Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference
Identifieur interne : 002E28 ( Pmc/Corpus ); précédent : 002E27; suivant : 002E29Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference
Auteurs : Susanne Maria Ziegler ; Marcus AltfeldSource :
- Frontiers in Immunology [ 1664-3224 ] ; 2017.
Abstract
The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.
Url:
DOI: 10.3389/fimmu.2017.01224
PubMed: 29033943
PubMed Central: 5625005
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PMC:5625005Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference</title><author><name sortKey="Ziegler, Susanne Maria" sort="Ziegler, Susanne Maria" uniqKey="Ziegler S" first="Susanne Maria" last="Ziegler">Susanne Maria Ziegler</name><affiliation><nlm:aff id="aff1"><institution>Heinrich Pette Institute, Leibniz Institute for Experimental Virology</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Altfeld, Marcus" sort="Altfeld, Marcus" uniqKey="Altfeld M" first="Marcus" last="Altfeld">Marcus Altfeld</name><affiliation><nlm:aff id="aff2"><institution>Institute of Immunology, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29033943</idno><idno type="pmc">5625005</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625005</idno><idno type="RBID">PMC:5625005</idno><idno type="doi">10.3389/fimmu.2017.01224</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002E28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference</title><author><name sortKey="Ziegler, Susanne Maria" sort="Ziegler, Susanne Maria" uniqKey="Ziegler S" first="Susanne Maria" last="Ziegler">Susanne Maria Ziegler</name><affiliation><nlm:aff id="aff1"><institution>Heinrich Pette Institute, Leibniz Institute for Experimental Virology</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Altfeld, Marcus" sort="Altfeld, Marcus" uniqKey="Altfeld M" first="Marcus" last="Altfeld">Marcus Altfeld</name><affiliation><nlm:aff id="aff2"><institution>Institute of Immunology, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lemp, Gf" uniqKey="Lemp G">GF Lemp</name></author><author><name sortKey="Hirozawa, Am" uniqKey="Hirozawa A">AM Hirozawa</name></author><author><name sortKey="Cohen, Jb" uniqKey="Cohen J">JB Cohen</name></author><author><name sortKey="Derish, Pa" uniqKey="Derish P">PA Derish</name></author><author><name sortKey="Mckinney, Kc" uniqKey="Mckinney K">KC McKinney</name></author><author><name sortKey="Hernandez, Sr" uniqKey="Hernandez S">SR Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaisson, Re" uniqKey="Chaisson R">RE Chaisson</name></author><author><name sortKey="Keruly, Jc" uniqKey="Keruly J">JC Keruly</name></author><author><name sortKey="Moore, Rd" uniqKey="Moore R">RD Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicolosi, A" uniqKey="Nicolosi A">A Nicolosi</name></author><author><name sortKey="Correa Leite, Ml" uniqKey="Correa Leite M">ML Correa Leite</name></author><author><name sortKey="Musicco, M" uniqKey="Musicco M">M Musicco</name></author><author><name sortKey="Arici, C" uniqKey="Arici C">C Arici</name></author><author><name sortKey="Gavazzeni, G" uniqKey="Gavazzeni G">G Gavazzeni</name></author><author><name sortKey="Lazzarin, A" uniqKey="Lazzarin A">A Lazzarin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anastos, K" uniqKey="Anastos K">K Anastos</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Lau, B" uniqKey="Lau B">B Lau</name></author><author><name sortKey="Weiser, B" uniqKey="Weiser B">B Weiser</name></author><author><name sortKey="Detels, R" uniqKey="Detels R">R Detels</name></author><author><name sortKey="Giorgi, Jv" uniqKey="Giorgi J">JV Giorgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farzadegan, H" uniqKey="Farzadegan H">H Farzadegan</name></author><author><name sortKey="Hoover, Dr" uniqKey="Hoover D">DR Hoover</name></author><author><name sortKey="Astemborski, J" uniqKey="Astemborski J">J Astemborski</name></author><author><name sortKey="Lyles, Cm" uniqKey="Lyles C">CM Lyles</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Markham, Rb" uniqKey="Markham R">RB Markham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sterling, Tr" uniqKey="Sterling T">TR Sterling</name></author><author><name sortKey="Lyles, Cm" uniqKey="Lyles C">CM Lyles</name></author><author><name sortKey="Vlahov, D" uniqKey="Vlahov D">D Vlahov</name></author><author><name sortKey="Astemborski, J" uniqKey="Astemborski J">J Astemborski</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sterling, Tr" uniqKey="Sterling T">TR Sterling</name></author><author><name sortKey="Vlahov, D" uniqKey="Vlahov D">D Vlahov</name></author><author><name sortKey="Astemborski, J" uniqKey="Astemborski J">J Astemborski</name></author><author><name sortKey="Hoover, Dr" uniqKey="Hoover D">DR Hoover</name></author><author><name sortKey="Margolick, Jb" uniqKey="Margolick J">JB Margolick</name></author><author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosn, J" uniqKey="Ghosn J">J Ghosn</name></author><author><name sortKey="Deveau, C" uniqKey="Deveau C">C Deveau</name></author><author><name sortKey="Chaix, Ml" uniqKey="Chaix M">ML Chaix</name></author><author><name sortKey="Goujard, C" uniqKey="Goujard C">C Goujard</name></author><author><name sortKey="Galimand, J" uniqKey="Galimand J">J Galimand</name></author><author><name sortKey="Zitoun, Y" uniqKey="Zitoun Y">Y Zitoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ngo Giang Huong, N" uniqKey="Ngo Giang Huong N">N Ngo-Giang-Huong</name></author><author><name sortKey="Deveau, C" uniqKey="Deveau C">C Deveau</name></author><author><name sortKey="Da Silva, I" uniqKey="Da Silva I">I Da Silva</name></author><author><name sortKey="Pellegrin, I" uniqKey="Pellegrin I">I Pellegrin</name></author><author><name sortKey="Venet, A" uniqKey="Venet A">A Venet</name></author><author><name sortKey="Harzic, M" uniqKey="Harzic M">M Harzic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cuzin, L" uniqKey="Cuzin L">L Cuzin</name></author><author><name sortKey="Pugliese, P" uniqKey="Pugliese P">P Pugliese</name></author><author><name sortKey="Saune, K" uniqKey="Saune K">K Saune</name></author><author><name sortKey="Allavena, C" uniqKey="Allavena C">C Allavena</name></author><author><name sortKey="Ghosn, J" uniqKey="Ghosn J">J Ghosn</name></author><author><name sortKey="Cottalorda, J" uniqKey="Cottalorda J">J Cottalorda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fourati, S" uniqKey="Fourati S">S Fourati</name></author><author><name sortKey="Flandre, P" uniqKey="Flandre P">P Flandre</name></author><author><name sortKey="Calin, R" uniqKey="Calin R">R Calin</name></author><author><name sortKey="Carcelain, G" uniqKey="Carcelain G">G Carcelain</name></author><author><name sortKey="Soulie, C" uniqKey="Soulie C">C Soulie</name></author><author><name sortKey="Lambert Niclot, S" uniqKey="Lambert Niclot S">S Lambert-Niclot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Utay, Ns" uniqKey="Utay N">NS Utay</name></author><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Odorizzi, Pm" uniqKey="Odorizzi P">PM Odorizzi</name></author><author><name sortKey="Wherry, Ej" uniqKey="Wherry E">EJ Wherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griesbeck, M" uniqKey="Griesbeck M">M Griesbeck</name></author><author><name sortKey="Scully, E" uniqKey="Scully E">E Scully</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santelli, Js" uniqKey="Santelli J">JS Santelli</name></author><author><name sortKey="Edelstein, Zr" uniqKey="Edelstein Z">ZR Edelstein</name></author><author><name sortKey="Mathur, S" uniqKey="Mathur S">S Mathur</name></author><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Orr, Mg" uniqKey="Orr M">MG Orr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seillet, C" uniqKey="Seillet C">C Seillet</name></author><author><name sortKey="Laffont, S" uniqKey="Laffont S">S Laffont</name></author><author><name sortKey="Tremollieres, F" uniqKey="Tremollieres F">F Tremollieres</name></author><author><name sortKey="Rouquie, N" uniqKey="Rouquie N">N Rouquie</name></author><author><name sortKey="Ribot, C" uniqKey="Ribot C">C Ribot</name></author><author><name sortKey="Arnal, Jf" uniqKey="Arnal J">JF Arnal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griesbeck, M" uniqKey="Griesbeck M">M Griesbeck</name></author><author><name sortKey="Ziegler, S" uniqKey="Ziegler S">S Ziegler</name></author><author><name sortKey="Laffont, S" uniqKey="Laffont S">S Laffont</name></author><author><name sortKey="Smith, N" uniqKey="Smith N">N Smith</name></author><author><name sortKey="Chauveau, L" uniqKey="Chauveau L">L Chauveau</name></author><author><name sortKey="Tomezsko, P" uniqKey="Tomezsko P">P Tomezsko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meier, A" uniqKey="Meier A">A Meier</name></author><author><name sortKey="Chang, Jj" uniqKey="Chang J">JJ Chang</name></author><author><name sortKey="Chan, Es" uniqKey="Chan E">ES Chan</name></author><author><name sortKey="Pollard, Rb" uniqKey="Pollard R">RB Pollard</name></author><author><name sortKey="Sidhu, Hk" uniqKey="Sidhu H">HK Sidhu</name></author><author><name sortKey="Kulkarni, S" uniqKey="Kulkarni S">S Kulkarni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Libert, C" uniqKey="Libert C">C Libert</name></author><author><name sortKey="Dejager, L" uniqKey="Dejager L">L Dejager</name></author><author><name sortKey="Pinheiro, I" uniqKey="Pinheiro I">I Pinheiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fish, En" uniqKey="Fish E">EN Fish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markle, Jg" uniqKey="Markle J">JG Markle</name></author><author><name sortKey="Fish, En" uniqKey="Fish E">EN Fish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yurkovetskiy, L" uniqKey="Yurkovetskiy L">L Yurkovetskiy</name></author><author><name sortKey="Burrows, M" uniqKey="Burrows M">M Burrows</name></author><author><name sortKey="Khan, Aa" uniqKey="Khan A">AA Khan</name></author><author><name sortKey="Graham, L" uniqKey="Graham L">L Graham</name></author><author><name sortKey="Volchkov, P" uniqKey="Volchkov P">P Volchkov</name></author><author><name sortKey="Becker, L" uniqKey="Becker L">L Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagen, S" uniqKey="Hagen S">S Hagen</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Addo, Mm" uniqKey="Addo M">MM Addo</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziegler, S" uniqKey="Ziegler S">S Ziegler</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wawer, Mj" uniqKey="Wawer M">MJ Wawer</name></author><author><name sortKey="Gray, Rh" uniqKey="Gray R">RH Gray</name></author><author><name sortKey="Sewankambo, Nk" uniqKey="Sewankambo N">NK Sewankambo</name></author><author><name sortKey="Serwadda, D" uniqKey="Serwadda D">D Serwadda</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Laeyendecker, O" uniqKey="Laeyendecker O">O Laeyendecker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author><author><name sortKey="Gale, M" uniqKey="Gale M">M Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blasius, Al" uniqKey="Blasius A">AL Blasius</name></author><author><name sortKey="Beutler, B" uniqKey="Beutler B">B Beutler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jakobsen, Mr" uniqKey="Jakobsen M">MR Jakobsen</name></author><author><name sortKey="Bak, Ro" uniqKey="Bak R">RO Bak</name></author><author><name sortKey="Andersen, A" uniqKey="Andersen A">A Andersen</name></author><author><name sortKey="Berg, Rk" uniqKey="Berg R">RK Berg</name></author><author><name sortKey="Jensen, Sb" uniqKey="Jensen S">SB Jensen</name></author><author><name sortKey="Tengchuan, J" uniqKey="Tengchuan J">J Tengchuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, D" uniqKey="Gao D">D Gao</name></author><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Wu, Yt" uniqKey="Wu Y">YT Wu</name></author><author><name sortKey="Du, F" uniqKey="Du F">F Du</name></author><author><name sortKey="Aroh, C" uniqKey="Aroh C">C Aroh</name></author><author><name sortKey="Yan, N" uniqKey="Yan N">N Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogensen, Th" uniqKey="Mogensen T">TH Mogensen</name></author><author><name sortKey="Melchjorsen, J" uniqKey="Melchjorsen J">J Melchjorsen</name></author><author><name sortKey="Larsen, Cs" uniqKey="Larsen C">CS Larsen</name></author><author><name sortKey="Paludan, Sr" uniqKey="Paludan S">SR Paludan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodbourn, S" uniqKey="Goodbourn S">S Goodbourn</name></author><author><name sortKey="Didcock, L" uniqKey="Didcock L">L Didcock</name></author><author><name sortKey="Randall, Re" uniqKey="Randall R">RE Randall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pestka, S" uniqKey="Pestka S">S Pestka</name></author><author><name sortKey="Krause, Cd" uniqKey="Krause C">CD Krause</name></author><author><name sortKey="Walter, Mr" uniqKey="Walter M">MR Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schreiber, G" uniqKey="Schreiber G">G Schreiber</name></author><author><name sortKey="Piehler, J" uniqKey="Piehler J">J Piehler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibbert, K" uniqKey="Gibbert K">K Gibbert</name></author><author><name sortKey="Schlaak, Jf" uniqKey="Schlaak J">JF Schlaak</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Dittmer, U" uniqKey="Dittmer U">U Dittmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kent, Sj" uniqKey="Kent S">SJ Kent</name></author><author><name sortKey="Kelleher, Ad" uniqKey="Kelleher A">AD Kelleher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyer, Ss" uniqKey="Iyer S">SS Iyer</name></author><author><name sortKey="Bibollet Ruche, F" uniqKey="Bibollet Ruche F">F Bibollet-Ruche</name></author><author><name sortKey="Sherrill Mix, S" uniqKey="Sherrill Mix S">S Sherrill-Mix</name></author><author><name sortKey="Learn, Gh" uniqKey="Learn G">GH Learn</name></author><author><name sortKey="Plenderleith, L" uniqKey="Plenderleith L">L Plenderleith</name></author><author><name sortKey="Smith, Ag" uniqKey="Smith A">AG Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parrish, Nf" uniqKey="Parrish N">NF Parrish</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Giorgi, Ee" uniqKey="Giorgi E">EE Giorgi</name></author><author><name sortKey="Barbian, Hj" uniqKey="Barbian H">HJ Barbian</name></author><author><name sortKey="Parrish, Eh" uniqKey="Parrish E">EH Parrish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenton May, Ae" uniqKey="Fenton May A">AE Fenton-May</name></author><author><name sortKey="Dibben, O" uniqKey="Dibben O">O Dibben</name></author><author><name sortKey="Emmerich, T" uniqKey="Emmerich T">T Emmerich</name></author><author><name sortKey="Ding, H" uniqKey="Ding H">H Ding</name></author><author><name sortKey="Pfafferott, K" uniqKey="Pfafferott K">K Pfafferott</name></author><author><name sortKey="Aasa Chapman, Mm" uniqKey="Aasa Chapman M">MM Aasa-Chapman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veazey, Rs" uniqKey="Veazey R">RS Veazey</name></author><author><name sortKey="Pilch Cooper, Ha" uniqKey="Pilch Cooper H">HA Pilch-Cooper</name></author><author><name sortKey="Hope, Tj" uniqKey="Hope T">TJ Hope</name></author><author><name sortKey="Alter, G" uniqKey="Alter G">G Alter</name></author><author><name sortKey="Carias, Am" uniqKey="Carias A">AM Carias</name></author><author><name sortKey="Sips, M" uniqKey="Sips M">M Sips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavender, Kj" uniqKey="Lavender K">KJ Lavender</name></author><author><name sortKey="Gibbert, K" uniqKey="Gibbert K">K Gibbert</name></author><author><name sortKey="Peterson, Ke" uniqKey="Peterson K">KE Peterson</name></author><author><name sortKey="Van Dis, E" uniqKey="Van Dis E">E Van Dis</name></author><author><name sortKey="Francois, S" uniqKey="Francois S">S Francois</name></author><author><name sortKey="Woods, T" uniqKey="Woods T">T Woods</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Minambres, A" uniqKey="Garcia Minambres A">A Garcia-Minambres</name></author><author><name sortKey="Eid, Sg" uniqKey="Eid S">SG Eid</name></author><author><name sortKey="Mangan, Ne" uniqKey="Mangan N">NE Mangan</name></author><author><name sortKey="Pade, C" uniqKey="Pade C">C Pade</name></author><author><name sortKey="Lim, Ss" uniqKey="Lim S">SS Lim</name></author><author><name sortKey="Matthews, Ay" uniqKey="Matthews A">AY Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fung, Ky" uniqKey="Fung K">KY Fung</name></author><author><name sortKey="Mangan, Ne" uniqKey="Mangan N">NE Mangan</name></author><author><name sortKey="Cumming, H" uniqKey="Cumming H">H Cumming</name></author><author><name sortKey="Horvat, Jc" uniqKey="Horvat J">JC Horvat</name></author><author><name sortKey="Mayall, Jr" uniqKey="Mayall J">JR Mayall</name></author><author><name sortKey="Stifter, Sa" uniqKey="Stifter