Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study
Identifieur interne : 000616 ( Pmc/Curation ); précédent : 000615; suivant : 000617Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study
Auteurs : Tatiana Balaeva [Norvège, Russie] ; Andrej M. Grjibovski [Russie, Norvège, Kazakhstan] ; Oleg Sidorenkov [Norvège] ; Olga Samodova [Russie] ; Natalia Firsova [Russie] ; Anatoly Sannikov [Russie] ; Elise Klouman [Norvège]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2016.
Abstract
Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk.
1243 adults aged 18-39 years participated in a cross-sectional population-based study, recruited by a public opinion agency applying a quota sampling method to achieve a data set with similar age- and sex-distribution as the population in Arkhangelsk. All participants completed a standardized, self-administrated questionnaire and were tested for HSV-2. Associations between HSV-2 seropositivity and selected sociodemographic and behavioral factors, and self-reported history of sexually transmitted infections (STIs) were studied by multivariable logistic regression.
HSV-2 seroprevalence was 18.8 %: 12.2 % (95 % confidence interval, CI 9.7-15.2) among men and 24.0 % (95 % CI 20.1-27.3) among women. Among men, HSV-2 positivity was associated with being divorced/widowed (OR = 2.85, 95 % CI 1.06-7.70), cohabitation (OR = 2.45, 95 % CI 1.07-5.62), and a history of STIs (OR = 2.11, 95 % CI 1.14-3.91). In women, HSV-2 positivity was associated with high income (OR = 3.11, 95 % CI 1.45-6.71) and having a lifetime number of sexual partners between 2 and 5 (OR = 2.72, 95 % CI 1.14-6.51), whereas sexual debut at age 18 years or older was inversely associated with the outcome (OR = 0.47, 95 % CI 0.31-0.72). In both sexes, increasing age was the strongest correlate of HSV-2 seropositivity in multivariable analyses.
The HSV-2 seroprevalence was twice as high in women than in men and increased with age in both sexes, and similar to that reported from high-prevalence countries in Europe and the USA. The high prevalence of HSV-2 among women in childbearing age reveals the potential for HSV-2 transmission from mothers to infants and increased risk of acquisition HIV-infection; it also contributes to the burden GUD among both sexes. This emphasizes the public health implications of the HSV-2 epidemic in an urban population in North-West Russia.
Url:
DOI: 10.1186/s12879-016-1954-8
PubMed: 27793121
PubMed Central: 5084401
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Andrej M. Grjibovski<affiliation><nlm:aff id="Aff4">North-Eastern Federal University, 58 Belinsky Str, Yakutsk, 677000 Yakutsk, Republic of Sakha (Yakutia) Russia</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="Aff5">Department of International Public Health, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
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<affiliation wicri:level="1"><nlm:aff id="Aff6">Department of Preventive Medicine, International Kazakh-Turkish University, Turkestan, Kazakhstan</nlm:aff>
<country xml:lang="fr">Kazakhstan</country>
<wicri:regionArea>Department of Preventive Medicine, International Kazakh-Turkish University, Turkestan</wicri:regionArea>
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Le document en format XML
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<series><title level="j">BMC Infectious Diseases</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk.</p>
</sec>
<sec><title>Methods</title>
<p>1243 adults aged 18-39 years participated in a cross-sectional population-based study, recruited by a public opinion agency applying a quota sampling method to achieve a data set with similar age- and sex-distribution as the population in Arkhangelsk. All participants completed a standardized, self-administrated questionnaire and were tested for HSV-2. Associations between HSV-2 seropositivity and selected sociodemographic and behavioral factors, and self-reported history of sexually transmitted infections (STIs) were studied by multivariable logistic regression.</p>
</sec>
<sec><title>Results</title>
<p>HSV-2 seroprevalence was 18.8 %: 12.2 % (95 % confidence interval, CI 9.7-15.2) among men and 24.0 % (95 % CI 20.1-27.3) among women. Among men, HSV-2 positivity was associated with being divorced/widowed (OR = 2.85, 95 % CI 1.06-7.70), cohabitation (OR = 2.45, 95 % CI 1.07-5.62), and a history of STIs (OR = 2.11, 95 % CI 1.14-3.91). In women, HSV-2 positivity was associated with high income (OR = 3.11, 95 % CI 1.45-6.71) and having a lifetime number of sexual partners between 2 and 5 (OR = 2.72, 95 % CI 1.14-6.51), whereas sexual debut at age 18 years or older was inversely associated with the outcome (OR = 0.47, 95 % CI 0.31-0.72). In both sexes, increasing age was the strongest correlate of HSV-2 seropositivity in multivariable analyses.</p>
</sec>
<sec><title>Conclusion</title>
<p>The HSV-2 seroprevalence was twice as high in women than in men and increased with age in both sexes, and similar to that reported from high-prevalence countries in Europe and the USA. The high prevalence of HSV-2 among women in childbearing age reveals the potential for HSV-2 transmission from mothers to infants and increased risk of acquisition HIV-infection; it also contributes to the burden GUD among both sexes. This emphasizes the public health implications of the HSV-2 epidemic in an urban population in North-West Russia.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id>
<journal-title-group><journal-title>BMC Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2334</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27793121</article-id>
<article-id pub-id-type="pmc">5084401</article-id>
<article-id pub-id-type="publisher-id">1954</article-id>
<article-id pub-id-type="doi">10.1186/s12879-016-1954-8</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Seroprevalence and correlates of herpes simplex virus type 2 infection among young adults in Arkhangelsk, Northwest Russia: a population-based cross-sectional study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Balaeva</surname>
