HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality
Identifieur interne : 002971 ( Pmc/Corpus ); précédent : 002970; suivant : 002972HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality
Auteurs : Ana Maria Tavares ; Inês Fronteira ; Isabel Couto ; Diana Machado ; Miguel Viveiros ; Ana B. Abecasis ; S Nia DiasSource :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
International human migration has been rapidly growing. Migrants coming from low and middle income countries continue to be considerably vulnerable and at higher risk for infectious diseases, namely HIV (Human Immunodeficiency Virus) and tuberculosis (TB). In Europe, the number of patients with HIV-TB co-infection has been increasing and migration could be one of the potential driving forces.
This systematic review aims to improve the understanding on the burden of HIV-TB co-infection among migrants in Europe and to assess whether these populations are particularly vulnerable to this co-infection compared to nationals.
MEDLINE®, Web of Science® and Scopus® databases were searched from March to April 2016 using combinations of keywords. Titles and abstracts were screened and studies meeting the inclusion criteria proceeded for full-text revision. These articles were then selected for data extraction on the prevalence, incidence and mortality.
The majority of HIV-TB prevalence data reported in the analysed studies, including extrapulmonary/disseminated TB forms, was higher among migrant vs. nationals, some of the studies even showing increasing trends over time. Additionally, while HIV-TB incidence rates have decreased among migrants and nationals, migrants are still at a higher risk for this co-infection. Migrants with HIV-TB co-infection were also more prone to unsuccessful treatment outcomes, death and drug resistant TB. However, contradicting results also showed lower mortality compared to nationals.
Overall, a disproportionate vulnerability of migrants to acquire the HIV-TB co-infection was observed across studies. Such vulnerability has been associated to low socioeconomic status, poor living conditions and limited access to healthcare. Adequate social support, early detection, appropriate treatment, and adequate access to healthcare are key improvements to tackle HIV-TB co-infection among these populations.
Url:
DOI: 10.1371/journal.pone.0185526
PubMed: 28957400
PubMed Central: 5619775
Links to Exploration step
PMC:5619775Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality</title><author><name sortKey="Tavares, Ana Maria" sort="Tavares, Ana Maria" uniqKey="Tavares A" first="Ana Maria" last="Tavares">Ana Maria Tavares</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Fronteira, Ines" sort="Fronteira, Ines" uniqKey="Fronteira I" first="Inês" last="Fronteira">Inês Fronteira</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Couto, Isabel" sort="Couto, Isabel" uniqKey="Couto I" first="Isabel" last="Couto">Isabel Couto</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Machado, Diana" sort="Machado, Diana" uniqKey="Machado D" first="Diana" last="Machado">Diana Machado</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Viveiros, Miguel" sort="Viveiros, Miguel" uniqKey="Viveiros M" first="Miguel" last="Viveiros">Miguel Viveiros</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Abecasis, Ana B" sort="Abecasis, Ana B" uniqKey="Abecasis A" first="Ana B." last="Abecasis">Ana B. Abecasis</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Dias, S Nia" sort="Dias, S Nia" uniqKey="Dias S" first="S Nia" last="Dias">S Nia Dias</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28957400</idno><idno type="pmc">5619775</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619775</idno><idno type="RBID">PMC:5619775</idno><idno type="doi">10.1371/journal.pone.0185526</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002971</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002971</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality</title><author><name sortKey="Tavares, Ana Maria" sort="Tavares, Ana Maria" uniqKey="Tavares A" first="Ana Maria" last="Tavares">Ana Maria Tavares</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Fronteira, Ines" sort="Fronteira, Ines" uniqKey="Fronteira I" first="Inês" last="Fronteira">Inês Fronteira</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Couto, Isabel" sort="Couto, Isabel" uniqKey="Couto I" first="Isabel" last="Couto">Isabel Couto</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Machado, Diana" sort="Machado, Diana" uniqKey="Machado D" first="Diana" last="Machado">Diana Machado</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Viveiros, Miguel" sort="Viveiros, Miguel" uniqKey="Viveiros M" first="Miguel" last="Viveiros">Miguel Viveiros</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Abecasis, Ana B" sort="Abecasis, Ana B" uniqKey="Abecasis A" first="Ana B." last="Abecasis">Ana B. Abecasis</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Dias, S Nia" sort="Dias, S Nia" uniqKey="Dias S" first="S Nia" last="Dias">S Nia Dias</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>International human migration has been rapidly growing. Migrants coming from low and middle income countries continue to be considerably vulnerable and at higher risk for infectious diseases, namely HIV (Human Immunodeficiency Virus) and tuberculosis (TB). In Europe, the number of patients with HIV-TB co-infection has been increasing and migration could be one of the potential driving forces.</p></sec><sec id="sec002"><title>Objective</title><p>This systematic review aims to improve the understanding on the burden of HIV-TB co-infection among migrants in Europe and to assess whether these populations are particularly vulnerable to this co-infection compared to nationals.</p></sec><sec id="sec003"><title>Design</title><p>MEDLINE<sup>®</sup>, Web of Science<sup>®</sup> and Scopus<sup>®</sup> databases were searched from March to April 2016 using combinations of keywords. Titles and abstracts were screened and studies meeting the inclusion criteria proceeded for full-text revision. These articles were then selected for data extraction on the prevalence, incidence and mortality.</p></sec><sec id="sec004"><title>Results</title><p>The majority of HIV-TB prevalence data reported in the analysed studies, including extrapulmonary/disseminated TB forms, was higher among migrant vs. nationals, some of the studies even showing increasing trends over time. Additionally, while HIV-TB incidence rates have decreased among migrants and nationals, migrants are still at a higher risk for this co-infection. Migrants with HIV-TB co-infection were also more prone to unsuccessful treatment outcomes, death and drug resistant TB. However, contradicting results also showed lower mortality compared to nationals.</p></sec><sec id="sec005"><title>Conclusions</title><p>Overall, a disproportionate vulnerability of migrants to acquire the HIV-TB co-infection was observed across studies. Such vulnerability has been associated to low socioeconomic status, poor living conditions and limited access to healthcare. Adequate social support, early detection, appropriate treatment, and adequate access to healthcare are key improvements to tackle HIV-TB co-infection among these populations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Werf, Mj" uniqKey="Van Der Werf M">MJ van der Werf</name></author><author><name sortKey="Zellweger, Jp" uniqKey="Zellweger J">JP Zellweger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riccardo, F" uniqKey="Riccardo F">F Riccardo</name></author><author><name sortKey="Dente, Mg" uniqKey="Dente M">MG Dente</name></author><author><name sortKey="K Rki, T" uniqKey="K Rki T">T Kärki</name></author><author><name sortKey="Fabiani, M" uniqKey="Fabiani M">M Fabiani</name></author><author><name sortKey="Noori, T" uniqKey="Noori T">T Noori</name></author><author><name sortKey="Declich, S" uniqKey="Declich S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28957400</article-id><article-id pub-id-type="pmc">5619775</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0185526</article-id><article-id pub-id-type="publisher-id">PONE-D-17-20222</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Co-Infections</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Geographical Locations</subject><subj-group><subject>Europe</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and health sciences</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>HIV epidemiology</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Bacterial Diseases</subject><subj-group><subject>Tuberculosis</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Tropical Diseases</subject><subj-group><subject>Tuberculosis</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Immunodeficiency Viruses</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and life sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>RNA viruses</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Medical Microbiology</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Pathology and Laboratory Medicine</subject><subj-group><subject>Pathogens</subject><subj-group><subject>Microbial Pathogens</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Organisms</subject><subj-group><subject>Viruses</subject><subj-group><subject>Viral Pathogens</subject><subj-group><subject>Retroviruses</subject><subj-group><subject>Lentivirus</subject><subj-group><subject>HIV</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject><subj-group><subject>Geographical Locations</subject><subj-group><subject>Africa</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject><subj-group><subject>Database and Informatics Methods</subject><subj-group><subject>Database Searching</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>People and places</subject><subj-group><subject>Geographical locations</subject><subj-group><subject>Europe</subject><subj-group><subject>European Union</subject><subj-group><subject>Italy</subject></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality</article-title><alt-title alt-title-type="running-head">A systematic review on the HIV and tuberculosis co-infection among migrants in Europe</alt-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-4393-8387</contrib-id><name><surname>Tavares</surname><given-names>Ana Maria</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Investigation</role><role content-type="http://credit.casrai.org/">Methodology</role><role content-type="http://credit.casrai.org/">Visualization</role><role content-type="http://credit.casrai.org/">Writing – original draft</role><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="corresp" rid="cor001">*</xref><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Fronteira</surname><given-names>Inês</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Investigation</role><role content-type="http://credit.casrai.org/">Methodology</role><role content-type="http://credit.casrai.org/">Writing – original draft</role><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Couto</surname><given-names>Isabel</given-names></name><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Machado</surname><given-names>Diana</given-names></name><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Viveiros</surname><given-names>Miguel</given-names></name><role content-type="http://credit.casrai.org/">Methodology</role><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Abecasis</surname><given-names>Ana B.