S">SA Stifter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrison, Cs" uniqKey="Morrison C">CS Morrison</name></author><author><name sortKey="Chen, Pl" uniqKey="Chen P">PL Chen</name></author><author><name sortKey="Kwok, C" uniqKey="Kwok C">C Kwok</name></author><author><name sortKey="Baeten, Jm" uniqKey="Baeten J">JM Baeten</name></author><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="Crook, Am" uniqKey="Crook A">AM Crook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrison, Cs" uniqKey="Morrison C">CS Morrison</name></author><author><name sortKey="Chen, Pl" uniqKey="Chen P">PL Chen</name></author><author><name sortKey="Kwok, C" uniqKey="Kwok C">C Kwok</name></author><author><name sortKey="Richardson, Ba" uniqKey="Richardson B">BA Richardson</name></author><author><name sortKey="Chipato, T" uniqKey="Chipato T">T Chipato</name></author><author><name sortKey="Mugerwa, R" uniqKey="Mugerwa R">R Mugerwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blish, Ca" uniqKey="Blish C">CA Blish</name></author><author><name sortKey="Baeten, Jm" uniqKey="Baeten J">JM Baeten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baeten, Jm" uniqKey="Baeten J">JM Baeten</name></author><author><name sortKey="Benki, S" uniqKey="Benki S">S Benki</name></author><author><name sortKey="Chohan, V" uniqKey="Chohan V">V Chohan</name></author><author><name sortKey="Lavreys, L" uniqKey="Lavreys L">L Lavreys</name></author><author><name sortKey="Mcclelland, Rs" uniqKey="Mcclelland R">RS McClelland</name></author><author><name sortKey="Mandaliya, K" uniqKey="Mandaliya K">K Mandaliya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heffron, R" uniqKey="Heffron R">R Heffron</name></author><author><name sortKey="Donnell, D" uniqKey="Donnell D">D Donnell</name></author><author><name sortKey="Rees, H" uniqKey="Rees H">H Rees</name></author><author><name sortKey="Celum, C" uniqKey="Celum C">C Celum</name></author><author><name sortKey="Mugo, N" uniqKey="Mugo N">N Mugo</name></author><author><name sortKey="Were, E" uniqKey="Were E">E Were</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berghofer, B" uniqKey="Berghofer B">B Berghofer</name></author><author><name sortKey="Frommer, T" uniqKey="Frommer T">T Frommer</name></author><author><name sortKey="Haley, G" uniqKey="Haley G">G Haley</name></author><author><name sortKey="Fink, L" uniqKey="Fink L">L Fink</name></author><author><name sortKey="Bein, G" uniqKey="Bein G">G Bein</name></author><author><name sortKey="Hackstein, H" uniqKey="Hackstein H">H Hackstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziegler, Sm" uniqKey="Ziegler S">SM Ziegler</name></author><author><name sortKey="Beisel, C" uniqKey="Beisel C">C Beisel</name></author><author><name sortKey="Sutter, K" uniqKey="Sutter K">K Sutter</name></author><author><name sortKey="Griesbeck, M" uniqKey="Griesbeck M">M Griesbeck</name></author><author><name sortKey="Hildebrandt, H" uniqKey="Hildebrandt H">H Hildebrandt</name></author><author><name sortKey="Hagen, Sh" uniqKey="Hagen S">SH Hagen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name></author><author><name sortKey="Yanai, H" uniqKey="Yanai H">H Yanai</name></author><author><name sortKey="Negishi, H" uniqKey="Negishi H">H Negishi</name></author><author><name sortKey="Asagiri, M" uniqKey="Asagiri M">M Asagiri</name></author><author><name sortKey="Sato, M" uniqKey="Sato M">M Sato</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T Mizutani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marie, I" uniqKey="Marie I">I Marie</name></author><author><name sortKey="Durbin, Je" uniqKey="Durbin J">JE Durbin</name></author><author><name sortKey="Levy, De" uniqKey="Levy D">DE Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prakash, A" uniqKey="Prakash A">A Prakash</name></author><author><name sortKey="Smith, E" uniqKey="Smith E">E Smith</name></author><author><name sortKey="Lee, Ck" uniqKey="Lee C">CK Lee</name></author><author><name sortKey="Levy, De" uniqKey="Levy D">DE Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Rien, M" uniqKey="O Rien M">M O’Brien</name></author><author><name sortKey="Manches, O" uniqKey="Manches O">O Manches</name></author><author><name sortKey="Sabado, Rl" uniqKey="Sabado R">RL Sabado</name></author><author><name sortKey="Baranda, Sj" uniqKey="Baranda S">SJ Baranda</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Marie, I" uniqKey="Marie I">I Marie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taleb, K" uniqKey="Taleb K">K Taleb</name></author><author><name sortKey="Auffray, C" uniqKey="Auffray C">C Auffray</name></author><author><name sortKey="Villefroy, P" uniqKey="Villefroy P">P Villefroy</name></author><author><name sortKey="Pereira, A" uniqKey="Pereira A">A Pereira</name></author><author><name sortKey="Hosmalin, A" uniqKey="Hosmalin A">A Hosmalin</name></author><author><name sortKey="Gaudry, M" uniqKey="Gaudry M">M Gaudry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhamanage, A" uniqKey="Dhamanage A">A Dhamanage</name></author><author><name sortKey="Thakar, M" uniqKey="Thakar M">M Thakar</name></author><author><name sortKey="Paranjape, R" uniqKey="Paranjape R">R Paranjape</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Augui, S" uniqKey="Augui S">S Augui</name></author><author><name sortKey="Nora, Ep" uniqKey="Nora E">EP Nora</name></author><author><name sortKey="Heard, E" uniqKey="Heard E">E Heard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name></author><author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name></author><author><name sortKey="Cottle, Aa" uniqKey="Cottle A">AA Cottle</name></author><author><name sortKey="Goglin, Kc" uniqKey="Goglin K">KC Goglin</name></author><author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carrel, L" uniqKey="Carrel L">L Carrel</name></author><author><name sortKey="Willard, Hf" uniqKey="Willard H">HF Willard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laffont, S" uniqKey="Laffont S">S Laffont</name></author><author><name sortKey="Rouquie, N" uniqKey="Rouquie N">N Rouquie</name></author><author><name sortKey="Azar, P" uniqKey="Azar P">P Azar</name></author><author><name sortKey="Seillet, C" uniqKey="Seillet C">C Seillet</name></author><author><name sortKey="Plumas, J" uniqKey="Plumas J">J Plumas</name></author><author><name sortKey="Aspord, C" uniqKey="Aspord C">C Aspord</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pisitkun, P" uniqKey="Pisitkun P">P Pisitkun</name></author><author><name sortKey="Deane, Ja" uniqKey="Deane J">JA Deane</name></author><author><name sortKey="Difilippantonio, Mj" uniqKey="Difilippantonio M">MJ Difilippantonio</name></author><author><name sortKey="Tarasenko, T" uniqKey="Tarasenko T">T Tarasenko</name></author><author><name sortKey="Satterthwaite, Ab" uniqKey="Satterthwaite A">AB Satterthwaite</name></author><author><name sortKey="Bolland, S" uniqKey="Bolland S">S Bolland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karlsen, M" uniqKey="Karlsen M">M Karlsen</name></author><author><name sortKey="Jakobsen, K" uniqKey="Jakobsen K">K Jakobsen</name></author><author><name sortKey="Jonsson, R" uniqKey="Jonsson R">R Jonsson</name></author><author><name sortKey="Hammenfors, D" uniqKey="Hammenfors D">D Hammenfors</name></author><author><name sortKey="Hansen, T" uniqKey="Hansen T">T Hansen</name></author><author><name sortKey="Appel, S" uniqKey="Appel S">S Appel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laffont, S" uniqKey="Laffont S">S Laffont</name></author><author><name sortKey="Seillet, C" uniqKey="Seillet C">C Seillet</name></author><author><name sortKey="Guery, Jc" uniqKey="Guery J">JC Guery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, K" uniqKey="Honda K">K Honda</name></author><author><name sortKey="Takaoka, A" uniqKey="Takaoka A">A Takaoka</name></author><author><name sortKey="Taniguchi, T" uniqKey="Taniguchi T">T Taniguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoenemeyer, A" uniqKey="Schoenemeyer A">A Schoenemeyer</name></author><author><name sortKey="Barnes, Bj" uniqKey="Barnes B">BJ Barnes</name></author><author><name sortKey="Mancl, Me" uniqKey="Mancl M">ME Mancl</name></author><author><name sortKey="Latz, E" uniqKey="Latz E">E Latz</name></author><author><name sortKey="Goutagny, N" uniqKey="Goutagny N">N Goutagny</name></author><author><name sortKey="Pitha, Pm" uniqKey="Pitha P">PM Pitha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takaoka, A" uniqKey="Takaoka A">A Takaoka</name></author><author><name sortKey="Yanai, H" uniqKey="Yanai H">H Yanai</name></author><author><name sortKey="Kondo, S" uniqKey="Kondo S">S Kondo</name></author><author><name sortKey="Duncan, G" uniqKey="Duncan G">G Duncan</name></author><author><name sortKey="Negishi, H" uniqKey="Negishi H">H Negishi</name></author><author><name sortKey="Mizutani, T" uniqKey="Mizutani T">T Mizutani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mingjia, L" uniqKey="Mingjia L">L Mingjia</name></author><author><name sortKey="Short, R" uniqKey="Short R">R Short</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaushic, C" uniqKey="Kaushic C">C Kaushic</name></author><author><name sortKey="Roth, Kl" uniqKey="Roth K">KL Roth</name></author><author><name sortKey="Anipindi, V" uniqKey="Anipindi V">V Anipindi</name></author><author><name sortKey="Xiu, F" uniqKey="Xiu F">F Xiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sodora, Dl" uniqKey="Sodora D">DL Sodora</name></author><author><name sortKey="Gettie, A" uniqKey="Gettie A">A Gettie</name></author><author><name sortKey="Miller, Cj" uniqKey="Miller C">CJ Miller</name></author><author><name sortKey="Marx, Pa" uniqKey="Marx P">PA Marx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, F" uniqKey="Dominguez F">F Dominguez</name></author><author><name sortKey="Galan, A" uniqKey="Galan A">A Galan</name></author><author><name sortKey="Martin, Jj" uniqKey="Martin J">JJ Martin</name></author><author><name sortKey="Remohi, J" uniqKey="Remohi J">J Remohi</name></author><author><name sortKey="Pellicer, A" uniqKey="Pellicer A">A Pellicer</name></author><author><name sortKey="Simon, C" uniqKey="Simon C">C Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prakash, M" uniqKey="Prakash M">M Prakash</name></author><author><name sortKey="Kapembwa, Ms" uniqKey="Kapembwa M">MS Kapembwa</name></author><author><name sortKey="Gotch, F" uniqKey="Gotch F">F Gotch</name></author><author><name sortKey="Patterson, S" uniqKey="Patterson S">S Patterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheffield, Js" uniqKey="Sheffield J">JS Sheffield</name></author><author><name sortKey="Wendel, Gd" uniqKey="Wendel G">GD Wendel</name></author><author><name sortKey="Mcintire, Dd" uniqKey="Mcintire D">DD McIntire</name></author><author><name sortKey="Norgard, Mv" uniqKey="Norgard M">MV Norgard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vassiliadou, N" uniqKey="Vassiliadou N">N Vassiliadou</name></author><author><name sortKey="Tucker, L" uniqKey="Tucker L">L Tucker</name></author><author><name sortKey="Anderson, Dj" uniqKey="Anderson D">DJ Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meditz, Al" uniqKey="Meditz A">AL Meditz</name></author><author><name sortKey="Moreau, Kl" uniqKey="Moreau K">KL Moreau</name></author><author><name sortKey="Mawhinney, S" uniqKey="Mawhinney S">S MaWhinney</name></author><author><name sortKey="Gozansky, Ws" uniqKey="Gozansky W">WS Gozansky</name></author><author><name sortKey="Melander, K" uniqKey="Melander K">K Melander</name></author><author><name sortKey="Kohrt, Wm" uniqKey="Kohrt W">WM Kohrt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arruvito, L" uniqKey="Arruvito L">L Arruvito</name></author><author><name sortKey="Sanz, M" uniqKey="Sanz M">M Sanz</name></author><author><name sortKey="Banham, Ah" uniqKey="Banham A">AH Banham</name></author><author><name sortKey="Fainboim, L" uniqKey="Fainboim L">L Fainboim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Sm" uniqKey="Smith S">SM Smith</name></author><author><name sortKey="Mefford, M" uniqKey="Mefford M">M Mefford</name></author><author><name sortKey="Sodora, D" uniqKey="Sodora D">D Sodora</name></author><author><name sortKey="Klase, Z" uniqKey="Klase Z">Z Klase</name></author><author><name sortKey="Singh, M" uniqKey="Singh M">M Singh</name></author><author><name sortKey="Alexander, N" uniqKey="Alexander N">N Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Garcia, M" uniqKey="Rodriguez Garcia M">M Rodriguez-Garcia</name></author><author><name sortKey="Biswas, N" uniqKey="Biswas N">N Biswas</name></author><author><name sortKey="Patel, Mv" uniqKey="Patel M">MV Patel</name></author><author><name sortKey="Barr, Fd" uniqKey="Barr F">FD Barr</name></author><author><name sortKey="Crist, Sg" uniqKey="Crist S">SG Crist</name></author><author><name sortKey="Ochsenbauer, C" uniqKey="Ochsenbauer C">C Ochsenbauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giltay, Ej" uniqKey="Giltay E">EJ Giltay</name></author><author><name sortKey="Fonk, Jc" uniqKey="Fonk J">JC Fonk</name></author><author><name sortKey="Von Blomberg, Bm" uniqKey="Von Blomberg B">BM von Blomberg</name></author><author><name sortKey="Drexhage, Ha" uniqKey="Drexhage H">HA Drexhage</name></author><author><name sortKey="Schalkwijk, C" uniqKey="Schalkwijk C">C Schalkwijk</name></author><author><name sortKey="Gooren, Lj" uniqKey="Gooren L">LJ Gooren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mo, R" uniqKey="Mo R">R Mo</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Grolleau Julius, A" uniqKey="Grolleau Julius A">A Grolleau-Julius</name></author><author><name sortKey="Murphy, Hs" uniqKey="Murphy H">HS Murphy</name></author><author><name sortKey="Richardson, Bc" uniqKey="Richardson B">BC Richardson</name></author><author><name sortKey="Yung, Rl" uniqKey="Yung R">RL Yung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asin, Sn" uniqKey="Asin S">SN Asin</name></author><author><name sortKey="Heimberg, Am" uniqKey="Heimberg A">AM Heimberg</name></author><author><name sortKey="Eszterhas, Sk" uniqKey="Eszterhas S">SK Eszterhas</name></author><author><name sortKey="Rollenhagen, C" uniqKey="Rollenhagen C">C Rollenhagen</name></author><author><name sortKey="Howell, Al" uniqKey="Howell A">AL Howell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szotek, El" uniqKey="Szotek E">EL Szotek</name></author><author><name sortKey="Narasipura, Sd" uniqKey="Narasipura S">SD Narasipura</name></author><author><name sortKey="Al Harthi, L" uniqKey="Al Harthi L">L Al-Harthi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katagiri, D" uniqKey="Katagiri D">D Katagiri</name></author><author><name sortKey="Hayashi, H" uniqKey="Hayashi H">H Hayashi</name></author><author><name sortKey="Victoriano, Af" uniqKey="Victoriano A">AF Victoriano</name></author><author><name sortKey="Okamoto, T" uniqKey="Okamoto T">T Okamoto</name></author><author><name sortKey="Onozaki, K" uniqKey="Onozaki K">K Onozaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ragupathy, V" uniqKey="Ragupathy V">V Ragupathy</name></author><author><name sortKey="Devadas, K" uniqKey="Devadas K">K Devadas</name></author><author><name sortKey="Tang, S" uniqKey="Tang S">S Tang</name></author><author><name sortKey="Wood, O" uniqKey="Wood O">O Wood</name></author><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Dastyer, A" uniqKey="Dastyer A">A Dastyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Jj" uniqKey="Chang J">JJ Chang</name></author><author><name sortKey="Altfeld, M" uniqKey="Altfeld M">M Altfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardy, Ga" uniqKey="Hardy G">GA Hardy</name></author><author><name sortKey="Sieg, S" uniqKey="Sieg S">S Sieg</name></author><author><name sortKey="Rodriguez, B" uniqKey="Rodriguez B">B Rodriguez</name></author><author><name sortKey="Anthony, D" uniqKey="Anthony D">D Anthony</name></author><author><name sortKey="Asaad, R" uniqKey="Asaad R">R Asaad</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, S" uniqKey="Fernandez S">S Fernandez</name></author><author><name sortKey="Tanaskovic, S" uniqKey="Tanaskovic S">S Tanaskovic</name></author><author><name sortKey="Helbig, K" uniqKey="Helbig K">K Helbig</name></author><author><name sortKey="Rajasuriar, R" uniqKey="Rajasuriar R">R Rajasuriar</name></author><author><name sortKey="Kramski, M" uniqKey="Kramski M">M Kramski</name></author><author><name sortKey="Murray, Jm" uniqKey="Murray J">JM Murray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandler, Ng" uniqKey="Sandler N">NG Sandler</name></author><author><name sortKey="Bosinger, Se" uniqKey="Bosinger S">SE Bosinger</name></author><author><name sortKey="Estes, Jd" uniqKey="Estes J">JD Estes</name></author><author><name sortKey="Zhu, Rt" uniqKey="Zhu R">RT Zhu</name></author><author><name