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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence and risk factors of undernutrition among antiretroviral-therapy-naïve subjects aged under 5 years old in Makurdi, Nigeria: a retrospective study</title><author><name sortKey="Anigilaje, Emmanuel Ademola" sort="Anigilaje, Emmanuel Ademola" uniqKey="Anigilaje E" first="Emmanuel Ademola" last="Anigilaje">Emmanuel Ademola Anigilaje</name><affiliation><nlm:aff id="af1-ijgm-8-131">Department of Paediatrics, Benue State University, Makurdi, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Olutola, Ayodotun" sort="Olutola, Ayodotun" uniqKey="Olutola A" first="Ayodotun" last="Olutola">Ayodotun Olutola</name><affiliation><nlm:aff id="af2-ijgm-8-131">Center for Clinical Care and Clinical Research, Abuja, Nigeria</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25878511</idno><idno type="pmc">4386797</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386797</idno><idno type="RBID">PMC:4386797</idno><idno type="doi">10.2147/IJGM.S73881</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002559</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence and risk factors of undernutrition among antiretroviral-therapy-naïve subjects aged under 5 years old in Makurdi, Nigeria: a retrospective study</title><author><name sortKey="Anigilaje, Emmanuel Ademola" sort="Anigilaje, Emmanuel Ademola" uniqKey="Anigilaje E" first="Emmanuel Ademola" last="Anigilaje">Emmanuel Ademola Anigilaje</name><affiliation><nlm:aff id="af1-ijgm-8-131">Department of Paediatrics, Benue State University, Makurdi, Nigeria</nlm:aff></affiliation></author><author><name sortKey="Olutola, Ayodotun" sort="Olutola, Ayodotun" uniqKey="Olutola A" first="Ayodotun" last="Olutola">Ayodotun Olutola</name><affiliation><nlm:aff id="af2-ijgm-8-131">Center for Clinical Care and Clinical Research, Abuja, Nigeria</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of General Medicine</title><idno type="eISSN">1178-7074</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Undernutrition is common in human immunodeficiency virus (HIV) infection and it contributes significantly to its morbidity and mortality. However, as far as we are aware, few studies have described the risk factors of undernutrition among HIV-infected Nigerian children. The study reported here aimed to determine the prevalence and risk factors of undernutrition among HIV-infected, antiretroviral therapy (ART)-naïve children aged under 5 years old in Makurdi, Nigeria.</p></sec><sec><title>Methods</title><p>A retrospective, cross-sectional study was undertaken at the Federal Medical Centre, Makurdi, between June 2010 and June 2011. Logistic regression modelling was used to determine the risk factors of undernutrition.</p></sec><sec><title>Results</title><p>Data on 182 HIV-infected children (88 males and 94 females), aged between 6 weeks and 59 months were studied. The prevalence of undernutrition was 12.1%, 33.5%, and 54.4% for underweight, wasting, and stunting, respectively. In multivariate regression analyses, being female (adjusted odds ratio [AOR] 0.292, 95% [confidence interval] CI 0.104–0.820, <italic>P</italic>=0.019), the child’s caregiver being on ART (AOR 0.190, 95% CI 0.039–0.925, <italic>P</italic>=0.04), and the absence of tuberculosis in the child (AOR 0.034, 95% CI 0.003–0.357, <italic>P</italic>=0.005) were independently protective against underweight. Subjects who were exclusively breastfed in the first 6 months of life were protected from stunting (AOR 0.136, 95% CI 0.032–0.585, <italic>P</italic>=0.007). No factor impacted significantly on wasting in multivariate analyses.</p></sec><sec><title>Conclusion</title><p>Undernutrition among HIV-infected, ART-naïve children aged under 5 years old may be reduced if programmatic interventions are guided toward early initiation of ART among eligible HIV-infected caregivers and the promotion of HIV/tuberculosis coinfection control efforts. Also, the importance of exclusive breastfeeding in reducing undernutrition cannot be overemphasized.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ojoawo, A" uniqKey="Ojoawo A">A Ojoawo</name></author><author><name sortKey="Dairo, O" uniqKey="Dairo O">O Dairo</name></author><author><name sortKey="Ojetunde, A" uniqKey="Ojetunde A">A Ojetunde</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Anigilaje, Ea" uniqKey="Anigilaje E">EA Anígilájé</name></author><author><name sortKey="Dabit, Oj" uniqKey="Dabit O">OJ Dabit</name></author><author><name sortKey="Ageda, B" uniqKey="Ageda B">B Ageda</name></author><author><name sortKey="Hwande, S" uniqKey="Hwande S">S Hwande</name></author><author><name sortKey="Bitto, Tt" uniqKey="Bitto T">TT 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Gen Med</journal-id><journal-id journal-id-type="iso-abbrev">Int J Gen Med</journal-id><journal-id journal-id-type="publisher-id">International Journal of General Medicine</journal-id><journal-title-group><journal-title>International Journal of General Medicine</journal-title></journal-title-group><issn pub-type="epub">1178-7074</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25878511</article-id><article-id pub-id-type="pmc">4386797</article-id><article-id pub-id-type="doi">10.2147/IJGM.S73881</article-id><article-id pub-id-type="publisher-id">ijgm-8-131</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Prevalence and risk factors of undernutrition among antiretroviral-therapy-naïve subjects aged under 5 years old in Makurdi, Nigeria: a retrospective study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Anigilaje</surname><given-names>Emmanuel Ademola</given-names></name><xref ref-type="aff" rid="af1-ijgm-8-131">1</xref><xref ref-type="corresp" rid="c1-ijgm-8-131"></xref></contrib><contrib contrib-type="author"><name><surname>Olutola</surname><given-names>Ayodotun</given-names></name><xref ref-type="aff" rid="af2-ijgm-8-131">2</xref></contrib></contrib-group><aff id="af1-ijgm-8-131"><label>1</label>Department of Paediatrics, Benue State University, Makurdi, Nigeria</aff><aff id="af2-ijgm-8-131"><label>2</label>Center for Clinical Care and Clinical Research, Abuja, Nigeria</aff><author-notes><corresp id="c1-ijgm-8-131">Correspondence: Emmanuel Ademola Anigilaje, Department of Paediatrics, Benue State University, PMB 102119, Makurdi, Benue State, Nigeria, Tel +234 803 383 3839, Email <email>demolaanigilaje@yahoo.co.uk</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>31</day><month>3</month><year>2015</year></pub-date><volume>8</volume><fpage>131</fpage><lpage>141</lpage><permissions><copyright-statement>© 2015 Anigilaje and Olutola. