Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy
Identifieur interne : 000106 ( Pmc/Curation ); précédent : 000105; suivant : 000107Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy
Auteurs : Kamilu M. Karaye [Nigeria] ; Isah A. Yahaya ; Krister Lindmark [Suède] ; Michael Y. Henein [Suède]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2015.
Abstract
The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (
Url:
DOI: 10.3390/ijms16047644
PubMed: 25853263
PubMed Central: 4425040
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Karaye</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-16-07644">Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano</wicri:regionArea></affiliation><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Yahaya, Isah A" sort="Yahaya, Isah A" uniqKey="Yahaya I" first="Isah A." last="Yahaya">Isah A. Yahaya</name><affiliation><nlm:aff id="af3-ijms-16-07644">Department of Chemical Pathology, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria; E-Mail:<email>yahadagiri2@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Lindmark, Krister" sort="Lindmark, Krister" uniqKey="Lindmark K" first="Krister" last="Lindmark">Krister Lindmark</name><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-16-07644">Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Umea Heart Centre, SE-901 85 Umea</wicri:regionArea></affiliation></author><author><name sortKey="Henein, Michael Y" sort="Henein, Michael Y" uniqKey="Henein M" first="Michael Y." last="Henein">Michael Y. Henein</name><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-16-07644">Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Umea Heart Centre, SE-901 85 Umea</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25853263</idno><idno type="pmc">4425040</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425040</idno><idno type="RBID">PMC:4425040</idno><idno type="doi">10.3390/ijms16047644</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000106</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000106</idno><idno type="wicri:Area/Pmc/Curation">000106</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000106</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy</title><author><name sortKey="Karaye, Kamilu M" sort="Karaye, Kamilu M" uniqKey="Karaye K" first="Kamilu M." last="Karaye">Kamilu M. Karaye</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-16-07644">Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano</wicri:regionArea></affiliation><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Yahaya, Isah A" sort="Yahaya, Isah A" uniqKey="Yahaya I" first="Isah A." last="Yahaya">Isah A. Yahaya</name><affiliation><nlm:aff id="af3-ijms-16-07644">Department of Chemical Pathology, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria; E-Mail:<email>yahadagiri2@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Lindmark, Krister" sort="Lindmark, Krister" uniqKey="Lindmark K" first="Krister" last="Lindmark">Krister Lindmark</name><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-16-07644">Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Umea Heart Centre, SE-901 85 Umea</wicri:regionArea></affiliation></author><author><name sortKey="Henein, Michael Y" sort="Henein, Michael Y" uniqKey="Henein M" first="Michael Y." last="Henein">Michael Y. Henein</name><affiliation><nlm:aff id="af2-ijms-16-07644">Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ijms-16-07644">Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Cardiology, Umea Heart Centre, SE-901 85 Umea</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (<italic>p <</italic> 0.001). The prevalence of serum selenium <70 µg/L was significantly higher among patients (76.9%) than controls (22.0%) (<italic>p <</italic> 0.001). The mean ceruloplasmin and prevalence of socio-economic indices, multiparity, pregnancy-induced hypertension, obesity and twin pregnancy were not different between the groups (<italic>p ></italic> 0.05). Logistic regression showed that rural residency significantly increased the odds for serum selenium <70 µg/L by 2.773-fold (<italic>p =</italic> 0.037). Baseline serum levels of selenium and ceruloplasmin were not associated with six-month mortality. This study has shown that selenium deficiency is a risk factor for PPCM in Kano, Nigeria, and is related to rural residency. However, serum ceruloplasmin, customary birth practices and some other characteristics were not associated with PPCM in the study area.