sortKey="Tharp, Gk" uniqKey="Tharp G">GK Tharp</name></author><author><name sortKey="Boritz, E" uniqKey="Boritz E">E Boritz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ledwaba, L" uniqKey="Ledwaba L">L Ledwaba</name></author><author><name sortKey="Tavel, Ja" uniqKey="Tavel J">JA Tavel</name></author><author><name sortKey="Khabo, P" uniqKey="Khabo P">P Khabo</name></author><author><name sortKey="Maja, P" uniqKey="Maja P">P Maja</name></author><author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name></author><author><name sortKey="Sangweni, P" uniqKey="Sangweni P">P Sangweni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author><author><name sortKey="Tracy, R" uniqKey="Tracy R">R Tracy</name></author><author><name sortKey="Belloso, W" uniqKey="Belloso W">W Belloso</name></author><author><name sortKey="De Wit, S" uniqKey="De Wit S">S De Wit</name></author><author><name sortKey="Drummond, F" uniqKey="Drummond F">F Drummond</name></author><author><name sortKey="Lane, Hc" uniqKey="Lane H">HC Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sandler, Ng" uniqKey="Sandler N">NG Sandler</name></author><author><name sortKey="Wand, H" uniqKey="Wand H">H Wand</name></author><author><name sortKey="Roque, A" uniqKey="Roque A">A Roque</name></author><author><name sortKey="Law, M" uniqKey="Law M">M Law</name></author><author><name sortKey="Nason, Mc" uniqKey="Nason M">MC Nason</name></author><author><name sortKey="Nixon, De" uniqKey="Nixon D">DE Nixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Gettie, A" uniqKey="Gettie A">A Gettie</name></author><author><name sortKey="Salas, J" uniqKey="Salas J">J Salas</name></author><author><name sortKey="Russell, K" uniqKey="Russell K">K Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathad, Js" uniqKey="Mathad J">JS Mathad</name></author><author><name sortKey="Gupte, N" uniqKey="Gupte N">N Gupte</name></author><author><name sortKey="Balagopal, A" uniqKey="Balagopal A">A Balagopal</name></author><author><name sortKey="Asmuth, D" uniqKey="Asmuth D">D Asmuth</name></author><author><name sortKey="Hakim, J" uniqKey="Hakim J">J Hakim</name></author><author><name sortKey="Santos, B" uniqKey="Santos B">B Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krebs, Sj" uniqKey="Krebs S">SJ Krebs</name></author><author><name sortKey="Slike, Bm" uniqKey="Slike B">BM Slike</name></author><author><name sortKey="Sithinamsuwan, P" uniqKey="Sithinamsuwan P">P Sithinamsuwan</name></author><author><name sortKey="Allen, Ie" uniqKey="Allen I">IE Allen</name></author><author><name sortKey="Chalermchai, T" uniqKey="Chalermchai T">T Chalermchai</name></author><author><name sortKey="Tipsuk, S" uniqKey="Tipsuk S">S Tipsuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heaton, Rk" uniqKey="Heaton R">RK Heaton</name></author><author><name sortKey="Franklin, Dr" uniqKey="Franklin D">DR Franklin</name></author><author><name sortKey="Ellis, Rj" uniqKey="Ellis R">RJ Ellis</name></author><author><name sortKey="Mccutchan, Ja" uniqKey="Mccutchan J">JA McCutchan</name></author><author><name sortKey="Letendre, Sl" uniqKey="Letendre S">SL Letendre</name></author><author><name sortKey="Leblanc, S" uniqKey="Leblanc S">S Leblanc</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Front Immunol</journal-id><journal-id journal-id-type="publisher-id">Front. Immunol.</journal-id><journal-title-group><journal-title>Frontiers in Immunology</journal-title></journal-title-group><issn pub-type="epub">1664-3224</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29033943</article-id><article-id pub-id-type="pmc">5625005</article-id><article-id pub-id-type="doi">10.3389/fimmu.2017.01224</article-id><article-categories><subj-group subj-group-type="heading"><subject>Immunology</subject><subj-group><subject>Mini Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Human Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ziegler</surname><given-names>Susanne Maria</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/469856"></uri></contrib><contrib contrib-type="author"><name><surname>Altfeld</surname><given-names>Marcus</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1">*</xref><uri xlink:type="simple" xlink:href="http://frontiersin.org/people/u/114022"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Heinrich Pette Institute, Leibniz Institute for Experimental Virology</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></aff><aff id="aff2"><sup>2</sup><institution>Institute of Immunology, University Medical Center Hamburg-Eppendorf</institution>,<addr-line>Hamburg</addr-line>,<country>Germany</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Mustapha Chamekh, Free University of Brussels, Belgium</p></fn><fn fn-type="edited-by"><p>Reviewed by: Sally A. Huber, University of Vermont, United States; Lynn Pulliam, University of California, San Francisco, United States</p></fn><corresp content-type="corresp" id="cor1">*Correspondence: Marcus Altfeld, <email>m.altfeld@uke.de</email></corresp><fn fn-type="other" id="fn001"><p>Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology</p></fn></author-notes><pub-date pub-type="epub"><day>28</day><month>9</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>8</volume><elocation-id>1224</elocation-id><history><date date-type="received"><day>26</day><month>7</month><year>2017</year></date><date date-type="accepted"><day>15</day><month>9</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 Ziegler and Altfeld.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Ziegler and Altfeld</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men. Type I interferons (IFNs) play a prominent role in the control of HIV-1 transmission and replication. Continuous stimulation of type I IFNs in chronic viral infections can lead to increased levels of immune activation, which can be higher in HIV-1-infected women than in men. A role of steroid hormone signaling in regulating viral replication has been postulated, which might further account for sex differences observed in HIV-1 infections. Here, we review recent findings and current knowledge on sex-specific differences in HIV-1 infections.</p></abstract><kwd-group><kwd>type I interferon</kwd><kwd>human immunodeficiency virus 1</kwd><kwd>sex hormones</kwd><kwd>immune activation</kwd><kwd>sex differences</kwd><kwd>toll-like receptor 7</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="97"></ref-count><page-count count="7"></page-count><word-count count="5971"></word-count></counts></article-meta></front><body><sec sec-type="introduction" id="S1"><title>Introduction</title><p>Infections with human immunodeficiency virus (HIV)-1 still represent a global health problem with especially women and girls in sub-Saharan Africa being severely affected (<xref rid="B1" ref-type="bibr">1</xref>). The prevalence of HIV-1-infected girls and young women is twice as high as in men of same ages (<xref rid="B2" ref-type="bibr">2</xref>). While the overall survival does not differ between infected males and females (<xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B4" ref-type="bibr">4</xref>), women are at increased risk to acquire HIV-1 <italic>via</italic> heterosexual contact (<xref rid="B5" ref-type="bibr">5</xref>). It is now well established that sex-related biological factors affect HIV-1 disease manifestations and progression. During acute infection, HIV-1-infected females have lower HIV-1 viral load levels in comparison to men (<xref rid="B6" ref-type="bibr">6</xref>–<xref rid="B9" ref-type="bibr">9</xref>). Plasma viral load levels predict the size of the HIV-1 reservoir (<xref rid="B10" ref-type="bibr">10</xref>, <xref rid="B11" ref-type="bibr">11</xref>), hence lower viral load levels in HIV-1-infected females might contribute to a smaller size of the HIV-1 DNA reservoir (<xref rid="B12" ref-type="bibr">12</xref>, <xref rid="B13" ref-type="bibr">13</xref>). Type I interferons (IFNs) play a critical role in restricting viral replication through induction of host restriction factors and might contribute to this initial control of HIV-1 viremia. On the other hand, type I IFNs have been shown to increase systemic immune activation upon chronic viral infection (<xref rid="B14" ref-type="bibr">14</xref>, <xref rid="B15" ref-type="bibr">15</xref>).</p><p>Several factors have been suggested to influence the sex bias observed in the manifestations of HIV-1 infections, including sex and gender differences in comorbidities as well as socioeconomic factors (<xref rid="B16" ref-type="bibr">16</xref>, <xref rid="B17" ref-type="bibr">17</xref>). Dissecting biological mechanisms from socioeconomic factors represents a frequently challenging process. The elucidation of the biological mechanisms that underlie immunological differences between the sexes has become an emerging area of interest aimed at understanding the involvement of steroid hormones (<xref rid="B18" ref-type="bibr">18</xref>–<xref rid="B20" ref-type="bibr">20</xref>), the direct effects of X and Y chromosomal-linked factors (<xref rid="B21" ref-type="bibr">21</xref>–<xref rid="B23" ref-type="bibr">23</xref>) or epigenetic modifications that influence the composition and phenotype of immune cells, and the role of the microbiome (<xref rid="B24" ref-type="bibr">24</xref>). Recent reviews have already covered several aspects of sex-based differences in HIV-1 infection (<xref rid="B16" ref-type="bibr">16</xref>, <xref rid="B25" ref-type="bibr">25</xref>–<xref rid="B27" ref-type="bibr">27</xref>). This review will focus on the latest findings contributing to our understanding of the impact of sex-based differences in type I IFNs on HIV-1 disease pathogenesis.</p></sec><sec id="S2"><title>Type I IFNs Control HIV-1 Replication</title><p>The process of HIV-1 transmission through the mucosa of the female genital tract is comparatively unproductive (<xref rid="B28" ref-type="bibr">28</xref>). The innate immune system plays a major role in sensing incoming HIV-1 to initiate antiviral responses (<xref rid="B29" ref-type="bibr">29</xref>). HIV-1 can be recognized by multiple nucleic acid sensors, including toll-like receptors (TLRs) 3, 7, 8, and 9 (<xref rid="B30" ref-type="bibr">30</xref>), IFN-inducible protein (IFI) 16 (<xref rid="B31" ref-type="bibr">31</xref>), and cyclic GMP-AMP synthase (<xref rid="B32" ref-type="bibr">32</xref>). Recognition of HIV-1 by pattern recognition receptors leads to induction of antiviral and proinflammatory responses <italic>via</italic> JAK/STAT signaling, NF-κB, and interferon regulatory factors (IRFs) (<xref rid="B33" ref-type="bibr">33</xref>), ultimately resulting in the production of cytokines, chemokines, and type I IFNs. Type I IFNs are the first line of defense against viral infections, as they are capable of mediating immunregulatory, growth-inhibitory, and antiviral activities (<xref rid="B34" ref-type="bibr">34</xref>), through the induction of a multitude of interferon-stimulated genes (ISGs) that encode for antiviral proteins. In humans, the type I IFN family of genes consists of 13 highly homologous IFNα subtypes, IFNβ, IFNε, IFNκ, and IFNω (<xref rid="B35" ref-type="bibr">35</xref>). All type I IFNs bind to the same IFNα/β receptor (IFNAR) composed of two subunits IFNAR1 and IFNAR2, with varying affinities for the two subunits (<xref rid="B36" ref-type="bibr">36</xref>, <xref rid="B37" ref-type="bibr">37</xref>). IFNARs are expressed on most cell types and their activation induces the transcription of ISGs. Type I IFNs play an expanding role in restricting HIV-1 replication (<xref rid="B38" ref-type="bibr">38</xref>). Productive infections in a new host were shown to be established by HIV-1 strains (transmitted founder viruses) that were much less susceptible to the antiviral effects of type I IFNs <italic>in vitro</italic> (<xref rid="B39" ref-type="bibr">39</xref>–<xref rid="B41" ref-type="bibr">41</xref>). In line with these antiviral effects of type I IFNs that have to be overcome by transmitted founder viruses, one recent study demonstrated that vaginal IFNβ administration in rhesus macaques upregulated the expression of ISGs in vaginal suspensions and prevented SHIV-1 acquisition (<xref rid="B42" ref-type="bibr">42</xref>). The distinct capacities of the 13 different IFNα subtypes in controlling retroviral infections have been studied using humanized mouse models, suggesting that IFNα8 and IFNα14 suppress HIV-1 replication significantly better than other IFNα subtypes (<xref rid="B43" ref-type="bibr">43</xref>). Garcia-Minambres et al. recently described another, less prominent, type I IFN important in HIV-1 restriction (<xref rid="B44" ref-type="bibr">44</xref>). IFNε is expressed in the female genital tract of mice and humans and induces several HIV-1 restriction factors in T cells, with levels and antiviral effects similar to IFNα-mediated induction. IFNε reduced HIV-1 replication <italic>in vitro</italic> and HIV-1 strains that were grown in the presence of IFNε were less infectious than HIV-1 that was produced in the absence of IFNε (<xref rid="B44" ref-type="bibr">44</xref>). Interestingly, IFNε expression in the female reproductive tract is hormone dependent, with the highest expression during the proliferative phase of the menstrual cycle, when estrogen levels are peaking (<xref rid="B45" ref-type="bibr">45</xref>). During the secretory phase, which is characterized by a peak in progesterone, IFNε levels decline (<xref rid="B45" ref-type="bibr">45</xref>). This decrease in IFNε in the presence of high progesterone might play a role in the suggested increase in HIV-1 acquisition in females that take long-acting contraceptives (<xref rid="B46" ref-type="bibr">46</xref>–<xref rid="B50" ref-type="bibr">50</xref>). Taken together, type I IFN levels that are increased within the first weeks of HIV-1 infection induce expression of HIV-1 restriction factors, which play an important role in restricting HIV-1 spread and replication early in infection.</p></sec><sec id="S3"><title>Sex Differences in Type I IFN Production upon TLR7-Mediated Recognition of ssRNA</title><p>Plasmacytoid dendritic cells (pDCs) are innate immune cells that are specialized to produce type I IFNs and mediate cross-talk between innate and adaptive immunity. Multiple studies have contributed important knowledge on the role of pDCs in mediating sex-specific, HIV-1-associated immune activation. pDCs from females produce higher levels of IFNα upon TLR7 stimulation using HIV-1 derived ssRNA (<xref rid="B20" ref-type="bibr">20</xref>) or synthetic ligands (<xref rid="B18" ref-type="bibr">18</xref>, <xref rid="B19" ref-type="bibr">19</xref>, <xref rid="B51" ref-type="bibr">51</xref>, <xref rid="B52" ref-type="bibr">52</xref>) in comparison to men. In addition, we recently showed that pDCs from females express significantly higher mRNA levels of all 13 IFNα subtypes and IFNβ after TLR7-stimulation of peripheral blood mononuclear cells (PBMCs) (<xref rid="B52" ref-type="bibr">52</xref>). The mRNA expression levels of IFNα in pDCs were correlated with the expression levels of IFNβ in pDCs after TLR7 stimulation, but were independent from secondary signaling <italic>via</italic> IFNAR (<xref rid="B52" ref-type="bibr">52</xref>), as reported for TLR9 signaling or type I IFN production by other cell types than pDCs (<xref rid="B53" ref-type="bibr">53</xref>–<xref rid="B55" ref-type="bibr">55</xref>). Although IFNα produced by pDCs is able to inhibit HIV-1 replication by exerting growth-inhibitory and antiviral activities, the continuous exposure of pDCs to HIV-1 has opposing effects. HIV-1 recognition by pDCs leads to the expression of low levels of maturation molecules on pDCs and therefore skews pDCs toward a partially matured, persistently IFNα-secreting phenotype stimulating only weak T cell responses (<xref rid="B56" ref-type="bibr">56</xref>). The effect of chronic exposure to IFNα was recently studied in mice, showing that chronic IFNα stimulation was sufficient to suppress specific CD8 T cell responses to vaccinia virus infection by inducing the accumulation of suppressive Ly6Chi monocytes (<xref rid="B57" ref-type="bibr">57</xref>). HIV-1 in turn has been suggested to impair TLR7-mediated IFNα production by pDCs, potentially by binding to CD303 receptors expressed on pDCs (<xref rid="B58" ref-type="bibr">58</xref>).