Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa
Identifieur interne : 002861 ( Pmc/Corpus ); précédent : 002860; suivant : 002862Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa
Auteurs : Motasim Badri ; Gary Maartens ; Sundhiya Mandalia ; Linda-Gail Bekker ; John R. Penrod ; Robert W. Platt ; Robin Wood ; Eduard J. BeckSource :
- PLoS Medicine [ 1549-1277 ] ; 2005.
Abstract
Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices.
Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3) and 27 with AIDS (WHO stage 4) receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group). Costs of service provision (January 2004 prices, US$1 = 7.6 Rand) included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY), whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS.
For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97–1.19) for the HAART group versus 3.73 (95% CI: 3.55–3.97) for the No-ART group, and 8.71 (95% CI: 8.40–9.03) versus 4.35 (95% CI: 4.12–5.61), respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG) was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63–2.52) for the HAART versus 15.36 (95% CI: 13.97–16.85) for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81–8.49) compared with 6.60 (95% CI: 5.69–7.62) respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per LYG was cost saving for both scenarios. In a sensitivity analysis based on the lower (25%) and upper (75%) interquartile range survival percentiles, the incremental cost per LYG ranged from $1,557 to $1,772 for the group without AIDS and from cost saving to $111 for patients with AIDS.
HAART is a cost-effective intervention in South Africa, and cost saving when HAART prices are further reduced. Our estimates, however, were based on direct costs, and as such the actual cost saving might have been underestimated if indirect costs were also included.
Url:
DOI: 10.1371/journal.pmed.0030004
PubMed: 16318413
PubMed Central: 1298940
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PMC:1298940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa</title><author><name sortKey="Badri, Motasim" sort="Badri, Motasim" uniqKey="Badri M" first="Motasim" last="Badri">Motasim Badri</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mandalia, Sundhiya" sort="Mandalia, Sundhiya" uniqKey="Mandalia S" first="Sundhiya" last="Mandalia">Sundhiya Mandalia</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Bekker, Linda Gail" sort="Bekker, Linda Gail" uniqKey="Bekker L" first="Linda-Gail" last="Bekker">Linda-Gail Bekker</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Penrod, John R" sort="Penrod, John R" uniqKey="Penrod J" first="John R" last="Penrod">John R. Penrod</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Platt, Robert W" sort="Platt, Robert W" uniqKey="Platt R" first="Robert W" last="Platt">Robert W. Platt</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Wood, Robin" sort="Wood, Robin" uniqKey="Wood R" first="Robin" last="Wood">Robin Wood</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Beck, Eduard J" sort="Beck, Eduard J" uniqKey="Beck E" first="Eduard J" last="Beck">Eduard J. Beck</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16318413</idno><idno type="pmc">1298940</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298940</idno><idno type="RBID">PMC:1298940</idno><idno type="doi">10.1371/journal.pmed.0030004</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">002861</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002861</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa</title><author><name sortKey="Badri, Motasim" sort="Badri, Motasim" uniqKey="Badri M" first="Motasim" last="Badri">Motasim Badri</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Maartens, Gary" sort="Maartens, Gary" uniqKey="Maartens G" first="Gary" last="Maartens">Gary Maartens</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mandalia, Sundhiya" sort="Mandalia, Sundhiya" uniqKey="Mandalia S" first="Sundhiya" last="Mandalia">Sundhiya Mandalia</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Bekker, Linda Gail" sort="Bekker, Linda Gail" uniqKey="Bekker L" first="Linda-Gail" last="Bekker">Linda-Gail Bekker</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Penrod, John R" sort="Penrod, John R" uniqKey="Penrod J" first="John R" last="Penrod">John R. Penrod</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Platt, Robert W" sort="Platt, Robert W" uniqKey="Platt R" first="Robert W" last="Platt">Robert W. Platt</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Wood, Robin" sort="Wood, Robin" uniqKey="Wood R" first="Robin" last="Wood">Robin Wood</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Beck, Eduard J" sort="Beck, Eduard J" uniqKey="Beck E" first="Eduard J" last="Beck">Eduard J. Beck</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS Medicine</title><idno type="ISSN">1549-1277</idno><idno type="eISSN">1549-1676</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background</title><p>Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices.</p></sec><sec id="st2"><title>Methods and Findings</title><p>Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3) and 27 with AIDS (WHO stage 4) receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group). Costs of service provision (January 2004 prices, US$1 = 7.6 Rand) included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY), whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS.</p><p>For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97–1.19) for the HAART group versus 3.73 (95% CI: 3.55–3.97) for the No-ART group, and 8.71 (95% CI: 8.40–9.03) versus 4.35 (95% CI: 4.12–5.61), respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG) was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63–2.52) for the HAART versus 15.36 (95% CI: 13.97–16.85) for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81–8.49) compared with 6.60 (95% CI: 5.69–7.62) respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per LYG was cost saving for both scenarios. In a sensitivity analysis based on the lower (25%) and upper (75%) interquartile range survival percentiles, the incremental cost per LYG ranged from $1,557 to $1,772 for the group without AIDS and from cost saving to $111 for patients with AIDS.