</given-names></name><role content-type="http://credit.casrai.org/">Methodology</role><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Dias</surname><given-names>Sónia</given-names></name><role content-type="http://credit.casrai.org/">Conceptualization</role><role content-type="http://credit.casrai.org/">Methodology</role><role content-type="http://credit.casrai.org/">Supervision</role><role content-type="http://credit.casrai.org/">Writing – original draft</role><role content-type="http://credit.casrai.org/">Writing – review & editing</role><xref ref-type="corresp" rid="cor001">*</xref><xref ref-type="aff" rid="aff001"></xref></contrib></contrib-group><aff id="aff001"><addr-line>Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Ciccozzi</surname><given-names>Massimo</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>National Institute of Health, ITALY</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><corresp id="cor001">* E-mail: <email>SFDias@ihmt.unl.pt</email> (SD); <email>ana.tavares@ihmt.unl.pt</email> (AMT)</corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>9</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>12</volume><issue>9</issue><elocation-id>e0185526</elocation-id><history><date date-type="received"><day>26</day><month>5</month><year>2017</year></date><date date-type="accepted"><day>14</day><month>9</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 Tavares et al</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Tavares et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0185526.pdf"></self-uri><abstract><sec id="sec001"><title>Background</title><p>International human migration has been rapidly growing. Migrants coming from low and middle income countries continue to be considerably vulnerable and at higher risk for infectious diseases, namely HIV (Human Immunodeficiency Virus) and tuberculosis (TB). In Europe, the number of patients with HIV-TB co-infection has been increasing and migration could be one of the potential driving forces.</p></sec><sec id="sec002"><title>Objective</title><p>This systematic review aims to improve the understanding on the burden of HIV-TB co-infection among migrants in Europe and to assess whether these populations are particularly vulnerable to this co-infection compared to nationals.</p></sec><sec id="sec003"><title>Design</title><p>MEDLINE<sup>®</sup>, Web of Science<sup>®</sup> and Scopus<sup>®</sup> databases were searched from March to April 2016 using combinations of keywords. Titles and abstracts were screened and studies meeting the inclusion criteria proceeded for full-text revision. These articles were then selected for data extraction on the prevalence, incidence and mortality.</p></sec><sec id="sec004"><title>Results</title><p>The majority of HIV-TB prevalence data reported in the analysed studies, including extrapulmonary/disseminated TB forms, was higher among migrant vs. nationals, some of the studies even showing increasing trends over time. Additionally, while HIV-TB incidence rates have decreased among migrants and nationals, migrants are still at a higher risk for this co-infection. Migrants with HIV-TB co-infection were also more prone to unsuccessful treatment outcomes, death and drug resistant TB. However, contradicting results also showed lower mortality compared to nationals.</p></sec><sec id="sec005"><title>Conclusions</title><p>Overall, a disproportionate vulnerability of migrants to acquire the HIV-TB co-infection was observed across studies. Such vulnerability has been associated to low socioeconomic status, poor living conditions and limited access to healthcare. Adequate social support, early detection, appropriate treatment, and adequate access to healthcare are key improvements to tackle HIV-TB co-infection among these populations.</p></sec></abstract><funding-group><funding-statement>This study was funded by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e a Tecnologia - FCT, <ext-link ext-link-type="uri" xlink:href="http://www.FCT.pt">www.FCT.pt</ext-link>), through funds to the Global Health and Tropical Medicine Research Center (GHTM - UID/Multi/04413/2013) and through the project ‘MigrantHIV: Genomics, socio-behavioral and clinical data to prevent HIV transmission in migrants: an innovative approach’ (PTDC/DTP-EPI/7066/2014). This study was supported by funds of the GHTM, through the project “Characterization of Drug-Resistant TB and HIV, and Associated Socio-Behavioural Factors Among Migrants in Lisbon, Portugal”. AMT and DM were supported by FCT: grants PD/BD/105916/2014 and SFRH/BPD/100688/2014, respectively. ABA was funded by the Investigador FCT programme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><page-count count="16"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front><body><sec sec-type="intro" id="sec006"><title>Introduction</title><p>The number of international human migratory movements worldwide has been growing over the past fifteen years, reaching 244 million in 2015 [<xref rid="pone.0185526.ref001" ref-type="bibr">1</xref>]. Since the 1960s, a steady increase in the number of international migrants coming to and living in Europe has been recorded [<xref rid="pone.0185526.ref002" ref-type="bibr">2</xref>]. Migration is, therefore, recognized as a key component of population change in Europe [<xref rid="pone.0185526.ref003" ref-type="bibr">3</xref>]. In 2015, 1,046,599 migrants arrived to Europe [<xref rid="pone.0185526.ref002" ref-type="bibr">2</xref>], and 76 million international migrants were residing in Europe, a huge increase compared with the year 2000 (56 million) [<xref rid="pone.0185526.ref001" ref-type="bibr">1</xref>].</p><p>Due to these increasing numbers, and regardless of the abiding movements and recent social awareness for the human crisis affecting Europe, migrants remain among the most vulnerable members of the European societies [<xref rid="pone.0185526.ref001" ref-type="bibr">1</xref>], and can be at risk for diseases, including infectious diseases, due to poor living conditions or other disparities [<xref rid="pone.0185526.ref003" ref-type="bibr">3</xref>]. In fact, in the European Union, migrant populations are at a greater risk of HIV and/or TB acquisition than the general population [<xref rid="pone.0185526.ref004" ref-type="bibr">4</xref>].</p><p>HIV and TB have been influencing each other’s natural history and pathogenesis over time, enhancing the magnitude of HIV-TB co-infection epidemic [<xref rid="pone.0185526.ref005" ref-type="bibr">5</xref>]. HIV infection is the strongest known risk factor for developing active TB, which is also the most common opportunistic disease among HIV-infected patients [<xref rid="pone.0185526.ref006" ref-type="bibr">6</xref>]. People living with HIV/AIDS (Acquired Immunodeficiency Syndrome) and infected with <italic>Mycobacterium tuberculosis</italic> (latent TB) are at twenty-times greater risk of developing active TB [<xref rid="pone.0185526.ref006" ref-type="bibr">6</xref>,<xref rid="pone.0185526.ref007" ref-type="bibr">7</xref>], and the intersection of both diseases contributes to a significant higher morbidity and mortality [<xref rid="pone.0185526.ref006" ref-type="bibr">6</xref>].</p><p>Globalization and migration from endemic zones have been considered a major drive in the global spread of HIV-TB co-infection [<xref rid="pone.0185526.ref008" ref-type="bibr">8</xref>]. In the European Region of the World Health Organization (WHO), the number of patients with HIV-TB co-infection increased between 2008 and 2014 [<xref rid="pone.0185526.ref009" ref-type="bibr">9</xref>], which some authors attributed partially to migration [<xref rid="pone.0185526.ref010" ref-type="bibr">10</xref>]. Social, economic and political factors in the origin and destination countries influence the risk of migrant populations to HIV acquisition—poverty, separation from sexual partners, different social and cultural norms, language barriers, substandard living and exploitative working conditions, including sexual violence—force many migrants to engage into risky behaviours, increasing the risk for acquiring the infection. Moreover, living and working conditions in the host country (access to health services and social protection), travelling journey to Europe (higher risk in crowded transport vehicles with poorly ventilated spaces plus unhealthy conditions in many migrant camps across the journey), TB incidence in their country of origin and previous contact with an infectious case, are determinant factors for TB infection among migrants [<xref rid="pone.0185526.ref011" ref-type="bibr">11</xref>].