</p><p>TLR7 is encoded on the X chromosome (<xref rid="B22" ref-type="bibr">22</xref>). X chromosome inactivation (XCI) of one of the two female X chromosomes ensures dosage compensation in female mammals, in contrast to male mammals harboring only one X chromosome. Most genes on the X chromosome are assumed to be transcriptionally silent; however, the process of XCI is dynamic and relies on dosage-dependent activators. A number of genes are known to escape XCI and are expressed from both the active and inactive X chromosome (<xref rid="B59" ref-type="bibr">59</xref>–<xref rid="B62" ref-type="bibr">62</xref>). So far, there is no evidence for a higher expression of TLR7 genes in pDCs from women in humans (<xref rid="B51" ref-type="bibr">51</xref>, <xref rid="B63" ref-type="bibr">63</xref>), though TLR7 gene duplication has been associated with autoreactive B cell responses in mice (<xref rid="B64" ref-type="bibr">64</xref>) and increased levels of TLR7 and TLR8 have been found in PBMCs of patients with the primary Sjögren’s syndrome, an autoimmune disease with a female sex imbalance (<xref rid="B65" ref-type="bibr">65</xref>). Taken together, further research investigating the molecular mechanisms underlying TLR7 expression and regulation in pDCs will help to dissect the role of TLR7 signaling and its contribution to the sex bias in type I IFN production in HIV-1-infected individuals.</p></sec><sec id="S4"><title>Impact of Hormones on HIV-1 Disease</title><p>Steroid hormones have also been shown to modulate TLR-dependent responses of pDCs in humans. Estrogens and estrogen receptor-dependent regulations play key roles in dendritic cell development and function (<xref rid="B66" ref-type="bibr">66</xref>). pDCs from postmenopausal women display reduced TLR7-responsiveness and IFNα production in comparison to women of reproductive age. Estrogen replacement therapy of postmenopausal women increased the percentage of IFNα-producing pDCs after TLR7 and TLR9 stimulation (<xref rid="B18" ref-type="bibr">18</xref>). <italic>In vitro</italic> blockage of ER signaling during pDC-differentiation dampened the IFNα response of pDCs after TLR7 stimulation (<xref rid="B63" ref-type="bibr">63</xref>). IFNα-induction by pDCs is regulated by IRFs at the transcriptional level (<xref rid="B67" ref-type="bibr">67</xref>). IRF5 is one of the central mediators of TLR7 signaling (<xref rid="B68" ref-type="bibr">68</xref>, <xref rid="B69" ref-type="bibr">69</xref>) and has recently been shown to be expressed at higher basal levels in pDCs from females in comparison to males (<xref rid="B19" ref-type="bibr">19</xref>). While upregulation of IRF5 levels in pDCs resulted in increased IFNα secretion by pDCs, genetic ablation of the <italic>Esr1</italic> gene reduced IRF5 mRNA expression in pDCs and subsequent IFNα production in response to TLR7 stimulation (<xref rid="B19" ref-type="bibr">19</xref>).</p><p>Sex hormones have also been reported to directly modulate host factors that play a role in HIV-1 acquisition (<xref rid="B25" ref-type="bibr">25</xref>). Generally, progesterone increases susceptibility to viral infections whereas estrogen protects against HIV-1 acquisition (<xref rid="B70" ref-type="bibr">70</xref>, <xref rid="B71" ref-type="bibr">71</xref>). Studies of rhesus macaques support this general concept, as simian immunodeficiency virus (SIV) susceptibility was highest in the luteal phase of the menstrual cycle (high progesterone) compared with the follicular phase (high estrogen) (<xref rid="B72" ref-type="bibr">72</xref>). Several studies report an increase in expression of HIV-1 receptors on cervical CD4 T cells mediated by progesterone (<xref rid="B73" ref-type="bibr">73</xref>–<xref rid="B75" ref-type="bibr">75</xref>), supporting the reported increase in HIV-1 acquisition. Nevertheless, one <italic>in vitro</italic> study suggests that progesterone decreases the upregulation of CCR5 on CD4 T cells in peripheral blood (<xref rid="B76" ref-type="bibr">76</xref>). Furthermore, Meditz et al. showed that postmenopausal women, who have lower levels of progesterone, have elevated cervical CCR5 expression, which may increase their risk for HIV-1 acquisition (<xref rid="B77" ref-type="bibr">77</xref>). Estrogen exerts several biphasic effects on cells of the immune system, including modulation of T helper 1 versus T helper 2 cell differentiation (<xref rid="B22" ref-type="bibr">22</xref>) and expansion of regulatory T cells (<xref rid="B78" ref-type="bibr">78</xref>). Animal studies have shown that topical estrogen protects against vaginal SIV transmission in rhesus macaques (<xref rid="B79" ref-type="bibr">79</xref>). Estrogen was shown to downregulate the susceptibility of CD4 T cells and macrophages to HIV-1 <italic>in vitro</italic> (<xref rid="B80" ref-type="bibr">80</xref>), yet some studies suggest that <italic>in vivo</italic> hormone treatment with estrogens and antiandrogens in men to female transsexuals upregulates CCR5 on CD4 T cells over time (<xref rid="B81" ref-type="bibr">81</xref>), and also in mice (<xref rid="B82" ref-type="bibr">82</xref>).</p><p>The direct influence of steroid hormones on viral replication capacity of HIV-1 has been investigated in a few studies. Estradiol and progesterone can potentially regulate HIV-1 replication by directly altering HIV-1 transcriptional activation (<xref rid="B83" ref-type="bibr">83</xref>); however, the current results are controversial. In one study, <italic>in vitro</italic> estradiol treatment was shown to inhibit production of HIV-1 (<xref rid="B84" ref-type="bibr">84</xref>), while another study suggested an estrogen-based increase of transcriptional activity of HIV-1 LTRs (<xref rid="B85" ref-type="bibr">85</xref>). In addition, hormonal effects on HIV-1 replication were shown to be donor and HIV-1 subtype specific (<xref rid="B86" ref-type="bibr">86</xref>). Further studies are required to determine how the hormonal milieu might shape the outcome of HIV-1 infection <italic>in vivo</italic> and to identify the underlying molecular mechanisms.</p></sec><sec id="S5"><title>Sex Differences in Immune Activation in Chronic Retroviral Infections of Mammals</title><p>It is now well established that systemic immune activation is a strong predictor for HIV-1 disease progression to AIDS. Consistent with the finding that innate immune function is linked to higher responses to TLR7 stimulation of pDCs and subsequent type I IFN production, HIV-1-infected women have higher expression levels of ISGs than men for the same level of viral load (<xref rid="B87" ref-type="bibr">87</xref>). Furthermore, the surface expression levels of the common IFN-α/β receptor subunit 2 (IFNAR2) are significantly higher on pDCs from females in comparison to males and tends to be higher on other antigen-presenting cells from females as well (<xref rid="B52" ref-type="bibr">52</xref>). The increase in ISG expression in female HIV-1-infected individuals might explain increased levels of T cell activation (CD4/8<sup>+</sup> CD38<sup>+</sup> HLA-DR<sup>+</sup>) in HIV-1-infected females in comparison to male HIV-1-infected individuals for the same level of viral load (<xref rid="B20" ref-type="bibr">20</xref>). Higher expression levels of IFNAR2 might contribute to the increased levels of ISG expression in females in comparison to males. In addition, higher levels of IFNα have been associated with decreased CD4 counts (<xref rid="B88" ref-type="bibr">88</xref>), which is in line with one study showing that increased expression of ISGs in CD4 T cells was associated with CD4 T cell depletion in HIV-1-infected individuals (<xref rid="B89" ref-type="bibr">89</xref>). The importance of type I IFNs in HIV-1 infections, as well as the timing of their effects, was studied in SIV infections of rhesus macaques (<xref rid="B90" ref-type="bibr">90</xref>). Blockage of IFN α/β receptors in rhesus macaques reduced antiviral gene expression and reservoir size during acute infections; however, continued IFNα2a treatment led to a desensitisation toward type I IFNs, resulting in decreased antiviral gene expression, increased reservoir size and accelerated CD4 T cell loss (<xref rid="B90" ref-type="bibr">90</xref>). Several mechanisms that underlie the association of immune activation and progression to AIDS have been proposed (<xref rid="B14" ref-type="bibr">14</xref>). Overall, it appears that the timing of type I IFN-induced innate response to HIV/SIV infection largely influences overall disease pathogenesis.</p><p>Several markers of inflammation and immune activation, such as C-reactive protein, sCD14, IL-6, and TNFα, have been associated with increased progression and mortality in HIV-1 infections (<xref rid="B91" ref-type="bibr">91</xref>–<xref rid="B93" ref-type="bibr">93</xref>). A novel non-human primate model for the investigation of sex differences in HIV-1 disease progression was recently used to study sex differences in local innate immune activation and gut microbiota (<xref rid="B94" ref-type="bibr">94</xref>). Viral load, disease progression, microbiota, and immunological parameters were studied in rhesus macaques infected with SHIV-1. This non-human primate model showed the same sex bias in SHIV-1 infection as observed for HIV-1 in humans and linked an earlier and more robust proinflammatory immune response as well as increased expansion of Proteobacteria in the female rectal mucosa to the increased disease susceptibility in female macaques (<xref rid="B94" ref-type="bibr">94</xref>).</p><p>A recent longitudinal study investigated sex differences in inflammatory and immune activation markers in HIV-1-infected women and men after initiation of combination antiretroviral treatment (cART). After cART initiation, women experienced less cART-associated reduction in inflammation and immune activation, indicated by higher levels of IFNγ and TNFα 48 weeks after initiation of therapy (<xref rid="B95" ref-type="bibr">95</xref>). Another study analyzed sex differences in soluble markers in plasma and cerebrospinal fluid (CSF) in HIV-1-infected treatment-naive individuals with or without cognitive impairment from Thailand. Soluble markers were quantified before and 48 weeks after cART initiation to identify variations in markers that may contribute to differences in disease progression (<xref rid="B96" ref-type="bibr">96</xref>). In chronic untreated HIV-1 infection, up to 50% of infected individuals have been reported to have cognitive impairment, commonly termed HIV-1-associated neurological disorders (<xref rid="B97" ref-type="bibr">97</xref>). Treatment naive, HIV-1-infected women with impaired cognition had elevated levels of neopterin and TNF-RII, both correlative markers for HIV-1 progression and efficiency of cART, compared to women with normal cognition in both plasma and CSF, whereas no associations were observed between these markers and cognition in men. Furthermore, sex-specific differences in the levels of a number of markers, including MCP-1, IL-8, IL-10, I-FABP, and sCD14, were detected in response to treatment (<xref rid="B96" ref-type="bibr">96</xref>). This study therefore proposed sex-specific differences in markers that were associated with cognitive impairment and chronic inflammation. Overall, these data suggest that changes in soluble markers vary before and after initiation of antiretroviral therapy between chronically HIV-1-infected women and men and might be predictive for HIV-1 disease outcomes.</p></sec><sec id="S6"><title>Conclusion</title><p>The precise role of type I IFNs in HIV-1 disease progression still remains insufficiently understood. The outcomes of type I IFNs on disease outcome are multifactorial and appear to depend on timing and extend of the induction (local versus systemic), as well as on the specific IFNα subtypes that are induced. Sex differences in type I IFN responses are now widely accepted; however, the underlying mechanisms that lead to sex-based differences in type I IFN production and their impact on infectious diseases such as HIV-1, but also on autoimmune diseases, remain less well understood. The frequent under-representation of women in clinical studies furthermore impedes research progress in that area. Thoughtful designed experimental and clinical studies will have to fill in the current gaps in knowledge concerning the impact of chromosomal effects and/or hormonal influences on innate immune responses and the subsequent consequences for HIV-1 disease progression.</p></sec><sec id="S7"><title>Author Contributions</title><p>All authors have made a substantial, direct, and intellectual contribution to the work and approved it for publication.</p></sec><sec id="S8"><title>Conflict of Interest Statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></body><back><ack><p>We thank Sven Hagen for critical reading of the manuscript.</p></ack><ref-list><title>References</title><ref id="B1"><label>1</label><mixed-citation publication-type="webpage"><collab>WHO</collab>. <source>HIV/AIDS Fact sheet</source>. (<year>2017</year>). Available from: <uri xlink:type="simple" xlink:href="http://www.who.int/mediacentre/factsheets/fs360/en/">http://www.who.int/mediacentre/factsheets/fs360/en/</uri></mixed-citation></ref><ref id="B2"><label>2</label><mixed-citation publication-type="webpage"><collab>UNAIDS</collab>. <source>Report on the Global AIDS Epidemic 2013</source>. (<year>2017</year>). Available from: <uri xlink:type="simple" xlink:href="http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Global_Report_2013_en_1.pdf">http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Global_Report_2013_en_1.pdf</uri></mixed-citation></ref><ref id="B3"><label>3</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lemp</surname><given-names>GF</given-names></name><name><surname>Hirozawa</surname><given-names>AM</given-names></name><name><surname>Cohen</surname><given-names>JB</given-names></name><name><surname>Derish</surname><given-names>PA</given-names></name><name><surname>McKinney</surname><given-names>KC</given-names></name><name><surname>Hernandez</surname><given-names>SR</given-names></name></person-group>. <article-title>Survival for women and men with AIDS</article-title>. <source>J Infect Dis</source> (<year>1992</year>) <volume>166</volume>(<issue>1</issue>):<fpage>74</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1093/infdis/166.1.74</pub-id><pub-id pub-id-type="pmid">1607710</pub-id></mixed-citation></ref><ref id="B4"><label>4</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chaisson</surname><given-names>RE</given-names></name><name><surname>Keruly</surname><given-names>JC</given-names></name><name><surname>Moore</surname><given-names>RD</given-names></name></person-group>. <article-title>Race, sex, drug use, and progression of human immunodeficiency virus disease</article-title>. <source>N Engl J Med</source> (<year>1995</year>) <volume>333</volume>(<issue>12</issue>):<fpage>751</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1056/NEJM199509213331202</pub-id><pub-id pub-id-type="pmid">7643881</pub-id></mixed-citation></ref><ref id="B5"><label>5</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nicolosi</surname><given-names>A</given-names></name><name><surname>Correa Leite</surname><given-names>ML</given-names></name><name><surname>Musicco</surname><given-names>M</given-names></name><name><surname>Arici</surname><given-names>C</given-names></name><name><surname>Gavazzeni</surname><given-names>G</given-names></name><name><surname>Lazzarin</surname><given-names>A</given-names></name></person-group><article-title>The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Italian Study Group on HIV Heterosexual Transmission</article-title>. <source>Epidemiology</source> (<year>1994</year>) <volume>5</volume>(<issue>6</issue>):<fpage>570</fpage>–<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1097/00001648-199411000-00003</pub-id><pub-id pub-id-type="pmid">7841237</pub-id></mixed-citation></ref><ref id="B6"><label>6</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anastos</surname><given-names>K</given-names></name><name><surname>Gange</surname><given-names>SJ</given-names></name><name><surname>Lau</surname><given-names>B</given-names></name><name><surname>Weiser</surname><given-names>B</given-names></name><name><surname>Detels</surname><given-names>R</given-names></name><name><surname>Giorgi</surname><given-names>JV</given-names></name><etal></etal></person-group><article-title>Association of race and gender with HIV-1 RNA levels and immunologic progression</article-title>. <source>J Acquir Immune Defic Syndr</source> (<year>2000</year>) <volume>24</volume>(<issue>3</issue>):<fpage>218</fpage>–<lpage>26</lpage>.<pub-id pub-id-type="doi">10.1097/00126334-200007010-00004</pub-id><pub-id pub-id-type="pmid">10969345</pub-id></mixed-citation></ref><ref id="B7"><label>7</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Farzadegan</surname><given-names>H</given-names></name><name><surname>Hoover</surname><given-names>DR</given-names></name><name><surname>Astemborski</surname><given-names>J</given-names></name><name><surname>Lyles</surname><given-names>CM</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Markham</surname><given-names>RB</given-names></name><etal></etal></person-group><article-title>Sex differences in HIV-1 viral load and progression to AIDS</article-title>. <source>Lancet</source> (<year>1998</year>) <volume>352</volume>(<issue>9139</issue>):<fpage>1510</fpage>–<lpage>4</lpage>.