Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease
Identifieur interne : 002888 ( Pmc/Corpus ); précédent : 002887; suivant : 002889Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease
Auteurs : Yasmin Moolani ; Gene Bukhman ; Peter J. HotezSource :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2012.
Url:
DOI: 10.1371/journal.pntd.0001499
PubMed: 22745835
PubMed Central: 3383757
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PMC:3383757Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease</title><author><name sortKey="Moolani, Yasmin" sort="Moolani, Yasmin" uniqKey="Moolani Y" first="Yasmin" last="Moolani">Yasmin Moolani</name><affiliation><nlm:aff id="aff1"><addr-line>George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bukhman, Gene" sort="Bukhman, Gene" uniqKey="Bukhman G" first="Gene" last="Bukhman">Gene Bukhman</name><affiliation><nlm:aff id="aff2"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hotez, Peter J" sort="Hotez, Peter J" uniqKey="Hotez P" first="Peter J." last="Hotez">Peter J. Hotez</name><affiliation><nlm:aff id="aff3"><addr-line>Sabin Vaccine Institute and Texas Children's Center for Vaccine Development, Department of Pediatrics (Section of Pediatric Tropical Medicine) and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22745835</idno><idno type="pmc">3383757</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383757</idno><idno type="RBID">PMC:3383757</idno><idno type="doi">10.1371/journal.pntd.0001499</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002888</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease</title><author><name sortKey="Moolani, Yasmin" sort="Moolani, Yasmin" uniqKey="Moolani Y" first="Yasmin" last="Moolani">Yasmin Moolani</name><affiliation><nlm:aff id="aff1"><addr-line>George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bukhman, Gene" sort="Bukhman, Gene" uniqKey="Bukhman G" first="Gene" last="Bukhman">Gene Bukhman</name><affiliation><nlm:aff id="aff2"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hotez, Peter J" sort="Hotez, Peter J" uniqKey="Hotez P" first="Peter J." last="Hotez">Peter J. Hotez</name><affiliation><nlm:aff id="aff3"><addr-line>Sabin Vaccine Institute and Texas Children's Center for Vaccine Development, Department of Pediatrics (Section of Pediatric Tropical Medicine) and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murray, Cjl" uniqKey="Murray C">CJL Murray</name></author><author><name sortKey="Lopez, Ad" uniqKey="Lopez A">AD Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leeder, S" uniqKey="Leeder S">S Leeder</name></author><author><name sortKey="Raymond, S" uniqKey="Raymond S">S Raymond</name></author><author><name sortKey="Greenberg, H" uniqKey="Greenberg H">H Greenberg</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bloom, De" uniqKey="Bloom D">DE Bloom</name></author><author><name sortKey="Cafiero, Et" uniqKey="Cafiero E">ET Cafiero</name></author><author><name sortKey="Jane Llopis, E" uniqKey="Jane Llopis E">E Jané-Llopis</name></author><author><name sortKey="Abrahams Gessel, S" uniqKey="Abrahams Gessel S">S Abrahams-Gessel</name></author><author><name sortKey="Bloom, Lr" uniqKey="Bloom L">LR Bloom</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Commerford, P" uniqKey="Commerford P">P Commerford</name></author><author><name sortKey="Mayosi, B" uniqKey="Mayosi B">B Mayosi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sliwa, K" uniqKey="Sliwa K">K Sliwa</name></author><author><name sortKey="Wilkinson, D" uniqKey="Wilkinson D">D Wilkinson</name></author><author><name sortKey="Hansen, C" uniqKey="Hansen C">C Hansen</name></author><author><name sortKey="Ntyintyane, L" uniqKey="Ntyintyane L">L Ntyintyane</name></author><author><name sortKey="Tibazarwa, K" uniqKey="Tibazarwa K">K Tibazarwa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yacoub, S" uniqKey="Yacoub S">S Yacoub</name></author><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author><author><name sortKey="Yacoub, Mh" uniqKey="Yacoub M">MH Yacoub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benvenuti, La" uniqKey="Benvenuti L">LA Benvenuti</name></author><author><name sortKey="Roggerio, A" uniqKey="Roggerio A">A Roggério</name></author><author><name sortKey="Freitas, Hfg" uniqKey="Freitas H">HFG Freitas</name></author><author><name sortKey="Mansur, Aj" uniqKey="Mansur A">AJ Mansur</name></author><author><name sortKey="Fiorelli, A" uniqKey="Fiorelli A">A Fiorelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paixao, Lc" uniqKey="Paixao L">LC Paixão</name></author><author><name sortKey="Ribeiro, Al" uniqKey="Ribeiro A">AL Ribeiro</name></author><author><name sortKey="Valacio, Ra" uniqKey="Valacio R">RA Valacio</name></author><author><name sortKey="Teixeira, Al" uniqKey="Teixeira A">AL Teixeira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambiase, Nv" uniqKey="Sambiase N">NV Sambiase</name></author><author><name sortKey="Higuchi, Ml" uniqKey="Higuchi M">ML Higuchi</name></author><author><name sortKey="Benvenuti, La" uniqKey="Benvenuti L">LA Benvenuti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmunis, Ga" uniqKey="Schmunis G">GA Schmunis</name></author><author><name sortKey="Yadon, Ze" uniqKey="Yadon Z">ZE Yadon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barratt, Jln" uniqKey="Barratt J">JLN Barratt</name></author><author><name sortKey="Harkness, J" uniqKey="Harkness J">J Harkness</name></author><author><name sortKey="Marriott, D" uniqKey="Marriott D">D Marriott</name></author><author><name sortKey="Ellis, Jt" uniqKey="Ellis J">JT Ellis</name></author><author><name sortKey="Stark, D" uniqKey="Stark D">D Stark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carod Artal, Fj" uniqKey="Carod Artal F">FJ Carod-Artal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Kamath, A" uniqKey="Kamath A">A Kamath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author><author><name sortKey="Ferreira, Mb" uniqKey="Ferreira M">MB Ferreira</name></author><author><name sortKey="Sidi, D" uniqKey="Sidi D">D Sidi</name></author><author><name sortKey="Yacoub, Mh" uniqKey="Yacoub M">MH Yacoub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author><author><name sortKey="Yacoub, S" uniqKey="Yacoub S">S Yacoub</name></author><author><name sortKey="Yacoub, Mh" uniqKey="Yacoub M">MH Yacoub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sovari, Aa" uniqKey="Sovari A">AA Sovari</name></author><author><name sortKey="Kocheril, Ag" uniqKey="Kocheril A">AG Kocheril</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andy, Jj" uniqKey="Andy J">JJ Andy</name></author><author><name sortKey="Ogunowo, Po" uniqKey="Ogunowo P">PO Ogunowo</name></author><author><name sortKey="Akpan, Na" uniqKey="Akpan N">NA Akpan</name></author><author><name sortKey="Odigwe, Co" uniqKey="Odigwe C">CO Odigwe</name></author><author><name sortKey="Ekanem, Ia" uniqKey="Ekanem I">IA Ekanem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franco Paredes, C" uniqKey="Franco Paredes C">C Franco-Paredes</name></author><author><name sortKey="Rouphael, N" uniqKey="Rouphael N">N Rouphael</name></author><author><name sortKey="Mendez, J" uniqKey="Mendez J">J Méndez</name></author><author><name sortKey="Folch, E" uniqKey="Folch E">E Folch</name></author><author><name sortKey="Rodriguez Morales, Aj" uniqKey="Rodriguez Morales A">AJ Rodríguez-Morales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berenguer, A" uniqKey="Berenguer A">A Berenguer</name></author><author><name sortKey="Plancha, E" uniqKey="Plancha E">E Plancha</name></author><author><name sortKey="Gil, Jm" uniqKey="Gil J">JM Gil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ive, Fa" uniqKey="Ive F">FA Ive</name></author><author><name sortKey="Willis, Aj" uniqKey="Willis A">AJ Willis</name></author><author><name sortKey="Ikeme, Ac" uniqKey="Ikeme A">AC Ikeme</name></author><author><name sortKey="Brockington, If" uniqKey="Brockington I">IF Brockington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Mulligan, M" uniqKey="Mulligan M">M Mulligan</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukhman, G" uniqKey="Bukhman G">G Bukhman</name></author><author><name sortKey="Ziegler, J" uniqKey="Ziegler J">J Ziegler</name></author><author><name sortKey="Parry, E" uniqKey="Parry E">E Parry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheever, Aw" uniqKey="Cheever A">AW Cheever</name></author><author><name sortKey="Kamel, Ia" uniqKey="Kamel I">IA Kamel</name></author><author><name sortKey="Elwi, Am" uniqKey="Elwi A">AM Elwi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Cleva, R" uniqKey="De Cleva R">R De Cleva</name></author><author><name sortKey="Herman, P" uniqKey="Herman P">P Herman</name></author><author><name sortKey="Pugliese, V" uniqKey="Pugliese V">V Pugliese</name></author><author><name sortKey="Zilberstein, B" uniqKey="Zilberstein B">B Zilberstein</name></author><author><name sortKey="Saad, Wa" uniqKey="Saad W">WA Saad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, W" uniqKey="Morris W">W Morris</name></author><author><name sortKey="Knauer, Cm" uniqKey="Knauer C">CM Knauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mocumbi, Aoh" uniqKey="Mocumbi A">AOH Mocumbi</name></author><author><name sortKey="Ferreira, Mb" uniqKey="Ferreira M">MB Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lapa, M" uniqKey="Lapa M">M Lapa</name></author><author><name sortKey="Dias, B" uniqKey="Dias B">B Dias</name></author><author><name sortKey="Jardim, C" uniqKey="Jardim C">C Jardim</name></author><author><name sortKey="Fernandes, Cjc" uniqKey="Fernandes C">CJC Fernandes</name></author><author><name sortKey="Dourado, Pmm" uniqKey="Dourado P">PMM Dourado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, Ch" uniqKey="King C">CH King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Werf, Mj" uniqKey="Van Der Werf M">MJ Van Der Werf</name></author><author><name sortKey="De Vlas, Sj" uniqKey="De Vlas S">SJ De Vlas</name></author><author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name></author><author><name sortKey="Looman, Cwn" uniqKey="Looman C">CWN Looman</name></author><author><name sortKey="Nagelkerke, Njd" uniqKey="Nagelkerke N">NJD Nagelkerke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name></author><author><name sortKey="Bethony, Jm" uniqKey="Bethony J">JM Bethony</name></author><author><name sortKey="Bottazzi, Me" uniqKey="Bottazzi M">ME Bottazzi</name></author><author><name sortKey="Loukas, A" uniqKey="Loukas A">A Loukas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name></author><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Bundy, Dap" uniqKey="Bundy D">DAP Bundy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Jl" uniqKey="Smith J">JL Smith</name></author><author><name sortKey="Brooker, S" uniqKey="Brooker S">S Brooker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Bethony, Jm" uniqKey="Bethony J">JM Bethony</name></author><author><name sortKey="Diemert, Dj" uniqKey="Diemert D">DJ Diemert</name></author><author><name sortKey="Pearson, M" uniqKey="Pearson M">M Pearson</name></author><author><name sortKey="Loukas, A" uniqKey="Loukas A">A Loukas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Vaideeswar, P" uniqKey="Vaideeswar P">P Vaideeswar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leach, W" uniqKey="Leach W">W Leach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackman, Jd" uniqKey="Jackman J">JD Jackman</name></author><author><name sortKey="Radolf, Jd" uniqKey="Radolf J">JD Radolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cegielski, Jp" uniqKey="Cegielski J">JP Cegielski</name></author><author><name sortKey="Ramiya, K" uniqKey="Ramiya K">K Ramiya</name></author><author><name sortKey="Lallinger, Gj" uniqKey="Lallinger G">GJ Lallinger</name></author><author><name sortKey="Mtulia, Ia" uniqKey="Mtulia I">IA Mtulia</name></author><author><name sortKey="Mbaga, Im" uniqKey="Mbaga I">IM Mbaga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayosi, Bm" uniqKey="Mayosi B">BM