents Court, 30 Regent Street, Sheffield S1 4DA, UK</aff>
<author-notes>
<corresp>Correspondence to: Dr Andrew Furber
<break></break>
South East Sheffield Primary Care Trust, 9 Orgreave Road, Sheffield S13 9LQ, UK; a.furber@sheffield.ac.uk</corresp>
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<month>7</month>
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<copyright-statement>Copyright © 2007 BMJ Publishing Group</copyright-statement>
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<abstract>
<sec>
<title>Objectives</title>
<p>To systematically review the evidence of the relation between smoking tobacco and HIV seroconversion and progression to AIDS.</p>
</sec>
<sec>
<title>Methods</title>
<p>A systematic review was undertaken of studies to look at tobacco smoking as a risk factor for either HIV seroconversion or progression to AIDS.</p>
</sec>
<sec>
<title>Results</title>
<p>Six studies were identified with HIV seroconversion as an outcome measure. Five of these indicated that smoking tobacco was an independent risk factor after adjusting for important confounders with adjusted odds ratios ranging from 1.6 to 3.5. 10 studies were identified using progression to AIDS as an end point of which nine found no relation with tobacco smoking.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Tobacco smoking may be an independent risk factor for HIV infection although residual confounding is another possible explanation. Smoking did not appear to be related to progression to AIDS although this finding may not be true in developing countries or with the longer life expectancies seen with highly active antiretroviral therapy.</p>
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