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License</copyright-statement><copyright-year>2015</copyright-year><license><license-p>The full terms of the License are available at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><sec><title>Background</title><p>Undernutrition is common in human immunodeficiency virus (HIV) infection and it contributes significantly to its morbidity and mortality. However, as far as we are aware, few studies have described the risk factors of undernutrition among HIV-infected Nigerian children. The study reported here aimed to determine the prevalence and risk factors of undernutrition among HIV-infected, antiretroviral therapy (ART)-naïve children aged under 5 years old in Makurdi, Nigeria.</p></sec><sec><title>Methods</title><p>A retrospective, cross-sectional study was undertaken at the Federal Medical Centre, Makurdi, between June 2010 and June 2011. Logistic regression modelling was used to determine the risk factors of undernutrition.</p></sec><sec><title>Results</title><p>Data on 182 HIV-infected children (88 males and 94 females), aged between 6 weeks and 59 months were studied. The prevalence of undernutrition was 12.1%, 33.5%, and 54.4% for underweight, wasting, and stunting, respectively. In multivariate regression analyses, being female (adjusted odds ratio [AOR] 0.292, 95% [confidence interval] CI 0.104–0.820, <italic>P</italic>=0.019), the child’s caregiver being on ART (AOR 0.190, 95% CI 0.039–0.925, <italic>P</italic>=0.04), and the absence of tuberculosis in the child (AOR 0.034, 95% CI 0.003–0.357, <italic>P</italic>=0.005) were independently protective against underweight. Subjects who were exclusively breastfed in the first 6 months of life were protected from stunting (AOR 0.136, 95% CI 0.032–0.585, <italic>P</italic>=0.007). No factor impacted significantly on wasting in multivariate analyses.</p></sec><sec><title>Conclusion</title><p>Undernutrition among HIV-infected, ART-naïve children aged under 5 years old may be reduced if programmatic interventions are guided toward early initiation of ART among eligible HIV-infected caregivers and the promotion of HIV/tuberculosis coinfection control efforts. Also, the importance of exclusive breastfeeding in reducing undernutrition cannot be overemphasized.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>HIV infection</kwd><kwd>ART</kwd><kwd>HIV/tuberculosis coinfection</kwd><kwd>stunting</kwd><kwd>breastfeeding</kwd><kwd>mother-to-child transmission</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Regional differences in the HIV burden exist in Nigeria.<xref rid="b1-ijgm-8-131" ref-type="bibr">1</xref> The ANC HIV Sentinel Survey of pregnant women in antenatal care in Nigeria revealed that Benue State, located in the North Central region, has the highest human immunodeficiency virus (HIV) prevalence rates – 10% in 2005, 10.6% in 2008, and 12.7% in 2010.<xref rid="b1-ijgm-8-131" ref-type="bibr">1</xref> Reasons adduced for the high HIV prevalence in Benue State include the high level of poverty and illiteracy, some sociocultural practices, and the lack of financial empowerment for women.<xref rid="b2-ijgm-8-131" ref-type="bibr">2</xref> Unfortunately, 80% of HIV-infected pregnant women in Nigeria did not receive antiretroviral medicines for the prevention of mother-to-child transmission of HIV in 2012,<xref rid="b3-ijgm-8-131" ref-type="bibr">3</xref> and with the mother-to-child transmission rate as high as 34% in our own setting,<xref rid="b4-ijgm-8-131" ref-type="bibr">4</xref> the prospects of achieving a reduction in the burden of perinatal HIV infection appear bleak.</p><p>In 2008, the prevalence of undernutrition among Nigerian children aged under 5 years old in the general population was 41%, 23%, and 14% for stunting, underweight, and wasting, respectively,<xref rid="b5-ijgm-8-131" ref-type="bibr">5</xref> and 11% of children younger than 15 years old were also infected with HIV in the same year.<xref rid="b6-ijgm-8-131" ref-type="bibr">6</xref></p><p>Complex interactions exist between HIV infection and growth/nutrition, such that children with HIV infection are prone to undernutrition,<xref rid="b7-ijgm-8-131" ref-type="bibr">7</xref>–<xref rid="b11-ijgm-8-131" ref-type="bibr">11</xref> and mortality from severe acute malnutrition is more than three-times higher in HIV-positive children than their HIV-negative counterparts.<xref rid="b9-ijgm-8-131" ref-type="bibr">9</xref> In addition, undernutrition also results in an impaired response to ART in HIV infection.<xref rid="b12-ijgm-8-131" ref-type="bibr">12</xref></p><p>The mechanism for growth failure in HIV infection involves inadequate caloric intake, gastrointestinal infestations, opportunistic infections, abnormal resting energy expenditure, endocrine abnormalities, and HIV enteropathy.<xref rid="b10-ijgm-8-131" ref-type="bibr">10</xref>,<xref rid="b13-ijgm-8-131" ref-type="bibr">13</xref>–<xref rid="b15-ijgm-8-131" ref-type="bibr">15</xref></p><p>A review of the literature reveals that the prevalence of undernutrition among HIV-infected ART-naïve Nigerian children was 11.9% in Enugu, South Eastern region in 2005;<xref rid="b16-ijgm-8-131" ref-type="bibr">16</xref> 58.6% in Ile-Ife, South Western region (2007–2009);<xref rid="b17-ijgm-8-131" ref-type="bibr">17</xref> and 77.3% in Kano, Northern region in 2010.<xref rid="b18-ijgm-8-131" ref-type="bibr">18</xref> A high burden of undernutrition of 55% and 56.4% was also reported among HIV-infected ART-naïve children in Cameroon (2008–2009)<xref rid="b19-ijgm-8-131" ref-type="bibr">19</xref> and India (2004–2006), respectively.