</p></sec><sec id="st3"><title>Conclusion</title><p>HAART is a cost-effective intervention in South Africa, and cost saving when HAART prices are further reduced. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Med</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Med</journal-id><journal-id journal-id-type="publisher-id">pmed</journal-id><journal-id journal-id-type="pmc">plosmed</journal-id><journal-title-group><journal-title>PLoS Medicine</journal-title></journal-title-group><issn pub-type="ppub">1549-1277</issn><issn pub-type="epub">1549-1676</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16318413</article-id><article-id pub-id-type="pmc">1298940</article-id><article-id pub-id-type="doi">10.1371/journal.pmed.0030004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline"><subject>Infectious Diseases</subject><subject>Epidemiology/Public Health</subject><subject>Health Economics</subject><subject>Health Policy</subject><subject>HIV/AIDS</subject><subject>Sexual Health</subject></subj-group><subj-group subj-group-type="System Taxonomy"><subject>HIV Infection/AIDS</subject><subject>Medicine in Developing Countries</subject><subject>Health Economics</subject><subject>Chronic Disease Management</subject><subject>Resource allocation and rationing</subject></subj-group></article-categories><title-group><article-title>Cost-Effectiveness of Highly Active Antiretroviral Therapy in South Africa</article-title><alt-title alt-title-type="running-head">Cost-Effectiveness of HAART in RSA</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Badri</surname><given-names>Motasim</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Maartens</surname><given-names>Gary</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mandalia</surname><given-names>Sundhiya</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bekker</surname><given-names>Linda-Gail</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Penrod</surname><given-names>John R</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Platt</surname><given-names>Robert W</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Wood</surname><given-names>Robin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Beck</surname><given-names>Eduard J</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib></contrib-group><aff id="aff1"><bold>1</bold>Department of Medicine, Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa</aff><aff id="aff2"><bold>2</bold>Department of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa</aff><aff id="aff3"><bold>3</bold>NPMS-HHC Coordination and Analytic Centre, Chelsea and Westminster Hospital, London, United Kingdom</aff><aff id="aff4"><bold>4</bold>Department of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom</aff><aff id="aff5"><bold>5</bold>Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada</aff><aff id="aff6"><bold>6</bold>Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada</aff><contrib-group><contrib contrib-type="editor"><name><surname>Carr</surname><given-names>Andrew</given-names></name><role>Academic Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><institution>St. Vincent's Hospital</institution><country>Australia</country></aff><author-notes><corresp id="n1">*To whom correspondence should be addressed. E-mail: <email>motasim.badri@hiv-research.org.za</email></corresp><fn id="n2" fn-type="COI-statement"><p><bold>Competing Interests:</bold> Study was funded by Secure the Future, Bristol-Myers Squibb, through an unrestricted educational grant.</p></fn><fn id="n3" fn-type="con"><p><bold>Author Contributions:</bold> MB, GM, SM, LB, JRP, RWP, RW, and EJB contributed to the conceptualization of the study. MB, GM, SM, RW, and EJB designed the study. GM, LB, and RW enrolled patients. MB and SM performed the statistical analysis. MB wrote the first draft of the paper. All authors contributed to the writing of the final version of the manuscript.</p></fn></author-notes><pub-date pub-type="ppub"><month>1</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>6</day><month>12</month><year>2005</year></pub-date><volume>3</volume><issue>1</issue><elocation-id>e4</elocation-id><history><date date-type="received"><day>17</day><month>5</month><year>2005</year></date><date date-type="accepted"><day>27</day><month>9</month><year>2005</year></date></history><permissions><copyright-statement>Copyright: © 2006 Badri et al.</copyright-statement><copyright-year>2006</copyright-year><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><related-article id="d35e256" related-article-type="companion" ext-link-type="doi" xlink:href="10.1371/journal.pmed.0030037" xlink:title="synopsis" vol="3" page="e37"><article-title>HAART: A Cost-Effective Option for South Africa</article-title></related-article><abstract><sec id="st1"><title>Background</title><p>Little information exists on the impact of highly active antiretroviral therapy (HAART) on health-care provision in South Africa despite increasing scale-up of access to HAART and gradual reduction in HAART prices.</p></sec><sec id="st2"><title>Methods and Findings</title><p>Use and cost of services for 265 HIV-infected adults without AIDS (World Health Organization [WHO] stage 1, 2, or 3) and 27 with AIDS (WHO stage 4) receiving HAART between 1995 and 2000 in Cape Town were compared with HIV-infected controls matched for baseline WHO stage, CD4 count, age, and socioeconomic status, who did not receive antiretroviral therapy (ART; No-ART group). Costs of service provision (January 2004 prices, US$1 = 7.6 Rand) included local unit costs, and two scenarios for HAART prices for WHO recommended first-line regimens: scenario 1 used current South African public-sector ART drug prices of $730 per patient-year (PPY), whereas scenario 2 was based on the anticipated public-sector price for locally manufactured drug of $181 PPY. All analyses are presented in terms of patients without AIDS and patients with AIDS.