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Karaye, K M" uniqKey="Karaye K">K.M. Karaye</name></author><author><name sortKey="Saidu, H" uniqKey="Saidu H">H. Saidu</name></author><author><name sortKey="Bala, M S" uniqKey="Bala M">M.S. Bala</name></author><author><name sortKey="Yahaya, I A" uniqKey="Yahaya I">I.A. Yahaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K. Sliwa</name></author><author><name sortKey="Mayosi, B M" uniqKey="Mayosi B">B.M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id><journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id><journal-id journal-id-type="publisher-id">ijms</journal-id><journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title></journal-title-group><issn pub-type="epub">1422-0067</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25853263</article-id><article-id pub-id-type="pmc">4425040</article-id><article-id pub-id-type="doi">10.3390/ijms16047644</article-id><article-id pub-id-type="publisher-id">ijms-16-07644</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Serum Selenium and Ceruloplasmin in Nigerians with Peripartum Cardiomyopathy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Karaye</surname><given-names>Kamilu M.</given-names></name><xref ref-type="aff" rid="af1-ijms-16-07644">1</xref><xref ref-type="aff" rid="af2-ijms-16-07644">2</xref><xref rid="c1-ijms-16-07644" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Yahaya</surname><given-names>Isah A.</given-names></name><xref ref-type="aff" rid="af3-ijms-16-07644">3</xref></contrib><contrib contrib-type="author"><name><surname>Lindmark</surname><given-names>Krister</given-names></name><xref ref-type="aff" rid="af2-ijms-16-07644">2</xref><xref ref-type="aff" rid="af4-ijms-16-07644">4</xref></contrib><contrib contrib-type="author"><name><surname>Henein</surname><given-names>Michael Y.</given-names></name><xref ref-type="aff" rid="af2-ijms-16-07644">2</xref><xref ref-type="aff" rid="af4-ijms-16-07644">4</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Chen</surname><given-names>Yi-Han</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-ijms-16-07644"><label>1</label>Department of Medicine, Bayero University and Aminu Kano Teaching Hospital, PO Box 4445, Kano, Nigeria</aff><aff id="af2-ijms-16-07644"><label>2</label>Department of Public Health and Clinical Medicine, Umea University, SE-901 87 Umea, Sweden; E-Mails:<email>krister.lindmark@vll.se</email> (K.L.);<email>michael.henein@umu.se</email> (M.Y.H.)</aff><aff id="af3-ijms-16-07644"><label>3</label>Department of Chemical Pathology, Bayero University and Aminu Kano Teaching Hospital, Kano, Nigeria; E-Mail:<email>yahadagiri2@yahoo.com</email></aff><aff id="af4-ijms-16-07644"><label>4</label>Department of Cardiology, Umea Heart Centre, SE-901 85 Umea, Sweden</aff><author-notes><corresp id="c1-ijms-16-07644"><label>*</label> Author to whom correspondence should be addressed; E-Mail: <email>kkaraye@yahoo.co.uk</email>; Tel.: +234-803-704-2171.</corresp></author-notes><pub-date pub-type="epub"><day>07</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>4</month><year>2015</year></pub-date><volume>16</volume><issue>4</issue><fpage>7644</fpage><lpage>7654</lpage><history><date date-type="received"><day>17</day><month>1</month><year>2015</year></date><date date-type="accepted"><day>31</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2015</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>The study aimed to determine if selenium deficiency, serum ceruloplasmin and traditional birth practices are risk factors for peripartum cardiomyopathy (PPCM), in Kano, Nigeria. This is a case-control study carried out in three hospitals, and PPCM patients were followed up for six months. Critically low serum selenium concentration was defined as <70 µg/L. A total of 39 PPCM patients and 50 controls were consecutively recruited after satisfying the inclusion criteria. Mean serum selenium in patients (61.7 ± 14.9 µg/L) was significantly lower than in controls (118.4 ± 45.6 µg/L) (<italic>p <</italic> 0.001). The prevalence of serum selenium <70 µg/L was significantly higher among patients (76.9%) than controls (22.0%) (<italic>p <</italic> 0.001). The mean ceruloplasmin and prevalence of socio-economic indices, multiparity, pregnancy-induced hypertension, obesity and twin pregnancy were not different between the groups (<italic>p ></italic> 0.05). Logistic regression showed that rural residency significantly increased the odds for serum selenium <70 µg/L by 2.773-fold (<italic>p =</italic> 0.037). Baseline serum levels of selenium and ceruloplasmin were not associated with six-month mortality. This study has shown that selenium deficiency is a risk factor for PPCM in Kano, Nigeria, and is related to rural residency. However, serum ceruloplasmin, customary birth practices and some other characteristics were not associated with PPCM in the study area.</p></abstract><kwd-group><kwd>peripartum cardiomyopathy</kwd><kwd>risk factors</kwd><kwd>selenium deficiency</kwd><kwd>ceruloplasmin</kwd><kwd>heart failure</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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