</p><p>Many countries have made considerable progress in addressing HIV-TB co-infection, but many global targets have not been reached yet [<xref rid="pone.0185526.ref005" ref-type="bibr">5</xref>]. Despite the importance of TB and HIV as public health problems in the European Region of the WHO [<xref rid="pone.0185526.ref007" ref-type="bibr">7</xref>,<xref rid="pone.0185526.ref012" ref-type="bibr">12</xref>], data available is limited on the risk factors for HIV-TB co-infection [<xref rid="pone.0185526.ref012" ref-type="bibr">12</xref>] and the case-reporting is often incomplete [<xref rid="pone.0185526.ref013" ref-type="bibr">13</xref>]. The available information on the HIV-TB co-infection burden among migrants living in Europe is still limited. This information is crucial to provide a comprehensive view to inform policies and improve adequate care and support to these populations. In this study, a systematic review of literature was conducted aiming to improve the understanding of the burden of HIV-TB co-infection among migrants in Europe and to compare the prevalence, incidence and mortality in this population with nationals in Europe. This systematic review is one of the first addressing specifically on the burden of this co-infection among migrants and the results obtained clearly demonstrate the importance for the national HIV-TB programs to address this reality systematically in order to control the predicted impact on these vulnerable populations and on the national control programs.</p></sec><sec sec-type="materials|methods" id="sec007"><title>Materials and methods</title><p>A combination of key words and/or Medical Subject Headings (MeSH) terms was used to find relevant studies. Our search was defined, using specific tools available in the searched databases, to retrieve publications between 2000 and 2016. Only articles with abstracts and written in English, Spanish, French or Portuguese were considered. Books or book chapters, comments, editorials, reviews, guidelines, reports, newspaper articles and case-studies were not included.</p><p>The electronic databases MEDLINE<sup>®</sup>, Web of Science<sup>®</sup> and Scopus<sup>®</sup> were systematically searched between March and April 2016 for original articles using search terms presented in <xref ref-type="supplementary-material" rid="pone.0185526.s001">S1 Table</xref>. MEDLINE<sup>®</sup> was the first choice since it is one of the largest bibliographic databases focused on medical related fields [<xref rid="pone.0185526.ref014" ref-type="bibr">14</xref>,<xref rid="pone.0185526.ref015" ref-type="bibr">15</xref>]. Scopus<sup>®</sup> was also searched as it includes also EMBASE<sup>®</sup> database additionally to MEDLINE<sup>®</sup> content, plus other journals indirectly related to the medical field [<xref rid="pone.0185526.ref016" ref-type="bibr">16</xref>]. Web of Science<sup>®</sup> (via <ext-link ext-link-type="uri" xlink:href="https://www.webofknowledge.com">https://www.webofknowledge.com</ext-link>) was also included due to its coverage on medical or medically related journals missed by Pubmed and EMBASE<sup>®</sup> [<xref rid="pone.0185526.ref017" ref-type="bibr">17</xref>].</p><p>The titles and abstracts of all documents retrieved were screened by one main reviewer (Ana Maria Tavares—AMT). A second reviewer (Inês Fronteira—IF) performed screening in a random sample of retrieved documents—the minimum sample size was calculated in OpenEpi platform (in <ext-link ext-link-type="uri" xlink:href="http://www.openepi.com">www.openepi.com</ext-link>) using an anticipated frequency of 7.6%, for a 95% Confidence Interval (CI)—, in order to access sensibility and specificity of the inclusion criteria [<xref rid="pone.0185526.ref018" ref-type="bibr">18</xref>]. Disagreement between reviewers concerning this sample of documents was solved through reanalysis of the respective titles/abstracts and consensus.</p><p>Only the scientific papers meeting the following inclusion criteria were selected: 1) the studied population includes migrant subjects infected with HIV and TB, 2) it provides measures of prevalence, incidence and/or mortality; 3) the study and/or studied population was sampled in one or more European countries (of the 51 independent states [<xref rid="pone.0185526.ref019" ref-type="bibr">19</xref>]); 4) it is an observational study. The following exclusion criteria were defined: 1) articles in which the studied population does not mention human migrants (immigrants, emigrants and others); 2) articles with migrants not living in European countries; 3) articles about infectious diseases other than HIV and/or pulmonary tuberculosis; 4) articles about HIV or TB only, separately; 5) articles about co-infections other than HIV-TB co-infection; 6) articles without the outcomes of interest (prevalence, incidence and/or mortality).</p><p>After screening for titles and abstracts, the selected articles proceeded for fulltext review, in which, only articles meeting all inclusion criteria and not meeting any exclusion criteria were considered for data extraction. The data extraction process was performed by one researcher (AMT). Data on the prevalence, incidence and mortality associated with co-infection in migrants and nationals (when available) were extracted. Prevalence of extrapulmonary and/or disseminated TB and drug resistant TB among HIV-TB co-infection cases were also considered, as well as measures of risk and association related to HIV-TB co-infection in migrants.</p><p>For this systematic review no protocol was registered and no quality scoring system was applied.</p></sec><sec sec-type="results" id="sec008"><title>Results</title><p>A total of 746 articles were retrieved from databases (<xref ref-type="supplementary-material" rid="pone.0185526.s001">S1 Table</xref>) and, after removing duplicates (n = 251), 495 articles remained for title and abstract screening by one main reviewer (AMT). Of these, a sample of 214 articles was randomly selected for titles and abstracts screening by a second reviewer (IF).</p><p>During screening, 453 articles were excluded: 292 articles were eliminated after applying the inclusion and exclusion criteria, 54 articles were written in other foreign languages not considered, 85 documents were publication types not considered for this review, and 22 documents lacked an abstract available for screening. After screening, 42 articles remained for fulltext revision and, after applying inclusion and exclusion criteria, only 27 articles were retrieved for data extraction. The full details of the articles selection process is summarised in <xref ref-type="fig" rid="pone.0185526.g001">Fig 1</xref>.</p><fig id="pone.0185526.g001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0185526.g001</object-id><label>Fig 1</label><caption><title>PRISMA flow diagram.</title></caption><graphic xlink:href="pone.0185526.g001"></graphic></fig><sec id="sec009"><title>Characteristics of the studies</title><p>The studies included were published between 2003 and 2016, while the sampling for those studies was conducted between 1984 and 2013. Eight European countries were represented: eleven studies conducted in Spain [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>], five studies in Italy [<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>–<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>], three studies in France [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>–<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>], two studies in Portugal [<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>], Germany [<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>], and United Kingdom (UK) [<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>,<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>], and one study in Switzerland [<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>] and The Netherlands [<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>] (<xref ref-type="table" rid="pone.0185526.t001">Table 1</xref>).</p><table-wrap id="pone.0185526.t001" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0185526.t001</object-id><label>Table 1</label><caption><title>Main characteristics of the studies included in the review.</title></caption><alternatives><graphic id="pone.0185526.t001g" xlink:href="pone.0185526.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">First author</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Year</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Year of data collection</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Country</th><th align="center" colspan="3" style="border-top:thick;border-bottom:thick" rowspan="1">Sample</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Type of study</th></tr><tr><th align="center" style="border-bottom:thick" rowspan="1" colspan="1">Type</th><th align="center" style="border-bottom:thick" rowspan="1" colspan="1">Nr. Of subjects</th><th align="center" style="border-bottom:thick" rowspan="1" colspan="1">Origin</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Abgrall et al. (a) [<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">1997–2008</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">72580</td><td align="left" rowspan="1" colspan="1">France: 58 089 (80%); SSA: 9095 (12.5%); Others: 5396 (7.5%)</td><td align="left" rowspan="1" colspan="1">Prospective cohort study</td></tr><tr><td align="left" rowspan="1" colspan="1">Abgrall et al. (b) [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>]</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">1997–2008</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">72580</td><td align="left" rowspan="1" colspan="1">France: 58 089 (80%); SSA: 9095 (12.5%); Others: 5396 (7.5%)</td><td align="left" rowspan="1" colspan="1">Prospective cohort study</td></tr><tr><td align="left" rowspan="1" colspan="1">Baussano et al.[<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>]</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">2001</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">New TB immigrant patients</td><td align="left" rowspan="1" colspan="1">640</td><td align="left" rowspan="1" colspan="1">EE: 43 (25%); Africa: 89 (52%); LA: 20 (12%); Asia: 13 (8%)</td><td align="left" rowspan="1" colspan="1">Population-based study</td></tr><tr><td align="left" rowspan="1" colspan="1">Brindicci et al.[<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>]</td><td align="left" rowspan="1" colspan="1">2016</td><td align="left" rowspan="1" colspan="1">2005–2013</td><td align="left" rowspan="1" colspan="1">Italy (BAT Province)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">129</td><td align="left" rowspan="1" colspan="1">Italy: 85; Immigrants: 44 immigrants [EE: 25 (22.7%); SSA: 10 (22.7%); NA: 6 (13.6%)]</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Camoni et al.[<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">1993–2010</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">HIV-TB patients</td><td align="left" rowspan="1" colspan="1">4075</td><td align="left" rowspan="1" colspan="1">Italy: 2685 (65.9%); Immigrants: 1390 (34.1%) (Africa: 55.3%; SA: 29.0%; EE: 7.9%; Asia: 5.7%; Others: 2.1%</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Caro-Murillo et al.