</p><p>For patients without AIDS, the mean number of inpatient days PPY was 1.08 (95% confidence interval [CI]: 0.97–1.19) for the HAART group versus 3.73 (95% CI: 3.55–3.97) for the No-ART group, and 8.71 (95% CI: 8.40–9.03) versus 4.35 (95% CI: 4.12–5.61), respectively, for mean number of outpatient visits PPY. Average service provision PPY was $950 for the No-ART group versus $1,342 and $793 PPY for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per life-year gained (LYG) was $1,622 for scenario 1 and $675 for scenario 2. For patients with AIDS, mean inpatients days PPY was 2.04 (95% CI: 1.63–2.52) for the HAART versus 15.36 (95% CI: 13.97–16.85) for the No-ART group. Mean outpatient visits PPY was 7.62 (95% CI: 6.81–8.49) compared with 6.60 (95% CI: 5.69–7.62) respectively. Average service provision PPY was $3,520 for the No-ART group versus $1,513 and $964 for the HAART group for scenario 1 and 2, respectively, whereas the incremental cost per LYG was cost saving for both scenarios. In a sensitivity analysis based on the lower (25%) and upper (75%) interquartile range survival percentiles, the incremental cost per LYG ranged from $1,557 to $1,772 for the group without AIDS and from cost saving to $111 for patients with AIDS.</p></sec><sec id="st3"><title>Conclusion</title><p>HAART is a cost-effective intervention in South Africa, and cost saving when HAART prices are further reduced. Our estimates, however, were based on direct costs, and as such the actual cost saving might have been underestimated if indirect costs were also included.</p></sec></abstract><abstract abstract-type="toc"><p>Healthcare costs for HIV-infected South African adults on HAART compared with costs for HIV-infected controls not on HAART. Authors conclude HAART is cost effective.</p></abstract></article-meta></front><body><sec id="s1"><title>Introduction</title><p>South Africa is experiencing an HIV epidemic with enormous social and economic consequences. Recent estimates suggest that between 4.5 and 6.2 million of the 43 million South Africans are infected with HIV-1 [<xref rid="pmed-0030004-b001" ref-type="bibr">1</xref>]. There were 370,000 AIDS deaths during 2003 [<xref rid="pmed-0030004-b001" ref-type="bibr">1</xref>], and the cumulative projected AIDS mortality for 2010 is 4–7 million in absence of a highly active antiretroviral therapy (HAART) programme [<xref rid="pmed-0030004-b002" ref-type="bibr">2</xref>]. The largest impact of HIV on the public health sector lies in the hospital sector [<xref rid="pmed-0030004-b003" ref-type="bibr">3</xref>]. In the year 2000, HIV-related admissions amounted to 24% of all public hospital admissions [<xref rid="pmed-0030004-b004" ref-type="bibr">4</xref>] and 12.5% of the total public health budget [<xref rid="pmed-0030004-b005" ref-type="bibr">5</xref>]. Cost of inpatient and ambulatory health care of both private and public health-care sectors is expected to rise rapidly [<xref rid="pmed-0030004-b005" ref-type="bibr">5</xref>].</p><p>The cost-effectiveness of HAART, in terms of reducing HIV-related morbidity and mortality, has been documented in industrialized countries [<xref rid="pmed-0030004-b006" ref-type="bibr">6</xref>–<xref rid="pmed-0030004-b012" ref-type="bibr">12</xref>]. The introduction of combination HAART into routine clinical care in these countries has been associated with a shift from inpatient to outpatient-based hospital care [<xref rid="pmed-0030004-b011" ref-type="bibr">11</xref>–<xref rid="pmed-0030004-b017" ref-type="bibr">17</xref>]. Until recently the prevailing assumption was that the public sector of the South African health-care system was unable to afford the introduction of antiretroviral therapy (ART) in routine clinical care. However, the government of South Africa recently announced its commitment towards creating the necessary conditions for introducing ART into the public health sector [<xref rid="pmed-0030004-b018" ref-type="bibr">18</xref>]. In addition, the price of HAART for resource-poor countries decreased markedly since the year 2000 [<xref rid="pmed-0030004-b019" ref-type="bibr">19</xref>,<xref rid="pmed-0030004-b020" ref-type="bibr">20</xref>]. The South African Department of Health has recently awarded contracts for the supply of ART drugs to public health facilities countrywide to international pharmaceutical companies [<xref rid="pmed-0030004-b021" ref-type="bibr">21</xref>]. This tender is expected to reduce HAART price to $181 per patient-year (PPY).</p><p>The aim of this study was to compare use and cost of HIV-1–related service provision between patients receiving HAART and a comparison group not receiving ART, and assess the cost effectiveness of HAART.</p></sec><sec id="s2"><title>Methods</title><sec id="s2a"><title>Study Population</title><p>This study was based on the Cape Town AIDS Cohort (
CTAC); a prospective cohort study which has been described previously [<xref rid="pmed-0030004-b022" ref-type="bibr">22</xref>,<xref rid="pmed-0030004-b023" ref-type="bibr">23</xref>]. In brief, patients of this cohort were accrued from the HIV clinics affiliated to the University of Cape Town, who were referred from a wide range of primary HIV health-care providers. During the study period 1st January 1995 to 31st December 2000, HAART was not available in the publicly funded South African health-care sector. All patients in this study accessed HAART through the participation in the international HAART multicentre phase III clinical trials, as approved by the Research Ethics Committee of the University of Cape Town.