<pub-id pub-id-type="doi">10.1016/S0140-6736(98)02372-1</pub-id><pub-id pub-id-type="pmid">9820299</pub-id></mixed-citation></ref><ref id="B8"><label>8</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sterling</surname><given-names>TR</given-names></name><name><surname>Lyles</surname><given-names>CM</given-names></name><name><surname>Vlahov</surname><given-names>D</given-names></name><name><surname>Astemborski</surname><given-names>J</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name></person-group>. <article-title>Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters</article-title>. <source>J Infect Dis</source> (<year>1999</year>) <volume>180</volume>(<issue>3</issue>):<fpage>666</fpage>–<lpage>72</lpage>.<pub-id pub-id-type="doi">10.1086/314967</pub-id><pub-id pub-id-type="pmid">10438353</pub-id></mixed-citation></ref><ref id="B9"><label>9</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sterling</surname><given-names>TR</given-names></name><name><surname>Vlahov</surname><given-names>D</given-names></name><name><surname>Astemborski</surname><given-names>J</given-names></name><name><surname>Hoover</surname><given-names>DR</given-names></name><name><surname>Margolick</surname><given-names>JB</given-names></name><name><surname>Quinn</surname><given-names>TC</given-names></name></person-group>. <article-title>Initial plasma HIV-1 RNA levels and progression to AIDS in women and men</article-title>. <source>N Engl J Med</source> (<year>2001</year>) <volume>344</volume>(<issue>10</issue>):<fpage>720</fpage>–<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1056/NEJM200103083441003</pub-id><pub-id pub-id-type="pmid">11236775</pub-id></mixed-citation></ref><ref id="B10"><label>10</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ghosn</surname><given-names>J</given-names></name><name><surname>Deveau</surname><given-names>C</given-names></name><name><surname>Chaix</surname><given-names>ML</given-names></name><name><surname>Goujard</surname><given-names>C</given-names></name><name><surname>Galimand</surname><given-names>J</given-names></name><name><surname>Zitoun</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Despite being highly diverse, immunovirological status strongly correlates with clinical symptoms during primary HIV-1 infection: a cross-sectional study based on 674 patients enrolled in the ANRS CO 06 PRIMO cohort</article-title>. <source>J Antimicrob Chemother</source> (<year>2010</year>) <volume>65</volume>(<issue>4</issue>):<fpage>741</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="doi">10.1093/jac/dkq035</pub-id><pub-id pub-id-type="pmid">20167586</pub-id></mixed-citation></ref><ref id="B11"><label>11</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ngo-Giang-Huong</surname><given-names>N</given-names></name><name><surname>Deveau</surname><given-names>C</given-names></name><name><surname>Da Silva</surname><given-names>I</given-names></name><name><surname>Pellegrin</surname><given-names>I</given-names></name><name><surname>Venet</surname><given-names>A</given-names></name><name><surname>Harzic</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy</article-title>. <source>AIDS</source> (<year>2001</year>) <volume>15</volume>(<issue>6</issue>):<fpage>665</fpage>–<lpage>73</lpage>.<pub-id pub-id-type="doi">10.1097/00002030-200104130-00001</pub-id><pub-id pub-id-type="pmid">11371680</pub-id></mixed-citation></ref><ref id="B12"><label>12</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cuzin</surname><given-names>L</given-names></name><name><surname>Pugliese</surname><given-names>P</given-names></name><name><surname>Saune</surname><given-names>K</given-names></name><name><surname>Allavena</surname><given-names>C</given-names></name><name><surname>Ghosn</surname><given-names>J</given-names></name><name><surname>Cottalorda</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapy</article-title>. <source>AIDS</source> (<year>2015</year>) <volume>29</volume>(<issue>13</issue>):<fpage>1665</fpage>–<lpage>71</lpage>.<pub-id pub-id-type="doi">10.1097/QAD.0000000000000723</pub-id><pub-id pub-id-type="pmid">26372277</pub-id></mixed-citation></ref><ref id="B13"><label>13</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fourati</surname><given-names>S</given-names></name><name><surname>Flandre</surname><given-names>P</given-names></name><name><surname>Calin</surname><given-names>R</given-names></name><name><surname>Carcelain</surname><given-names>G</given-names></name><name><surname>Soulie</surname><given-names>C</given-names></name><name><surname>Lambert-Niclot</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Factors associated with a low HIV reservoir in patients with prolonged suppressive antiretroviral therapy</article-title>. <source>J Antimicrob Chemother</source> (<year>2014</year>) <volume>69</volume>(<issue>3</issue>):<fpage>753</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1093/jac/dkt428</pub-id><pub-id pub-id-type="pmid">24187041</pub-id></mixed-citation></ref><ref id="B14"><label>14</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Utay</surname><given-names>NS</given-names></name><name><surname>Douek</surname><given-names>DC</given-names></name></person-group>. <article-title>Interferons and HIV infection: the good, the bad, and the ugly</article-title>. <source>Pathog Immun</source> (<year>2016</year>) <volume>1</volume>(<issue>1</issue>):<fpage>107</fpage>–<lpage>16</lpage>.<pub-id pub-id-type="doi">10.20411/pai.v1i1.125</pub-id><pub-id pub-id-type="pmid">27500281</pub-id></mixed-citation></ref><ref id="B15"><label>15</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Odorizzi</surname><given-names>PM</given-names></name><name><surname>Wherry</surname><given-names>EJ</given-names></name></person-group><article-title>Immunology. An interferon paradox</article-title>. <source>Science</source> (<year>2013</year>) <volume>340</volume>(<issue>6129</issue>):<fpage>155</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1126/science.1237568</pub-id><pub-id pub-id-type="pmid">23580520</pub-id></mixed-citation></ref><ref id="B16"><label>16</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Griesbeck</surname><given-names>M</given-names></name><name><surname>Scully</surname><given-names>E</given-names></name><name><surname>Altfeld</surname><given-names>M</given-names></name></person-group>. <article-title>Sex and gender differences in HIV-1 infection</article-title>. <source>Clin Sci (Lond)</source> (<year>2016</year>) <volume>130</volume>(<issue>16</issue>):<fpage>1435</fpage>–<lpage>51</lpage>.<pub-id pub-id-type="doi">10.1042/CS20160112</pub-id><pub-id pub-id-type="pmid">27389589</pub-id></mixed-citation></ref><ref id="B17"><label>17</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Santelli</surname><given-names>JS</given-names></name><name><surname>Edelstein</surname><given-names>ZR</given-names></name><name><surname>Mathur</surname><given-names>S</given-names></name><name><surname>Wei</surname><given-names>Y</given-names></name><name><surname>Zhang</surname><given-names>W</given-names></name><name><surname>Orr</surname><given-names>MG</given-names></name><etal></etal></person-group><article-title>Behavioral, biological, and demographic risk and protective factors for new HIV infections among youth in Rakai, Uganda</article-title>. <source>J Acquir Immune Defic Syndr</source> (<year>2013</year>) <volume>63</volume>(<issue>3</issue>):<fpage>393</fpage>–<lpage>400</lpage>.<pub-id pub-id-type="doi">10.1097/QAI.0b013e3182926795</pub-id><pub-id pub-id-type="pmid">23535293</pub-id></mixed-citation></ref><ref id="B18"><label>18</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seillet</surname><given-names>C</given-names></name><name><surname>Laffont</surname><given-names>S</given-names></name><name><surname>Tremollieres</surname><given-names>F</given-names></name><name><surname>Rouquie</surname><given-names>N</given-names></name><name><surname>Ribot</surname><given-names>C</given-names></name><name><surname>Arnal</surname><given-names>JF</given-names></name><etal></etal></person-group><article-title>The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling</article-title>. <source>Blood</source> (<year>2012</year>) <volume>119</volume>(<issue>2</issue>):<fpage>454</fpage>–<lpage>64</lpage>.<pub-id pub-id-type="doi">10.1182/blood-2011-08-371831</pub-id><pub-id pub-id-type="pmid">22096248</pub-id></mixed-citation></ref><ref id="B19"><label>19</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Griesbeck</surname><given-names>M</given-names></name><name><surname>Ziegler</surname><given-names>S</given-names></name><name><surname>Laffont</surname><given-names>S</given-names></name><name><surname>Smith</surname><given-names>N</given-names></name><name><surname>Chauveau</surname><given-names>L</given-names></name><name><surname>Tomezsko</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-alpha production in women</article-title>. <source>J Immunol</source> (<year>2015</year>) <volume>195</volume>(<issue>11</issue>):<fpage>5327</fpage>–<lpage>36</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.1501684</pub-id><pub-id pub-id-type="pmid">26519527</pub-id></mixed-citation></ref><ref id="B20"><label>20</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meier</surname><given-names>A</given-names></name><name><surname>Chang</surname><given-names>JJ</given-names></name><name><surname>Chan</surname><given-names>ES</given-names></name><name><surname>Pollard</surname><given-names>RB</given-names></name><name><surname>Sidhu</surname><given-names>HK</given-names></name><name><surname>Kulkarni</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1</article-title>. <source>Nat Med</source> (<year>2009</year>) <volume>15</volume>(<issue>8</issue>):<fpage>955</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1038/nm.2004</pub-id><pub-id pub-id-type="pmid">19597505</pub-id></mixed-citation></ref><ref id="B21"><label>21</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Libert</surname><given-names>C</given-names></name><name><surname>Dejager</surname><given-names>L</given-names></name><name><surname>Pinheiro</surname><given-names>I</given-names></name></person-group>. <article-title>The X chromosome in immune functions: when a chromosome makes the difference</article-title>. <source>Nat Rev Immunol</source> (<year>2010</year>) <volume>10</volume>(<issue>8</issue>):<fpage>594</fpage>–<lpage>604</lpage>.<pub-id pub-id-type="doi">10.1038/nri2815</pub-id><pub-id pub-id-type="pmid">20651746</pub-id></mixed-citation></ref><ref id="B22"><label>22</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fish</surname><given-names>EN</given-names></name></person-group>. <article-title>The X-files in immunity: sex-based differences predispose immune responses</article-title>. <source>Nat Rev Immunol</source> (<year>2008</year>) <volume>8</volume>(<issue>9</issue>):<fpage>737</fpage>–<lpage>44</lpage>.<pub-id pub-id-type="doi">10.1038/nri2394</pub-id><pub-id pub-id-type="pmid">18728636</pub-id></mixed-citation></ref><ref id="B23"><label>23</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Markle</surname><given-names>JG</given-names></name><name><surname>Fish</surname><given-names>EN</given-names></name></person-group><article-title>SeXX matters in immunity</article-title>. <source>Trends Immunol</source> (<year>2014</year>) <volume>35</volume>(<issue>3</issue>):<fpage>97</fpage>–<lpage>104</lpage>.<pub-id pub-id-type="doi">10.1016/j.it.2013.10.006</pub-id><pub-id pub-id-type="pmid">24239225</pub-id></mixed-citation></ref><ref id="B24"><label>24</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yurkovetskiy</surname><given-names>L</given-names></name><name><surname>Burrows</surname><given-names>M</given-names></name><name><surname>Khan</surname><given-names>AA</given-names></name><name><surname>Graham</surname><given-names>L</given-names></name><name><surname>Volchkov</surname><given-names>P</given-names></name><name><surname>Becker</surname><given-names>L</given-names></name><etal></etal></person-group><article-title>Gender bias in autoimmunity is influenced by microbiota</article-title>. <source>Immunity</source> (<year>2013</year>) <volume>39</volume>(<issue>2</issue>):<fpage>400</fpage>–<lpage>12</lpage>.<pub-id pub-id-type="doi">10.1016/j.immuni.2013.08.013</pub-id><pub-id pub-id-type="pmid">23973225</pub-id></mixed-citation></ref><ref id="B25"><label>25</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hagen</surname><given-names>S</given-names></name><name><surname>Altfeld</surname><given-names>M</given-names></name></person-group>. <article-title>The X awakens: multifactorial ramifications of sex-specific differences in HIV-1 infection</article-title>. <source>J Virus Erad</source> (<year>2016</year>) <volume>2</volume>(<issue>2</issue>):<fpage>78</fpage>–<lpage>81</lpage>.<pub-id pub-id-type="pmid">27482439</pub-id></mixed-citation></ref><ref id="B26"><label>26</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Addo</surname><given-names>MM</given-names></name><name><surname>Altfeld</surname><given-names>M</given-names></name></person-group>. <article-title>Sex-based differences in HIV type 1 pathogenesis</article-title>. <source>J Infect Dis</source> (<year>2014</year>) <volume>209</volume>(<issue>Suppl 3</issue>):<fpage>S86</fpage>–<lpage>92</lpage>.<pub-id pub-id-type="doi">10.1093/infdis/jiu175</pub-id><pub-id pub-id-type="pmid">24966195</pub-id></mixed-citation></ref><ref id="B27"><label>27</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ziegler</surname><given-names>S</given-names></name><name><surname>Altfeld</surname><given-names>M</given-names></name></person-group>. <article-title>Sex differences in HIV-1-mediated immunopathology</article-title>. <source>Curr Opin HIV AIDS</source> (<year>2016</year>) <volume>11</volume>(<issue>2</issue>):<fpage>209</fpage>–<lpage>15</lpage>.<pub-id pub-id-type="doi">10.1097/COH.0000000000000237</pub-id><pub-id pub-id-type="pmid">26845674</pub-id></mixed-citation></ref><ref id="B28"><label>28</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wawer</surname><given-names>MJ</given-names></name><name><surname>Gray</surname><given-names>RH</given-names></name><name><surname>Sewankambo</surname><given-names>NK</given-names></name><name><surname>Serwadda</surname><given-names>D</given-names></name><name><surname>Li</surname><given-names>X</given-names></name><name><surname>Laeyendecker</surname><given-names>O</given-names></name><etal></etal></person-group><article-title>Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda</article-title>. <source>J Infect Dis</source> (<year>2005</year>) <volume>191</volume>(<issue>9</issue>):<fpage>1403</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1086/429411</pub-id><pub-id pub-id-type="pmid">15809897</pub-id></mixed-citation></ref><ref id="B29"><label>29</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Altfeld</surname><given-names>M</given-names></name><name><surname>Gale</surname><given-names>M</given-names><suffix>Jr</suffix></name></person-group>. <article-title>Innate immunity against HIV-1 infection</article-title>. <source>Nat Immunol</source> (<year>2015</year>) <volume>16</volume>(<issue>6</issue>):<fpage>554</fpage>–<lpage>62</lpage>.<pub-id pub-id-type="doi">10.1038/ni.3157</pub-id><pub-id pub-id-type="pmid">25988887</pub-id></mixed-citation></ref><ref id="B30"><label>30</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Blasius</surname><given-names>AL</given-names></name><name><surname>Beutler</surname><given-names>B</given-names></name></person-group>. <article-title>Intracellular toll-like receptors</article-title>. <source>Immunity</source> (<year>2010</year>) <volume>32</volume>(<issue>3</issue>):<fpage>305</fpage>–<lpage>15</lpage>.<pub-id pub-id-type="doi">10.1016/j.immuni.2010.03.012</pub-id><pub-id pub-id-type="pmid">20346772</pub-id></mixed-citation></ref><ref id="B31"><label>31</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jakobsen</surname><given-names>MR</given-names></name><name><surname>Bak</surname><given-names>RO</given-names></name><name><surname>Andersen</surname><given-names>A</given-names></name><name><surname>Berg</surname><given-names>RK</given-names></name><name><surname>Jensen</surname><given-names>SB</given-names></name><name><surname>Tengchuan</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication</article-title>. <source>Proc Natl Acad Sci U S A</source> (<year>2013</year>) <volume>110</volume>(<issue>48</issue>):<fpage>E4571</fpage>–<lpage>80</lpage>.