Mayosi</name></author><author><name sortKey="Volmink, Ja" uniqKey="Volmink J">JA Volmink</name></author><author><name sortKey="Commerford, Pj" uniqKey="Commerford P">PJ Commerford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larrieu, Aj" uniqKey="Larrieu A">AJ Larrieu</name></author><author><name sortKey="Tyers, Gfo" uniqKey="Tyers G">GFO Tyers</name></author><author><name sortKey="Williams, Eh" uniqKey="Williams E">EH Williams</name></author><author><name sortKey="Derrick, Jr" uniqKey="Derrick J">JR Derrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trautner, Bw" uniqKey="Trautner B">BW Trautner</name></author><author><name sortKey="Darouiche, Ro" uniqKey="Darouiche R">RO Darouiche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayosi, Bm" uniqKey="Mayosi B">BM Mayosi</name></author><author><name sortKey="Wiysonge, Cs" uniqKey="Wiysonge C">CS Wiysonge</name></author><author><name sortKey="Ntsekhe, M" uniqKey="Ntsekhe M">M Ntsekhe</name></author><author><name sortKey="Gumedze, F" uniqKey="Gumedze F">F Gumedze</name></author><author><name sortKey="Volmink, Ja" uniqKey="Volmink J">JA Volmink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ntsekhe, M" uniqKey="Ntsekhe M">M Ntsekhe</name></author><author><name sortKey="Mayosi, Bm" uniqKey="Mayosi B">BM Mayosi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magula, Np" uniqKey="Magula N">NP Magula</name></author><author><name sortKey="Mayosi, Bm" uniqKey="Mayosi B">BM Mayosi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carapetis, Jr" uniqKey="Carapetis J">JR Carapetis</name></author><author><name sortKey="Steer, Ac" uniqKey="Steer A">AC Steer</name></author><author><name sortKey="Mulholland, Ek" uniqKey="Mulholland E">EK Mulholland</name></author><author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carapetis, Jr" uniqKey="Carapetis J">JR Carapetis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marijon, E" uniqKey="Marijon E">E Marijon</name></author><author><name sortKey="Ou, P" uniqKey="Ou P">P Ou</name></author><author><name sortKey="Celermajer, Ds" uniqKey="Celermajer D">DS Celermajer</name></author><author><name sortKey="Ferreira, B" uniqKey="Ferreira B">B Ferreira</name></author><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yacoub, S" uniqKey="Yacoub S">S Yacoub</name></author><author><name sortKey="Griffiths, A" uniqKey="Griffiths A">A Griffiths</name></author><author><name sortKey="Chau, Tth" uniqKey="Chau T">TTH Chau</name></author><author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name></author><author><name sortKey="Wills, B" uniqKey="Wills B">B Wills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ik" uniqKey="Lee I">IK Lee</name></author><author><name sortKey="Lee, Wh" uniqKey="Lee W">WH Lee</name></author><author><name sortKey="Liu, Jw" uniqKey="Liu J">JW Liu</name></author><author><name sortKey="Yang, Kd" uniqKey="Yang K">KD Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salgado, Dm" uniqKey="Salgado D">DM Salgado</name></author><author><name sortKey="Eltit, Jm" uniqKey="Eltit J">JM Eltit</name></author><author><name sortKey="Mansfield, K" uniqKey="Mansfield K">K Mansfield</name></author><author><name sortKey="Panqueba, C" uniqKey="Panqueba C">C Panqueba</name></author><author><name sortKey="Castro, D" uniqKey="Castro D">D Castro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carapetis, Jr" uniqKey="Carapetis J">JR Carapetis</name></author><author><name sortKey="Zuhlke, Lj" uniqKey="Zuhlke L">LJ Zuhlke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yacoub, S" uniqKey="Yacoub S">S Yacoub</name></author><author><name sortKey="Kotit, S" uniqKey="Kotit S">S Kotit</name></author><author><name sortKey="Mocumbi, Ao" uniqKey="Mocumbi A">AO Mocumbi</name></author><author><name sortKey="Yacoub, Mh" uniqKey="Yacoub M">MH Yacoub</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bukhman, G" uniqKey="Bukhman G">G Bukhman</name></author><author><name sortKey="Kidder, A" uniqKey="Kidder A">A Kidder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukhman, G" uniqKey="Bukhman G">G Bukhman</name></author><author><name sortKey="Kidder, A" uniqKey="Kidder A">A Kidder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Pecoul, B" uniqKey="Pecoul B">B Pecoul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lannes Vieira, J" uniqKey="Lannes Vieira J">J Lannes-Vieira</name></author><author><name sortKey="De Araujo Jorge, Tc" uniqKey="De Araujo Jorge T">TC de Araújo-Jorge</name></author><author><name sortKey="De Nazare Correia Soeiro, M" uniqKey="De Nazare Correia Soeiro M">M de Nazaré Correia Soeiro</name></author><author><name sortKey="Gadelha, P" uniqKey="Gadelha P">P Gadelha</name></author><author><name sortKey="Correa Oliveira, R" uniqKey="Correa Oliveira R">R Corrêa-Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Dumonteil, E" uniqKey="Dumonteil E">E Dumonteil</name></author><author><name sortKey="Heffernan, Mj" uniqKey="Heffernan M">MJ Heffernan</name></author><author><name sortKey="Bottazzi, Me" uniqKey="Bottazzi M">ME Bottazzi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kaufmann, She" uniqKey="Kaufmann S">SHE Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tenter, Am" uniqKey="Tenter A">AM Tenter</name></author><author><name sortKey="Heckeroth, Ar" uniqKey="Heckeroth A">AR Heckeroth</name></author><author><name sortKey="Weiss, Lm" uniqKey="Weiss L">LM Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Longo Mbenza, B" uniqKey="Longo Mbenza B">B Longo-Mbenza</name></author><author><name sortKey="Seghers, Kv" uniqKey="Seghers K">KV Seghers</name></author><author><name sortKey="Phuati, M" uniqKey="Phuati M">M Phuati</name></author><author><name sortKey="Nkiabungu Bikangi, F" uniqKey="Nkiabungu Bikangi F">F Nkiabungu Bikangi</name></author><author><name sortKey="Mubagwa, K" uniqKey="Mubagwa K">K Mubagwa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hotez, Pj" uniqKey="Hotez P">PJ Hotez</name></author><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Fenwick, A" uniqKey="Fenwick A">A Fenwick</name></author><author><name sortKey="Kumaresan, J" uniqKey="Kumaresan J">J Kumaresan</name></author><author><name sortKey="Sachs, Se" uniqKey="Sachs S">SE Sachs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrison, Lw" uniqKey="Harrison L">LW Harrison</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Khongphatthanayothin, A" uniqKey="Khongphatthanayothin A">A Khongphatthanayothin</name></author><author><name sortKey="Lertsapcharoen, P" uniqKey="Lertsapcharoen P">P Lertsapcharoen</name></author><author><name sortKey="Supachokchaiwattana, P" uniqKey="Supachokchaiwattana P">P Supachokchaiwattana</name></author><author><name sortKey="La Orkhun, V" uniqKey="La Orkhun V">V La-orkhun</name></author><author><name sortKey="Khumtonvong, A" uniqKey="Khumtonvong A">A Khumtonvong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisenberg, Mj" uniqKey="Eisenberg M">MJ Eisenberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Negl Trop Dis</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Negl Trop Dis</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosntds</journal-id><journal-title-group><journal-title>PLoS Neglected Tropical Diseases</journal-title></journal-title-group><issn pub-type="ppub">1935-2727</issn><issn pub-type="epub">1935-2735</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22745835</article-id><article-id pub-id-type="pmc">3383757</article-id><article-id pub-id-type="publisher-id">PNTD-D-11-01010</article-id><article-id pub-id-type="doi">10.1371/journal.pntd.0001499</article-id><article-categories><subj-group subj-group-type="heading"><subject>Editorial</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Cardiovascular</subject></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Neglected Tropical Diseases</subject></subj-group></subj-group><subj-group><subject>Oncology</subject></subj-group></subj-group></article-categories><title-group><article-title>Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Moolani</surname><given-names>Yasmin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>¤</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bukhman</surname><given-names>Gene</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hotez</surname><given-names>Peter J.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States of America</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Sabin Vaccine Institute and Texas Children's Center for Vaccine Development, Department of Pediatrics (Section of Pediatric Tropical Medicine) and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>hotez@bcm.edu</email></corresp><fn id="fn1" fn-type="current-aff"><p><bold>¤:</bold> Current address: Baylor College of Medicine, Houston, Texas, United States of America</p></fn><fn fn-type="other"><p>Yasmin Moolani, MD, recently graduated from medical school at George Washington University and started Internal Medicine residency training at Baylor College of Medicine; Gene Bukhman, MD, PhD, is Assistant Professor of Medicine, Assistant Professor of Global Health and Social Medicine, and Director of the Program in Global Non-Communicable Disease and Social Change at Harvard Medical School; Peter Hotez, MD, PhD, is Co-Editor-in-Chief of <italic>PLoS Neglected Tropical Diseases</italic>, Texas Children's Hospital Endowed Chair of Tropical Pediatrics, Professor of Pediatrics and Molecular Virology & Microbiology, and Dean of the National School of Tropical Medicine, Baylor College of Medicine.</p></fn></author-notes><pub-date pub-type="collection"><month>6</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>26</day><month>6</month><year>2012</year></pub-date><volume>6</volume><issue>6</issue><elocation-id>e1499</elocation-id><permissions><copyright-statement>Moolani et al.</copyright-statement><copyright-year>2012</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><counts><page-count count="6"></page-count></counts></article-meta></front><body><p><italic>An important component of the burden of cardiovascular disease in low- and middle-income countries may be attributed to the neglected tropical diseases.</italic></p><p>There is a growing awareness of the importance of chronic non-communicable diseases (CNCDs) in the world's low- and middle-income countries (LMICs). Beginning in the 1990s, Murray and Lopez predicted a doubling of death rates due to cardiovascular disease in developing countries by 2020 <xref rid="pntd.0001499-Murray1" ref-type="bibr">[1]</xref>, while a substantial rise was also predicted by Leeder et al. <xref rid="pntd.0001499-Leeder1" ref-type="bibr">[2]</xref>. Based on World Health Organization (WHO) predictions, 75% of the burden of cardiovascular disease is found in LMICs <xref rid="pntd.0001499-World1" ref-type="bibr">[3]</xref>. Alarming increases have also been noted for other CNCDs in LMICs including cancer, chronic respiratory diseases, and diabetes <xref rid="pntd.0001499-World2" ref-type="bibr">[4]</xref>. In September 2011, a report by the World Economic Forum and the Harvard School of Public Health estimated the global economic burden of CNCDs over the next two decades to be US$47 trillion <xref rid="pntd.0001499-Bloom1" ref-type="bibr">[5]</xref>. During this same month, the United Nations General Assembly held a high-level meeting to discuss prevention and control of CNCDs, including cardiovascular diseases, in LMICs <xref rid="pntd.0001499-United1" ref-type="bibr">[6]</xref>. These initiatives have focused on preventable risk factors attributable to lifestyle changes such as tobacco and alcohol use, prolonged unhealthy nutrition, and physical inactivity, which currently account for a high proportion of cardiovascular deaths in North America and Europe <xref rid="pntd.0001499-World2" ref-type="bibr">[4]</xref>–<xref rid="pntd.0001499-United1" ref-type="bibr">[6]</xref>.