</p><p>For the purpose of this study, all patients who participated in the clinical trials and received at least three ART drugs—a non-nucleoside reverse transcriptase inhibitor or protease inhibitor together with two nucleoside analogues or three nucleoside analogues—were included as the treated arm of the study (HAART group). Patients were excluded from the clinical trials if they were active injecting-drug users, were diagnosed with an acute opportunistic infection at the time of recruitment, were reported to have significant laboratory abnormalities, or if they were treated with immune-modulating or systemic chemotherapeutic agents. Lactating or pregnant women were also excluded. The trial visit schedule was usually at weeks 2, 4, and 8 and then every two to three months thereafter.</p><p>Patients who did not participate in these clinical trials and never had access to ART throughout the study period (No-ART group) but received other HIV-related care were the sample from which a “comparator” group was identified for the HAART group.</p><p>At each clinic visit, all patients were routinely examined for HIV related manifestations and staged using the World Health Organization (WHO) clinical HIV staging system [<xref rid="pmed-0030004-b024" ref-type="bibr">24</xref>]. HIV-1 infection was diagnosed by enzyme-linked immunosorbent assay (ELISA) tests and confirmed by Western blot or a second enzyme-linked immunosorbent assay test. Viral load (which was available only for the HAART group) was determined by reverse transcriptase-polymerase chain reaction (Amplicor; Roche Molecular Systems, Branchburg, New Jersey, United States) and CD4<sup>+</sup> count, measured by flow cytometry (Beckman Coulter, Miami, Florida, United States).</p></sec><sec id="s2b"><title>Analysis</title><p>This analysis calculated the use and cost of HIV service provision and compared the clinical outcome, in terms of disease progression or life year gained (LYG) by clinical stage of HIV infection, between patients receiving HAART and a matched comparison group who did not receive ART (No-ART group). Patients were classified as either being non-AIDS (WHO stages 1, 2, or 3) or AIDS (WHO stage 4) patients.</p><p>Several strategies were employed to ensure that the two groups studied were clinically, immunologically, and socioeconomically similar and matched for the same variables used to recruit the HAART group into the clinical trials. Logistic regression models were fitted to identify factors associated with receiving HAART in this cohort using SAS GENMODE procedure with logit link function and binomial error distribution [<xref rid="pmed-0030004-b025" ref-type="bibr">25</xref>]. HAART patients were individually matched with randomly selected No-ART patients on the basis of variables independently associated with the likelihood of receiving HAART. The socioeconomic status of each patient was classified into “low” or “high”, using a composite index developed by the Cape Metropolitan Council [<xref rid="pmed-0030004-b026" ref-type="bibr">26</xref>]. A subgroup logistic regression analysis was performed for the HAART group, to examine whether the likelihood of hospitalisation differed by HAART class.</p><p>To examine for residual confounding, the matched case–control data were analysed using a conditional logistic regression model, stratified by matching variables. The model was fitted using the SAS PHREG procedure with discrete logistic model. All data analyses were performed in SAS version 8.02. χ<sup>2</sup> was used to compare categorical variables, and the non-parametric median test was used to compare continuous non-normally distributed variables. All <italic>p-</italic>values quoted are two sided, with a <italic>p-</italic>value < 0.05 considered as significant.</p></sec><sec id="s2c"><title>Use and Cost of Services</title><p>Information on inpatient and outpatient care was obtained from the computerized hospital information systems supplemented by case notes. The mean number of inpatient days and outpatient visits PPY were calculated for the non-AIDS (WHO stage 1, 2, and 3) and AIDS (WHO stage 4) WHO clinical stages for both HAART and No-ART groups. A patient-year was defined as 365.25 days of follow up and methods used for calculating the mean use of services were similar to those used in other studies [<xref rid="pmed-0030004-b012" ref-type="bibr">12</xref>,<xref rid="pmed-0030004-b016" ref-type="bibr">16</xref>,<xref rid="pmed-0030004-b017" ref-type="bibr">17</xref>,<xref rid="pmed-0030004-b027" ref-type="bibr">27</xref>]. The denominator consisted of the total duration of follow up for all patients seen during the study period and numerators were calculated by summing the use of each service. Mean and 95% confidence intervals (CI) of inpatient and outpatient service use PPY by WHO stage were calculated for the two groups using the binomial distribution, and were compared between the two groups by calculating the odds ratio (OR) of the use of inpatient and outpatient services, using the No-ART group as a reference group.</p><p>The costs of hospital HIV service provision were calculated from a public health-care system perspective [<xref rid="pmed-0030004-b028" ref-type="bibr">28</xref>–<xref rid="pmed-0030004-b030" ref-type="bibr">30</xref>]. Unit costs were obtained from a detailedcosting study of HIV inpatient and outpatient care conducted in the year 2000 [<xref rid="pmed-0030004-b031" ref-type="bibr">31</xref>], and were adjusted for inflation to financial year 2004 prices using the South African Consumer Price Index [<xref rid="pmed-0030004-b032" ref-type="bibr">32</xref>]. Prices were converted from South African Rand to US dollars using the average exchange rate for 2004 (US dollars = 7.6 Rand) [<xref rid="pmed-0030004-b033" ref-type="bibr">33</xref>]. The unit cost was $215 for an inpatient day and $33 for an outpatient visit and included costs for tests including CD4 counts, procedures, and non-ART drug costs. The non-ART drugs included all drugs other than ART dispensed to the patients during the course of care, including treatment and prophylaxis for opportunistic infections. Mean inpatient days and outpatient visits PPY were multiplied by their respective unit costs to estimate the PPY cost of service provision.