[<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>]</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">2004–2006</td><td align="left" rowspan="1" colspan="1">Spain</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">2507</td><td align="left" rowspan="1" colspan="1">Spain: 1793 (71.5%); WE: 93 (3.7%); EE: 42 (1.7%); SSA: 145 (5.8%); NA: 34 (1,4%); LA/Caribbean: 400 (16.0%)</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Diz et al.[<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>]</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">1990–2002</td><td align="left" rowspan="1" colspan="1">Spain</td><td align="left" rowspan="1" colspan="1">Immigrant patients</td><td align="left" rowspan="1" colspan="1">1353</td><td align="left" rowspan="1" colspan="1">LA: 55%; Africa (37%).</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Ennemoser et al.[<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>]</td><td align="left" rowspan="1" colspan="1">2015</td><td align="left" rowspan="1" colspan="1">1994–2013</td><td align="left" rowspan="1" colspan="1">Germany</td><td align="left" rowspan="1" colspan="1">HIV-TB/TB immigrant patients</td><td align="left" rowspan="1" colspan="1">47; 46</td><td align="left" rowspan="1" colspan="1">Africa: 53; Asia: 34; EE: 6</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Eszol et al.[<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>]</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">2000–2006</td><td align="left" rowspan="1" colspan="1">Spain (Alicante)</td><td align="left" rowspan="1" colspan="1">immigrant HIV patients</td><td align="left" rowspan="1" colspan="1">69</td><td align="left" rowspan="1" colspan="1">LA: 38; SSA: 23; EE: 7; NA: 1</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Girardi et al.,[<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">-</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">HIV-TB patients</td><td align="left" rowspan="1" colspan="1">246</td><td align="left" rowspan="1" colspan="1">Italy: 162; Foreign-born: 84</td><td align="left" rowspan="1" colspan="1">Multicenter prospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Karo et al.[<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>]</td><td align="left" rowspan="1" colspan="1">2014</td><td align="left" rowspan="1" colspan="1">2001–2011</td><td align="left" rowspan="1" colspan="1">Germany</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">11693</td><td align="left" rowspan="1" colspan="1">-</td><td align="left" rowspan="1" colspan="1">Cohort study</td></tr><tr><td align="left" rowspan="1" colspan="1">Kesselring et al.[<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">1996–2008</td><td align="left" rowspan="1" colspan="1">Netherlands</td><td align="left" rowspan="1" colspan="1">Foreign-born HIV patients</td><td align="left" rowspan="1" colspan="1">6057</td><td align="left" rowspan="1" colspan="1">WE/North America: 3947 (65%); SSA: 989 (16%); Southeast Asia: 237 (4%); LA/Caribbean: 695 (11%); Others: 189 (3%)</td><td align="left" rowspan="1" colspan="1">Cohort study</td></tr><tr><td align="left" rowspan="1" colspan="1">Llenas-Garcia et al.[<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">1992–2009</td><td align="left" rowspan="1" colspan="1">Spain (Madrid)</td><td align="left" rowspan="1" colspan="1">Immigrant HIV patients</td><td align="left" rowspan="1" colspan="1">371</td><td align="left" rowspan="1" colspan="1">LA: 197 (53.1%); SSA: 91 (24.5%); Caribbean: 32 (8.6%); EE/Central Asia: 20 (5.4%); Central-WE: 20 (5.4%); NA/Middle East: 9 (2.4%); North America: 1 (0.3%); South and Southeast Asia: 1 (0.3%)</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Martin et al.[<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">1994–2005</td><td align="left" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" rowspan="1" colspan="1">AIDS patients</td><td align="left" rowspan="1" colspan="1">3600</td><td align="left" rowspan="1" colspan="1">Spain: 3279; Immigrants: 321</td><td align="left" rowspan="1" colspan="1">Retrospective study of prevalence</td></tr><tr><td align="left" rowspan="1" colspan="1">Meyssonier et al.[<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">1995–2008</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">new TB patients</td><td align="left" rowspan="1" colspan="1">14610</td><td align="left" rowspan="1" colspan="1">France: 7481; Foreign-born: 7129 [SSA: 2770 (39%); Maghreb: 2101 (30%); Asia: 1243 (17%); Europe: 695 (9.8%) (EE/Balkans: 308 (44%); Central Europe: 53 (8%); WE: 334 (48%))].</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Ortega et al.[<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>]</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">2001–2005</td><td align="left" rowspan="1" colspan="1">Spain (Madrid)</td><td align="left" rowspan="1" colspan="1">Foreign-born HIV patients</td><td align="left" rowspan="1" colspan="1">78</td><td align="left" rowspan="1" colspan="1">SSA: 41 (56.9%); SA: 19 (26.4%); Others: 18 (16.7%)</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Ospina et al.[<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">2000–2002 and 2003–2005</td><td align="left" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" rowspan="1" colspan="1">Foreign-born TB patients</td><td align="left" rowspan="1" colspan="1">572 (2000–2002); 388 (2003–2005)</td><td align="left" rowspan="1" colspan="1">2000–2002 –LA: 202 (35.3%); India/Pakistan: 136 (23.8%); NA: 92 (16.1%); Others: 142 (24.8%). 2003–2005 –LA: 152 (39.2%); India/Pakistan: 112 (28.9%); NA: 42 (10.8%); SSA: 16 (4.1%); Others: 66 (17%)</td><td align="left" rowspan="1" colspan="1">Quasi-experimental study</td></tr><tr><td align="left" rowspan="1" colspan="1">Paulino et al.[<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>]</td><td align="left" rowspan="1" colspan="1">2016</td><td align="left" rowspan="1" colspan="1">2008–2012</td><td align="left" rowspan="1" colspan="1">Portugal</td><td align="left" rowspan="1" colspan="1">native-born TB patients; foreign-born TB patients</td><td align="left" rowspan="1" colspan="1">4131; 2009</td><td align="left" rowspan="1" colspan="1">Nationals: 4131; Foreign-born: 2009 [Africa: 1484 (73.9%); SA: 209 (10.4%); EE: 197 (9.8%); Asia: 104 (5.2%); Others: (0.7%)]</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Rajamanoharan et al.[<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>]</td><td align="left" rowspan="1" colspan="1">2004</td><td align="left" rowspan="1" colspan="1">2001–2002</td><td align="left" rowspan="1" colspan="1">United Kingdom</td><td align="left" rowspan="1" colspan="1">Persons with insecure immigration/ seeking asylum</td><td align="left" rowspan="1" colspan="1">-</td><td align="left" rowspan="1" colspan="1">-</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Ramos et al.[<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>]</td><td align="left" rowspan="1" colspan="1">2004</td><td align="left" rowspan="1" colspan="1">1999–2002</td><td align="left" rowspan="1" colspan="1">Spain (Elche)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">105</td><td align="left" rowspan="1" colspan="1">Nationals: 83; Immigrants: 22 [Morocco: 5 (22.7%); SA: 9 (40.9%); EE: 4 (18,2%); SSA: 4 (18,2%)]</td><td align="left" rowspan="1" colspan="1">-</td></tr><tr><td align="left" rowspan="1" colspan="1">Rice et al.[<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>]</td><td align="left" rowspan="1" colspan="1">2013</td><td align="left" rowspan="1" colspan="1">2002–2010</td><td align="left" rowspan="1" colspan="1">England and Wales</td><td align="left" rowspan="1" colspan="1">HIV-TB patients</td><td align="left" rowspan="1" colspan="1">45322</td><td align="left" rowspan="1" colspan="1">Foreign-born: 3163 (96% - 3163/in 3310 patients co-infected)</td><td align="left" rowspan="1" colspan="1">Population-based register</td></tr><tr><td align="left" rowspan="1" colspan="1">Rifes and Villar[<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>]</td><td align="left" rowspan="1" colspan="1">2003</td><td align="left" rowspan="1" colspan="1">1996–2000</td><td align="left" rowspan="1" colspan="1">Portugal (Amadora)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">1013</td><td align="left" rowspan="1" colspan="1">Nationals: 765; Immigrants: 248 [Cape Verde: 107 (43,1%); Angola: 60 (24,2%); Guinea: 40 (16,1%); S.Tome and Principe: 21 (8,5%); Mozambique: 12 (4,8%); Timor: 1 (0,4%); Others: 7 (2,8%)</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Rodriguez-Valin et al.[<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>]</td><td align="left" rowspan="1" colspan="1">2015</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Spain</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">5880</td><td align="left" rowspan="1" colspan="1">Nationals: 3992; Foreign-born: 1888</td><td align="left" rowspan="1" colspan="1">Retrospective study</td></tr><tr><td align="left" rowspan="1" colspan="1">Scotto et al.[<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>]</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">2003</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">immigrant patients</td><td align="left" rowspan="1" colspan="1">2392</td><td align="left" rowspan="1" colspan="1">Africa: 145 (48.3%); Asia: 60 (20%); EE: 61 (20.3%); SA: 34 (11.3%)</td><td align="left" rowspan="1" colspan="1">Multicentric study</td></tr><tr><td align="left" rowspan="1" colspan="1">Staehelin et al.[<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>]</td><td align="left" rowspan="1" colspan="1">2003</td><td align="left" rowspan="1" colspan="1">1989–2001</td><td align="left" rowspan="1" colspan="1">Switzerland</td><td align="left" rowspan="1" colspan="1">HIV immigrant patients</td><td align="left" rowspan="1" colspan="1">11872</td><td align="left" rowspan="1" colspan="1">Northwestern Europe: 9420 (79%); SSA: 671 (6%); Others: 1781 (15%).</td><td align="left" rowspan="1" colspan="1">Prospective national cohort study</td></tr><tr><td align="left" rowspan="1" colspan="1">Supervía et al.