</p><p>While there is no question that obesity, tobacco, and alcohol represent major underlying conditions responsible for the rise of cardiovascular and other CNCDs in LMICs, they do not provide a complete picture. In March of 2011, Partners in Health and Harvard Medical School sponsored a conference entitled “The Long Tail of Global Health Equity: Tackling the Endemic Non-Communicable Diseases of the Bottom Billion” to examine in more detail some of the neglected causes of CNCDs, particularly those that are unique to the world's poorest people in LMICs. The conference highlighted important risk factors apart from the lifestyle changes linked to CNCDs in high-income countries <xref rid="pntd.0001499-Partners1" ref-type="bibr">[7]</xref>. Specifically with respect to neglected populations, an important component of cardiovascular disease may be attributable to neglected tropical diseases (NTDs) and other infections of poverty. For example, the Heart of Soweto Study from South Africa identified rheumatic heart disease, tuberculosis, and HIV as significant contributors to heart disease and more common than coronary artery disease. Even in the urbanized region of Soweto where there is a high prevalence of vascular risk factors, non-ischemic etiologies are still the dominant cause of heart failure <xref rid="pntd.0001499-Commerford1" ref-type="bibr">[8]</xref>, <xref rid="pntd.0001499-Sliwa1" ref-type="bibr">[9]</xref>.</p><p>On a global level, the contribution of infections of poverty to heart disease can be seen in analyzing the Global Burden of Disease estimates from the WHO. According to this data, approximately 8.8% of the disability-adjusted life years (DALYs) of LMICs may be attributable to cardiovascular disease <xref rid="pntd.0001499-World1" ref-type="bibr">[3]</xref>. Almost one-half of this cardiovascular disease burden is attributable to ischemic heart disease, more than one-third to cerebrovascular disease, and the remainder to hypertensive and inflammatory causes, as well as rheumatic heart disease (<xref ref-type="fig" rid="pntd-0001499-g001">Figure 1</xref>). A detailed analysis of these conditions suggests that NTDs and other neglected infections may account for a significant component of each of these cardiovascular disease categories (<xref ref-type="table" rid="pntd-0001499-t001">Table 1</xref>).</p><fig id="pntd-0001499-g001" position="float"><object-id pub-id-type="doi">10.1371/journal.pntd.0001499.g001</object-id><label>Figure 1</label><caption><title>Distribution of DALYs attributed to cardiovascular disease among low- and middle-income countries (LMICs).</title><p>Data obtained from WHO 2008 Global Burden of Disease estimates <xref rid="pntd.0001499-World1" ref-type="bibr">[3]</xref>.</p></caption><graphic xlink:href="pntd.0001499.g001"></graphic></fig><table-wrap id="pntd-0001499-t001" position="float"><object-id pub-id-type="doi">10.1371/journal.pntd.0001499.t001</object-id><label>Table 1</label><caption><title>Estimated Prevalence of Cardiovascular Disease Caused by Neglected Tropical Diseases and Neglected Infections of Poverty.</title></caption><alternatives><graphic id="pntd-0001499-t001-1" xlink:href="pntd.0001499.t001"></graphic><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col><col align="center" span="1"></col></colgroup><thead><tr><td align="left" rowspan="1" colspan="1">NTD</td><td align="left" rowspan="1" colspan="1">Type of Cardiovascular Disease<xref ref-type="table-fn" rid="nt101">a</xref></td><td align="left" rowspan="1" colspan="1">Estimated Number of People with the Infection</td><td align="left" rowspan="1" colspan="1">Number of Cases of Heart Disease or Related Conditions</td><td align="left" rowspan="1" colspan="1">References</td></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><bold>Chagas disease</bold></td><td align="left" rowspan="1" colspan="1">Ischemic, cerebrovascular, and inflammatory</td><td align="left" rowspan="1" colspan="1">10 million</td><td align="left" rowspan="1" colspan="1">2–3 million</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-World3" ref-type="bibr">[10]</xref>–<xref rid="pntd.0001499-Sambiase1" ref-type="bibr">[14]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>HAT</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">50,000–70,000 in sub-Saharan Africa</td><td align="left" rowspan="1" colspan="1">Not determined</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Barratt1" ref-type="bibr">[16]</xref>–<xref rid="pntd.0001499-Hotez1" ref-type="bibr">[18]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Toxoplasmosis</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">Up to 77% seroprevalence worldwide</td><td align="left" rowspan="1" colspan="1">19% of AIDS cardiomyopathy associated with acute myocarditis</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Magula1" ref-type="bibr">[50]</xref>, <xref rid="pntd.0001499-Tenter1" ref-type="bibr">[67]</xref>, <xref rid="pntd.0001499-LongoMbenza1" ref-type="bibr">[68]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>EMF</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">12 million</td><td align="left" rowspan="1" colspan="1">All</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-FrancoParedes1" ref-type="bibr">[23]</xref>, <xref rid="pntd.0001499-Yacoub3" ref-type="bibr">[58]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Schistosomiasis</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory (cardiomyopathy)</td><td align="left" rowspan="1" colspan="1">200 million</td><td align="left" rowspan="1" colspan="1">>270,000 with pulmonary hypertentsion</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Cheever1" ref-type="bibr">[28]</xref>–<xref rid="pntd.0001499-VanDerWerf1" ref-type="bibr">[34]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Hookworm</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory (CHF)</td><td align="left" rowspan="1" colspan="1">600 million</td><td align="left" rowspan="1" colspan="1">Not determined</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Hotez2" ref-type="bibr">[35]</xref>–<xref rid="pntd.0001499-Smith1" ref-type="bibr">[37]</xref>, <xref rid="pntd.0001499-Hotez6" ref-type="bibr">[69]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Syphillis</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">12 million</td><td align="left" rowspan="1" colspan="1">Untreated, 10% develop late cardiovascular complications</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-World5" ref-type="bibr">[40]</xref>, <xref rid="pntd.0001499-Vaideeswar1" ref-type="bibr">[41]</xref>, <xref rid="pntd.0001499-Harrison1" ref-type="bibr">[70]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Tuberculosis</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">2 billion (>10 million coinfected with HIV)</td><td align="left" rowspan="1" colspan="1">1%–2% of people with pulmonary TB develop TB pericarditis</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Larrieu1" ref-type="bibr">[46]</xref>, <xref rid="pntd.0001499-Mayosi2" ref-type="bibr">[48]</xref>, <xref rid="pntd.0001499-World6" ref-type="bibr">[71]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>HIV</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory (pericarditis, cardiomyopathy)</td><td align="left" rowspan="1" colspan="1">34 million people worldwide with HIV and AIDS</td><td align="left" rowspan="1" colspan="1">Pericarditis: 19%–32% of asymptomatic people with AIDS not on HAART; Cardiomyopathy: 15%–57% of symptomatic and asymptomatic people with AIDS not on HAART</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Ntsekhe1" ref-type="bibr">[49]</xref>, <xref rid="pntd.0001499-Magula1" ref-type="bibr">[50]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Dengue</bold></td><td align="left" rowspan="1" colspan="1">Inflammatory</td><td align="left" rowspan="1" colspan="1">50–100 million cases annually</td><td align="left" rowspan="1" colspan="1">Myocardial dysfunction in 6.7% with DF, 13.8% with DHF, 36% with DSS</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Yacoub2" ref-type="bibr">[54]</xref>–<xref rid="pntd.0001499-Salgado1" ref-type="bibr">[56]</xref>, <xref rid="pntd.0001499-No1" ref-type="bibr">[72]</xref>, <xref rid="pntd.0001499-Khongphatthanayothin1" ref-type="bibr">[73]</xref></td></tr><tr><td align="left" rowspan="1" colspan="1"><bold>Rheumatic heart disease</bold></td><td align="left" rowspan="1" colspan="1">Ischemic, cerebrovascular, rheumatic</td><td align="left" rowspan="1" colspan="1">RF: Up to 206/100,000 in developing world</td><td align="left" rowspan="1" colspan="1">RHD: Up to 18.6/100,000 in developing world</td><td align="left" rowspan="1" colspan="1"><xref rid="pntd.0001499-Carapetis1" ref-type="bibr">[51]</xref>, <xref rid="pntd.0001499-Carapetis2" ref-type="bibr">[52]</xref>, <xref rid="pntd.0001499-Eisenberg1" ref-type="bibr">[74]</xref></td></tr></tbody></table></alternatives><table-wrap-foot><fn id="nt101"><label>a</label><p>Based on WHO Global Burden of Disease categories.</p></fn><fn id="nt102"><label></label><p>NTD, neglected tropical disease; HAT, human African trypanosomiasis; AIDS, acquired immune deficiency syndrome; EMF, endomyocardial fibrosis; CHF, congestive heart failure; HIV, human immunodeficiency virus; TB, tuberculosis; HAART, highly active antiretroviral therapy; DF, dengue fever; DHF, dengue hemorrhagic fever without shock; DSS, dengue shock syndrome; RF, rheumatic fever; RHD, rheumatic heart disease.</p></fn></table-wrap-foot></table-wrap><sec id="s2"><title>Protozoan NTDs: American and African Trypanosomiasis</title><p>Approximately 10 million people are infected with <italic>Trypanosoma cruzi</italic>, the etiologic agent of Chagas disease (American trypanosomiasis), of whom up to 30% will develop Chagasic cardiomyopathy associated with heart failure, arrhythmias, and mural thrombi causing pulmonary and systemic emboli and sudden death <xref rid="pntd.0001499-World3" ref-type="bibr">[10]</xref>–<xref rid="pntd.0001499-Sambiase1" ref-type="bibr">[14]</xref>. Chronic heart failure is thought to be due to the persistence of trypanosome amastigotes in the heart, leading to a cascade of tissue destruction, myocarditis, fibrosis, and ultimately ventricular dilation <xref rid="pntd.0001499-Benvenuti1" ref-type="bibr">[12]</xref>. Arrhythmias are similarly caused by fibrosis. The arrhythmias then predispose to various forms of emboli, and Chagas disease has been linked to ischemia and cerebrovascular disease and even stroke <xref rid="pntd.0001499-Paixo1" ref-type="bibr">[13]</xref>, <xref rid="pntd.0001499-Sambiase1" ref-type="bibr">[14]</xref>. Thus, roughly 2–3 million people at any given time may be affected by Chagas cardiomyopathy, which can present either as ischemic or inflammatory heart disease or with mixed features of both <xref rid="pntd.0001499-Benvenuti1" ref-type="bibr">[12]</xref>–<xref rid="pntd.0001499-Sambiase1" ref-type="bibr">[14]</xref>. While 99% of the DALYs associated with Chagas disease have been traditionally attributed to LMICs in the Americas, the “globalization” of Chagas disease from emigration is now recognized as a factor in a previously hidden burden of heart disease in the United States and Europe, especially Spain <xref rid="pntd.0001499-Schmunis1" ref-type="bibr">[15]</xref>. Globally, Chagas disease, therefore, accounts for a significant burden of ischemic and inflammatory heart disease in LMICs of the Americas and now accounts for an as yet undefined burden in some high-income countries as well. Similarly, human African trypanosomiasis (HAT) can be associated with myocarditis and pericarditis, especially in the acute stages of the illness when the trypamastigote stages of the parasite spread through the blood and lymphatics to cause endarteritis <xref rid="pntd.0001499-Barratt1" ref-type="bibr">[16]</xref>. On electrocardiography repolarizaton changes, prolonged QT intervals and low voltage can be seen in infected individuals <xref rid="pntd.0001499-CarodArtal1" ref-type="bibr">[17]</xref>. About 50,000 to 70,000 people in sub-Saharan Africa are thought to be infected with <italic>Trypanosoma brucei</italic>, with an annual incidence of approximately 17,000, and of infected patients 70% develop the above mentioned electrocardiographic changes <xref rid="pntd.0001499-CarodArtal1" ref-type="bibr">[17]</xref>, <xref rid="pntd.0001499-Hotez1" ref-type="bibr">[18]</xref>.