</p><p>ART prices used in this study are those currently available to the public health-care sector (Ministry of Health, Provincial Administration of the Western Cape). HAART drug-price scenarios presented were (1) present public sector prices, which amounted to $730 per annum, and (2) anticipated public sector price for locally manufactured drugs, which amounted to $181 per annum, for the WHO-recommended regimen for resource-limited settings [<xref rid="pmed-0030004-b034" ref-type="bibr">34</xref>].</p><p>To estimate the total cost of service provision PPY for HAART patients for the two scenarios, average ART drug costs PPY were added to the average inpatient and outpatient PPY costs. In sensitivity analysis, minimum and maximum ART drug PPY costs for the two scenarios were also added to the lower and upper limit of the 95% CI: inpatient and outpatient PPY cost of care to provide a range of costs. Viral load was not measured for the No-ART group because it was not available in publicly funded institutions during the study period and, therefore, PPY cost of viral-load investigation of $79 (D. Roditti, personal communication) was only added to the annual cost of service provision for the HAART group.</p></sec><sec id="s2d"><title>Cost of LYG by WHO Stage of HIV Infection</title><p>Progression times were calculated from date of entry into non-AIDS (WHO stage 1, 2, or 3) to date of progression to AIDS (WHO stage 4) or death, and from initial diagnosis of AIDS (WHO stage 4) to death for AIDS patients. Patients not known to have progressed during follow-up were censored at either the most recent visit to the clinic or when lost to follow-up. Median progression times were estimated using the product-limit Kaplan-Meier survival method, and these were compared for the HAART and No-ART groups using log-rank test. Due to the small number of individuals who progressed during the follow-up period, median and interquartile ranges (IQR) for time to progression to AIDS or death were extrapolated from the product-limit time to failure estimates using the maximum likelihood least squares method. The progression-free times for non-AIDS and AIDS patients for each group were multiplied by the average PPY cost of service provision, and the additional life years gained of non-AIDS and AIDS groups was calculated as the incremental cost per LYG, based on the difference in the estimated median progression times of the two groups [<xref rid="pmed-0030004-b027" ref-type="bibr">27</xref>].</p><p>Because discounting health benefits remains controversial [<xref rid="pmed-0030004-b035" ref-type="bibr">35</xref>], only non-discounted estimates are presented. However, given the relatively short time in each WHO stage, it is unlikely that an analysis with a non-zero discount rate would yield qualitatively different results than those presented here.</p></sec><sec id="s2e"><title>Sensitivity Analysis</title><p>Robustness of results was assessed in a sensitivity analysis; accounting for variances associated with treatment effects and total cost of service provision. IQRs between the lower (25%) and upper (75%) progression-free times percentiles of the non-AIDS and AIDS patients were multiplied by the average and 95% CI of the cost of service provision, and the incremental cost per LYG was calculated.</p></sec></sec><sec id="s3"><title>Results</title><sec id="s3a"><title>Study Sample</title><p>Of the 1,630 patients in the cohort, 292 patients (265 non-AIDS and 27 with AIDS) received HAART through participation in the clinical trials. The rest of the patients (<italic>n</italic> = 1,328; 1,093 non-AIDS and 235 with AIDS) did not have access to ART during the study period and comprised the population from which the No-ART comparator group for the 292 patients who received HAART was identified. Baseline CD4 count, WHO stage, age, and socioeconomic status were independently associated with the likelihood of receiving HAART (<xref ref-type="table" rid="pmed-0030004-t001">Table 1</xref>), but gender was not, and therefore this variable was not considered in further analyses. Matching was therefore based on WHO stage, CD4 count (<200, 200–350, and >350 cells/μl), age (less than the median age or equal to the median age or greater of the non-AIDS and AIDS groups respectively) and socioeconomic status (low or high socioeconomic status).</p><table-wrap id="pmed-0030004-t001" position="float"><label>Table 1</label><caption><title>Univariate and Multivariate Logistic Regression Analyses of Factors Associated with the Likelihood of Receiving HAART</title></caption><graphic xlink:href="pmed.0030004.t001"></graphic></table-wrap><p>HAART drug classes were not independently associated with increased risk of hospitalisation (<xref ref-type="table" rid="pmed-0030004-t002">Table 2</xref>) and were therefore analysed as one category. The characteristics of the final study population of the 292 patients who received HAART and the 292 matched No-ART patients are described in <xref ref-type="table" rid="pmed-0030004-t003">Table 3</xref>.</p><table-wrap id="pmed-0030004-t002" position="float"><label>Table 2</label><caption><title>Logistic Regression Analysis of Factors Associated with Hospitalisation among the Treated Group</title></caption><graphic xlink:href="pmed.0030004.t002"></graphic></table-wrap><table-wrap id="pmed-0030004-t003" position="float"><label>Table 3</label><caption><title>Baseline Demographic and Clinical Characteristics of the Matched Non-AIDS and AIDS Groups</title></caption><graphic xlink:href="pmed.0030004.t003"></graphic></table-wrap></sec><sec id="s3b"><title>The Non-AIDS Population (WHO Stage 1, 2, or 3)</title><p>The matched non-AIDS group included 265 patients both in the HAART and No-ART group. Approximately one-third of the patients in the two groups had a baseline CD4 count <200 cell/μl and (49.4%) were of low socioeconomic status. Median age at inclusion into study did not differ in the two groups; 32 y, [IQR: 28–39 y] in the HAART group versus 32 y [IQR: 28–40 y] in the No-ART group (median test <italic>p</italic> = 0.48). Although not matched for, gender distribution did not differ statistically in the two groups (χ<sup>2</sup> = 0.07, <italic>p</italic> = 0.79; <xref ref-type="table" rid="pmed-0030004-t003">Table 3</xref>). Median progression time was significantly longer in the HAART group compared with the No-ART group at 4.1 and 3.0 y respectively (log-rank test χ<sup>2</sup> = 36.6, <italic>p</italic> < 0.001; <xref ref-type="fig" rid="pmed-0030004-g001">Figure 1</xref>).