<given-names>Tatiana</given-names>
</name>
<address><email>arkhangelsk.tatiana@rambler.ru</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grjibovski</surname>
<given-names>Andrej M.</given-names>
</name>
<address><email>andrei.grjibovski@fhi.no</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
<xref ref-type="aff" rid="Aff5">5</xref>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sidorenkov</surname>
<given-names>Oleg</given-names>
</name>
<address><email>oleg.sidorenkov@uit.no</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Samodova</surname>
<given-names>Olga</given-names>
</name>
<address><email>ovsamodova@mail.ru</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Firsova</surname>
<given-names>Natalia</given-names>
</name>
<address><email>firs-natali1@yandex.ru</email>
</address>
<xref ref-type="aff" rid="Aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sannikov</surname>
<given-names>Anatoly</given-names>
</name>
<address><email>jsannikov@yandex.ru</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-5970-5521</contrib-id>
<name><surname>Klouman</surname>
<given-names>Elise</given-names>
</name>
<address><email>elise.klouman@uit.no</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Community Medicine, UiT The Arctic University of Norway, PO Box 6050 Langnes, N-9037 Tromso, Norway</aff>
<aff id="Aff2"><label>2</label>
Northern State Medical University, Troitski Av. 51, Arkhangelsk, 163000 Russia</aff>
<aff id="Aff3"><label>3</label>
Center of Hygiene and Epidemiology in the Arkhangelsk Region, Troitski Av. 164-1, Arkhangelsk, 163000 Russia</aff>
<aff id="Aff4"><label>4</label>
North-Eastern Federal University, 58 Belinsky Str, Yakutsk, 677000 Yakutsk, Republic of Sakha (Yakutia) Russia</aff>
<aff id="Aff5"><label>5</label>
Department of International Public Health, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403 Oslo, Norway</aff>
<aff id="Aff6"><label>6</label>
Department of Preventive Medicine, International Kazakh-Turkish University, Turkestan, Kazakhstan</aff>
<aff id="Aff7"><label>7</label>
Arkhangelsk Regional Dermatovenerologic Dispensary, Sibiryakovtsev Street 2-1, Arkhangelsk, 163045 Russia</aff>
</contrib-group>
<pub-date pub-type="epub"><day>28</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>28</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>16</volume>
<elocation-id>616</elocation-id>
<history><date date-type="received"><day>6</day>
<month>1</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>25</day>
<month>10</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Herpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcer disease (GUD) worldwide. Mother to child transmission causes high morbidity and mortality among infants. Russia is on the brink of a generalized HIV-epidemic, but Arkhangelsk is still a low-prevalence area. HSV-2 infection is associated with a three-fold increased risk of HIV-infection. The evidence on the seroprevalence of HSV-2 in Russia is limited. The aim of this study was to assess HSV-2 seroprevalence and correlates among young adults in the city of Arkhangelsk.</p>
</sec>
<sec><title>Methods</title>
<p>1243 adults aged 18-39 years participated in a cross-sectional population-based study, recruited by a public opinion agency applying a quota sampling method to achieve a data set with similar age- and sex-distribution as the population in Arkhangelsk. All participants completed a standardized, self-administrated questionnaire and were tested for HSV-2. Associations between HSV-2 seropositivity and selected sociodemographic and behavioral factors, and self-reported history of sexually transmitted infections (STIs) were studied by multivariable logistic regression.</p>
</sec>
<sec><title>Results</title>
<p>HSV-2 seroprevalence was 18.8 %: 12.2 % (95 % confidence interval, CI 9.7-15.2) among men and 24.0 % (95 % CI 20.1-27.3) among women. Among men, HSV-2 positivity was associated with being divorced/widowed (OR = 2.85, 95 % CI 1.06-7.70), cohabitation (OR = 2.45, 95 % CI 1.07-5.62), and a history of STIs (OR = 2.11, 95 % CI 1.14-3.91). In women, HSV-2 positivity was associated with high income (OR = 3.11, 95 % CI 1.45-6.71) and having a lifetime number of sexual partners between 2 and 5 (OR = 2.72, 95 % CI 1.14-6.51), whereas sexual debut at age 18 years or older was inversely associated with the outcome (OR = 0.47, 95 % CI 0.31-0.72). In both sexes, increasing age was the strongest correlate of HSV-2 seropositivity in multivariable analyses.</p>
</sec>
<sec><title>Conclusion</title>
<p>The HSV-2 seroprevalence was twice as high in women than in men and increased with age in both sexes, and similar to that reported from high-prevalence countries in Europe and the USA. The high prevalence of HSV-2 among women in childbearing age reveals the potential for HSV-2 transmission from mothers to infants and increased risk of acquisition HIV-infection; it also contributes to the burden GUD among both sexes. This emphasizes the public health implications of the HSV-2 epidemic in an urban population in North-West Russia.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Herpes simplex virus type 2</kwd>
<kwd>HSV-2</kwd>
<kwd>Correlates of HSV-2</kwd>
<kwd>Self-reported STIs</kwd>
<kwd>Seroprevalence</kwd>
<kwd>Population-based</kwd>
<kwd>Northwest Russia</kwd>
<kwd>Eastern Europe</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution>Research Council of Norway</institution>
</funding-source>
<award-id>Project no. 184931/S50</award-id>
</award-group>
<award-group><funding-source><institution>Ministry of Foreign Affairs of Finland</institution>
</funding-source>
</award-group>
<award-group><funding-source><institution>The Russian President’s Stipendium for Study Abroad.</institution>
</funding-source>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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