<pub-id pub-id-type="doi">10.1073/pnas.1311669110</pub-id><pub-id pub-id-type="pmid">24154727</pub-id></mixed-citation></ref><ref id="B32"><label>32</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gao</surname><given-names>D</given-names></name><name><surname>Wu</surname><given-names>J</given-names></name><name><surname>Wu</surname><given-names>YT</given-names></name><name><surname>Du</surname><given-names>F</given-names></name><name><surname>Aroh</surname><given-names>C</given-names></name><name><surname>Yan</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses</article-title>. <source>Science</source> (<year>2013</year>) <volume>341</volume>(<issue>6148</issue>):<fpage>903</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1126/science.1240933</pub-id><pub-id pub-id-type="pmid">23929945</pub-id></mixed-citation></ref><ref id="B33"><label>33</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mogensen</surname><given-names>TH</given-names></name><name><surname>Melchjorsen</surname><given-names>J</given-names></name><name><surname>Larsen</surname><given-names>CS</given-names></name><name><surname>Paludan</surname><given-names>SR</given-names></name></person-group>. <article-title>Innate immune recognition and activation during HIV infection</article-title>. <source>Retrovirology</source> (<year>2010</year>) <volume>7</volume>:<fpage>54</fpage>.<pub-id pub-id-type="doi">10.1186/1742-4690-7-54</pub-id><pub-id pub-id-type="pmid">20569472</pub-id></mixed-citation></ref><ref id="B34"><label>34</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Goodbourn</surname><given-names>S</given-names></name><name><surname>Didcock</surname><given-names>L</given-names></name><name><surname>Randall</surname><given-names>RE</given-names></name></person-group><article-title>Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures</article-title>. <source>J Gen Virol</source> (<year>2000</year>) <volume>81</volume>(<issue>Pt 10</issue>):<fpage>2341</fpage>–<lpage>64</lpage>.<pub-id pub-id-type="doi">10.1099/0022-1317-81-10-2341</pub-id><pub-id pub-id-type="pmid">10993923</pub-id></mixed-citation></ref><ref id="B35"><label>35</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pestka</surname><given-names>S</given-names></name><name><surname>Krause</surname><given-names>CD</given-names></name><name><surname>Walter</surname><given-names>MR</given-names></name></person-group>. <article-title>Interferons, interferon-like cytokines, and their receptors</article-title>. <source>Immunol Rev</source> (<year>2004</year>) <volume>202</volume>:<fpage>8</fpage>–<lpage>32</lpage>.<pub-id pub-id-type="doi">10.1111/j.0105-2896.2004.00204.x</pub-id><pub-id pub-id-type="pmid">15546383</pub-id></mixed-citation></ref><ref id="B36"><label>36</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schreiber</surname><given-names>G</given-names></name><name><surname>Piehler</surname><given-names>J</given-names></name></person-group>. <article-title>The molecular basis for functional plasticity in type I interferon signaling</article-title>. <source>Trends Immunol</source> (<year>2015</year>) <volume>36</volume>(<issue>3</issue>):<fpage>139</fpage>–<lpage>49</lpage>.<pub-id pub-id-type="doi">10.1016/j.it.2015.01.002</pub-id><pub-id pub-id-type="pmid">25687684</pub-id></mixed-citation></ref><ref id="B37"><label>37</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gibbert</surname><given-names>K</given-names></name><name><surname>Schlaak</surname><given-names>JF</given-names></name><name><surname>Yang</surname><given-names>D</given-names></name><name><surname>Dittmer</surname><given-names>U</given-names></name></person-group><article-title>IFN-alpha subtypes: distinct biological activities in anti-viral therapy</article-title>. <source>Br J Pharmacol</source> (<year>2013</year>) <volume>168</volume>(<issue>5</issue>):<fpage>1048</fpage>–<lpage>58</lpage>.<pub-id pub-id-type="doi">10.1111/bph.12010</pub-id><pub-id pub-id-type="pmid">23072338</pub-id></mixed-citation></ref><ref id="B38"><label>38</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kent</surname><given-names>SJ</given-names></name><name><surname>Kelleher</surname><given-names>AD</given-names></name></person-group><article-title>Expanding role for type I interferons in restricting HIV growth</article-title>. <source>Immunol Cell Biol</source> (<year>2017</year>) <volume>95</volume>(<issue>5</issue>):<fpage>417</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="doi">10.1038/icb.2017.15</pub-id><pub-id pub-id-type="pmid">28440312</pub-id></mixed-citation></ref><ref id="B39"><label>39</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Iyer</surname><given-names>SS</given-names></name><name><surname>Bibollet-Ruche</surname><given-names>F</given-names></name><name><surname>Sherrill-Mix</surname><given-names>S</given-names></name><name><surname>Learn</surname><given-names>GH</given-names></name><name><surname>Plenderleith</surname><given-names>L</given-names></name><name><surname>Smith</surname><given-names>AG</given-names></name><etal></etal></person-group><article-title>Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness</article-title>. <source>Proc Natl Acad Sci U S A</source> (<year>2017</year>) <volume>114</volume>(<issue>4</issue>):<fpage>E590</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1073/pnas.1620144114</pub-id><pub-id pub-id-type="pmid">28069935</pub-id></mixed-citation></ref><ref id="B40"><label>40</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Parrish</surname><given-names>NF</given-names></name><name><surname>Gao</surname><given-names>F</given-names></name><name><surname>Li</surname><given-names>H</given-names></name><name><surname>Giorgi</surname><given-names>EE</given-names></name><name><surname>Barbian</surname><given-names>HJ</given-names></name><name><surname>Parrish</surname><given-names>EH</given-names></name><etal></etal></person-group><article-title>Phenotypic properties of transmitted founder HIV-1</article-title>. <source>Proc Natl Acad Sci U S A</source> (<year>2013</year>) <volume>110</volume>(<issue>17</issue>):<fpage>6626</fpage>–<lpage>33</lpage>.<pub-id pub-id-type="doi">10.1073/pnas.1304288110</pub-id><pub-id pub-id-type="pmid">23542380</pub-id></mixed-citation></ref><ref id="B41"><label>41</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fenton-May</surname><given-names>AE</given-names></name><name><surname>Dibben</surname><given-names>O</given-names></name><name><surname>Emmerich</surname><given-names>T</given-names></name><name><surname>Ding</surname><given-names>H</given-names></name><name><surname>Pfafferott</surname><given-names>K</given-names></name><name><surname>Aasa-Chapman</surname><given-names>MM</given-names></name><etal></etal></person-group><article-title>Relative resistance of HIV-1 founder viruses to control by interferon-alpha</article-title>. <source>Retrovirology</source> (<year>2013</year>) <volume>10</volume>:<fpage>146</fpage>.<pub-id pub-id-type="doi">10.1186/1742-4690-10-146</pub-id><pub-id pub-id-type="pmid">24299076</pub-id></mixed-citation></ref><ref id="B42"><label>42</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Veazey</surname><given-names>RS</given-names></name><name><surname>Pilch-Cooper</surname><given-names>HA</given-names></name><name><surname>Hope</surname><given-names>TJ</given-names></name><name><surname>Alter</surname><given-names>G</given-names></name><name><surname>Carias</surname><given-names>AM</given-names></name><name><surname>Sips</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Prevention of SHIV transmission by topical IFN-beta treatment</article-title>. <source>Mucosal Immunol</source> (<year>2016</year>) <volume>9</volume>(<issue>6</issue>):<fpage>1528</fpage>–<lpage>36</lpage>.<pub-id pub-id-type="doi">10.1038/mi.2015.146</pub-id><pub-id pub-id-type="pmid">26838048</pub-id></mixed-citation></ref><ref id="B43"><label>43</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lavender</surname><given-names>KJ</given-names></name><name><surname>Gibbert</surname><given-names>K</given-names></name><name><surname>Peterson</surname><given-names>KE</given-names></name><name><surname>Van Dis</surname><given-names>E</given-names></name><name><surname>Francois</surname><given-names>S</given-names></name><name><surname>Woods</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Interferon alpha subtype-specific suppression of HIV-1 infection in vivo</article-title>. <source>J Virol</source> (<year>2016</year>) <volume>90</volume>(<issue>13</issue>):<fpage>6001</fpage>–<lpage>13</lpage>.<pub-id pub-id-type="doi">10.1128/JVI.00451-16</pub-id><pub-id pub-id-type="pmid">27099312</pub-id></mixed-citation></ref><ref id="B44"><label>44</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garcia-Minambres</surname><given-names>A</given-names></name><name><surname>Eid</surname><given-names>SG</given-names></name><name><surname>Mangan</surname><given-names>NE</given-names></name><name><surname>Pade</surname><given-names>C</given-names></name><name><surname>Lim</surname><given-names>SS</given-names></name><name><surname>Matthews</surname><given-names>AY</given-names></name><etal></etal></person-group><article-title>Interferon epsilon promotes HIV restriction at multiple steps of viral replication</article-title>. <source>Immunol Cell Biol</source> (<year>2017</year>) <volume>95</volume>(<issue>5</issue>):<fpage>478</fpage>–<lpage>83</lpage>.<pub-id pub-id-type="doi">10.1038/icb.2016.123</pub-id><pub-id pub-id-type="pmid">28045025</pub-id></mixed-citation></ref><ref id="B45"><label>45</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fung</surname><given-names>KY</given-names></name><name><surname>Mangan</surname><given-names>NE</given-names></name><name><surname>Cumming</surname><given-names>H</given-names></name><name><surname>Horvat</surname><given-names>JC</given-names></name><name><surname>Mayall</surname><given-names>JR</given-names></name><name><surname>Stifter</surname><given-names>SA</given-names></name><etal></etal></person-group><article-title>Interferon-epsilon protects the female reproductive tract from viral and bacterial infection</article-title>. <source>Science</source> (<year>2013</year>) <volume>339</volume>(<issue>6123</issue>):<fpage>1088</fpage>–<lpage>92</lpage>.<pub-id pub-id-type="doi">10.1126/science.1233321</pub-id><pub-id pub-id-type="pmid">23449591</pub-id></mixed-citation></ref><ref id="B46"><label>46</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morrison</surname><given-names>CS</given-names></name><name><surname>Chen</surname><given-names>PL</given-names></name><name><surname>Kwok</surname><given-names>C</given-names></name><name><surname>Baeten</surname><given-names>JM</given-names></name><name><surname>Brown</surname><given-names>J</given-names></name><name><surname>Crook</surname><given-names>AM</given-names></name><etal></etal></person-group><article-title>Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis</article-title>. <source>PLoS Med</source> (<year>2015</year>) <volume>12</volume>(<issue>1</issue>):<fpage>e1001778</fpage>.<pub-id pub-id-type="doi">10.1371/journal.pmed.1001778</pub-id><pub-id pub-id-type="pmid">25612136</pub-id></mixed-citation></ref><ref id="B47"><label>47</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morrison</surname><given-names>CS</given-names></name><name><surname>Chen</surname><given-names>PL</given-names></name><name><surname>Kwok</surname><given-names>C</given-names></name><name><surname>Richardson</surname><given-names>BA</given-names></name><name><surname>Chipato</surname><given-names>T</given-names></name><name><surname>Mugerwa</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling</article-title>. <source>AIDS</source> (<year>2010</year>) <volume>24</volume>(<issue>11</issue>):<fpage>1778</fpage>–<lpage>81</lpage>.<pub-id pub-id-type="doi">10.1097/QAD.0b013e32833a2537</pub-id><pub-id pub-id-type="pmid">20588106</pub-id></mixed-citation></ref><ref id="B48"><label>48</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Blish</surname><given-names>CA</given-names></name><name><surname>Baeten</surname><given-names>JM</given-names></name></person-group>. <article-title>Hormonal contraception and HIV-1 transmission</article-title>. <source>Am J Reprod Immunol</source> (<year>2011</year>) <volume>65</volume>(<issue>3</issue>):<fpage>302</fpage>–<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1111/j.1600-0897.2010.00930.x</pub-id><pub-id pub-id-type="pmid">21087338</pub-id></mixed-citation></ref><ref id="B49"><label>49</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baeten</surname><given-names>JM</given-names></name><name><surname>Benki</surname><given-names>S</given-names></name><name><surname>Chohan</surname><given-names>V</given-names></name><name><surname>Lavreys</surname><given-names>L</given-names></name><name><surname>McClelland</surname><given-names>RS</given-names></name><name><surname>Mandaliya</surname><given-names>K</given-names></name><etal></etal></person-group><article-title>Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women</article-title>. <source>AIDS</source> (<year>2007</year>) <volume>21</volume>(<issue>13</issue>):<fpage>1771</fpage>–<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1097/QAD.0b013e328270388a</pub-id><pub-id pub-id-type="pmid">17690576</pub-id></mixed-citation></ref><ref id="B50"><label>50</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heffron</surname><given-names>R</given-names></name><name><surname>Donnell</surname><given-names>D</given-names></name><name><surname>Rees</surname><given-names>H</given-names></name><name><surname>Celum</surname><given-names>C</given-names></name><name><surname>Mugo</surname><given-names>N</given-names></name><name><surname>Were</surname><given-names>E</given-names></name><etal></etal></person-group><article-title>Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study</article-title>. <source>Lancet Infect Dis</source> (<year>2012</year>) <volume>12</volume>(<issue>1</issue>):<fpage>19</fpage>–<lpage>26</lpage>.<pub-id pub-id-type="doi">10.1016/S1473-3099(11)70247-X</pub-id><pub-id pub-id-type="pmid">21975269</pub-id></mixed-citation></ref><ref id="B51"><label>51</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Berghofer</surname><given-names>B</given-names></name><name><surname>Frommer</surname><given-names>T</given-names></name><name><surname>Haley</surname><given-names>G</given-names></name><name><surname>Fink</surname><given-names>L</given-names></name><name><surname>Bein</surname><given-names>G</given-names></name><name><surname>Hackstein</surname><given-names>H</given-names></name></person-group>. <article-title>TLR7 ligands induce higher IFN-alpha production in females</article-title>. <source>J Immunol</source> (<year>2006</year>) <volume>177</volume>(<issue>4</issue>):<fpage>2088</fpage>–<lpage>96</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.177.4.2088</pub-id><pub-id pub-id-type="pmid">16887967</pub-id></mixed-citation></ref><ref id="B52"><label>52</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ziegler</surname><given-names>SM</given-names></name><name><surname>Beisel</surname><given-names>C</given-names></name><name><surname>Sutter</surname><given-names>K</given-names></name><name><surname>Griesbeck</surname><given-names>M</given-names></name><name><surname>Hildebrandt</surname><given-names>H</given-names></name><name><surname>Hagen</surname><given-names>SH</given-names></name><etal></etal></person-group><article-title>Human pDCs display sex-specific differences in type I interferon subtypes and interferon alpha/beta receptor expression</article-title>. <source>Eur J Immunol</source> (<year>2017</year>) <volume>47</volume>(<issue>2</issue>):<fpage>251</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1002/eji.201646725</pub-id><pub-id pub-id-type="pmid">27891600</pub-id></mixed-citation></ref><ref id="B53"><label>53</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Honda</surname><given-names>K</given-names></name><name><surname>Yanai</surname><given-names>H</given-names></name><name><surname>Negishi</surname><given-names>H</given-names></name><name><surname>Asagiri</surname><given-names>M</given-names></name><name><surname>Sato</surname><given-names>M</given-names></name><name><surname>Mizutani</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>IRF-7 is the master regulator of type-I interferon-dependent immune responses</article-title>. <source>Nature</source> (<year>2005</year>) <volume>434</volume>(<issue>7034</issue>):<fpage>772</fpage>–<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1038/nature03464</pub-id><pub-id pub-id-type="pmid">15800576</pub-id></mixed-citation></ref><ref id="B54"><label>54</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marie</surname><given-names>I</given-names></name><name><surname>Durbin</surname><given-names>JE</given-names></name><name><surname>Levy</surname><given-names>DE</given-names></name></person-group>. <article-title>Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7</article-title>. <source>EMBO J</source> (<year>1998</year>) <volume>17</volume>(<issue>22</issue>):<fpage>6660</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1093/emboj/17.22.6660</pub-id><pub-id pub-id-type="pmid">9822609</pub-id></mixed-citation></ref><ref id="B55"><label>55</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prakash</surname><given-names>A</given-names></name><name><surname>Smith</surname><given-names>E</given-names></name><name><surname>Lee</surname><given-names>CK</given-names></name><name><surname>Levy</surname><given-names>DE</given-names></name></person-group>. <article-title>Tissue-specific positive feedback requirements for production of type I interferon following virus infection</article-title>. <source>J Biol Chem</source> (<year>2005</year>) <volume>280</volume>(<issue>19</issue>):<fpage>18651</fpage>–<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1074/jbc.M501289200</pub-id><pub-id pub-id-type="pmid">15767254</pub-id></mixed-citation></ref><ref id="B56"><label>56</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>O’Brien</surname><given-names>M</given-names></name><name><surname>Manches</surname><given-names>O</given-names></name><name><surname>Sabado</surname><given-names>RL</given-names></name><name><surname>Baranda</surname><given-names>SJ</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Marie</surname><given-names>I</given-names></name><etal></etal></person-group><article-title>Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype</article-title>. <source>J Clin Invest</source> (<year>2011</year>) <volume>121</volume>(<issue>3</issue>):<fpage>1088</fpage>–<lpage>101</lpage>.