</p><fig id="pmed-0030004-g001" position="float"><label>Figure 1</label><caption><title>Progression of HIV-Infected Individuals from Non-AIDS Stages (WHO Stage 1, 2, or 3) for Patients on HAART and Not on ART</title><p>The solid line indicates patients on HAART, and the dotted line indicates patients not on ART.</p></caption><graphic xlink:href="pmed.0030004.g001"></graphic></fig></sec><sec id="s3c"><title>Use and Cost of Services and Cost per LYG</title><p>Patients on HAART had 1.08 (95% CI: 0.97–1.19) mean inpatient days, significantly fewer than the 3.75 d (95% CI: 3.55–3.97) of the No-ART group; χ<sup>2</sup> = 147, OR = 0.29, 95% CI: 0.23–0.36, <italic>p</italic> < 0.001; but had significantly more outpatient visits of 8.71 (95% CI: 8.40–9.03) compared with 4.35 (95% CI: 4.12–5.61); χ<sup>2</sup> = 145, OR = 2.00, 95% CI: 1.78–2.25, <italic>p</italic> < 0.0001 (<xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>). The average PPY inpatient cost in the HAART group was significantly less than that for the No-ART group, while the average costs of outpatient visits PPY for the No-ART group were less than those for the HAART group (<xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>).</p><table-wrap id="pmed-0030004-t004" position="float"><label>Table 4</label><caption><title>Mean Number of Inpatient Days, Outpatient Visits, and Associated Cost<sup>a</sup> PPY</title></caption><graphic xlink:href="pmed.0030004.t004"></graphic></table-wrap><p>Based on the two HAART price scenarios, the average cost of service provision PPY for the HAART group ranged from a minimum of $760 to $1,377 PPY, with scenario 2 having the lowest service provision cost (<xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>). The incremental cost per LYG for median progression time was $1,622 (95% CI: 1,607–1,627) for scenario 1 and $675 (95% CI: 659–679) for scenario 2 (<xref ref-type="table" rid="pmed-0030004-t005">Table 5</xref>). When a sensitivity analysis was performed based on the IQR of the progression times, the incremental cost per LYG varied between $1,578 (95% CI: 1,557–1,581) and $1,759 (95% CI: 1,748–1,772) for the 25th and 75th percentiles respectively (<xref ref-type="table" rid="pmed-0030004-t005">Table 5</xref>).</p><table-wrap id="pmed-0030004-t005" position="float"><label>Table 5</label><caption><title>Incremental Cost-Effectiveness Ratio (US$) for Current ART Rollout Prices (US$730 Per Annum—Scenario 1) and Anticipated Tender Prices (US$181 Per Annum—Scenario 2), Comparing HAART and No-ART Groups for Non-AIDS and AIDS Groups at 25th, 50th (Median), and 75th Progression-Free Times Percentiles</title></caption><graphic xlink:href="pmed.0030004.t005"></graphic></table-wrap></sec><sec id="s3d"><title>The AIDS Population (WHO Stage 4)</title><p>The AIDS population included 27 patients in each group. The majority of patients in the two groups presented with a CD4 count <200 cell/μl (77%), and 40.74% were of low socioeconomic status. Median age did not differ in the two groups; 35 y (IQR: 32–41) in the HAART group versus 37 y (IQR: 33–50) in the No-ART group (median test <italic>p</italic> = 0.27). Gender distribution, with 63% and 70.4% males in the HAART and No-ART groups respectively, was not significantly different in the two groups (χ<sup>2</sup> = 0.33, <italic>p</italic> = 0.56) (see <xref ref-type="table" rid="pmed-0030004-t003">Table 3</xref>). Median progression time was significantly longer in the HAART group compared with the No-ART group; at 3.1 and 1.4 y respectively (log-rank χ<sup>2</sup> = 5.28, <italic>p</italic> = 0.02; <xref ref-type="fig" rid="pmed-0030004-g002">Figure 2</xref>).</p><fig id="pmed-0030004-g002" position="float"><label>Figure 2</label><caption><title>Progression of HIV-Infected Individuals from WHO Stage 4 for Patients on HAART and Not on ART</title><p>The solid line indicates patients on HAART, and the dotted line indicates patients not on ART.</p></caption><graphic xlink:href="pmed.0030004.g002"></graphic></fig></sec><sec id="s3e"><title>Use and Cost of Services and Cost per LYG</title><p>Patients on HAART had significantly fewer mean PPY inpatient days at 2.04 d (95% CI: 1.63–2.52) compared with 15.36 d (95% CI: 13.97–16.85) for the No-ART group (χ<sup>2</sup> = 1,019, OR = 0.13, 95 CI: 0.11–0.15, <italic>p</italic> < 0.0001). Mean outpatient visits PPY in the two groups did differ significantly; at 7.62 (95% CI: 6.81–8.49) for the HAART group compared with 6.60 (95% CI: 5.69–7.62) for the No-ART group; χ<sup>2</sup> = 7.3, OR = 1.15, 95% CI: 1.04–1.28, <italic>p</italic> = 0.007, though not as substantially as for the non-AIDS group (see <xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>). The average inpatient cost PPY in the HAART group was significantly less than that for the No-ART group, but the average costs of outpatient visits PPY in the groups were not significantly (see <xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>).</p><p>Based on the two HAART price scenarios, the average cost of service provision PPY for the HAART group ranged from a minimum of $850 to $1,645 PPY, with the lowest care cost observed for scenario 2 (see <xref ref-type="table" rid="pmed-0030004-t004">Table 4</xref>). For patients diagnosed with AIDS, the incremental cost per LYG for the median progression time was cost saving for both HAART price scenarios (<xref ref-type="table" rid="pmed-0030004-t005">Table 5</xref>). When a sensitivity analysis was performed based on the IQR of the progression times, the incremental cost per LYG varied between $71 (95% CI: 43–111) and cost saving for the 25th and 75th progression-free time percentiles respectively (<xref ref-type="table" rid="pmed-0030004-t005">Table 5</xref>).