<xref rid="b20-ijgm-8-131" ref-type="bibr">20</xref></p><p>As far as we are aware, the study reported here is the first to describe the burden of undernutrition among HIV-infected ART-naïve children in Makurdi, a city with a high burden of perinatal HIV infection in North Central Nigeria.<xref rid="b1-ijgm-8-131" ref-type="bibr">1</xref> This study is important because undernutrition, regardless of its etiology, contributes to under-5 mortality,<xref rid="b5-ijgm-8-131" ref-type="bibr">5</xref> impairs immunity and predisposes a child to infectious illnesses, and also impairs the child’s motor and cognitive development.<xref rid="b21-ijgm-8-131" ref-type="bibr">21</xref></p><p>The need for this study was also strengthened by the fact that although highly active antiretroviral therapy (HAART) has been shown to improve the nutritional status of HIV-infected children by some studies,<xref rid="b22-ijgm-8-131" ref-type="bibr">22</xref>,<xref rid="b23-ijgm-8-131" ref-type="bibr">23</xref> a Tanzanian study<xref rid="b24-ijgm-8-131" ref-type="bibr">24</xref> also found that HAART alone is not enough to resolve the nutritional problems in HIV-infected children, underscoring the need for a more robust specific nutritional therapy. Moreover, in Nigeria, very few (less than 12%) children in need of HAART were receiving it, in 2012.<xref rid="b25-ijgm-8-131" ref-type="bibr">25</xref></p><p>Although knowledge about the growth response of our HIV-infected children to HAART is important and also being studied by the authors, the present study focuses on the prevalence of undernutrition and its risk factors among ART-naïve HIV-infected children at enrollment into an ART program. We expect programmatic nutritional interventions to be better guided if the risk factors of undernutrition are well elucidated, especially among our HIV-infected children who require nutritional interventions, either alone in care or in conjunction with HAART in treatment.</p></sec><sec sec-type="materials|methods"><title>Materials and methods</title><sec sec-type="methods"><title>Study design</title><p>This was a retrospective cross-sectional study among HIV-infected ART-naïve children.</p></sec><sec sec-type="methods"><title>Study area</title><p>The study took place between June 2010 and June 2011 at the Paediatric ART Clinic of the Federal Medical Centre (FMC), Makurdi, Benue State, Nigeria. The facility is supported by the AIDS Prevention Initiative in Nigeria (APIN)/Harvard [US] President’s Emergency Program for AIDS Relief (PEPFAR). Benue State lies within the middle belt region of Nigeria. The state has a population of over 5 million people and occupies a landmass of 34,059 square kilometers. The state experiences two distinct seasons, the wet/rainy season and the dry/summer season. The rainy season, during which farming takes place, lasts from April to October, with an annual rainfall in the range of 100–200 mm. The dry season begins in November and ends in March. Temperatures fluctuate between 23°C and 37°C.</p></sec><sec><title>Ethical considerations</title><p>Upon enrollment into care, all parents or caregivers of the HIV-infected children were required to provide written informed consent (and assent from the children if aged ≥7 years) for the use of their data for research as approved by the Hospital Research and Ethics Committee (HREC) of the FMC, Makurdi, and the APIN/Harvard PEPFAR. For this study, permission was sought for and received from the HREC of the FMC for the use of the relevant data.</p></sec><sec><title>Inclusion criteria</title><p>Included in the study were HIV-infected children (≤15 years of age) who were ART naïve and whose anthropometrical growth parameters and records of potential risk factors of undernutrition were available on enrollment into our ART program.</p></sec><sec sec-type="methods|subjects"><title>Recruitment of subjects and data collection</title><p>FMC, Makurdi, provides pediatric HIV care and treatment in accordance with the Nigerian guidelines on pediatric HIV/AIDS treatment and care.<xref rid="b25-ijgm-8-131" ref-type="bibr">25</xref>,<xref rid="b26-ijgm-8-131" ref-type="bibr">26</xref> Children were recruited into care and treatment if they were confirmed to be HIV infected. All subjects aged ≥18 months had initial double-rapid HIV antibody tests using Determine™ HIV-1/2 first and then HIV 1/2 STAT-PAK<sup>®</sup>. HIV infection was confirmed in those with a reactive rapid test by the Western blot test. Two HIV DNA polymerase-chain-reaction positivity tests for those aged <18 months confirmed HIV infection in this age group.</p><p>A study proforma was developed to capture the following information that had been recorded on each subject’s initial clinical evaluation form at enrollment into our program: mode of HIV transmission, caregiver HIV status, whether caregiver was on ART, caregiver marital status, place of residence (rural vs urban), number of people in the household, whether the child was an orphan, mode of infant feeding, HIV/AIDS clinical stage, anthropometric measurements, and other diagnosed comorbidities/opportunistic infections (tuberculosis, oropharyngeal and esophageal candidiasis, diarrheal disease, presumed sepsis, malaria fever, pneumonia, and hepatitis B and hepatitis C viral infections).</p></sec><sec><title>Operational definitions</title><p>For the purpose of the study, the following terms were defined. “Exclusive breastfeeding” (EBF) was defined as the infant receiving only breast milk for the first 6 months of life from his/her mother and no other liquids or solids, with the exception of drops or syrups consisting of vitamins, mineral supplements, or drugs.<xref rid="b27-ijgm-8-131" ref-type="bibr">27</xref> “Exclusive breast-milk-substitute feeding” (EBMS) was defined as the administration of infant formula for the first 6 months of life and the exclusion of all breastfeeding.<xref rid="b27-ijgm-8-131" ref-type="bibr">27</xref> “Mixed feeding” (MF) was defined as giving breast milk with breast-milk substitute or other liquids or solid foods;<xref rid="b27-ijgm-8-131" ref-type="bibr">27</xref> two episodes of instances of mixed feeding were required for this definition to apply.