<pub-id pub-id-type="doi">10.1172/JCI44960</pub-id><pub-id pub-id-type="pmid">21339641</pub-id></mixed-citation></ref><ref id="B57"><label>57</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taleb</surname><given-names>K</given-names></name><name><surname>Auffray</surname><given-names>C</given-names></name><name><surname>Villefroy</surname><given-names>P</given-names></name><name><surname>Pereira</surname><given-names>A</given-names></name><name><surname>Hosmalin</surname><given-names>A</given-names></name><name><surname>Gaudry</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Chronic type I IFN is sufficient to promote immunosuppression through accumulation of myeloid-derived suppressor cells</article-title>. <source>J Immunol</source> (<year>2017</year>) <volume>198</volume>(<issue>3</issue>):<fpage>1156</fpage>–<lpage>63</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.1502638</pub-id><pub-id pub-id-type="pmid">28003378</pub-id></mixed-citation></ref><ref id="B58"><label>58</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dhamanage</surname><given-names>A</given-names></name><name><surname>Thakar</surname><given-names>M</given-names></name><name><surname>Paranjape</surname><given-names>R</given-names></name></person-group>. <article-title>Human immunodeficiency virus-1 impairs IFN-alpha production induced by TLR-7 agonist in plasmacytoid dendritic cells</article-title>. <source>Viral Immunol</source> (<year>2017</year>) <volume>30</volume>(<issue>1</issue>):<fpage>28</fpage>–<lpage>34</lpage>.<pub-id pub-id-type="doi">10.1089/vim.2016.0084</pub-id><pub-id pub-id-type="pmid">27809682</pub-id></mixed-citation></ref><ref id="B59"><label>59</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Augui</surname><given-names>S</given-names></name><name><surname>Nora</surname><given-names>EP</given-names></name><name><surname>Heard</surname><given-names>E</given-names></name></person-group>. <article-title>Regulation of X-chromosome inactivation by the X-inactivation centre</article-title>. <source>Nat Rev Genet</source> (<year>2011</year>) <volume>12</volume>(<issue>6</issue>):<fpage>429</fpage>–<lpage>42</lpage>.<pub-id pub-id-type="doi">10.1038/nrg2987</pub-id><pub-id pub-id-type="pmid">21587299</pub-id></mixed-citation></ref><ref id="B60"><label>60</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carrel</surname><given-names>L</given-names></name><name><surname>Willard</surname><given-names>HF</given-names></name></person-group>. <article-title>X-inactivation profile reveals extensive variability in X-linked gene expression in females</article-title>. <source>Nature</source> (<year>2005</year>) <volume>434</volume>(<issue>7031</issue>):<fpage>400</fpage>–<lpage>4</lpage>.<pub-id pub-id-type="doi">10.1038/nature03479</pub-id><pub-id pub-id-type="pmid">15772666</pub-id></mixed-citation></ref><ref id="B61"><label>61</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carrel</surname><given-names>L</given-names></name><name><surname>Cottle</surname><given-names>AA</given-names></name><name><surname>Goglin</surname><given-names>KC</given-names></name><name><surname>Willard</surname><given-names>HF</given-names></name></person-group>. <article-title>A first-generation X-inactivation profile of the human X chromosome</article-title>. <source>Proc Natl Acad Sci U S A</source> (<year>1999</year>) <volume>96</volume>(<issue>25</issue>):<fpage>14440</fpage>–<lpage>4</lpage>.<pub-id pub-id-type="doi">10.1073/pnas.96.25.14440</pub-id><pub-id pub-id-type="pmid">10588724</pub-id></mixed-citation></ref><ref id="B62"><label>62</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carrel</surname><given-names>L</given-names></name><name><surname>Willard</surname><given-names>HF</given-names></name></person-group>. <article-title>Heterogeneous gene expression from the inactive X chromosome: an X-linked gene that escapes X inactivation in some human cell lines but is inactivated in others</article-title>. <source>Proc Natl Acad Sci U S A</source> (<year>1999</year>) <volume>96</volume>(<issue>13</issue>):<fpage>7364</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1073/pnas.96.13.7364</pub-id><pub-id pub-id-type="pmid">10377420</pub-id></mixed-citation></ref><ref id="B63"><label>63</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Laffont</surname><given-names>S</given-names></name><name><surname>Rouquie</surname><given-names>N</given-names></name><name><surname>Azar</surname><given-names>P</given-names></name><name><surname>Seillet</surname><given-names>C</given-names></name><name><surname>Plumas</surname><given-names>J</given-names></name><name><surname>Aspord</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-alpha production of plasmacytoid dendritic cells from women</article-title>. <source>J Immunol</source> (<year>2014</year>) <volume>193</volume>(<issue>11</issue>):<fpage>5444</fpage>–<lpage>52</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.1303400</pub-id><pub-id pub-id-type="pmid">25339659</pub-id></mixed-citation></ref><ref id="B64"><label>64</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pisitkun</surname><given-names>P</given-names></name><name><surname>Deane</surname><given-names>JA</given-names></name><name><surname>Difilippantonio</surname><given-names>MJ</given-names></name><name><surname>Tarasenko</surname><given-names>T</given-names></name><name><surname>Satterthwaite</surname><given-names>AB</given-names></name><name><surname>Bolland</surname><given-names>S</given-names></name></person-group>. <article-title>Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication</article-title>. <source>Science</source> (<year>2006</year>) <volume>312</volume>(<issue>5780</issue>):<fpage>1669</fpage>–<lpage>72</lpage>.<pub-id pub-id-type="doi">10.1126/science.1124978</pub-id><pub-id pub-id-type="pmid">16709748</pub-id></mixed-citation></ref><ref id="B65"><label>65</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Karlsen</surname><given-names>M</given-names></name><name><surname>Jakobsen</surname><given-names>K</given-names></name><name><surname>Jonsson</surname><given-names>R</given-names></name><name><surname>Hammenfors</surname><given-names>D</given-names></name><name><surname>Hansen</surname><given-names>T</given-names></name><name><surname>Appel</surname><given-names>S</given-names></name></person-group><article-title>Expression of toll-like receptors in peripheral blood mononuclear cells of patients with primary Sjogren’s syndrome</article-title>. <source>Scand J Immunol</source> (<year>2017</year>) <volume>85</volume>(<issue>3</issue>):<fpage>220</fpage>–<lpage>6</lpage>.<pub-id pub-id-type="doi">10.1111/sji.12520</pub-id><pub-id pub-id-type="pmid">27943374</pub-id></mixed-citation></ref><ref id="B66"><label>66</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Laffont</surname><given-names>S</given-names></name><name><surname>Seillet</surname><given-names>C</given-names></name><name><surname>Guery</surname><given-names>JC</given-names></name></person-group>. <article-title>Estrogen receptor-dependent regulation of dendritic cell development and function</article-title>. <source>Front Immunol</source> (<year>2017</year>) <volume>8</volume>:<fpage>108</fpage>.<pub-id pub-id-type="doi">10.3389/fimmu.2017.00108</pub-id><pub-id pub-id-type="pmid">28239379</pub-id></mixed-citation></ref><ref id="B67"><label>67</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Honda</surname><given-names>K</given-names></name><name><surname>Takaoka</surname><given-names>A</given-names></name><name><surname>Taniguchi</surname><given-names>T</given-names></name></person-group>. <article-title>Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors</article-title>. <source>Immunity</source> (<year>2006</year>) <volume>25</volume>(<issue>3</issue>):<fpage>349</fpage>–<lpage>60</lpage>.<pub-id pub-id-type="doi">10.1016/j.immuni.2006.08.009</pub-id><pub-id pub-id-type="pmid">16979567</pub-id></mixed-citation></ref><ref id="B68"><label>68</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schoenemeyer</surname><given-names>A</given-names></name><name><surname>Barnes</surname><given-names>BJ</given-names></name><name><surname>Mancl</surname><given-names>ME</given-names></name><name><surname>Latz</surname><given-names>E</given-names></name><name><surname>Goutagny</surname><given-names>N</given-names></name><name><surname>Pitha</surname><given-names>PM</given-names></name><etal></etal></person-group><article-title>The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling</article-title>. <source>J Biol Chem</source> (<year>2005</year>) <volume>280</volume>(<issue>17</issue>):<fpage>17005</fpage>–<lpage>12</lpage>.<pub-id pub-id-type="doi">10.1074/jbc.M412584200</pub-id><pub-id pub-id-type="pmid">15695821</pub-id></mixed-citation></ref><ref id="B69"><label>69</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takaoka</surname><given-names>A</given-names></name><name><surname>Yanai</surname><given-names>H</given-names></name><name><surname>Kondo</surname><given-names>S</given-names></name><name><surname>Duncan</surname><given-names>G</given-names></name><name><surname>Negishi</surname><given-names>H</given-names></name><name><surname>Mizutani</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors</article-title>. <source>Nature</source> (<year>2005</year>) <volume>434</volume>(<issue>7030</issue>):<fpage>243</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1038/nature03308</pub-id><pub-id pub-id-type="pmid">15665823</pub-id></mixed-citation></ref><ref id="B70"><label>70</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mingjia</surname><given-names>L</given-names></name><name><surname>Short</surname><given-names>R</given-names></name></person-group>. <article-title>How oestrogen or progesterone might change a woman’s susceptibility to HIV-1 infection</article-title>. <source>Aust N Z J Obstet Gynaecol</source> (<year>2002</year>) <volume>42</volume>(<issue>5</issue>):<fpage>472</fpage>–<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1111/j.0004-8666.2002.00472.x</pub-id><pub-id pub-id-type="pmid">12495087</pub-id></mixed-citation></ref><ref id="B71"><label>71</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kaushic</surname><given-names>C</given-names></name><name><surname>Roth</surname><given-names>KL</given-names></name><name><surname>Anipindi</surname><given-names>V</given-names></name><name><surname>Xiu</surname><given-names>F</given-names></name></person-group>. <article-title>Increased prevalence of sexually transmitted viral infections in women: the role of female sex hormones in regulating susceptibility and immune responses</article-title>. <source>J Reprod Immunol</source> (<year>2011</year>) <volume>88</volume>(<issue>2</issue>):<fpage>204</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1016/j.jri.2010.12.004</pub-id><pub-id pub-id-type="pmid">21296427</pub-id></mixed-citation></ref><ref id="B72"><label>72</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sodora</surname><given-names>DL</given-names></name><name><surname>Gettie</surname><given-names>A</given-names></name><name><surname>Miller</surname><given-names>CJ</given-names></name><name><surname>Marx</surname><given-names>PA</given-names></name></person-group>. <article-title>Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks</article-title>. <source>AIDS Res Hum Retroviruses</source> (<year>1998</year>) <volume>14</volume>(<issue>Suppl 1</issue>):<fpage>S119</fpage>–<lpage>23</lpage>.<pub-id pub-id-type="pmid">9581895</pub-id></mixed-citation></ref><ref id="B73"><label>73</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dominguez</surname><given-names>F</given-names></name><name><surname>Galan</surname><given-names>A</given-names></name><name><surname>Martin</surname><given-names>JJ</given-names></name><name><surname>Remohi</surname><given-names>J</given-names></name><name><surname>Pellicer</surname><given-names>A</given-names></name><name><surname>Simon</surname><given-names>C</given-names></name></person-group>. <article-title>Hormonal and embryonic regulation of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in the human endometrium and the human blastocyst</article-title>. <source>Mol Hum Reprod</source> (<year>2003</year>) <volume>9</volume>(<issue>4</issue>):<fpage>189</fpage>–<lpage>98</lpage>.<pub-id pub-id-type="doi">10.1093/molehr/gag024</pub-id><pub-id pub-id-type="pmid">12651900</pub-id></mixed-citation></ref><ref id="B74"><label>74</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prakash</surname><given-names>M</given-names></name><name><surname>Kapembwa</surname><given-names>MS</given-names></name><name><surname>Gotch</surname><given-names>F</given-names></name><name><surname>Patterson</surname><given-names>S</given-names></name></person-group>. <article-title>Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4(+) T cells in the cervical epithelium of healthy women</article-title>. <source>J Reprod Immunol</source> (<year>2002</year>) <volume>54</volume>(<issue>1–2</issue>):<fpage>117</fpage>–<lpage>31</lpage>.<pub-id pub-id-type="doi">10.1016/S0165-0378(01)00125-5</pub-id><pub-id pub-id-type="pmid">11839399</pub-id></mixed-citation></ref><ref id="B75"><label>75</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sheffield</surname><given-names>JS</given-names></name><name><surname>Wendel</surname><given-names>GD</given-names><suffix>Jr</suffix></name><name><surname>McIntire</surname><given-names>DD</given-names></name><name><surname>Norgard</surname><given-names>MV</given-names></name></person-group>. <article-title>The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression</article-title>. <source>Reprod Sci</source> (<year>2009</year>) <volume>16</volume>(<issue>1</issue>):<fpage>20</fpage>–<lpage>31</lpage>.