</p></sec></sec><sec id="s4"><title>Discussion</title><p>This study, employing methods used in similar studies from industrialized countries [<xref rid="pmed-0030004-b027" ref-type="bibr">27</xref>], provides a unique contemporaneous comparison of the use, cost, and outcome of hospital service provision for a group of HIV-infected patients in Cape Town receiving HAART compared with an immunologically, clinically, and socioeconomically similar group of patients who did not receive ART. Use of HAART was associated with decreased disease progression, AIDS, and death. The HAART group used fewer inpatient services than the No-ART group, and the magnitude of these changes did not differ by HAART regimens used in this study. The reduction in use of inpatient services, which has been observed in similar studies in industrialized countries [<xref rid="pmed-0030004-b010" ref-type="bibr">10</xref>–<xref rid="pmed-0030004-b015" ref-type="bibr">15</xref>], was most likely due to a reduction in morbidity and mortality [<xref rid="pmed-0030004-b006" ref-type="bibr">6</xref>,<xref rid="pmed-0030004-b012" ref-type="bibr">12</xref>]. The use of services increased for both groups with increased severity of HIV infection, resulting in an increased cost of service provision. The increased use of inpatient services for patients with AIDS is most likely related to AIDS-related events or their terminal phase of their illness [<xref rid="pmed-0030004-b036" ref-type="bibr">36</xref>–<xref rid="pmed-0030004-b041" ref-type="bibr">41</xref>]. In Zimbabwe, medical insurance claims of privately insured HIV-infected patients in the last few months of their lives were 700% higher than that of uninfected patients in the same age group [<xref rid="pmed-0030004-b042" ref-type="bibr">42</xref>].</p><p>To date, very few cost-effectiveness studies have been performed on HAART in a South African setting [<xref rid="pmed-0030004-b043" ref-type="bibr">43</xref>]. The incremental cost per LYG ranged from being cost saving to $1,772. The cut-off point for what constitutes a cost-effective intervention per outcome measure varies from society to another. For instance, the cost-effective cut-off point in the United States is currently considered to be $50,000 per outcome measure and £30,000 in the United Kingdom [<xref rid="pmed-0030004-b030" ref-type="bibr">30</xref>]. To date such a consensus on what would constitute a realistic threshold for South Africa has not yet emerged, but a cut-off of twice the per capita gross domestic product (GDP) has been suggested as a reasonable cut-off point for developing countries [<xref rid="pmed-0030004-b044" ref-type="bibr">44</xref>]. For the year 2004, the per capita gross domestic product in South Africa was $3,480, and therefore this threshold would amount to $6,960 [<xref rid="pmed-0030004-b045" ref-type="bibr">45</xref>]. The cost per LYG of two HAART cost scenarios for the non-AIDS and AIDS patients showed that introducing HAART in this hospital setting would be a very cost-effective intervention. However, it is clear that the cost-effectiveness ratios were very sensitive to the price of HAART. If prices of the awarded tender could be achieved, the introduction of HAART will be a very cost-effective intervention in Cape Town and probably in similar settings in sub-Saharan Africa, because HIV accounts for between 40% and 70% of the public sector inpatient service provision in the region [<xref rid="pmed-0030004-b003" ref-type="bibr">3</xref>,<xref rid="pmed-0030004-b036" ref-type="bibr">36</xref>–<xref rid="pmed-0030004-b040" ref-type="bibr">40</xref>].</p><p>Concern has been expressed that increased access to HAART in sub-Saharan Africa will result in the widespread viral resistance due to poor adherence [<xref rid="pmed-0030004-b046" ref-type="bibr">46</xref>]. Studies performed in a number of sub-Saharan African countries, however, have shown that the proportion of individuals maintaining viral suppression is comparable to that reported from developed countries [<xref rid="pmed-0030004-b047" ref-type="bibr">47</xref>–<xref rid="pmed-0030004-b049" ref-type="bibr">49</xref>].</p><p>This study did have a number of limitations. Because HAART was not used in routine clinical practice, we had to compare a group of patients enrolled in clinical trials with a control group that was not part of the trials. Individuals who take part in clinical trials have to fulfil certain entry criteria, as well as to conform to well-defined protocols and scheduled attendances. It is therefore difficult to exclude the possibility that a selection bias might have resulted from the inclusion/exclusion criteria of these clinical trials. However, the No-ART control group was selected on the basis of clinical, socioeconomic, and immunologic characteristics similar to those individuals recruited into the HAART trials conducted in this study. The frequency of inpatient and outpatient services utilization of the HAART and No-ART patients in this study is similar to that reported by UK and Canadian observational studies [<xref rid="pmed-0030004-b012" ref-type="bibr">12</xref>,<xref rid="pmed-0030004-b027" ref-type="bibr">27</xref>]. However, in this study, the sample is relatively small for the AIDS group.</p><p>This study was focused on hospital services provided at the level of a teaching hospital. Therefore the costs incurred through primary, community, or secondary hospital care were not included, but this reflected the configuration of services available to the majority of HIV-infected people in Cape Town at the time of the study. Similarly, the costs included were direct costs only and did not incorporate the indirect or intangible costs, such as loss of productivity or quality of life associated with this illness, because currently no such data exist in South Africa. Some studies from the United Kingdom have demonstrated that from a public sector perspective, indirect costs can comprise between 58% and 124% of direct treatment costs for HAART or between 45% and 102% from a societal perspective [<xref rid="pmed-0030004-b030" ref-type="bibr">30</xref>]. If these costs were all included, it is likely that the cost-effectiveness ratio would even be more favourable. Our estimates did not incorporate the costs of providing the infrastructure required to support appropriate HAART provision in rollout programmes. However the rollout programmes were designed to start from settings where infrastructure currently exists, which would predominantly be urban. Recent reports estimated that if the public sector included HAART as part of a package of HIV treatment and care in the year 2003, the cost would be 1.2% of the South African GNP, which is unlikely to push health-care expenditure beyond prudent levels [<xref rid="pmed-0030004-b050" ref-type="bibr">50</xref>,<xref rid="pmed-0030004-b051" ref-type="bibr">51</xref>].