</p><p>To define “undernutrition” in children aged less than 5 years old, anthropometric computations and comparisons were conducted using World Health Organization (WHO) Anthro software (version 2.0, 2008), which is based on WHO child-growth standards of 2006.<xref rid="b28-ijgm-8-131" ref-type="bibr">28</xref> “Underweight” was defined as a weight-for-age Z-score (WAZ-score) less than −2 standard deviations (SD) from the reference median values. “Stunting” was defined as a height-for-age Z-score (HAZ-score) of less than −2SD from the reference median values. A weight-for-height Z-score (WHZ-score) less than −2SD from the reference median defined “wasting”.</p><p>The definitions of “diarrhea”, “chronic diarrhea”, “pneumonia”, “tuberculosis”, “oropharyngeal candidiasis”, “esophageal candidiasis”, and “sepsis” used were those described in the WHO <italic>Pocket Book of Hospital Care for Children: Guidelines for the Management of Common Childhood Illnesses</italic>.<xref rid="b29-ijgm-8-131" ref-type="bibr">29</xref></p></sec><sec><title>Laboratory measurements</title><p>The cluster of differentiation 4 (CD4) count and the viral load of the subjects were determined at enrollment. Venous blood samples were also collected for malaria parasites (Giemsa stain), hepatitis B surface antigen, and hepatitis C virus antibody (the third-generation enzyme-linked immunosorbent assay technique was used for hepatitis B surface antigen and hepatitis C virus antibody). All tests were done at the APIN/PEPFAR laboratory of FMC, Makurdi.</p></sec><sec sec-type="methods"><title>Statistical analysis</title><p>Descriptive statistics were tabulated as medians for continuous variables and numbers and percentages for categorical variables. The medians were compared using the Mann–Whitney U test. The main outcome variables in the analysis were undernutrition (ie, underweight, stunting, and wasting) versus no undernutrition. The prevalence of undernutrition was calculated. Age was stratified at 2 years because of the known increased risk of undernutrition as children reach their second year of life.<xref rid="b30-ijgm-8-131" ref-type="bibr">30</xref> Potential risk factors of undernutrition were tested for significance in a bivariate logistic regression. Variables that achieved a significance level of 0.1 were considered eligible for multivariate logistic regression analysis. For all analyses, <italic>P</italic>-values less than 0.05 were considered statistically significant. Statistical analysis was done using SPSS software (v 16).</p></sec></sec><sec sec-type="results"><title>Results</title><p>A total of 192 HIV-infected children were seen within the study period but only 182 satisfied the inclusion criteria. Excluded were ten children with incomplete/missing data of interest. <xref ref-type="table" rid="t1-ijgm-8-131">Table 1</xref> is the age, sex and undernutrition distribution among the 182 subjects. The 182 subjects were between 6 weeks and 59 months of age, with a median age of 36 months and interquartile range of 24–48 months.</p><p>There were 88 males (M) and 94 females (F) with an M:F ratio of 1.0:1.1. The prevalence of undernutrition was 12.1% (ie, 22/182), 33.5% (61/182), and 54.4% (99/182) for underweight, wasting, and stunting, respectively. Sixty-nine subjects (37.9%) did not have any form of undernutrition. <xref ref-type="table" rid="t2-ijgm-8-131">Table 2</xref> shows the prevalence and risk factors of underweight among the subjects.</p><p>In multivariate analyses, only the subject’s sex, whether the caregivers of the child were on ART, and the presence of coinfection with tuberculosis were independently associated with underweight. The trend was such that female subjects were 0.292 less likely to be underweight (AOR 0.292, 95% CI 0.104–0.820, <italic>P</italic>=0.019) and when the child came from a household in which their caregiver was on ART, the child was also significantly protected against underweight (AOR 0.190, 95% CI 0.039–0.925, <italic>P</italic>=0.04). Also, the absence of tuberculosis in the child protected against underweight (AOR 0.034, 95% CI 0.003–0.357, <italic>P</italic>=0.005).</p><p><xref ref-type="table" rid="t3-ijgm-8-131">Table 3</xref> reveals the prevalence and risk factors of wasting among the subjects. No variable was found to be significantly associated with wasting in multivariate analyses.</p><p><xref ref-type="table" rid="t4-ijgm-8-131">Table 4</xref> is the prevalence and risk factors of stunting among the subjects. Only the mode of early infant feeding was significantly associated with stunting in the multivariate analyses. EBF was found to be significantly protective against stunting compared with EBMS (AOR 0.136, 95% CI 0.032–0.585, <italic>P</italic>=0.007), although fewer subjects practiced EBF than EBMS (12.6% [13/182] vs 44.6% [81/182]).</p></sec><sec sec-type="discussion"><title>Discussion</title><p>In the present study, among the HIV-infected ART-naïve children, the prevalence of undernutrition was 12.1%, 33.5%, and 54.4% for underweight, wasting, and stunting, respectively. The prevalence of undernutrition in this study was lower than the prevalence of 58.6% and 48.6% for underweight and stunting, respectively, but was higher than the 31.4% for wasting, among similarly HIV-infected ART-naïve children in Ile-Ife, Osun State, in the South Western region of Nigeria.<xref rid="b17-ijgm-8-131" ref-type="bibr">17</xref> Furthermore, the prevalence of undernutrition in this study was lower than the 63% and 58% reported for underweight and stunting, respectively, but higher than the 16% reported for wasting among HIV-infected ART-naïve Indian children.<xref rid="b31-ijgm-8-131" ref-type="bibr">31</xref></p><p>Differences in prenatal growth patterns, varying food supplementation/socioeconomic conditions, and differences in disease manifestation due to differing HIV subtypes among the infected children in the different study settings could explain the dissimilarities observed between our study and the studies of others.<xref rid="b17-ijgm-8-131" ref-type="bibr">17</xref>,<xref rid="b31-ijgm-8-131" ref-type="bibr">31</xref></p><p>“Underweight” (weight for age) is a composite index of weight-for-height and height-for-age. It does not distinguish between acute malnutrition (wasting) and chronic malnutrition (stunting), but it is a good overall indicator of a population’s nutritional health.