</p></sec><sec id="s3"><title>Helminthic NTDs: Endomyocardial Fibrosis, Schistosomiasis, and Hookworm Infection</title><p>Endomyocardial fibrosis (EMF) causing restrictive cardiomyopathy is most prevalent in tropical and subtropical regions in the world. In endemic areas of sub-Saharan Africa, the prevalence of EMF reaches close to 20% and affects mostly children and young adults <xref rid="pntd.0001499-Mocumbi1" ref-type="bibr">[19]</xref>, <xref rid="pntd.0001499-Mocumbi2" ref-type="bibr">[20]</xref>. EMF is currently the fourth leading cause of heart disease in Nigeria, Africa's most populous country <xref rid="pntd.0001499-Sovari1" ref-type="bibr">[21]</xref>, <xref rid="pntd.0001499-Andy1" ref-type="bibr">[22]</xref>. EMF is also associated with pericarditis, arrhythmias, and mural thrombi <xref rid="pntd.0001499-Andy1" ref-type="bibr">[22]</xref>, <xref rid="pntd.0001499-FrancoParedes1" ref-type="bibr">[23]</xref>. The etiology of tropical EMF remains unclear; however, a number of factors and helminthic parasites have been implicated in its pathogenesis, particularly because its occurrence has been linked to eosinophilia and hypereosinophilia <xref rid="pntd.0001499-Andy1" ref-type="bibr">[22]</xref>, <xref rid="pntd.0001499-Berenguer1" ref-type="bibr">[24]</xref>. For that reason, endemic filarial infections such as those caused by <italic>Loa loa</italic> and <italic>Onchocerca volvulus</italic> are among the leading candidate infections linked to this condition <xref rid="pntd.0001499-Andy1" ref-type="bibr">[22]</xref>, <xref rid="pntd.0001499-Ive1" ref-type="bibr">[25]</xref>–<xref rid="pntd.0001499-Bukhman1" ref-type="bibr">[27]</xref>. Two other helminths, <italic>Schistosoma mansoni</italic> and <italic>Schistosoma japonicum</italic>, cause chronic hepatosplenic schistosomiasis, an important cause of pulmonary hypertension and cor pulmonale. These pathologies occur in response to parasite egg deposition, hepatosplenic fibrosis, and portal hypertension <xref rid="pntd.0001499-Cheever1" ref-type="bibr">[28]</xref>–<xref rid="pntd.0001499-Mocumbi3" ref-type="bibr">[31]</xref>. Lapa et al. calculate that an estimated 200 million people worldwide are infected with any <italic>Schistosoma</italic> species, of whom 4%–8% develop hepatosplenic disease, and greater than 270,000 will go on to develop pulmonary artery hypertension <xref rid="pntd.0001499-Lapa1" ref-type="bibr">[32]</xref>. However, more recently, King et al. suggest that previous estimates have been underestimating the true impact, and the prevalence of schistosomiasis-related disease is closer to 400–600 million worldwide <xref rid="pntd.0001499-King1" ref-type="bibr">[33]</xref>. Based on even the most conservative estimates, schistosomiasis may rank among the most prevalent causes of pulmonary hypertension worldwide <xref rid="pntd.0001499-Lapa1" ref-type="bibr">[32]</xref>, <xref rid="pntd.0001499-VanDerWerf1" ref-type="bibr">[34]</xref>. Finally, among helminths causing cardiovascular disease, hookworm infection is a leading cause of iron deficiency anemia in LMICs <xref rid="pntd.0001499-Hotez2" ref-type="bibr">[35]</xref>. Recent systematic reviews confirm strong links between hookworm infection and anemia among children and both pregnant and non-pregnant adults <xref rid="pntd.0001499-Brooker1" ref-type="bibr">[36]</xref>, <xref rid="pntd.0001499-Smith1" ref-type="bibr">[37]</xref>. In Africa and Brazil, hookworm and <italic>S. mansoni</italic> schistosomiasis were shown to be synergistic <xref rid="pntd.0001499-Hotez3" ref-type="bibr">[38]</xref>. Severe anemia is an important co-factor in congestive heart failure, although the contribution of hookworm disease and anemia to this condition is unknown.</p></sec><sec id="s4"><title>Bacterial and Viral NTDs and Neglected Bacterial Infections</title><p>In their first ever report on NTDs in 2010, the WHO classified the endemic treponematoses, including <italic>Trepomema pallidum</italic> (the cause of syphilis), as NTDs <xref rid="pntd.0001499-World4" ref-type="bibr">[39]</xref>. Late cardiovascular complications of syphilis, affecting 10% of untreated cases, cause obliterative endarteritis leading to syphilitic aortitis. The complications of syphilitic aortitis are coronary artery disease, valvular disease, and left ventricular volume overload hypertrophy <xref rid="pntd.0001499-World5" ref-type="bibr">[40]</xref>. A recent study in India assessing the prevalence of syphilitic aortitis in non-atherosclerotic aortic disease found 23% of aortic disease to be due to syphilis <xref rid="pntd.0001499-Vaideeswar1" ref-type="bibr">[41]</xref>. Tertiary syphilis can also, less commonly, cause gummatous myocarditis <xref rid="pntd.0001499-Leach1" ref-type="bibr">[42]</xref>. Of note, however, cardiovascular syphilis is considered a rare disease in developed countries <xref rid="pntd.0001499-Jackman1" ref-type="bibr">[43]</xref>. A more ubiquitous bacteria, <italic>Mycobacterium tuberculosis</italic>, leads to another cardiac manifestation, tuberculous pericarditis. Among patients with pulmonary tuberculosis, 1% to 2% develop tuberculous pericarditis. The various manifestations can include myopericarditis, pericardial constriction, pericardial effusion, and effusive-constrictive pericarditis <xref rid="pntd.0001499-Mocumbi3" ref-type="bibr">[31]</xref>. In sub-Saharan Africa, 70% to 90% of large pericardial effusions and 10% of cases of congestive heart failure are caused by <italic>M. tuberculosis</italic><xref rid="pntd.0001499-Mocumbi3" ref-type="bibr">[31]</xref>, <xref rid="pntd.0001499-Cegielski1" ref-type="bibr">[44]</xref>, <xref rid="pntd.0001499-Mayosi1" ref-type="bibr">[45]</xref>. While the vast majority of cases of tuberculosis occur in developing countries, it is also seen in immigrant populations of developed countries, and thus the prevalence of tuberculous pericarditis reflects this distribution <xref rid="pntd.0001499-Larrieu1" ref-type="bibr">[46]</xref>, <xref rid="pntd.0001499-Trautner1" ref-type="bibr">[47]</xref>. The disease is frequently diagnosed in HIV-positive patients, and when it is, it carries a mortality rate of 40% in 6 months compared to 17% in those without co-morbid HIV infection <xref rid="pntd.0001499-Mayosi2" ref-type="bibr">[48]</xref>. This form of pericarditis is associated with significant morbidity and mortality due to the effusions and constriction that occur despite appropriate medical therapy <xref rid="pntd.0001499-Mayosi2" ref-type="bibr">[48]</xref>. In the absence of <italic>M. tuberculosis</italic>, untreated HIV can still cause pericarditis as well as other forms of cardiovascular disease, including pulmonary hypertension and cardiomyopathy <xref rid="pntd.0001499-Ntsekhe1" ref-type="bibr">[49]</xref>. In Africa, toxoplasmosis and cryptococcosis are also important opportunistic infections associated with cardiomyopathy <xref rid="pntd.0001499-Magula1" ref-type="bibr">[50]</xref>. Finally, 80% of rheumatic heart disease associated with group A streptococcal infection occurs in LMICs <xref rid="pntd.0001499-Carapetis1" ref-type="bibr">[51]</xref>. The WHO data depicted in <xref ref-type="fig" rid="pntd-0001499-g002">Figure 2</xref> demonstrate the skewed burden weighted toward LMICs of the world, specifically in the Middle East and Asia, where substantially higher disease burdens (as measured in DALYs) exist <xref rid="pntd.0001499-World1" ref-type="bibr">[3]</xref>. These projections likely even underestimate the true burden of disease based on recent evidence <xref rid="pntd.0001499-Carapetis1" ref-type="bibr">[51]</xref>. The weighted burden toward LMICs is a relatively new phenomenon. Prior to the 1970s, rheumatic fever was an important cause of morbidity in developed countries; however, in the 1970s and 1980s, the prevalence of rheumatic fever began to decrease, while the rates in developing countries are an ongoing challenge and contribute significantly to the burden of disease <xref rid="pntd.0001499-Carapetis2" ref-type="bibr">[52]</xref>. The inequity between the wealthy and the poor can be seen even in high-income countries today where rheumatic heart disease disproportionately affects people living in poverty and indigenous populations <xref rid="pntd.0001499-Carapetis1" ref-type="bibr">[51]</xref>, <xref rid="pntd.0001499-Marijon1" ref-type="bibr">[53]</xref>. Without adequate treatment, the mitral valve abnormalities characteristic of rheumatic heart disease predispose patients to other cardiac pathologies such as infectious endocarditis <xref rid="pntd.0001499-Commerford1" ref-type="bibr">[8]</xref>, thus making rheumatic heart disease a contributing factor to both ischemic and cerebrovascular disease. Among the viral NTDs, most notably dengue fever has been associated with systolic and diastolic cardiac impairments <xref rid="pntd.0001499-Yacoub2" ref-type="bibr">[54]</xref>, as well as myocarditis <xref rid="pntd.0001499-Lee1" ref-type="bibr">[55]</xref>, <xref rid="pntd.0001499-Salgado1" ref-type="bibr">[56]</xref>.</p><fig id="pntd-0001499-g002" position="float"><object-id pub-id-type="doi">10.1371/journal.pntd.0001499.g002</object-id><label>Figure 2</label><caption><title>Distribution of DALYs attributed to rheumatic heart disease among low- and middle-income countries (LMICs).</title><p>Rheumatic heart disease disproportionately affects LMICs. WHO Regions include Africa, the Americas, Eastern Mediterranean, Europe, South-East Asia, and Western Pacific (see <xref ref-type="supplementary-material" rid="pntd.0001499.s001">Table S1</xref> for list of countries in each region). The regions with the highest DALYs, greater than 500,000, include LMICs of Eastern Mediterranean (577,000), of South-East Asia (2,407,000), and of Western Pacific (1,095,000). DALYs attributed to rheumatic heart disease in LMICs of Africa amount to 317,000 and in LMICs of the Americas total 101,000 <xref rid="pntd.0001499-World1" ref-type="bibr">[3]</xref>. Map created using qGIS version 1.6.0 Capiapo.</p></caption><graphic xlink:href="pntd.0001499.g002"></graphic></fig></sec><sec id="s5"><title>Policy Recommendations</title><p>We lack adequate data to determine the true extent of human cardiovascular disease that results from NTDs and other neglected infections of poverty. It also remains unclear how much of the world's ischemic heart disease and cerebrovascular disease, which account for most of the disease burden, may be due to neglected causes. There is an urgent need to understand the contribution of neglected diseases to heart disease in LMICs in order to design appropriate intervention strategies. This has been highlighted by others in the field who also acknowledge the presence of unique risk factors and heart pathologies in LMICs <xref rid="pntd.0001499-Commerford1" ref-type="bibr">[8]</xref>, <xref rid="pntd.0001499-Yacoub1" ref-type="bibr">[11]</xref>, <xref rid="pntd.0001499-Mocumbi2" ref-type="bibr">[20]</xref>, <xref rid="pntd.0001499-Mocumbi3" ref-type="bibr">[31]</xref>, <xref rid="pntd.0001499-Carapetis3" ref-type="bibr">[57]</xref>, <xref rid="pntd.0001499-Yacoub3" ref-type="bibr">[58]</xref>. Towards that goal, stepped up measures for some of the neglected parasitic diseases might include increased screening for Chagas disease in the Americas (including the United states), Europe, and elsewhere using antibody-based testing now available <xref rid="pntd.0001499-Centers1" ref-type="bibr">[59]</xref>, Doppler testing for pulmonary hypertension that results from schistosomiasis in Africa, and investigations into the etiology of EMF, especially tropical EMF linked to eosinophilia. Similarly, the extent to which bacterial infections such as syphilis, tuberculous pericarditis, and rheumatic heart disease (RHD) contribute to cardiovascular disease in LMICs remains unclear and requires improved diagnostic capabilities and testing. For RHD in particular, echocardiographic screening in school-aged populations is recognized as an important method of identifying subclinical rheumatic heart disease in the early stages prior to the progression to heart failure <xref rid="pntd.0001499-Marijon1" ref-type="bibr">[53]</xref>. Such diagnostics and testing requires improved health systems in the developing world. Bukhman and Kidder have outlined novel methods of integrating services for RHD and heart failure into existing health systems in LMICs <xref rid="pntd.0001499-Bukhman2" ref-type="bibr">[60]</xref>, <xref rid="pntd.0001499-Bukhman3" ref-type="bibr">[61]</xref>. This can be expanded upon and tailored to specific regions.