[<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>]</td><td align="left" rowspan="1" colspan="1">2015</td><td align="left" rowspan="1" colspan="1">2006–2012</td><td align="left" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" rowspan="1" colspan="1">new TB immigrant patients</td><td align="left" rowspan="1" colspan="1">94</td><td align="left" rowspan="1" colspan="1">Asia: 49; LA: 45</td><td align="left" rowspan="1" colspan="1">Retrospective descriptive study</td></tr><tr><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">Velasco et al.[<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>]</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">2008</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">1984–2000</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">Spain (Madrid)</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">HIV-TB patients</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">1284</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">Nationals: 1185; Immigrants: 99 [Africa: 62.6%; Central/SA: 16.2%; EE: 4%; WE: 14%; Asia: 3%].</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">-</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t001fn001"><p>BAT—Barletta-Andria-Trani; EE- Eastern Europe; LA—Latin America; NA—North Africa; SA—South America; Sub-Saharan Africa—SSA; WE—Western Europe</p></fn></table-wrap-foot></table-wrap><p>The main study design was retrospective—eight studies [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>–<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>]—followed by six prospective/cohort studies [<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>,<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>] (one of them also multicentric [<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>]), two population-based studies [<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>,<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>], one quasi-experimental study [<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>] and one multicentric study [<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>]. The remaining studies did not mention the adopted study design [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>,<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>] (<xref ref-type="table" rid="pone.0185526.t001">Table 1</xref>). Four studies provided data from national registries [<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>].</p><p>The sample size ranged between studies from 69 [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>] to 72580 subjects [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]. The included subjects varied between studies: some studies included patients diagnosed with TB [<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>,<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>–<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>], HIV/AIDS [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>], or HIV-TB co-infection [<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>,<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>]. Other studies included immigrant patients [<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>], immigrant/foreign-born TB patients [<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>], immigrant/foreign-born HIV patients [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>], and immigrant/foreign-born HIV-TB patients [<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>].</p><p>Considering the region of origin, Africa was predominant, with higher percentages of immigrants born in Africa in 10 retrieved studies [<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>–<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>,<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>], followed by Latin America [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>], and Western/Eastern Europe [<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>] (<xref ref-type="table" rid="pone.0185526.t001">Table 1</xref>).</p></sec><sec id="sec010"><title>Prevalence of HIV-TB co-infection among migrants</title><p>Prevalence measures of HIV-TB co-infection were reported in 20 of the 27 studies selected in this review (<xref ref-type="table" rid="pone.0185526.t002">Table 2</xref>).</p><table-wrap id="pone.0185526.t002" orientation="portrait" position="float"><object-id pub-id-type="doi">10.1371/journal.pone.0185526.t002</object-id><label>Table 2</label><caption><title>Prevalence of HIV-TB co-infection among national and migrant patients.</title></caption><alternatives><graphic id="pone.0185526.t002g" xlink:href="pone.0185526.t002"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col><col align="left" valign="middle" span="1"></col></colgroup><thead><tr><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">References</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Year</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Country</th><th align="center" rowspan="2" style="border-top:thick;border-bottom:thick" colspan="1">Sample</th><th align="center" colspan="2" style="border-top:thick;border-bottom:thick" rowspan="1">Prevalence of HIV-TB cases</th></tr><tr><th align="center" style="border-bottom:thick" rowspan="1" colspan="1">Nationals—n (%)</th><th align="center" style="border-bottom:thick" rowspan="1" colspan="1">Migrants—n (%)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Abgrall et al. (a)</bold> [<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">1394 (2.4%)</td><td align="left" rowspan="1" colspan="1">1231 (8.5%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Baussano et al.</bold>[<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>]</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">New TB immigrant patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">32 (5%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Brindicci et al.</bold>[<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>]</td><td align="left" rowspan="1" colspan="1">2016</td><td align="left" rowspan="1" colspan="1">Italy (BAT Province)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">9.4% HIV-TB (p>0.05)</td><td align="left" rowspan="1" colspan="1">6.8% HIV-TB (p>0.05)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Caro-Murillo et al.</bold>[<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>]</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Spain</td><td align="left" rowspan="1" colspan="1">HIV patients</td><td align="left" rowspan="1" colspan="1">41 (2.3%)</td><td align="left" rowspan="1" colspan="1">4 (2.8%) from SSA; 12 (3%) from LA/Caribbean; 3 (3.2%) from WE</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Diz et al.</bold>[<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>]</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">Spain</td><td align="left" rowspan="1" colspan="1">Immigrant patients</td><td align="left" rowspan="1" colspan="1">37%</td><td align="left" rowspan="1" colspan="1">6% (p<0.001) (14% from Africa, 2% from LA)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Ennemoser et al.</bold>[<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>]</td><td align="left" rowspan="1" colspan="1">2015</td><td align="left" rowspan="1" colspan="1">Germany</td><td align="left" rowspan="1" colspan="1">HIV-TB and TB immigrant patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">47 (51%): (higher proportion of patients from Africa [36 (76.6%]</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Eszol et al.</bold>[<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>]</td><td align="left" rowspan="1" colspan="1">2009</td><td align="left" rowspan="1" colspan="1">Spain (Alicante)</td><td align="left" rowspan="1" colspan="1">Immigrant HIV patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">8 (11.6%): 4 (17.4%) from SSA, 1 (2.6%) from LA, 3 (42.8%) from EE.</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Kesselring et al.</bold>[<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]</td><td align="left" rowspan="1" colspan="1">2010</td><td align="left" rowspan="1" colspan="1">Netherlands</td><td align="left" rowspan="1" colspan="1">Foreign-born HIV patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">58 (1%): (higher proportion in patients from SSA vs. WE/North America—3.0% vs. 0.4%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Llenas-Garcia et al.</bold>[<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Spain (Madrid)</td><td align="left" rowspan="1" colspan="1">Immigrant HIV patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">36 (9.7%): 13.2% from SSA, 33.3% from North Africa/Middle East, 6.1% from LA, 6.3% from Caribbean, 20% from Central/WE, 10% from EE/Central Asia</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Martin et al.</bold>[<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]</td><td align="left" rowspan="1" colspan="1">2011</td><td align="left" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" rowspan="1" colspan="1">AIDS patients</td><td align="left" rowspan="1" colspan="1">30.8% (p = 0.02)</td><td align="left" rowspan="1" colspan="1">37.1% (p = 0.02): 50% from North Africa/Middle East, 50% from SSA, 31.7% from LA/Caribbean, 36.4% from South Asia/East Asia/Pacific, 29.9% from WE/North America, 45.5% from Europe/Central Asia</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Meyssonier et al.</bold>[<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">France</td><td align="left" rowspan="1" colspan="1">New TB patients</td><td align="left" rowspan="1" colspan="1">6.5%</td><td align="left" rowspan="1" colspan="1">11%</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Ortega et al.</bold>[<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>]</td><td align="left" rowspan="1" colspan="1">2007</td><td align="left" rowspan="1" colspan="1">Spain (Madrid)</td><td align="left" rowspan="1" colspan="1">Foreign-born HIV patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">16 (20.5%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Ospina et al.</bold>[<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>]</td><td align="left" rowspan="1" colspan="1">2012</td><td align="left" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" rowspan="1" colspan="1">Foreign-born TB patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">49 (8.6%) in 2000–2002, 36 (9.3%) in 2003–2005</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Paulino et al.