<xref rid="b32-ijgm-8-131" ref-type="bibr">32</xref> In the present study, female HIV-infected subjects were 0.292 less likely to be underweight. In a Tanzanian study,<xref rid="b33-ijgm-8-131" ref-type="bibr">33</xref> male children born to HIV-infected women were 28% more likely to become underweight in comparison to females. Similarly, in a study from Andhra Pradesh, India, male children in the general population were twice as likely and 50% more likely than females to be wasted and underweight, respectively, after controlling for multiple other risk factors in the respective analyses.<xref rid="b34-ijgm-8-131" ref-type="bibr">34</xref> McDonald et al<xref rid="b33-ijgm-8-131" ref-type="bibr">33</xref> had earlier suggested a preferential treatment toward girls in terms of health care-seeking behavior or dietary consumption. Contrarywise, in our own cultural setting, preferential treatment by the parents argues more in favor of a male child, since there is a strong societal preference for a male child and this makes the association found in our study more difficult to explain.</p><p>Also, the present study reveals that when the HIV-infected caregivers of our subjects were on HAART, a significant protection against underweight in the child was seen. A combination of reduced earnings due to frailty, reduced savings and assets, and high adult mortality causes food insecurity in HIV households, and food insecurity increases the risk of malnutrition among children in the household.<xref rid="b35-ijgm-8-131" ref-type="bibr">35</xref>,<xref rid="b36-ijgm-8-131" ref-type="bibr">36</xref> However, following the commencement of ART in caregivers, employment and income have been found to increase, thereby improving food security and the nutritional status of all the household members.<xref rid="b35-ijgm-8-131" ref-type="bibr">35</xref>–<xref rid="b37-ijgm-8-131" ref-type="bibr">37</xref> This observation may also explain our finding of the protective effect against underweight seen among children of caregivers who had been initiated on ART in this study.</p><p>Not surprisingly, absence of tuberculosis in the child was found to protect against underweight in the present study. Coinfection with HIV and tuberculosis is an extremely common problem, and, in areas of high prevalence, it is the most common coinfection in HIV-positive children.<xref rid="b35-ijgm-8-131" ref-type="bibr">35</xref> HIV and tuberculosis pathogens interact, resulting in weight loss, which is the presenting feature in almost 50% of cases of tuberculosis, and persistent anorexia, a feature in approximately one-quarter of cases, also contributes to undernutrition.<xref rid="b38-ijgm-8-131" ref-type="bibr">38</xref> Furthermore, malnutrition is a risk factor for the acquisition of primary tuberculosis infection, as well as progression to active disease. Unfortunately, most health facilities in Nigeria, including our own, have not adopted the use of isoniazid preventive therapy for tuberculosis, while intensified case-finding of tuberculosis and infection control for tuberculosis, the other two components of the “three Is” for HIV/tuberculosis coinfection control, are still suboptimal in Nigeria.</p><p>Stunting is an indicator of a cumulative effect of chronic malnutrition<xref rid="b32-ijgm-8-131" ref-type="bibr">32</xref> and EBF was found to be significantly protective against stunting compared with formula feeding in the present study. Similarly, an Eastern Uganda study reported that children on EBF were less likely to be stunted.<xref rid="b39-ijgm-8-131" ref-type="bibr">39</xref> However, fewer than 12.6% of our subjects practiced EBF compared with 44.6% who practiced EBMS. In our ART program and during the period of study, infant formula was provided free of cost to the mothers, and may thus explain the higher preference for this mode of infant feeding, even after the provision of the necessary information to guide mothers’ decisions. Breastfeeding has been shown to help prevent growth faltering and stunting, particularly as it reduces the risk of infectious diseases,<xref rid="b40-ijgm-8-131" ref-type="bibr">40</xref>–<xref rid="b44-ijgm-8-131" ref-type="bibr">44</xref> which are the important determinants of stunting.<xref rid="b40-ijgm-8-131" ref-type="bibr">40</xref>,<xref rid="b45-ijgm-8-131" ref-type="bibr">45</xref> Although breastfed children may still become stunted if they do not receive an adequate quantity and quality of complementary foods from the age of 6 months onward,<xref rid="b46-ijgm-8-131" ref-type="bibr">46</xref> the risk may be less among early exclusively breastfed infants in the first 6 months of life, as seen in the present study.</p></sec><sec><title>Limitations of the study</title><p>Although we considered a comprehensive set of variables in our analyses, residual confounding covariates that were unmeasured and/or missing in the records were not tested. Being a retrospective study, these covariates were not given attention at the point of recruitment into our ART program and we were therefore constrained in this regard. We would have loved to test these other a priori covariates of child undernutrition, including child-level factors such as gestational age and birth weight; maternal-level factors such as maternal size, age, and education; household-level factors such as food insecurity, pattern of complementary feeding, and socioeconomic status; and community-level factors such as sanitation and environmental factors.<xref rid="b47-ijgm-8-131" ref-type="bibr">47</xref>–<xref rid="b49-ijgm-8-131" ref-type="bibr">49</xref> Also, parasitic infestations that impact negatively on nutritional status and growth could not be determined, because stool microscopy is not a routine investigation for our subjects on enrollment into our ART program.</p><p>Moreover, being a cross-sectional study, establishing a cause and effect relationship between the tested variables and undernutrition was limited.