</p><p>There also remains a dearth of adequate control tools, that is, new drugs or vaccines for the neglected causes of human cardiovascular disease in LMICs. For instance, benznidazole and nifurtimox, the currently available drugs for treating Chagasic cardiomyopathy, require long treatment courses, and exhibit high levels of toxicities <xref rid="pntd.0001499-Hotez4" ref-type="bibr">[62]</xref>. Their efficacy in achieving parasitologic cure is also in doubt and complicated by the absence of adequate biomarkers for assessing either progression of disease or clinical outcomes <xref rid="pntd.0001499-LannesVieira1" ref-type="bibr">[63]</xref>, <xref rid="pntd.0001499-Hotez5" ref-type="bibr">[64]</xref>. As an alternative intervention, efforts are in progress to develop and test therapeutic vaccines for Chagas disease <xref rid="pntd.0001499-Hotez5" ref-type="bibr">[64]</xref>. Without a clear etiology, interventions for EMF beyond palliative surgeries for restrictive cardiomyopathy will be difficult to develop and test, while for schistosomiasis and hookworm there are needs to greatly expand coverage for annual mass drug administration using currently available anthelminthic drugs, as well as develop new anthelminthic vaccines to prevent anemia and heart disease, and forestall drug resistance <xref rid="pntd.0001499-Hotez3" ref-type="bibr">[38]</xref>. For neglected bacterial infections, there is a need to accelerate new vaccines for tuberculosis <xref rid="pntd.0001499-Aeras1" ref-type="bibr">[65]</xref>, <xref rid="pntd.0001499-Kaufmann1" ref-type="bibr">[66]</xref> and RHD <xref rid="pntd.0001499-Carapetis3" ref-type="bibr">[57]</xref> now in different stages of development, while the incidence of syphilis-associated heart disease may be reduced through expanded drug coverage.</p><p>Finally, as identified by Commerford and Mayosi, when the etiology and control mechanisms are known, research should include identifying social determinants that prevent disease management. Social determinants such as health systems, attitudes, and perceptions of both patients and physicians and socioeconomic factors should all be explored and recognized as important aspects of cardiovascular disease control and variable between ethnic groups <xref rid="pntd.0001499-Commerford1" ref-type="bibr">[8]</xref>. With all the information gathered, the cost of prevention and control can be compared to the burden cost of the various causes of cardiovascular disease in LMICs.</p><p>Together, these interventions will address significant neglected causes of cardiovascular disease burden especially prevalent in LMICs. The growing interest in cardiovascular disease in these resource-poor settings is necessary to ensuring the health of the working-age population. Careful analysis reveals the need to look beyond lifestyle risk factors of developed countries and appreciate the nuances of chronic disease in developing countries. In doing so, we will more effectively facilitate the economic advancement of low- and middle-income populations.</p></sec><sec sec-type="supplementary-material" id="s6"><title>Supporting Information</title><supplementary-material content-type="local-data" id="pntd.0001499.s001"><label>Table S1</label><caption><p><bold>List of countries in WHO income-based regions.</bold></p><p>(DOCX)</p></caption><media xlink:href="pntd.0001499.s001.docx"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></body><back><fn-group><fn fn-type="COI-statement"><p>Dr. Peter Hotez is principal investigator on a vaccine in development against Chagas disease.</p></fn><fn fn-type="financial-disclosure"><p>The authors received no funding for this work.</p></fn></fn-group><ref-list><title>References</title><ref id="pntd.0001499-Murray1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Murray</surname><given-names>CJL</given-names></name><name><surname>Lopez</surname><given-names>AD</given-names></name></person-group><year>1996</year><article-title>Annex tables.</article-title><source>The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to</source><volume>2020</volume><fpage>553</fpage></element-citation></ref><ref id="pntd.0001499-Leeder1"><label>2</label><element-citation publication-type="other"><person-group person-group-type="author"><name><surname>Leeder</surname><given-names>S</given-names></name><name><surname>Raymond</surname><given-names>S</given-names></name><name><surname>Greenberg</surname><given-names>H</given-names></name></person-group><year>2004</year><article-title>A race against time. The challenge of cardiovascular diseases in developing economies.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.earthinstitute.columbia.edu/news/2004/images/raceagainsttime_FINAL_051104.pdf">http://www.earthinstitute.columbia.edu/news/2004/images/raceagainsttime_FINAL_051104.pdf</ext-link>. Accessed 24 May 2012</comment></element-citation></ref><ref id="pntd.0001499-World1"><label>3</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>2011</year><article-title>Projections of mortality and burden of disease, 2004–2030; standard DALYs (3% discounting, age weights) - baseline scenario; 2008; WHO regions.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/entity/healthinfo/global_burden_disease/DALY7_2008.xls">http://www.who.int/entity/healthinfo/global_burden_disease/DALY7_2008.xls</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-World2"><label>4</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>2005</year><article-title>Preventing chronic disease: a vital assessment.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/chp/chronic_disease_report/en/">http://www.who.int/chp/chronic_disease_report/en/</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Bloom1"><label>5</label><element-citation publication-type="other"><person-group person-group-type="author"><name><surname>Bloom</surname><given-names>DE</given-names></name><name><surname>Cafiero</surname><given-names>ET</given-names></name><name><surname>Jané-Llopis</surname><given-names>E</given-names></name><name><surname>Abrahams-Gessel</surname><given-names>S</given-names></name><name><surname>Bloom</surname><given-names>LR</given-names></name><etal></etal></person-group><year>2011</year><article-title>The global economic burden of non-communicable diseases.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommunicableDiseases_2011.pdf">http://www3.weforum.org/docs/WEF_Harvard_HE_GlobalEconomicBurdenNonCommunicableDiseases_2011.pdf</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-United1"><label>6</label><element-citation publication-type="other"><collab>United Nations Web Services Section, Department of Public Information</collab><year>2011</year><article-title>2011 high level meeting on prevention and control of non-communicable diseases.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.un.org/en/ga/ncdmeeting2011/">http://www.un.org/en/ga/ncdmeeting2011/</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Partners1"><label>7</label><element-citation publication-type="other"><collab>Partners In Health</collab><year>2011</year><article-title>The long tail of global health equity: tackling the endemic non-communicable diseases of the bottom billion.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.pih.org/pages/harvardncd">http://www.pih.org/pages/harvardncd</ext-link></comment></element-citation></ref><ref id="pntd.0001499-Commerford1"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Commerford</surname><given-names>P</given-names></name><name><surname>Mayosi</surname><given-names>B</given-names></name></person-group><year>2006</year><article-title>An appropriate research agenda for heart disease in Africa.</article-title><source>Lancet</source><volume>367</volume><issue>9526</issue><fpage>1884</fpage><lpage>1886</lpage><pub-id pub-id-type="pmid">16765744</pub-id></element-citation></ref><ref id="pntd.0001499-Sliwa1"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sliwa</surname><given-names>K</given-names></name><name><surname>Wilkinson</surname><given-names>D</given-names></name><name><surname>Hansen</surname><given-names>C</given-names></name><name><surname>Ntyintyane</surname><given-names>L</given-names></name><name><surname>Tibazarwa</surname><given-names>K</given-names></name><etal></etal></person-group><year>2008</year><article-title>Spectrum of heart disease and risk factors in a black urban population in South Africa (the Heart of Soweto Study): a cohort study.</article-title><source>Lancet</source><volume>371</volume><fpage>915</fpage><lpage>922</lpage><pub-id pub-id-type="pmid">18342686</pub-id></element-citation></ref><ref id="pntd.0001499-World3"><label>10</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>2011</year><article-title>Chagas disease (American trypanosomiasis).</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/mediacentre/factsheets/fs340/en/index.html">http://www.who.int/mediacentre/factsheets/fs340/en/index.html</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Yacoub1"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yacoub</surname><given-names>S</given-names></name><name><surname>Mocumbi</surname><given-names>AO</given-names></name><name><surname>Yacoub</surname><given-names>MH</given-names></name></person-group><year>2008</year><article-title>Neglected tropical cardiomyopathies: I. Chagas disease.</article-title><source>Heart</source><volume>94</volume><issue>2</issue><fpage>244</fpage><lpage>248</lpage><pub-id pub-id-type="pmid">18195131</pub-id></element-citation></ref><ref id="pntd.0001499-Benvenuti1"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benvenuti</surname><given-names>LA</given-names></name><name><surname>Roggério</surname><given-names>A</given-names></name><name><surname>Freitas</surname><given-names>HFG</given-names></name><name><surname>Mansur</surname><given-names>AJ</given-names></name><name><surname>Fiorelli</surname><given-names>A</given-names></name><etal></etal></person-group><year>2008</year><article-title>Chronic american trypanosomiasis: parasite persistence in endomyocardial biopsies is associated with high-grade myocarditis.</article-title><source>Ann Trop Med Parasitol</source><volume>102</volume><issue>6</issue><fpage>481</fpage><lpage>487</lpage><pub-id pub-id-type="pmid">18782487</pub-id></element-citation></ref><ref id="pntd.0001499-Paixo1"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paixão</surname><given-names>LC</given-names></name><name><surname>Ribeiro</surname><given-names>AL</given-names></name><name><surname>Valacio</surname><given-names>RA</given-names></name><name><surname>Teixeira</surname><given-names>AL</given-names></name></person-group><year>2009</year><article-title>Chagas disease: independent risk factor for stroke.</article-title><source>Stroke</source><volume>40</volume><issue>12</issue><fpage>3691</fpage><lpage>3694</lpage><pub-id pub-id-type="pmid">19834017</pub-id></element-citation></ref><ref id="pntd.0001499-Sambiase1"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sambiase</surname><given-names>NV</given-names></name><name><surname>Higuchi</surname><given-names>ML</given-names></name><name><surname>Benvenuti</surname><given-names>LA</given-names></name></person-group><year>2010</year><article-title>Narrowed lumen of the right coronary artery in chronic chagasic patients is associated with ischemic lesions of segmental thinnings of ventricles.