</bold>[<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>]</td><td align="left" rowspan="1" colspan="1">2016</td><td align="left" rowspan="1" colspan="1">Portugal</td><td align="left" rowspan="1" colspan="1">Native and foreign-born TB patients</td><td align="left" rowspan="1" colspan="1">671 (16%)</td><td align="left" rowspan="1" colspan="1">452 (22%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Rajamanoharan et al.</bold>[<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>]</td><td align="left" rowspan="1" colspan="1">2004</td><td align="left" rowspan="1" colspan="1">United Kingdom</td><td align="left" rowspan="1" colspan="1">Persons with insecure immigration/ seeking asylum</td><td align="left" rowspan="1" colspan="1">15% (p<0.001)</td><td align="left" rowspan="1" colspan="1">85% (p<0.001)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Ramos et al.</bold>[<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>]</td><td align="left" rowspan="1" colspan="1">2004</td><td align="left" rowspan="1" colspan="1">Spain (Elche)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">12 (14.5%) (p = 0.4)</td><td align="left" rowspan="1" colspan="1">2 (9.1%) (p = 0.4)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Rifes and Villar</bold>[<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>]</td><td align="left" rowspan="1" colspan="1">2003</td><td align="left" rowspan="1" colspan="1">Portugal (Amadora)</td><td align="left" rowspan="1" colspan="1">TB patients</td><td align="left" rowspan="1" colspan="1">182 (18%)</td><td align="left" rowspan="1" colspan="1">66 (26.6%)</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Scotto et al.</bold>[<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>]</td><td align="left" rowspan="1" colspan="1">2006</td><td align="left" rowspan="1" colspan="1">Italy</td><td align="left" rowspan="1" colspan="1">Immigrant patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">31 (10.3%): 18 from Africa, 8 from LA, 3 from EE, 2 from Asia,</td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Staehelin et al.</bold>[<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>]</td><td align="left" rowspan="1" colspan="1">2003</td><td align="left" rowspan="1" colspan="1">Switzerland</td><td align="left" rowspan="1" colspan="1">HIV immigrant patients</td><td align="left" rowspan="1" colspan="1">NA</td><td align="left" rowspan="1" colspan="1">7 (1%) (from SSA)</td></tr><tr><td align="left" style="border-bottom:thick" rowspan="1" colspan="1"><bold>Supervía et al.</bold>[<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>]</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">2015</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">Spain (Barcelona)</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">New TB immigrant patients</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">NA</td><td align="left" style="border-bottom:thick" rowspan="1" colspan="1">5 (11.1%) (from LA)</td></tr></tbody></table></alternatives><table-wrap-foot><fn id="t002fn001"><p>BAT—Barletta-Andria-Trani; EE- Eastern Europe; NA- not applicable; SSA- Sub-Saharan Africa; LA—Latin America; WE—Western Europe</p></fn></table-wrap-foot></table-wrap><p>Among these, 10 studies reported prevalence numbers of HIV-TB co-infection in immigrants and nationals [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>–<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>,<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>]. Prevalence of co-infection was higher among immigrants than among nationals in 7 studies conducted in France, Portugal, Spain and UK [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>–<xref rid="pone.0185526.ref040" ref-type="bibr">40</xref>,<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>]—range of 2.8%-85% among migrants vs. 2.3%-30.8% among nationals (<xref ref-type="table" rid="pone.0185526.t002">Table 2</xref>)—, of which, one study was based on national registries from Portugal (2008–2012) [<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>]. Contradictory results were observed in 3 studies [<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0185526.ref027" ref-type="bibr">27</xref>,<xref rid="pone.0185526.ref032" ref-type="bibr">32</xref>]—ranging between 6%-6.8% among migrants vs. 2.3%-37% among nationals (<xref ref-type="table" rid="pone.0185526.t002">Table 2</xref>). Studies including only migrant patients, most conducted in Spain, showed prevalences of HIV-TB co-infection ranging from 1% to 76.6% [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>,<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>] (<xref ref-type="table" rid="pone.0185526.t002">Table 2</xref>).</p><p>Increases in prevalence of HIV-TB co-infection among migrants during data collection periods were reported in 3 studies. In the city of Barcelona, a significant increase was observed in the prevalence of HIV-TB co-infection in migrants, from 6.5% in 1994 to 37.1% in 2004, contrarily to nationals, in which a significant decrease has been observed [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]. Another study in Barcelona also reported a small increase in the prevalence of HIV-TB co-infection among migrants from 8.6% in 2000–2002 to 9.3% in 2003–2005 [<xref rid="pone.0185526.ref026" ref-type="bibr">26</xref>]. This increasing trend was also observed in the UK in the number of HIV-TB cases either among persons with insecure immigration or seeking asylum, from 45 in 2001 to 78 in 2002 [<xref rid="pone.0185526.ref044" ref-type="bibr">44</xref>].</p><p>Ten studies reported prevalence of HIV-TB co-infection per migrants’ region of origin [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>], namely African [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>,<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>], Latin American [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref029" ref-type="bibr">29</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>], European [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>], and Asian regions [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>]. The highest HIV-TB percentages were observed in migrants from African regions (range 1%-76.6%) [<xref rid="pone.0185526.ref042" ref-type="bibr">42</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>], particularly migrants from SSA (range 1%-50% [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref045" ref-type="bibr">45</xref>]), followed by migrants from Europe [3.2% (Western Europe) - 42.8% (Eastern Europe) [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>,<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>]], from Asia (36.4% from South Asia/East Asia/Pacific [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]), and from Latin America (range 2% to 31.7% [<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>,<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]) (<xref ref-type="table" rid="pone.0185526.t002">Table 2</xref>).</p><p>Concerning the prevalence of various TB forms among HIV infected patients, seven studies reported extrapulmonary and/or disseminated TB cases [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>–<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>,<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>,<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>], of which, three, all conducted in Spain, compared prevalence between migrants and nationals. Higher percentage of extrapulmonary TB was reported among HIV-infected migrants (75.8% vs. 68.4% in nationals) from 1984 to 2000, however non-significantly [<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>]. Contradictory results were observed between 1990 and 2002, with a higher rate of disseminated TB among HIV-infected nationals (33%) [<xref rid="pone.0185526.ref021" ref-type="bibr">21</xref>]. However, between 2004 and 2006 a significantly higher percentage of extrapulmonary TB was observed among HIV-infected migrants from Eastern Europe/Russia, Sub-Saharan Africa, Western Europe, North Africa, and Latin America/Caribbean (9.5%, 5.5%, 4.3%, 2.9%, and 2%, respectively vs. 2.5% in nationals) [<xref rid="pone.0185526.ref020" ref-type="bibr">20</xref>].</p><p>In Italy, a study including only migrants reported 13% of lymph node TB, 9.7% of multiple localization TB; 3.2% of osteoarticular TB, 3.2% of central nervous system TB, and 3.2% of intestinal TB in 2003 among HIV-TB infected migrants [<xref rid="pone.0185526.ref035" ref-type="bibr">35</xref>]. In Spain, studies performed in Alicante and Madrid, reported similar figures of disseminated TB—5.8% and 7.7%, respectively—, from 2000 to 2006 [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref025" ref-type="bibr">25</xref>]. Another study in Madrid reported 37.1% cases of disseminated TB, 14.3% cases of ganglionar TB, 5.7% cases of tuberculous meningitis and 2.9% cases of pleural TB from 1992 to 2009 [<xref rid="pone.0185526.ref023" ref-type="bibr">23</xref>].</p><p>Among the included studies, 4 analysed proportion of migrants among co-infected cases [<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>]: two showing higher percentages of immigrants among co-infected patients [<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>], and two showing increasing trends in the proportion of migrants among co-infected patients during data collection [<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>].</p><p>Only a study in France reported prevalence of drug resistant TB among HIV-TB co-infected migrants and nationals, with a significantly higher percentage of resistance to streptomycin, isoniazid, rifampicin among foreign born patients compared to nationals (12.5%, 10.4% and 3.6%, vs. 8.0%, 6.7% and 1.2%, respectively) [<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>].