<pub-id pub-id-type="doi">10.1177/1933719108325510</pub-id><pub-id pub-id-type="pmid">19144888</pub-id></mixed-citation></ref><ref id="B76"><label>76</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vassiliadou</surname><given-names>N</given-names></name><name><surname>Tucker</surname><given-names>L</given-names></name><name><surname>Anderson</surname><given-names>DJ</given-names></name></person-group><article-title>Progesterone-induced inhibition of chemokine receptor expression on peripheral blood mononuclear cells correlates with reduced HIV-1 infectability in vitro</article-title>. <source>J Immunol</source> (<year>1999</year>) <volume>162</volume>(<issue>12</issue>):<fpage>7510</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="pmid">10358206</pub-id></mixed-citation></ref><ref id="B77"><label>77</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meditz</surname><given-names>AL</given-names></name><name><surname>Moreau</surname><given-names>KL</given-names></name><name><surname>MaWhinney</surname><given-names>S</given-names></name><name><surname>Gozansky</surname><given-names>WS</given-names></name><name><surname>Melander</surname><given-names>K</given-names></name><name><surname>Kohrt</surname><given-names>WM</given-names></name><etal></etal></person-group><article-title>CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women</article-title>. <source>J Acquir Immune Defic Syndr</source> (<year>2012</year>) <volume>59</volume>(<issue>3</issue>):<fpage>221</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="doi">10.1097/QAI.0b013e31823fd215</pub-id><pub-id pub-id-type="pmid">22083068</pub-id></mixed-citation></ref><ref id="B78"><label>78</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arruvito</surname><given-names>L</given-names></name><name><surname>Sanz</surname><given-names>M</given-names></name><name><surname>Banham</surname><given-names>AH</given-names></name><name><surname>Fainboim</surname><given-names>L</given-names></name></person-group>. <article-title>Expansion of CD4+CD25+and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction</article-title>. <source>J Immunol</source> (<year>2007</year>) <volume>178</volume>(<issue>4</issue>):<fpage>2572</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.178.4.2572</pub-id><pub-id pub-id-type="pmid">17277167</pub-id></mixed-citation></ref><ref id="B79"><label>79</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>SM</given-names></name><name><surname>Mefford</surname><given-names>M</given-names></name><name><surname>Sodora</surname><given-names>D</given-names></name><name><surname>Klase</surname><given-names>Z</given-names></name><name><surname>Singh</surname><given-names>M</given-names></name><name><surname>Alexander</surname><given-names>N</given-names></name><etal></etal></person-group><article-title>Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect</article-title>. <source>AIDS</source> (<year>2004</year>) <volume>18</volume>(<issue>12</issue>):<fpage>1637</fpage>–<lpage>43</lpage>.<pub-id pub-id-type="doi">10.1097/01.aids.0000131393.76221.cc</pub-id><pub-id pub-id-type="pmid">15280774</pub-id></mixed-citation></ref><ref id="B80"><label>80</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodriguez-Garcia</surname><given-names>M</given-names></name><name><surname>Biswas</surname><given-names>N</given-names></name><name><surname>Patel</surname><given-names>MV</given-names></name><name><surname>Barr</surname><given-names>FD</given-names></name><name><surname>Crist</surname><given-names>SG</given-names></name><name><surname>Ochsenbauer</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Estradiol reduces susceptibility of CD4+ T cells and macrophages to HIV-infection</article-title>. <source>PLoS One</source> (<year>2013</year>) <volume>8</volume>(<issue>4</issue>):<fpage>e62069</fpage>.<pub-id pub-id-type="doi">10.1371/journal.pone.0062069</pub-id><pub-id pub-id-type="pmid">23614015</pub-id></mixed-citation></ref><ref id="B81"><label>81</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Giltay</surname><given-names>EJ</given-names></name><name><surname>Fonk</surname><given-names>JC</given-names></name><name><surname>von Blomberg</surname><given-names>BM</given-names></name><name><surname>Drexhage</surname><given-names>HA</given-names></name><name><surname>Schalkwijk</surname><given-names>C</given-names></name><name><surname>Gooren</surname><given-names>LJ</given-names></name></person-group>. <article-title>In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans</article-title>. <source>J Clin Endocrinol Metab</source> (<year>2000</year>) <volume>85</volume>(<issue>4</issue>):<fpage>1648</fpage>–<lpage>57</lpage>.<pub-id pub-id-type="doi">10.1210/jcem.85.4.6562</pub-id><pub-id pub-id-type="pmid">10770211</pub-id></mixed-citation></ref><ref id="B82"><label>82</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mo</surname><given-names>R</given-names></name><name><surname>Chen</surname><given-names>J</given-names></name><name><surname>Grolleau-Julius</surname><given-names>A</given-names></name><name><surname>Murphy</surname><given-names>HS</given-names></name><name><surname>Richardson</surname><given-names>BC</given-names></name><name><surname>Yung</surname><given-names>RL</given-names></name></person-group>. <article-title>Estrogen regulates CCR gene expression and function in T lymphocytes</article-title>. <source>J Immunol</source> (<year>2005</year>) <volume>174</volume>(<issue>10</issue>):<fpage>6023</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.4049/jimmunol.174.10.6023</pub-id><pub-id pub-id-type="pmid">15879095</pub-id></mixed-citation></ref><ref id="B83"><label>83</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Asin</surname><given-names>SN</given-names></name><name><surname>Heimberg</surname><given-names>AM</given-names></name><name><surname>Eszterhas</surname><given-names>SK</given-names></name><name><surname>Rollenhagen</surname><given-names>C</given-names></name><name><surname>Howell</surname><given-names>AL</given-names></name></person-group>. <article-title>Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cells</article-title>. <source>AIDS Res Hum Retroviruses</source> (<year>2008</year>) <volume>24</volume>(<issue>5</issue>):<fpage>701</fpage>–<lpage>16</lpage>.<pub-id pub-id-type="doi">10.1089/aid.2007.0108</pub-id><pub-id pub-id-type="pmid">18462082</pub-id></mixed-citation></ref><ref id="B84"><label>84</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Szotek</surname><given-names>EL</given-names></name><name><surname>Narasipura</surname><given-names>SD</given-names></name><name><surname>Al-Harthi</surname><given-names>L</given-names></name></person-group><article-title>17beta-Estradiol inhibits HIV-1 by inducing a complex formation between beta-catenin and estrogen receptor alpha on the HIV promoter to suppress HIV transcription</article-title>. <source>Virology</source> (<year>2013</year>) <volume>443</volume>(<issue>2</issue>):<fpage>375</fpage>–<lpage>83</lpage>.<pub-id pub-id-type="doi">10.1016/j.virol.2013.05.027</pub-id><pub-id pub-id-type="pmid">23769242</pub-id></mixed-citation></ref><ref id="B85"><label>85</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katagiri</surname><given-names>D</given-names></name><name><surname>Hayashi</surname><given-names>H</given-names></name><name><surname>Victoriano</surname><given-names>AF</given-names></name><name><surname>Okamoto</surname><given-names>T</given-names></name><name><surname>Onozaki</surname><given-names>K</given-names></name></person-group>. <article-title>Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1)</article-title>. <source>Int Immunopharmacol</source> (<year>2006</year>) <volume>6</volume>(<issue>2</issue>):<fpage>170</fpage>–<lpage>81</lpage>.<pub-id pub-id-type="doi">10.1016/j.intimp.2005.07.017</pub-id><pub-id pub-id-type="pmid">16399621</pub-id></mixed-citation></ref><ref id="B86"><label>86</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ragupathy</surname><given-names>V</given-names></name><name><surname>Devadas</surname><given-names>K</given-names></name><name><surname>Tang</surname><given-names>S</given-names></name><name><surname>Wood</surname><given-names>O</given-names></name><name><surname>Lee</surname><given-names>S</given-names></name><name><surname>Dastyer</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Effect of sex steroid hormones on replication and transmission of major HIV subtypes</article-title>. <source>J Steroid Biochem Mol Biol</source> (<year>2013</year>) <volume>138</volume>:<fpage>63</fpage>–<lpage>71</lpage>.<pub-id pub-id-type="doi">10.1016/j.jsbmb.2013.03.002</pub-id><pub-id pub-id-type="pmid">23542659</pub-id></mixed-citation></ref><ref id="B87"><label>87</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chang</surname><given-names>JJ</given-names></name><name><surname>Altfeld</surname><given-names>M</given-names></name></person-group>. <article-title>Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model</article-title>. <source>J Infect Dis</source> (<year>2013</year>) <volume>208</volume>(<issue>Suppl 2</issue>):<fpage>S145</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1093/infdis/jit402</pub-id><pub-id pub-id-type="pmid">24151321</pub-id></mixed-citation></ref><ref id="B88"><label>88</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hardy</surname><given-names>GA</given-names></name><name><surname>Sieg</surname><given-names>S</given-names></name><name><surname>Rodriguez</surname><given-names>B</given-names></name><name><surname>Anthony</surname><given-names>D</given-names></name><name><surname>Asaad</surname><given-names>R</given-names></name><name><surname>Jiang</surname><given-names>W</given-names></name><etal></etal></person-group><article-title>Interferon-alpha is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers</article-title>. <source>PLoS One</source> (<year>2013</year>) <volume>8</volume>(<issue>2</issue>):<fpage>e56527</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0056527</pub-id><pub-id pub-id-type="pmid">23437155</pub-id></mixed-citation></ref><ref id="B89"><label>89</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fernandez</surname><given-names>S</given-names></name><name><surname>Tanaskovic</surname><given-names>S</given-names></name><name><surname>Helbig</surname><given-names>K</given-names></name><name><surname>Rajasuriar</surname><given-names>R</given-names></name><name><surname>Kramski</surname><given-names>M</given-names></name><name><surname>Murray</surname><given-names>JM</given-names></name><etal></etal></person-group><article-title>CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells</article-title>. <source>J Infect Dis</source> (<year>2011</year>) <volume>204</volume>(<issue>12</issue>):<fpage>1927</fpage>–<lpage>35</lpage>.<pub-id pub-id-type="doi">10.1093/infdis/jir659</pub-id><pub-id pub-id-type="pmid">22006994</pub-id></mixed-citation></ref><ref id="B90"><label>90</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sandler</surname><given-names>NG</given-names></name><name><surname>Bosinger</surname><given-names>SE</given-names></name><name><surname>Estes</surname><given-names>JD</given-names></name><name><surname>Zhu</surname><given-names>RT</given-names></name><name><surname>Tharp</surname><given-names>GK</given-names></name><name><surname>Boritz</surname><given-names>E</given-names></name><etal></etal></person-group><article-title>Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression</article-title>. <source>Nature</source> (<year>2014</year>) <volume>511</volume>(<issue>7511</issue>):<fpage>601</fpage>–<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1038/nature13554</pub-id><pub-id pub-id-type="pmid">25043006</pub-id></mixed-citation></ref><ref id="B91"><label>91</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ledwaba</surname><given-names>L</given-names></name><name><surname>Tavel</surname><given-names>JA</given-names></name><name><surname>Khabo</surname><given-names>P</given-names></name><name><surname>Maja</surname><given-names>P</given-names></name><name><surname>Qin</surname><given-names>J</given-names></name><name><surname>Sangweni</surname><given-names>P</given-names></name><etal></etal></person-group><article-title>Pre-ART levels of inflammation and coagulation markers are strong predictors of death in a South African cohort with advanced HIV disease</article-title>. <source>PLoS One</source> (<year>2012</year>) <volume>7</volume>(<issue>3</issue>):<fpage>e24243</fpage>.<pub-id pub-id-type="doi">10.1371/journal.pone.0024243</pub-id><pub-id pub-id-type="pmid">22448211</pub-id></mixed-citation></ref><ref id="B92"><label>92</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kuller</surname><given-names>LH</given-names></name><name><surname>Tracy</surname><given-names>R</given-names></name><name><surname>Belloso</surname><given-names>W</given-names></name><name><surname>De Wit</surname><given-names>S</given-names></name><name><surname>Drummond</surname><given-names>F</given-names></name><name><surname>Lane</surname><given-names>HC</given-names></name><etal></etal></person-group><article-title>Inflammatory and coagulation biomarkers and mortality in patients with HIV infection</article-title>. <source>PLoS Med</source> (<year>2008</year>) <volume>5</volume>(<issue>10</issue>):<fpage>e203</fpage>.<pub-id pub-id-type="doi">10.1371/journal.pmed.0050203</pub-id><pub-id pub-id-type="pmid">18942885</pub-id></mixed-citation></ref><ref id="B93"><label>93</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sandler</surname><given-names>NG</given-names></name><name><surname>Wand</surname><given-names>H</given-names></name><name><surname>Roque</surname><given-names>A</given-names></name><name><surname>Law</surname><given-names>M</given-names></name><name><surname>Nason</surname><given-names>MC</given-names></name><name><surname>Nixon</surname><given-names>DE</given-names></name><etal></etal></person-group><article-title>Plasma levels of soluble CD14 independently predict mortality in HIV infection</article-title>. <source>J Infect Dis</source> (<year>2011</year>) <volume>203</volume>(<issue>6</issue>):<fpage>780</fpage>–<lpage>90</lpage>.<pub-id pub-id-type="doi">10.1093/infdis/jiq118</pub-id><pub-id pub-id-type="pmid">21252259</pub-id></mixed-citation></ref><ref id="B94"><label>94</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ren</surname><given-names>W</given-names></name><name><surname>Ma</surname><given-names>Y</given-names></name><name><surname>Yang</surname><given-names>L</given-names></name><name><surname>Gettie</surname><given-names>A</given-names></name><name><surname>Salas</surname><given-names>J</given-names></name><name><surname>Russell</surname><given-names>K</given-names></name><etal></etal></person-group><article-title>Fast disease progression in simian HIV-infected female macaque is accompanied by a robust local inflammatory innate immune and microbial response</article-title>. <source>AIDS</source> (<year>2015</year>) <volume>29</volume>(<issue>10</issue>):<fpage>F1</fpage>–<lpage>8</lpage>.<pub-id pub-id-type="doi">10.1097/QAD.0000000000000711</pub-id><pub-id pub-id-type="pmid">26035329</pub-id></mixed-citation></ref><ref id="B95"><label>95</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mathad</surname><given-names>JS</given-names></name><name><surname>Gupte</surname><given-names>N</given-names></name><name><surname>Balagopal</surname><given-names>A</given-names></name><name><surname>Asmuth</surname><given-names>D</given-names></name><name><surname>Hakim</surname><given-names>J</given-names></name><name><surname>Santos</surname><given-names>B</given-names></name><etal></etal></person-group><article-title>Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation</article-title>. <source>J Acquir Immune Defic Syndr</source> (<year>2016</year>) <volume>73</volume>(<issue>2</issue>):<fpage>123</fpage>–<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1097/QAI.0000000000001095</pub-id><pub-id pub-id-type="pmid">27258230</pub-id></mixed-citation></ref><ref id="B96"><label>96</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Krebs</surname><given-names>SJ</given-names></name><name><surname>Slike</surname><given-names>BM</given-names></name><name><surname>Sithinamsuwan</surname><given-names>P</given-names></name><name><surname>Allen</surname><given-names>IE</given-names></name><name><surname>Chalermchai</surname><given-names>T</given-names></name><name><surname>Tipsuk</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Sex differences in soluble markers vary before and after the initiation of antiretroviral therapy in chronically HIV-infected individuals</article-title>. <source>AIDS</source> (<year>2016</year>) <volume>30</volume>(<issue>10</issue>):<fpage>1533</fpage>–<lpage>42</lpage>.<pub-id pub-id-type="doi">10.1097/QAD.0000000000001096</pub-id><pub-id pub-id-type="pmid">26990631</pub-id></mixed-citation></ref><ref id="B97"><label>97</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heaton</surname><given-names>RK</given-names></name><name><surname>Franklin</surname><given-names>DR</given-names></name><name><surname>Ellis</surname><given-names>RJ</given-names></name><name><surname>McCutchan</surname><given-names>JA</given-names></name><name><surname>Letendre</surname><given-names>SL</given-names></name><name><surname>Leblanc</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors</article-title>. <source>J Neurovirol</source> (<year>2011</year>) <volume>17</volume>(<issue>1</issue>):<fpage>3</fpage>–<lpage>16</lpage>.<pub-id pub-id-type="doi">10.1007/s13365-010-0006-1</pub-id><pub-id pub-id-type="pmid">21174240</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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