</article-title><source>Invest Clin</source><volume>51</volume><issue>4</issue><fpage>531</fpage><lpage>539</lpage><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.scielo.org.ve/pdf/ic/v51n4/art09.pdf">http://www.scielo.org.ve/pdf/ic/v51n4/art09.pdf</ext-link>. Accessed 25 May 2012</comment><pub-id pub-id-type="pmid">21361147</pub-id></element-citation></ref><ref id="pntd.0001499-Schmunis1"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schmunis</surname><given-names>GA</given-names></name><name><surname>Yadon</surname><given-names>ZE</given-names></name></person-group><year>2010</year><article-title>Chagas disease: A Latin American health problem becoming a world health problem.</article-title><source>Acta Trop</source><volume>115</volume><issue>1–2</issue><fpage>14</fpage><lpage>21</lpage><pub-id pub-id-type="pmid">19932071</pub-id></element-citation></ref><ref id="pntd.0001499-Barratt1"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barratt</surname><given-names>JLN</given-names></name><name><surname>Harkness</surname><given-names>J</given-names></name><name><surname>Marriott</surname><given-names>D</given-names></name><name><surname>Ellis</surname><given-names>JT</given-names></name><name><surname>Stark</surname><given-names>D</given-names></name></person-group><year>2010</year><article-title>Importance of nonenteric protozoan infections in immunocompromised people.</article-title><source>Clin Microbiol Rev</source><volume>23</volume><issue>4</issue><fpage>795</fpage><lpage>836</lpage><pub-id pub-id-type="pmid">20930074</pub-id></element-citation></ref><ref id="pntd.0001499-CarodArtal1"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carod-Artal</surname><given-names>FJ</given-names></name></person-group><year>2010</year><article-title>Trypanosomiasis, cardiomyopathy and the risk of ischemic stroke.</article-title><source>Expert Rev Cardiovasc Ther</source><volume>8</volume><issue>5</issue><fpage>717</fpage><lpage>728</lpage><pub-id pub-id-type="pmid">20450304</pub-id></element-citation></ref><ref id="pntd.0001499-Hotez1"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Kamath</surname><given-names>A</given-names></name></person-group><year>2009</year><article-title>Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden.</article-title><source>PLoS Negl Trop Dis</source><volume>3</volume><issue>8</issue><fpage>e412</fpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pntd.0000412">10.1371/journal.pntd.0000412</ext-link></comment><pub-id pub-id-type="pmid">19707588</pub-id></element-citation></ref><ref id="pntd.0001499-Mocumbi1"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mocumbi</surname><given-names>AO</given-names></name><name><surname>Ferreira</surname><given-names>MB</given-names></name><name><surname>Sidi</surname><given-names>D</given-names></name><name><surname>Yacoub</surname><given-names>MH</given-names></name></person-group><year>2008</year><article-title>A population study of endomyocardial fibrosis in a rural area of mozambique.</article-title><source>N Engl J Med</source><volume>359</volume><issue>1</issue><fpage>43</fpage><lpage>49</lpage><pub-id pub-id-type="pmid">18596273</pub-id></element-citation></ref><ref id="pntd.0001499-Mocumbi2"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mocumbi</surname><given-names>AO</given-names></name><name><surname>Yacoub</surname><given-names>S</given-names></name><name><surname>Yacoub</surname><given-names>MH</given-names></name></person-group><year>2008</year><article-title>Neglected tropical cardiomyopathies: II. Endomyocardial fibrosis.</article-title><source>Heart</source><volume>94</volume><issue>3</issue><fpage>384</fpage><lpage>390</lpage><pub-id pub-id-type="pmid">18276824</pub-id></element-citation></ref><ref id="pntd.0001499-Sovari1"><label>21</label><element-citation publication-type="other"><person-group person-group-type="author"><name><surname>Sovari</surname><given-names>AA</given-names></name><name><surname>Kocheril</surname><given-names>AG</given-names></name></person-group><year>2010</year><article-title>Endomyocardial fibrosis. (1/21).</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://emedicine.medscape.com/article/154931-overview#a0199">http://emedicine.medscape.com/article/154931-overview#a0199</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Andy1"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Andy</surname><given-names>JJ</given-names></name><name><surname>Ogunowo</surname><given-names>PO</given-names></name><name><surname>Akpan</surname><given-names>NA</given-names></name><name><surname>Odigwe</surname><given-names>CO</given-names></name><name><surname>Ekanem</surname><given-names>IA</given-names></name><etal></etal></person-group><year>1998</year><article-title>Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria.</article-title><source>Acta Trop</source><volume>69</volume><issue>2</issue><fpage>127</fpage><lpage>140</lpage><pub-id pub-id-type="pmid">9588233</pub-id></element-citation></ref><ref id="pntd.0001499-FrancoParedes1"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Franco-Paredes</surname><given-names>C</given-names></name><name><surname>Rouphael</surname><given-names>N</given-names></name><name><surname>Méndez</surname><given-names>J</given-names></name><name><surname>Folch</surname><given-names>E</given-names></name><name><surname>Rodríguez-Morales</surname><given-names>AJ</given-names></name><etal></etal></person-group><year>2007</year><article-title>Cardiac manifestations of parasitic infections part 3: pericardial and miscellaneous cardiopulmonary manifestations.</article-title><source>Clin Cardiol</source><volume>30</volume><issue>6</issue><fpage>277</fpage><lpage>280</lpage><pub-id pub-id-type="pmid">17551959</pub-id></element-citation></ref><ref id="pntd.0001499-Berenguer1"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Berenguer</surname><given-names>A</given-names></name><name><surname>Plancha</surname><given-names>E</given-names></name><name><surname>Gil</surname><given-names>JM</given-names></name></person-group><year>2003</year><article-title>Right ventricular endomyocardial fibrosis and microfilarial infection.</article-title><source>Int J Cardiol</source><volume>87</volume><issue>2–3</issue><fpage>287</fpage><lpage>289</lpage><pub-id pub-id-type="pmid">12559553</pub-id></element-citation></ref><ref id="pntd.0001499-Ive1"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ive</surname><given-names>FA</given-names></name><name><surname>Willis</surname><given-names>AJ</given-names></name><name><surname>Ikeme</surname><given-names>AC</given-names></name><name><surname>Brockington</surname><given-names>IF</given-names></name></person-group><year>1967</year><article-title>Endomyocardial fibrosis and filariasis.</article-title><source>Q J Med</source><volume>36</volume><issue>144</issue><fpage>495</fpage><lpage>516</lpage><pub-id pub-id-type="pmid">6077228</pub-id></element-citation></ref><ref id="pntd.0001499-Nutman1"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nutman</surname><given-names>TB</given-names></name><name><surname>Miller</surname><given-names>KD</given-names></name><name><surname>Mulligan</surname><given-names>M</given-names></name><name><surname>Ottesen</surname><given-names>EA</given-names></name></person-group><year>1986</year><article-title>Loa loa infection in temporary residents of endemic regions: recognition of a hyperresponsive syndrome with characteristic clinical manifestations.</article-title><source>J Infect Dis</source><volume>154</volume><issue>1</issue><fpage>10</fpage><lpage>18</lpage><pub-id pub-id-type="pmid">3458832</pub-id></element-citation></ref><ref id="pntd.0001499-Bukhman1"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bukhman</surname><given-names>G</given-names></name><name><surname>Ziegler</surname><given-names>J</given-names></name><name><surname>Parry</surname><given-names>E</given-names></name></person-group><year>2008</year><article-title>Endomyocardial fibrosis: still a mystery after 60 years.</article-title><source>PLoS Negl Trop Dis</source><volume>2</volume><issue>2</issue><fpage>e97</fpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pntd.0000097">10.1371/journal.pntd.0000097</ext-link></comment><pub-id pub-id-type="pmid">18301727</pub-id></element-citation></ref><ref id="pntd.0001499-Cheever1"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheever</surname><given-names>AW</given-names></name><name><surname>Kamel</surname><given-names>IA</given-names></name><name><surname>Elwi</surname><given-names>AM</given-names></name></person-group><year>1978</year><article-title>Schistosoma mansoni and S. haematobium infections in Egypt. III. extrahepatic pathology.</article-title><source>Am J Trop Med Hyg</source><volume>27</volume><issue>1 I</issue><fpage>55</fpage><lpage>75</lpage><pub-id pub-id-type="pmid">626283</pub-id></element-citation></ref><ref id="pntd.0001499-DeCleva1"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Cleva</surname><given-names>R</given-names></name><name><surname>Herman</surname><given-names>P</given-names></name><name><surname>Pugliese</surname><given-names>V</given-names></name><name><surname>Zilberstein</surname><given-names>B</given-names></name><name><surname>Saad</surname><given-names>WA</given-names></name><etal></etal></person-group><year>2003</year><article-title>Prevalence of pulmonary hypertension in patients with hepatosplenic mansonic schistosomiasis - prospective study.</article-title><source>Hepatogastroenterology</source><volume>50</volume><issue>54</issue><fpage>2028</fpage><lpage>2030</lpage><pub-id pub-id-type="pmid">14696458</pub-id></element-citation></ref><ref id="pntd.0001499-Morris1"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morris</surname><given-names>W</given-names></name><name><surname>Knauer</surname><given-names>CM</given-names></name></person-group><year>1997</year><article-title>Cardiopulmonary manifestations of schistosomiasis.</article-title><source>Semin Respir Infect</source><volume>12</volume><issue>2</issue><fpage>159</fpage><lpage>170</lpage><pub-id pub-id-type="pmid">9195681</pub-id></element-citation></ref><ref id="pntd.0001499-Mocumbi3"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mocumbi</surname><given-names>AOH</given-names></name><name><surname>Ferreira</surname><given-names>MB</given-names></name></person-group><year>2010</year><article-title>Neglected cardiovascular diseases in Africa. Challenges and opportunities.</article-title><source>J Am Coll Cardiol</source><volume>55</volume><issue>7</issue><fpage>680</fpage><lpage>687</lpage><pub-id pub-id-type="pmid">20170795</pub-id></element-citation></ref><ref id="pntd.0001499-Lapa1"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lapa</surname><given-names>M</given-names></name><name><surname>Dias</surname><given-names>B</given-names></name><name><surname>Jardim</surname><given-names>C</given-names></name><name><surname>Fernandes</surname><given-names>CJC</given-names></name><name><surname>Dourado</surname><given-names>PMM</given-names></name><etal></etal></person-group><year>2009</year><article-title>Cardiopulmonary manifestations of hepatosplenic schistosomiasis.</article-title><source>Circulation</source><volume>119</volume><issue>11</issue><fpage>1518</fpage><lpage>1523</lpage><pub-id pub-id-type="pmid">19273723</pub-id></element-citation></ref><ref id="pntd.0001499-King1"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>King</surname><given-names>CH</given-names></name></person-group><year>2010</year><article-title>Parasites and poverty: the case of schistosomiasis.