</p></sec><sec id="sec011"><title>Incidence of HIV-TB co-infection among migrants</title><p>Incidence rates of HIV-TB co-infection among migrants were reported in 6 studies [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>,<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]. Two studies conducted in France by the same authors on the same patients’ cohort reported a higher incidence rate among migrants—1.03/100 person-years; 95% CI: 0.95–1.11 vs. 0.28/100 person-years; 95% CI: 0.26–0.30 in nationals [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>], despite of a significantly higher proportion of incident cases among nationals—564 (55.6%) vs. 330 (48.6%) in migrants—observed between 1997 and 2008 in one of the studies [<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]. In the same two studies, the adjusted incidence rates showed an increase in the incidence of HIV-TB co-infection either among migrants (0.77/100 person-years in 1997; 1.60/100 in 2000; 1.24/100 person-years in 2002; 1.94/100 in 2008) and among nationals (0.46/100 person-years in 1997 person-years; 0.57/100 in 2000; 0.64/100 in 2002; 0.86/100 in 2008) during the study period [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]. Similarly, in Italy a higher incidence rate was observed among migrants—2.97/100 000 person years vs. 0.11/100 000 person years among nationals—, with a decrease over time among migrants (5.16/100 000 person-years in 1993 to 1.20/100 000 person-years in 2010) and nationals (0.17 /100 000 person-years in 1993 to 0.05/100 000 person-years in 2010) [<xref rid="pone.0185526.ref033" ref-type="bibr">33</xref>]. In England and Wales, HIV-TB incidence was higher among foreign-born patients in 2002 (42.5/1000 person-years vs. 8.6/1000 person-years among nationals) and 2010 (10.9/1000 person-years vs. 83.3/1000 person-years among nationals), also showing a decline in the HIV-TB incidence between 2002 and 2010 either for foreign-born (decline in 74.3%) or national patients (decline in 61.2%) [<xref rid="pone.0185526.ref043" ref-type="bibr">43</xref>]. A study conducted in Barcelona also showed higher incidence rates among male immigrants aged 29–49 years (15.8 vs. 12.7/100000 national inhabitants aged 20–29 years; 41.8 vs. 37.5/100000 national inhabitants aged 30–39 years; 33.4 vs. 14.7/100000 national inhabitants aged 40–49 years) and female immigrants aged 40–50 years old (7.9 vs. 1.3/100000 national inhabitants aged 40–49 years; 4.7 vs. 0.4/100000 national inhabitants aged 50–59 years), with an average rate decrease of 20% per year between 1994 and 2005 among both nationals and immigrants [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>].</p><p>Three studies compared the incidence rates within migrants’ region of origin. A study conducted in Germany reported a significantly higher incidence density rate of HIV-TB co-infection in patients from Sub-Saharan Africa (1.20/100 vs. 0.21/100 person years in nationals) and other countries (0.52/100 vs. 0.21/100 person years in nationals) between 2001 and 2011 [<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>]. Similarly, in a study conducted in The Netherlands, the cumulative TB incidence after 7 years of combined antiretroviral therapy (cART) treatment was higher among HIV-positive patients from Sub-Saharan Africa compared with HIV-TB patients from Western Europe/North America (4.5% vs. 0.5%) [<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]. A study conducted on the region of Piedmont, Italy, with new cases of TB among immigrant patients, showed annual incidence rate ratios of HIV-TB co-infection among patients from low prevalence countries of 179.3/100 000; 95% CI: 88.7–269.9 population among patients < 50 years, and 681.6/100 000; 95% CI: 212.7–1150.5 population among patients ≥50 years. Among patients from higher prevalence countries the annual incidence rate ratios were of 1139.5/100 000; 95% CI 403.1–1857.9 population among patients <50 years, and no incident cases among patients ≥50 years [<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>].</p></sec><sec id="sec012"><title>Mortality and survival among HIV-TB infected migrants</title><p>Mortality and survival measures were reported in four studies [<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>], all with data on migrants and nationals. A study conducted in Germany from 2001 to 2011 observed a significantly lower survival in co-infected patients from Sub-Saharan Africa, compared to co-infected nationals (93% vs. 99% among nationals) [<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>]. However, contrasting results were shown previously in a study conducted in Spain from 1984 to 2000, with a significantly better survival of co-infected immigrants (median 8.7 vs. 5.4 years among nationals) and also a significantly lower mortality rate (0.42 vs. 0.45 among nationals) [<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>]. Another study conducted in Spain in 2012 also showed lower percentage of deaths among immigrant HIV-TB patients (6.99% vs. 8.79% among nationals) [<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>]. Similarly, a study from Italy reported a lower percentage of deaths among co-infected foreign-born patients (8.3% vs. 17.9% among nationals), however without statistical significance [<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>].</p></sec><sec id="sec013"><title>Indicators and trends of risk and association</title><p>Eleven studies reported measures of risk and/or association [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>,<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>,<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>,<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>,<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>–<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]. Two studies performed in France between 1997 and 2008 using the same patients’ cohort observed twice more risk of TB among HIV-infected migrants—adjusted risk ratio (aRR) = 2.01; 95% CI: 1.79–2.26 [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>,<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]. An increased risk of HIV-TB from 2000/2001 to 2008 among nationals and migrants was also observed in one of the studies—aRR = 1.85; 95% CI: 1.27–2.70 [<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>]. Also, a non-significant 21% risk increase among nationals (aRR = 1.21, 95% CI: 0.86–1.70) and a significant 49% risk increase among migrants (aRR = 1.49, 95% CI 1.04–2.14) were observed from 2002–2003 to 2008 in the other study [<xref rid="pone.0185526.ref036" ref-type="bibr">36</xref>].</p><p>Three studies evaluated the risk of HIV-TB acquisition considering the regions of origin [<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>,<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>,<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]. A study conducted in The Netherlands between 1996 and 2008 observed a 5-fold higher risk of HIV-TB among immigrants born in Sub-Saharan Africa compared to immigrants from Western Europe or North America (Hazard ratio (HR) = 5.08, 95% CI: 2.22–11.60) [<xref rid="pone.0185526.ref046" ref-type="bibr">46</xref>]. Similarly, a study conducted in Germany between 2001 and 2011 showed that being born in Sub-Saharan Africa significantly rendered a higher risk for HIV-TB [HR = 4.05; 95% CI: 1.87–8.78 among patients who never started combination antiretroviral therapy (cART) and HR = 5.15; 95% CI 2.76–9.60 among patients on cART], as well as being born in other countries than Germany (HR = 2.22; 95% CI 1.18–4.20 among patients on cART) [<xref rid="pone.0185526.ref041" ref-type="bibr">41</xref>]. A study in the Italian region of Piedmont referred that an HIV-positive status appeared to promote TB among immigrants from low and high prevalence countries, with a higher risk among those originating from low prevalence countries—incidence rate ratio of 51.9; 95% CI: 30.2–89.4 vs. 11.4; 95% CI 5.8–22.5 among those originating from high prevalence countries [<xref rid="pone.0185526.ref031" ref-type="bibr">31</xref>].</p><p>Four studies reported associations between migration and HIV-TB co-infection. A study conducted in Barcelona from 1994 to 2005 observed an association between being born in Sub-Saharan Africa and having TB and AIDS defining illness—adjusted odds ratio (aOR) = 2.2; 95% CI: 1.2–4.6 [<xref rid="pone.0185526.ref024" ref-type="bibr">24</xref>]. However, another study from Spain, performed between 2000 and 2006, showed a strong significant association of HIV-TB co-infection with being born in Eastern Europe—OR = 8.55; IC 95%: 1.5–49.4—and a negative association with being born in Latin America—OR = 0.09; 95% CI: 0.01–0.89 [<xref rid="pone.0185526.ref022" ref-type="bibr">22</xref>]. In a study in Portugal conducted between 2008 and 2012, the odds of being a foreign-born TB case among the HIV-positive population was approximately double compared to nationals—OR = 2.137; IC 95%: 1.65–2.77 [<xref rid="pone.0185526.ref039" ref-type="bibr">39</xref>]. Moreover, the abovementioned study conducted in France from 1997 to 2008 observed a higher risk for HIV-TB co-infection among migrants from Sub-Saharan Africa—adjusted risk ratio (aRR): 2.16 (95% CI: 1.88–2.48)—and other regions—aRR: 1.83 (95% CI 1.57–2.14)—, compared to nationals [<xref rid="pone.0185526.ref037" ref-type="bibr">37</xref>].</p><p>A study conducted in Italy referred an association between being a migrant with HIV-TB and unsuccessful treatment outcomes (i.e. lost to follow-up, failure, being transferred out, default)—OR = 3.38, 95% CI 1.38–8.29) [<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>]. Similarly, in a study in Spain a higher association with potentially unsuccessful outcomes and death was observed among co-infected foreign-born patients than in nationals (OR = 1.7; 95% CI: 1.15–2.60 vs. OR = 1.6; 95% CI: 1.09–2.29 and OR = 3.2; 95% CI: 1.53–6.76 vs. OR = 2.7; 95% CI: 1.63–4.54, respectively) [<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>]. In a study conducted in France, an association between being a migrant with HIV-TB and having TB resistance to streptomycin (OR = 1.6; 95% CI: 1.3–2.0), isoniazid (OR = 1.6; 95% CI: 1.3–2.1) and rifampicin (OR: 2.9; 95% CI: 1.9–4.6) was also observed, whereas co-infection in French-born patients was only associated with rifampicin resistance (OR: 4.7; 95% CI: 2.1–10.5) [<xref rid="pone.0185526.ref038" ref-type="bibr">38</xref>].</p></sec></sec><sec sec-type="conclusions" id="sec014"><title>Discussion</title><p>In this systematic review we investigated the burden of HIV-TB co-infection among migrants comparatively to national populations.