</p><p>The recent commitment towards scale-up of HAART in South Africa as part of HIV treatment and care has been an important and positive development. The urgent need to introduce HAART as part of routine HIV treatment and care was recently re-iterated in a World Bank report, which indicated that if this is not done soon, failure to do so would have devastating effects on this and future generations of South Africans [<xref rid="pmed-0030004-b052" ref-type="bibr">52</xref>].</p><p>Although the primary rationale for wider access to HAART is humanitarian, a national HAART programme targeting patients with symptomatic HIV disease, using low-cost HAART prices would also significantly decrease hospital services utilization by HIV-infected patients, resulting in either health expenditure saving by cost deferral or freeing substantial resources for health care of non-HIV patients.</p><boxed-text id="pmed-0030004-box001" position="float"><sec id="sb1"><title>Patient Summary</title><sec id="sb1a"><title>Background</title><p>The number of cases of AIDS continues to increase worldwide; the disease is a major threat to humanity, with Africa facing the very worst problems. In South Africa alone there were 370,000 AIDS deaths in 2003. AIDS is caused by a type of retrovirus—the human immunodeficiency virus (HIV). Highly active antiretroviral treatment (HAART) is a treatment that uses a combination of three or more antiretroviral drugs that attack different parts of the virus. HAART is expensive, making it difficult for poor countries to provide treatment for all who need it. Prices are falling, however, and South Africa is one country where efforts are now being made to improve access to treatment.</p></sec><sec id="sb1b"><title>Why Was This Study Done?</title><p>The cost-effectiveness of HAART has been studied in developed countries, but developing countries also need to know how much it is going to cost their health services if they introduce HAART, and whether there will be financial savings because of switching to a more effective treatment.</p></sec><sec id="sb1c"><title>What Did the Researchers Do and Find?</title><p>During the study period (January 1995 to 31 December 2000), HAART was not available in the publicly funded South African health-care sector. The study, funded by the drug manufacturer Bristol-Myers Squibb, took place in HIV clinics affiliated with the University of Cape Town. The researchers compared the cost of services for 292 patients who were given HAART with the costs for a comparison group (with the same number of patients) who were not given any antiretroviral drugs. Twenty-seven patients in each group had AIDS; the others were HIV-infected but did not have AIDS. The researchers calculated costs per patient year (PPY) and per life-year gained (LYG), i.e., the total cost divided by the number of extra years the treated patients lived. Calculations were done separately for patients with AIDS and those without AIDS. Patients on HAART required fewer hospital admissions. Depending on how long the patient survived and the price of antiretrovirals, it cost less to treat the HAART patients with AIDS. For this group, the cost saving ranged from $219 to $2,116 (in U.S. dollars). For patients without AIDS, the cost of treatment (ranging from $597 to $1,772) was, by the South African standard of cost of living, affordable. However, it is expected that South Africa will soon be able to manufacture antiretroviral drugs locally and more cheaply. This would increase the amount saved by introducing HAART.</p></sec><sec id="sb1d"><title>What Does This Mean?</title><p>HAART seems to be a more cost-effective way for South African hospitals to treat HIV infection than simply waiting for patients to come to hospital and then dealing with their symptoms. However, it should be noted that when a person is infected with HIV and becomes ill or dies from AIDS, it is not only hospitals that face costs. The patient, their family, and the country suffer financially. Effective treatment might also lower these “indirect” costs, but this was not an issue examined in this research.</p></sec><sec id="sb1e"><title>Where Can I Find More Information Online?</title><p>For a comprehensive source of information on HIV/AIDS:</p><p><ext-link ext-link-type="uri" xlink:href="http://www.thebody.com">http://www.thebody.com</ext-link></p><p>The site also includes a useful section on HAART:</p><p><ext-link ext-link-type="uri" xlink:href="http://www.thebody.com/Forums/AIDS/Infections/Archive/NewMedications/Q12178.html">http://www.thebody.com/Forums/AIDS/Infections/Archive/NewMedications/Q12178.html</ext-link></p><p>For information about the global AIDS situation and the position in different countries:</p><p><ext-link ext-link-type="uri" xlink:href="http://www.unaids.org">http://www.unaids.org</ext-link>.</p></sec></sec></boxed-text></sec></body><back><ack><p>We are indebted to staff and patients of the HIV clinics from Somerset Hospital (NSH) and Groote Schuur Hospital (GSH). We are particularly indebted to Douglas Wilson, Rosalind Mayniar, Elizabeth Fielder, Mostafa Golayz, and Robin Hawkins at NSH and GSH. We are also grateful for the contributions of Jim Hanley at McGill University, Di McIntyre from the University of Cape Town, and Brian Gazzard from Chelsea and Westminster Hospital, United Kingdom. Study was funded by Secure the Future, Bristol-Myers Squibb, through an unrestricted educational grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</p></ack><fn-group><fn id="n4" fn-type="other"><p>Citation: Badri M, Maartens G, Mandalia S, Bekker L, Penrod JR, et al. (2006) Cost-effectiveness of highly active antiretroviral therapy in South Africa. 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