</p><p>In addition, the lack of significant association in our multivariate analyses between wasting and the tested variables may be due to the small sample size of the study, and it is also possible that these variables may have been present but had resolved in many more subjects before enrollment into our ART program, and, therefore, the absence of statistical significance has to be considered cautiously.</p><p>Finally, the lack of data on undernutrition in a comparable group of HIV-negative children in the same setting during the same period of study limits interpretation of the results of this study.</p></sec><sec><title>Conclusion</title><p>Despite the outlined limitations, the present study shows that the prevalence of undernutrition among HIV-infected ART-naïve under-5-year-olds is high, at 12.1%, 33.5%, and 54.4% for underweight, wasting, and stunting, respectively. Multivariate analyses showed that being female, having a caregiver on ART, and the absence of tuberculosis in the child are protective against underweight, and that when subjects had EBF in the first 6 months of life, protection against stunting was seen. Therefore, programmatic intervention should be well guided toward the early initiation of HAART among eligible HIV-infected caregivers and the promotion of the “three Is” of HIV/tuberculosis coinfection control: isoniazid preventive therapy, intensified case-finding of tuberculosis, and the infection control for tuberculosis. Also, the importance of EBF in reducing the prevalence of undernutrition and its consequent morbidity and mortality among our HIV-infected ART-naïve children cannot be overemphasized.</p></sec></body><back><ack><title>Acknowledgments</title><p>This work was funded in part by the US Department of Health and Human Services, Health Resources and Services Administration (U51HA02522) and the Centers for Disease Control and Prevention through APIN (PS001058).</p></ack><fn-group><fn><p><bold>Author contributions</bold></p><p>This work was carried out by both authors in collaboration. Emmanuel Ademola Anigilaje designed the study, wrote the protocol and collated the data, performed and reviewed the statistical analysis, did literature searches, wrote the first draft of the manuscript and also critically reviewed it for intellectual content. Ayodotun Olutola was involved in the design of the study, reviewed the statistical analyses, provided literature reviews, and critically reviewed the article for intellectual content. 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distribution among the 182 subjects</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Characteristic</th><th valign="top" align="left" rowspan="1" colspan="1">Number (%)</th></tr></thead><tbody><tr><td colspan="2" valign="top" align="left" rowspan="1">Age (months)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 0–23</td><td valign="top" align="left" rowspan="1" colspan="1">34 (18.7)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 24–59</td><td valign="top" align="left" rowspan="1" colspan="1">148 (81.3)</td></tr><tr><td colspan="2" valign="top" align="left" rowspan="1">Sex</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Male</td><td valign="top" align="left" rowspan="1" colspan="1">88 (48.4)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Female</td><td valign="top" align="left" rowspan="1" colspan="1">94 (51.6)</td></tr><tr><td colspan="2" valign="top" align="left" rowspan="1">Undernutrition (not mutually exclusive)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Underweight</td><td valign="top" align="left" rowspan="1" colspan="1">22 (12.1)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Wasting</td><td valign="top" align="left" rowspan="1" colspan="1">61 (33.5)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Stunting</td><td valign="top" align="left" rowspan="1" colspan="1">99 (54.4)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No undernutrition</td><td valign="top" align="left" rowspan="1" colspan="1">69 (37.9)</td></tr></tbody></table></table-wrap><table-wrap id="t2-ijgm-8-131" position="float"><label>Table 2</label><caption><p>Prevalence and risk factors of underweight among subjects aged under 5 years old</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" valign="top" align="left" colspan="1">Clinical variable</th><th rowspan="2" valign="top" align="left" colspan="1">Underweight (WAZ-score < −2SD)<break></break>N (%)</th><th rowspan="2" valign="top" align="left" colspan="1">Not underweight (WAZ-score ≥ −2SD)<break></break>N (%)</th><th colspan="3" valign="top" align="left" rowspan="1">Bivariate analysis
<hr></hr></th><th colspan="3" valign="top" align="left" rowspan="1">Multivariate analysis
<hr></hr></th></tr><tr><th valign="top" align="left" rowspan="1" colspan="1">OR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th><th valign="top" align="left" rowspan="1" colspan="1">AOR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Demography</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Age (months)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median</td><td valign="top" align="left" rowspan="1" colspan="1">2.00</td><td valign="top" align="left" rowspan="1" colspan="1">3.00</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.033</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 0–23</td><td valign="top" align="left" rowspan="1" colspan="1">16 (26.2)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (14.9)</td><td valign="top" align="left" rowspan="1" colspan="1">2.035</td><td valign="top" align="left" rowspan="1" colspan="1">0.952–4.346</td><td valign="top" align="left" rowspan="1" colspan="1">0.064</td><td valign="top" align="left" rowspan="1" colspan="1">0.706</td><td valign="top" align="left" rowspan="1" colspan="1">0.204–2.437</td><td valign="top" align="left" rowspan="1" colspan="1">0.581</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 24–59 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">45 (73.8)</td><td valign="top" align="left" rowspan="1" colspan="1">103 (85.