</p><p>The results have shown that migrant populations are disproportionately affected by HIV-TB co-infection when compared to nationals. The majority of the studies reporting prevalence of HIV-TB co-infection showed significantly higher values among migrants compared to nationals, and some studies also showed a higher prevalence of extrapulmonary/disseminated TB among HIV-infected migrants. Moreover, in all the studies in which prevalence fluctuations of HIV-TB co-infection were shown, most of them conducted in Spain, a more pronounced increasing trend was observed among migrants, whereas a decreasing pattern was observed in some national populations. These results are in line with a 2017 ECDC report, describing an increase in the absolute number of patients with HIV-TB co-infection in the European Region of the WHO from 11652 cases in 2011 to 16380 in 2015 [<xref rid="pone.0185526.ref047" ref-type="bibr">47</xref>]. As previously described in a systematic review conducted in 2011, the increasing trends of HIV-TB co-infection might be related to migration, especially in countries such as Spain and Italy [<xref rid="pone.0185526.ref010" ref-type="bibr">10</xref>], which were also the countries of the majority of our studies. Nevertheless, considering that the comparison of HIV-TB prevalences between nationals and migrants was only performed in 10 of the 20 articles reporting prevalence of HIV-TB co-infection, such findings must be interpreted with caution, as we cannot disregard that different findings could be observed if more studies compared prevalence between the two populations.</p><p>When considering the country of origin, the highest prevalences were observed in migrants originating from African regions. It has been documented that HIV epidemic among the communities of sub-Saharan African migrants in Europe partially resembles the magnitude of the HIV epidemics in their home countries [<xref rid="pone.0185526.ref048" ref-type="bibr">48</xref>]. Also, the described reasons underlying the burden of TB among migrants are the interaction of migration from high TB burden countries and the reactivation in host countries [<xref rid="pone.0185526.ref049" ref-type="bibr">49</xref>]. Therefore, these prevalences might be related with origin from high HIV and TB prevalence countries in Africa, especially those from Sub-Saharan region. However, more data regarding regions of origin could provide a clearer view.</p><p>The incidence rates of HIV-TB were also shown to be significantly higher among migrant populations, as well as the risk for co-infection, affecting especially those from high prevalence regions, such as Sub-Saharan Africa. In fact, Africa is still the most common origin of migration to Europe and since the late 1980s there has been a hastening of emigration from this region to Europe [<xref rid="pone.0185526.ref050" ref-type="bibr">50</xref>]. Moreover, the prevalence of HIV-TB co-infection is the highest in the African region [<xref rid="pone.0185526.ref051" ref-type="bibr">51</xref>]. Therefore, it is not unexpected that migrants from Sub-Saharan Africa were observed to be at higher risk of co-infection in the analysed studies, since HIV co-infection has been found to be more likely in TB cases originating from Africa [<xref rid="pone.0185526.ref047" ref-type="bibr">47</xref>].</p><p>In this review, many studies reported a decrease in the incidence of HIV-TB co-infection over the data collection period among migrants and nationals. These promising findings may be interpreted as a success of control and prevention measures in Europe. However, a report from WHO refers that the incidence of HIV-TB co-infection has been slowly increasing since 1990 in the WHO European Region, being 2.2/100000 population in 2014 [<xref rid="pone.0185526.ref051" ref-type="bibr">51</xref>]. Therefore, no firm conclusions can yet be drawn based on these findings.</p><p>Being a migrant infected with HIV-TB was also associated with unsuccessful outcomes (treatment failure, being transferred out, and others), death and drug resistant TB, the later also observed in a previous review by Hargreaves et al. (2016) [<xref rid="pone.0185526.ref052" ref-type="bibr">52</xref>]. These findings are possibly related with factors influencing patients’ adherence to treatment, such as financial and social support, medication burden, side effects, stigma, beliefs and poor communication with health professionals [<xref rid="pone.0185526.ref053" ref-type="bibr">53</xref>]. Some of the studies [<xref rid="pone.0185526.ref028" ref-type="bibr">28</xref>,<xref rid="pone.0185526.ref030" ref-type="bibr">30</xref>,<xref rid="pone.0185526.ref034" ref-type="bibr">34</xref>] also referred that migrants co-infected with HIV-TB seemed to have lower mortality than nationals with the same co-infection. These results are quite contradictory in the light of the disproportionate vulnerability of migrants to HIV-TB observed in the previous results. Similar findings have been documented in a review by Domnich et al. (2012) and associated with the not yet fully understood and paradoxical “healthy migrant” effect—migrant populations may present a better health compared to nationals—, caused by a previous self-selection process prior to migration, in which only healthier and younger subjects are fit for emigration [<xref rid="pone.0185526.ref054" ref-type="bibr">54</xref>]. This effect would cause better chances of survival in case of infection, what could explain the lower mortality rates observed among migrants. However, according to Domnich et al. (2012), the “healthy migrant” effect is a temporary state that diminishes as time passes after immigration, possibly due to the disparities in the access to healthcare, and in the socioeconomic status [<xref rid="pone.0185526.ref054" ref-type="bibr">54</xref>]. These are factors that also might negatively impact the unsuccessful outcomes and TB resistance observed in our study. Although better survival was observed among migrants in this systematic review, Europe is one of the world’s regions with higher mortality rates caused by HIV-TB co-infection [<xref rid="pone.0185526.ref055" ref-type="bibr">55</xref>] and, therefore, it is important to understand the role of migration in HIV-TB associated mortality in European countries.</p><p>Methodological heterogeneity was observed in analysed studies, especially regarding study design, sample size, sampling procedure and epidemiological outcomes. Such differences rendered a challenging interpretation and comparison between studies.</p><p>Limitations of this systematic review must be acknowledged. Given the vast existing number of articles on the HIV, TB and/or migrants subjects, a narrow search strategy was used, very focused on the objectives of this review. MeSH terms were criteriously selected to be used in the MEDLINE<sup>®</sup> database search, as well as restrictions for titles and abstracts search at Scopus<sup>®</sup> database. Broader search terms could have also been used in the search expressions, such as “vulnerable populations” and “Europe”. We acknowledge that such methodological choices may imply a loss of comprehensiveness in our search. Also, the outcomes observed in the selected studies comprised different data collection periods, some of them taking place before the dawn of the combined antiretroviral therapy in 1996 [<xref rid="pone.0185526.ref056" ref-type="bibr">56</xref>]. In such studies, no distinction was made between data from pre and post-HAART period. No differences were observed when comparing the data from studies conducted before and after the introduction of HAART. Even so, we cannot exclude potential bias in the outcomes assessed in this review. Moreover, many retrieved studies were conducted on a specific region or city and, therefore, lack epidemiological representativeness of the problem in a certain country. In such cases, only a descriptive synthesis of evidence was possible and the findings must be interpreted only in the context of the represented region.</p><p>In this work we have been able to highlight the disproportionate vulnerability of migrants to acquire HIV-TB compared to nationals, a clear trend in the majority of the studies included. Higher prevalence, incidence, unsuccessful outcomes and drug resistance figures were observed among migrants living in European countries. The low socioeconomic status, the poor and overcrowded living and working conditions, malnutrition, substance use induced by marginalization, social exclusion [<xref rid="pone.0185526.ref057" ref-type="bibr">57</xref>], and barriers in the access to health care [<xref rid="pone.0185526.ref058" ref-type="bibr">58</xref>], are well described factors that may contribute for this disproportion between migrants and nationals. In order to tackle such inequities, European health systems must keep their efforts on the early detection and appropriate treatment of these infections among these populations, as well as to guarantee an adequate access to healthcare and efficient social support. Moreover, policies of inclusion and integration of these populations in the host society are of utmost importance in the preventive care of these diseases. Further research should continue on data collection from national registries on the HIV-TB co-infection among migrants, providing information on the epidemiological situation of each European country, and also in interventions to improve the main barriers to health care perceived by migrant patients infected with HIV-TB. Information on length of stay among migrants was also poorly explored in the included studies of this Systematic Review. Therefore, future research should also take into account this variable in order to allow better understanding of how the burden of HIV-TB co-infection varies with time of residency in the host country. This work highlights the importance for the national HIV-TB programs to thoroughly address this problem in order to mitigate the impact on these vulnerable populations and on the national control programs.</p></sec><sec sec-type="supplementary-material" id="sec015"><title>Supporting information</title><supplementary-material content-type="local-data" id="pone.0185526.s001"><label>S1 Table</label><caption><title>Database searches.</title><p>(DOCX)</p></caption><media xlink:href="pone.0185526.s001.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material><supplementary-material content-type="local-data" id="pone.0185526.s002"><label>S2 Table</label><caption><title>PRISMA checklist.</title><p>(DOC)</p></caption><media xlink:href="pone.0185526.s002.doc"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><ref-list><title>References</title><ref id="pone.0185526.ref001"><label>1</label><mixed-citation publication-type="other">United Nations, Department of Economic and Social Affairs PD. 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