</article-title><source>Acta Trop</source><volume>113</volume><issue>2</issue><fpage>95</fpage><lpage>104</lpage><pub-id pub-id-type="pmid">19962954</pub-id></element-citation></ref><ref id="pntd.0001499-VanDerWerf1"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Der Werf</surname><given-names>MJ</given-names></name><name><surname>De Vlas</surname><given-names>SJ</given-names></name><name><surname>Brooker</surname><given-names>S</given-names></name><name><surname>Looman</surname><given-names>CWN</given-names></name><name><surname>Nagelkerke</surname><given-names>NJD</given-names></name><etal></etal></person-group><year>2003</year><article-title>Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa.</article-title><source>Acta Trop</source><volume>86</volume><issue>2–3</issue><fpage>125</fpage><lpage>139</lpage><pub-id pub-id-type="pmid">12745133</pub-id></element-citation></ref><ref id="pntd.0001499-Hotez2"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Brooker</surname><given-names>S</given-names></name><name><surname>Bethony</surname><given-names>JM</given-names></name><name><surname>Bottazzi</surname><given-names>ME</given-names></name><name><surname>Loukas</surname><given-names>A</given-names></name><etal></etal></person-group><year>2004</year><article-title>Hookworm infection.</article-title><source>N Engl J Med</source><volume>351</volume><issue>8</issue><fpage>799</fpage><lpage>807+841</lpage><pub-id pub-id-type="pmid">15317893</pub-id></element-citation></ref><ref id="pntd.0001499-Brooker1"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brooker</surname><given-names>S</given-names></name><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Bundy</surname><given-names>DAP</given-names></name></person-group><year>2008</year><article-title>Hookworm-related anaemia among pregnant women: a systematic review.</article-title><source>PLoS Negl Trop Dis</source><volume>2</volume><issue>9</issue><fpage>291</fpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pntd.0000291">10.1371/journal.pntd.0000291</ext-link></comment></element-citation></ref><ref id="pntd.0001499-Smith1"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname><given-names>JL</given-names></name><name><surname>Brooker</surname><given-names>S</given-names></name></person-group><year>2010</year><article-title>Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review.</article-title><source>Trop Med Int Health</source><volume>15</volume><issue>7</issue><fpage>776</fpage><lpage>795</lpage><pub-id pub-id-type="pmid">20500563</pub-id></element-citation></ref><ref id="pntd.0001499-Hotez3"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Bethony</surname><given-names>JM</given-names></name><name><surname>Diemert</surname><given-names>DJ</given-names></name><name><surname>Pearson</surname><given-names>M</given-names></name><name><surname>Loukas</surname><given-names>A</given-names></name></person-group><year>2010</year><article-title>Developing vaccines to combat hookworm infection and intestinal schistosomiasis.</article-title><source>Nat Rev Microbiol</source><volume>8</volume><issue>11</issue><fpage>814</fpage><lpage>826</lpage><pub-id pub-id-type="pmid">20948553</pub-id></element-citation></ref><ref id="pntd.0001499-World4"><label>39</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>2010</year><article-title>First WHO report on neglected tropical diseases: working to overcome the global impact of neglected tropical diseases.</article-title><comment>Available <ext-link ext-link-type="uri" xlink:href="http://www.who.int/neglected_diseases/2010report/en/">http://www.who.int/neglected_diseases/2010report/en/</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-World5"><label>40</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>2001</year><article-title>Global prevalence and incidence of selected curable sexually transmitted infections: overview of estimates.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/reproductivehealth/publications/rtis/HIV_AIDS_2001_2/en/index.html">http://www.who.int/reproductivehealth/publications/rtis/HIV_AIDS_2001_2/en/index.html</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Vaideeswar1"><label>41</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vaideeswar</surname><given-names>P</given-names></name></person-group><year>2010</year><article-title>Syphilitic aortitis: rearing of the ugly head.</article-title><source>Indian J Pathol Microbiol</source><volume>53</volume><issue>4</issue><fpage>624</fpage><lpage>627</lpage><pub-id pub-id-type="pmid">21045381</pub-id></element-citation></ref><ref id="pntd.0001499-Leach1"><label>42</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leach</surname><given-names>W</given-names></name></person-group><year>1960</year><article-title>Case report: gummatous myocarditis.</article-title><source>Br Heart J</source><volume>22</volume><fpage>149</fpage><lpage>152</lpage><pub-id pub-id-type="pmid">14414929</pub-id></element-citation></ref><ref id="pntd.0001499-Jackman1"><label>43</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jackman</surname><given-names>JD</given-names><suffix>Jr</suffix></name><name><surname>Radolf</surname><given-names>JD</given-names></name></person-group><year>1989</year><article-title>Cardiovascular syphilis.</article-title><source>Am J Med</source><volume>87</volume><issue>4</issue><fpage>425</fpage><lpage>433</lpage><pub-id pub-id-type="pmid">2679075</pub-id></element-citation></ref><ref id="pntd.0001499-Cegielski1"><label>44</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cegielski</surname><given-names>JP</given-names></name><name><surname>Ramiya</surname><given-names>K</given-names></name><name><surname>Lallinger</surname><given-names>GJ</given-names></name><name><surname>Mtulia</surname><given-names>IA</given-names></name><name><surname>Mbaga</surname><given-names>IM</given-names></name></person-group><year>1990</year><article-title>Pericardial disease and human immunodeficiency virus in Dar es Salaam, Tanzania.</article-title><source>Lancet</source><volume>335</volume><fpage>209</fpage><lpage>212</lpage><pub-id pub-id-type="pmid">1967676</pub-id></element-citation></ref><ref id="pntd.0001499-Mayosi1"><label>45</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Mayosi</surname><given-names>BM</given-names></name><name><surname>Volmink</surname><given-names>JA</given-names></name><name><surname>Commerford</surname><given-names>PJ</given-names></name></person-group><year>2007</year><article-title>Pericardial disease: an evidence-based approach to diagnosis and treatment.</article-title><person-group person-group-type="editor"><name><surname>Yusuf</surname><given-names>S</given-names></name><name><surname>Cairns</surname><given-names>JA</given-names></name><name><surname>Camm</surname><given-names>AJ</given-names></name><name><surname>Fallen</surname><given-names>EL</given-names></name><name><surname>Gersh</surname><given-names>BJ</given-names></name></person-group><source>Evidence-based cardiology. Second edition</source><publisher-loc>London</publisher-loc><publisher-name>BMJ Books</publisher-name></element-citation></ref><ref id="pntd.0001499-Larrieu1"><label>46</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Larrieu</surname><given-names>AJ</given-names></name><name><surname>Tyers</surname><given-names>GFO</given-names></name><name><surname>Williams</surname><given-names>EH</given-names></name><name><surname>Derrick</surname><given-names>JR</given-names></name></person-group><year>1980</year><article-title>Recent experience with tuberculous pericarditis.</article-title><source>Ann Thorac Surg</source><volume>29</volume><issue>5</issue><fpage>464</fpage><lpage>468</lpage><pub-id pub-id-type="pmid">7377888</pub-id></element-citation></ref><ref id="pntd.0001499-Trautner1"><label>47</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Trautner</surname><given-names>BW</given-names></name><name><surname>Darouiche</surname><given-names>RO</given-names></name></person-group><year>2001</year><article-title>Tuberculous pericarditis: optimal diagnosis and management.</article-title><source>Clin Infect Dis</source><volume>33</volume><issue>7</issue><fpage>954</fpage><lpage>961</lpage><pub-id pub-id-type="pmid">11528565</pub-id></element-citation></ref><ref id="pntd.0001499-Mayosi2"><label>48</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mayosi</surname><given-names>BM</given-names></name><name><surname>Wiysonge</surname><given-names>CS</given-names></name><name><surname>Ntsekhe</surname><given-names>M</given-names></name><name><surname>Gumedze</surname><given-names>F</given-names></name><name><surname>Volmink</surname><given-names>JA</given-names></name><etal></etal></person-group><year>2008</year><article-title>Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.</article-title><source>S Afr Med J</source><volume>98</volume><issue>1</issue><fpage>36</fpage><lpage>40</lpage><pub-id pub-id-type="pmid">18270639</pub-id></element-citation></ref><ref id="pntd.0001499-Ntsekhe1"><label>49</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ntsekhe</surname><given-names>M</given-names></name><name><surname>Mayosi</surname><given-names>BM</given-names></name></person-group><year>2009</year><article-title>Cardiac manifestations of HIV infection: an African perspective.</article-title><source>Nat Clin Pract Cardiovasc Med</source><volume>6</volume><issue>2</issue><fpage>120</fpage><lpage>127</lpage><pub-id pub-id-type="pmid">19104517</pub-id></element-citation></ref><ref id="pntd.0001499-Magula1"><label>50</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Magula</surname><given-names>NP</given-names></name><name><surname>Mayosi</surname><given-names>BM</given-names></name></person-group><year>2003</year><article-title>Cardiac involvement in HIV-infected people living in africa: a review.</article-title><source>Cardiovasc J S Afr</source><volume>14</volume><issue>5</issue><fpage>231</fpage><lpage>237</lpage><pub-id pub-id-type="pmid">14610610</pub-id></element-citation></ref><ref id="pntd.0001499-Carapetis1"><label>51</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carapetis</surname><given-names>JR</given-names></name><name><surname>Steer</surname><given-names>AC</given-names></name><name><surname>Mulholland</surname><given-names>EK</given-names></name><name><surname>Weber</surname><given-names>M</given-names></name></person-group><year>2005</year><article-title>The global burden of group A streptococcal diseases.</article-title><source>Lancet Infect Dis</source><volume>5</volume><issue>11</issue><fpage>685</fpage><lpage>694</lpage><pub-id pub-id-type="pmid">16253886</pub-id></element-citation></ref><ref id="pntd.0001499-Carapetis2"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carapetis</surname><given-names>JR</given-names></name></person-group><year>2007</year><article-title>Rheumatic heart disease in developing countries.</article-title><source>N Engl J Med</source><volume>357</volume><issue>5</issue><fpage>439</fpage><lpage>441</lpage><pub-id pub-id-type="pmid">17671252</pub-id></element-citation></ref><ref id="pntd.0001499-Marijon1"><label>53</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marijon</surname><given-names>E</given-names></name><name><surname>Ou</surname><given-names>P</given-names></name><name><surname>Celermajer</surname><given-names>DS</given-names></name><name><surname>Ferreira</surname><given-names>B</given-names></name><name><surname>Mocumbi</surname><given-names>AO</given-names></name><etal></etal></person-group><year>2007</year><article-title>Prevalence of rheumatic heart disease detected by echocardiographic screening.</article-title><source>New Engl J Med</source><volume>357</volume><issue>5</issue><fpage>470</fpage><lpage>476</lpage><pub-id pub-id-type="pmid">17671255</pub-id></element-citation></ref><ref id="pntd.0001499-Yacoub2"><label>54</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yacoub</surname><given-names>S</given-names></name><name><surname>Griffiths</surname><given-names>A</given-names></name><name><surname>Chau</surname><given-names>TTH</given-names></name><name><surname>Simmons</surname><given-names>CP</given-names></name><name><surname>Wills</surname><given-names>B</given-names></name><etal></etal></person-group><year>2011</year><article-title>Cardiac function in Vietnamese patients with different dengue severity grades.