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sex</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Male</td><td valign="top" align="left" rowspan="1" colspan="1">36 (59.0)</td><td valign="top" align="left" rowspan="1" colspan="1">52 (43.0)</td><td valign="top" align="left" rowspan="1" colspan="1">1.911</td><td valign="top" align="left" rowspan="1" colspan="1">1.1023–3.568</td><td valign="top" align="left" rowspan="1" colspan="1">0.041</td><td valign="top" align="left" rowspan="1" colspan="1">0.292</td><td valign="top" align="left" rowspan="1" colspan="1">0.104–0.820</td><td valign="top" align="left" rowspan="1" colspan="1">0.019</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Female (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">25 (41.0)</td><td valign="top" align="left" rowspan="1" colspan="1">69 (57.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Orphanhood</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">22 (36.1)</td><td valign="top" align="left" rowspan="1" colspan="1">27 (22.3)</td><td valign="top" align="left" rowspan="1" colspan="1">1.964</td><td valign="top" align="left" rowspan="1" colspan="1">0.999–3.859</td><td valign="top" align="left" rowspan="1" colspan="1">0.048</td><td valign="top" align="left" rowspan="1" colspan="1">1.224</td><td valign="top" align="left" rowspan="1" colspan="1">0.285–5.248</td><td valign="top" align="left" rowspan="1" colspan="1">0.786</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">39 (63.9)</td><td valign="top" align="left" rowspan="1" colspan="1">94 (77.7)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Family/socioeconomic factors</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Mode of HIV transmission</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Vertical</td><td valign="top" align="left" rowspan="1" colspan="1">61 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">101 (83.5)</td><td valign="top" align="left" rowspan="1" colspan="1">0.623</td><td valign="top" align="left" rowspan="1" colspan="1">0.553–0.703</td><td valign="top" align="left" rowspan="1" colspan="1">0.001</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Blood transfusion (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (16.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Mode of infant feeding</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBMS</td><td valign="top" align="left" rowspan="1" colspan="1">39 (63.9)</td><td valign="top" align="left" rowspan="1" colspan="1">42 (34.7)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">6.902</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">0.998</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> MF</td><td valign="top" align="left" rowspan="1" colspan="1">3 (4.9)</td><td valign="top" align="left" rowspan="1" colspan="1">75 (62.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">1.005</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.998</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBF (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">19 (31.1)</td><td valign="top" align="left" rowspan="1" colspan="1">4 (3.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregivers’ HIV status</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Infected</td><td valign="top" align="left" rowspan="1" colspan="1">61 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">103 (85.1)</td><td valign="top" align="left" rowspan="1" colspan="1">0.628</td><td valign="top" align="left" rowspan="1" colspan="1">0.558–0.707</td><td valign="top" align="left" rowspan="1" colspan="1">0.002</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Not infected (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (14.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregiver on HAART</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">20 (32.8)</td><td valign="top" align="left" rowspan="1" colspan="1">8 (7.8)</td><td valign="top" align="left" rowspan="1" colspan="1">5.793</td><td valign="top" align="left" rowspan="1" colspan="1">2.360–14.219</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.190</td><td valign="top" align="left" rowspan="1" colspan="1">0.039–0.925</td><td valign="top" align="left" rowspan="1" colspan="1">0.040</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">41 (67.2)</td><td valign="top" align="left" rowspan="1" colspan="1">95 (92.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Marital status of caregiver</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Without partner</td><td valign="top" align="left" rowspan="1" colspan="1">16 (26.2)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (7.4)</td><td valign="top" align="left" rowspan="1" colspan="1">4.425</td><td valign="top" align="left" rowspan="1" colspan="1">1.823–10.741</td><td valign="top" align="left" rowspan="1" colspan="1">0.001</td><td valign="top" align="left" rowspan="1" colspan="1">0.134</td><td valign="top" align="left" rowspan="1" colspan="1">0.017–1.028</td><td valign="top" align="left" rowspan="1" colspan="1">0.053</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> With a partner (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">45 (73.8)</td><td valign="top" align="left" rowspan="1" colspan="1">112 (92.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Number of people in the household</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >5</td><td valign="top" align="left" rowspan="1" colspan="1">37 (60.7)</td><td valign="top" align="left" rowspan="1" colspan="1">59 (48.8)</td><td valign="top" align="left" rowspan="1" colspan="1">1.620</td><td valign="top" align="left" rowspan="1" colspan="1">0.867–3.027</td><td valign="top" align="left" rowspan="1" colspan="1">0.129</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤5 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">24 (39.3)</td><td valign="top" align="left" rowspan="1" colspan="1">62 (51.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Place of residence</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Urban</td><td valign="top" align="left" rowspan="1" colspan="1">9 (14.8)</td><td valign="top" align="left" rowspan="1" colspan="1">15 (12.4)</td><td valign="top" align="left" rowspan="1" colspan="1">1.223</td><td valign="top" align="left" rowspan="1" colspan="1">0.502–2.980</td><td valign="top" align="left" rowspan="1" colspan="1">0.657</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Rural (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">52 (85.2)</td><td valign="top" align="left" rowspan="1" colspan="1">106 (87.