</article-title><source>Crit Care Med</source><volume>40</volume><issue>2</issue><fpage>477</fpage><lpage>483</lpage></element-citation></ref><ref id="pntd.0001499-Lee1"><label>55</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>IK</given-names></name><name><surname>Lee</surname><given-names>WH</given-names></name><name><surname>Liu</surname><given-names>JW</given-names></name><name><surname>Yang</surname><given-names>KD</given-names></name></person-group><year>2010</year><article-title>Acute myocarditis in dengue hemorrhagic fever: A case report and review of cardiac complications in dengue-affected patients.</article-title><source>Int J Infect Dis</source><volume>14</volume><issue>10</issue><fpage>e919</fpage><lpage>e922</lpage><pub-id pub-id-type="pmid">20851651</pub-id></element-citation></ref><ref id="pntd.0001499-Salgado1"><label>56</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salgado</surname><given-names>DM</given-names></name><name><surname>Eltit</surname><given-names>JM</given-names></name><name><surname>Mansfield</surname><given-names>K</given-names></name><name><surname>Panqueba</surname><given-names>C</given-names></name><name><surname>Castro</surname><given-names>D</given-names></name><etal></etal></person-group><year>2010</year><article-title>Heart and skeletal muscle are targets of dengue virus infection.</article-title><source>Pediatr Infect Dis J</source><volume>29</volume><issue>3</issue><fpage>238</fpage><lpage>242</lpage><pub-id pub-id-type="pmid">20032806</pub-id></element-citation></ref><ref id="pntd.0001499-Carapetis3"><label>57</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carapetis</surname><given-names>JR</given-names></name><name><surname>Zuhlke</surname><given-names>LJ</given-names></name></person-group><year>2011</year><article-title>Global research priorities in rheumatic fever and rheumatic heart disease.</article-title><source>Ann Pediatr Card</source><volume>4</volume><issue>1</issue><fpage>4</fpage><lpage>12</lpage></element-citation></ref><ref id="pntd.0001499-Yacoub3"><label>58</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yacoub</surname><given-names>S</given-names></name><name><surname>Kotit</surname><given-names>S</given-names></name><name><surname>Mocumbi</surname><given-names>AO</given-names></name><name><surname>Yacoub</surname><given-names>MH</given-names></name></person-group><year>2008</year><article-title>Neglected diseases in cardiology: a call for urgent action.</article-title><source>Nat Clin Pract Cardiovasc Med</source><volume>5</volume><issue>4</issue><fpage>176</fpage><lpage>177</lpage><pub-id pub-id-type="pmid">18317476</pub-id></element-citation></ref><ref id="pntd.0001499-Centers1"><label>59</label><element-citation publication-type="other"><collab>Centers for Disease Control and Prevention</collab><year>2010</year><article-title>Chagas disease - resources for health professionals - diagnosis.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/parasites/chagas/health_professionals/dx.html">http://www.cdc.gov/parasites/chagas/health_professionals/dx.html</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Bukhman2"><label>60</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bukhman</surname><given-names>G</given-names></name><name><surname>Kidder</surname><given-names>A</given-names></name></person-group><year>2008</year><article-title>Cardiovascular disease and global health equity: lessons from tuberculosis control then and now.</article-title><source>Am J Public Health</source><volume>98</volume><fpage>44</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">18048779</pub-id></element-citation></ref><ref id="pntd.0001499-Bukhman3"><label>61</label><element-citation publication-type="other"><person-group person-group-type="editor"><name><surname>Bukhman</surname><given-names>G</given-names></name><name><surname>Kidder</surname><given-names>A</given-names></name></person-group><year>2010</year><article-title>The Partners In Health guide to chronic care integration for endemic non-communicable diseases - Rwanda edition. Partners In Health.</article-title><comment>eds. (</comment><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.pih.org/publications/entry/the-pih-guide-to-chronic-care-integration-for-endemic-ncd">http://www.pih.org/publications/entry/the-pih-guide-to-chronic-care-integration-for-endemic-ncd</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Hotez4"><label>62</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Pecoul</surname><given-names>B</given-names></name></person-group><year>2010</year><article-title>“Manifesto” for advancing the control and elimination of neglected tropical diseases.</article-title><source>PLoS Negl Trop Dis</source><volume>4</volume><issue>5</issue><fpage>e718</fpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pntd.0000718">10.1371/journal.pntd.0000718</ext-link></comment><pub-id pub-id-type="pmid">20520793</pub-id></element-citation></ref><ref id="pntd.0001499-LannesVieira1"><label>63</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lannes-Vieira</surname><given-names>J</given-names></name><name><surname>de Araújo-Jorge</surname><given-names>TC</given-names></name><name><surname>de Nazaré Correia Soeiro</surname><given-names>M</given-names></name><name><surname>Gadelha</surname><given-names>P</given-names></name><name><surname>Corrêa-Oliveira</surname><given-names>R</given-names></name></person-group><year>2010</year><article-title>The centennial of the discovery of chagas disease: facing the current challenges.</article-title><source>PLoS Negl Trop Dis</source><volume>4</volume><issue>6</issue><fpage>e645</fpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1371/journal.pntd.0000645">10.1371/journal.pntd.0000645</ext-link></comment><pub-id pub-id-type="pmid">20614014</pub-id></element-citation></ref><ref id="pntd.0001499-Hotez5"><label>64</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Dumonteil</surname><given-names>E</given-names></name><name><surname>Heffernan</surname><given-names>MJ</given-names></name><name><surname>Bottazzi</surname><given-names>ME</given-names></name></person-group><article-title>Innovation for the “bottom billion”: eliminating neglected tropical diseases in the Americas through mass drug administration and new vaccines for hookworm and Chagas disease.</article-title><source>Adv Exp Med Biol</source><comment>In press</comment></element-citation></ref><ref id="pntd.0001499-Aeras1"><label>65</label><element-citation publication-type="other"><collab>Aeras Global TB Vaccine Foundation</collab><year>2010</year><article-title>Aeras annual report 2011: answering the call for a TB free world.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.aeras.org/annualreport2010/">http://www.aeras.org/annualreport2010/</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-Kaufmann1"><label>66</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kaufmann</surname><given-names>SHE</given-names></name></person-group><year>2000</year><article-title>Is the development of a new tuberculosis vaccine possible?</article-title><source>Nat Med</source><volume>6</volume><issue>9</issue><fpage>955</fpage><lpage>960</lpage><pub-id pub-id-type="pmid">10973302</pub-id></element-citation></ref><ref id="pntd.0001499-Tenter1"><label>67</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tenter</surname><given-names>AM</given-names></name><name><surname>Heckeroth</surname><given-names>AR</given-names></name><name><surname>Weiss</surname><given-names>LM</given-names></name></person-group><year>2000</year><article-title>Toxoplasma gondii: from animals to humans.</article-title><source>Int J Parasitol</source><volume>30</volume><issue>12–13</issue><fpage>1217</fpage><lpage>1258</lpage><pub-id pub-id-type="pmid">11113252</pub-id></element-citation></ref><ref id="pntd.0001499-LongoMbenza1"><label>68</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Longo-Mbenza</surname><given-names>B</given-names></name><name><surname>Seghers</surname><given-names>KV</given-names></name><name><surname>Phuati</surname><given-names>M</given-names></name><name><surname>Nkiabungu Bikangi</surname><given-names>F</given-names></name><name><surname>Mubagwa</surname><given-names>K</given-names></name></person-group><year>1998</year><article-title>Heart involvement and HIV infection in African patients: determinants of survival.</article-title><source>Int J Cardiol</source><volume>64</volume><issue>1</issue><fpage>63</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">9579818</pub-id></element-citation></ref><ref id="pntd.0001499-Hotez6"><label>69</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hotez</surname><given-names>PJ</given-names></name><name><surname>Molyneux</surname><given-names>DH</given-names></name><name><surname>Fenwick</surname><given-names>A</given-names></name><name><surname>Kumaresan</surname><given-names>J</given-names></name><name><surname>Sachs</surname><given-names>SE</given-names></name><etal></etal></person-group><year>2007</year><article-title>Control of neglected tropical diseases.</article-title><source>N Engl J Med</source><volume>357</volume><issue>10</issue><fpage>1018</fpage><lpage>1027</lpage><pub-id pub-id-type="pmid">17804846</pub-id></element-citation></ref><ref id="pntd.0001499-Harrison1"><label>70</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harrison</surname><given-names>LW</given-names></name></person-group><year>1956</year><article-title>The Oslo study of untreated syphilis, review and commentary.</article-title><source>Br J Vener Dis</source><volume>32</volume><issue>2</issue><fpage>70</fpage><lpage>78</lpage><comment>doi:<ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1136/sti.32.2.70">10.1136/sti.32.2.70</ext-link></comment><pub-id pub-id-type="pmid">13355994</pub-id></element-citation></ref><ref id="pntd.0001499-World6"><label>71</label><element-citation publication-type="other"><collab>World Health Organization</collab><year>1999</year><article-title>The world health report 1999 - making a difference.</article-title><comment>Available: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/whr/1999/en/index.html">http://www.who.int/whr/1999/en/index.html</ext-link>. Accessed 25 May 2012</comment></element-citation></ref><ref id="pntd.0001499-No1"><label>72</label><element-citation publication-type="journal"><collab>[No authors listed]</collab><year>2000</year><article-title>TDR research on dengue: recommendations of a scientific working group. June 2000.</article-title><source>TDR News</source><issue>62</issue><fpage>3, 15</fpage><pub-id pub-id-type="pmid">12296148</pub-id></element-citation></ref><ref id="pntd.0001499-Khongphatthanayothin1"><label>73</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khongphatthanayothin</surname><given-names>A</given-names></name><name><surname>Lertsapcharoen</surname><given-names>P</given-names></name><name><surname>Supachokchaiwattana</surname><given-names>P</given-names></name><name><surname>La-orkhun</surname><given-names>V</given-names></name><name><surname>Khumtonvong</surname><given-names>A</given-names></name><etal></etal></person-group><year>2007</year><article-title>Myocardial depression in dengue hemorrhagic fever: prevalence and clinical description.</article-title><source>Pediatr Crit Care Med</source><volume>8</volume><issue>6</issue><fpage>524</fpage><lpage>529</lpage><pub-id pub-id-type="pmid">17906598</pub-id></element-citation></ref><ref id="pntd.0001499-Eisenberg1"><label>74</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eisenberg</surname><given-names>MJ</given-names></name></person-group><year>1993</year><article-title>Rheumatic heart disease in the developing world: prevalence, prevention, and control.</article-title><source>Eur Heart J</source><volume>14</volume><issue>1</issue><fpage>122</fpage><lpage>128</lpage><pub-id pub-id-type="pmid">8432279</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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