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Clinical/laboratory findings</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">WHO clinical staging</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 3 and 4</td><td valign="top" align="left" rowspan="1" colspan="1">29 (47.5)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (16.5)</td><td valign="top" align="left" rowspan="1" colspan="1">4.577</td><td valign="top" align="left" rowspan="1" colspan="1">2.285–9.167</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">2.818</td><td valign="top" align="left" rowspan="1" colspan="1">0.355–22.367</td><td valign="top" align="left" rowspan="1" colspan="1">0.327</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 1 and 2 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">32 (52.5)</td><td valign="top" align="left" rowspan="1" colspan="1">101 (83.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">CD4 count</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">552.50 (268.0–938.75)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">0.31</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤200</td><td valign="top" align="left" rowspan="1" colspan="1">15 (24.6)</td><td valign="top" align="left" rowspan="1" colspan="1">17 (14.0)</td><td valign="top" align="left" rowspan="1" colspan="1">1.995</td><td valign="top" align="left" rowspan="1" colspan="1">0.918–4.335</td><td valign="top" align="left" rowspan="1" colspan="1">0.078</td><td valign="top" align="left" rowspan="1" colspan="1">0.698</td><td valign="top" align="left" rowspan="1" colspan="1">0.196–2.481</td><td valign="top" align="left" rowspan="1" colspan="1">0.578</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> <200 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">46 (75.4)</td><td valign="top" align="left" rowspan="1" colspan="1">104 (86.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Viral load (copies/mL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median log10 (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">4.66 (3.71–5.31)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.237</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >10,000</td><td valign="top" align="left" rowspan="1" colspan="1">43 (70.5)</td><td valign="top" align="left" rowspan="1" colspan="1">81 (66.9)</td><td valign="top" align="left" rowspan="1" colspan="1">1.180</td><td valign="top" align="left" rowspan="1" colspan="1">0.605–2.301</td><td valign="top" align="left" rowspan="1" colspan="1">0.628</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> <10,000 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (29.5)</td><td valign="top" align="left" rowspan="1" colspan="1">40 (33.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis B surface antigen</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">7 (11.5)</td><td valign="top" align="left" rowspan="1" colspan="1">11 (9.1)</td><td valign="top" align="left" rowspan="1" colspan="1">1.296</td><td valign="top" align="left" rowspan="1" colspan="1">0.476–3.531</td><td valign="top" align="left" rowspan="1" colspan="1">0.611</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">54 (88.5)</td><td valign="top" align="left" rowspan="1" colspan="1">110 (90.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis C antibodies</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">2 (3.3)</td><td valign="top" align="left" rowspan="1" colspan="1">3 (2.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.322</td><td valign="top" align="left" rowspan="1" colspan="1">0.215–8.130</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">59 (96.7)</td><td valign="top" align="left" rowspan="1" colspan="1">117 (97.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Diagnosed comorbidities/opportunistic infections</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Tuberculosis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">25 (41.0)</td><td valign="top" align="left" rowspan="1" colspan="1">12 (9.9)</td><td valign="top" align="left" rowspan="1" colspan="1">6.308</td><td valign="top" align="left" rowspan="1" colspan="1">2.878–13.825</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.034</td><td valign="top" align="left" rowspan="1" colspan="1">0.003–0.357</td><td valign="top" align="left" rowspan="1" colspan="1">0.005</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">36 (59.0)</td><td valign="top" align="left" rowspan="1" colspan="1">109 (90.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Oropharyngeal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">9 (14.8)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (7.4)</td><td valign="top" align="left" rowspan="1" colspan="1">2.154</td><td valign="top" align="left" rowspan="1" colspan="1">0.808–5.743</td><td valign="top" align="left" rowspan="1" colspan="1">0.119</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">52 (85.2)</td><td valign="top" align="left" rowspan="1" colspan="1">112 (92.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Esophageal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (6.6)</td><td valign="top" align="left" rowspan="1" colspan="1">1 (0.8)</td><td valign="top" align="left" rowspan="1" colspan="1">8.421</td><td valign="top" align="left" rowspan="1" colspan="1">0.920–77.062</td><td valign="top" align="left" rowspan="1" colspan="1">0.080</td><td valign="top" align="left" rowspan="1" colspan="1">0.233</td><td valign="top" align="left" rowspan="1" colspan="1">0.009–6.174</td><td valign="top" align="left" rowspan="1" colspan="1">0.383</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">57 (93.4)</td><td valign="top" align="left" rowspan="1" colspan="1">120 (99.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Diarrheal disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">2 (3.3)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (4.1)</td><td valign="top" align="left" rowspan="1" colspan="1">0.786</td><td valign="top" align="left" rowspan="1" colspan="1">0.148–4.176</td><td valign="top" align="left" rowspan="1" colspan="1">0.777</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">59 (96.7)</td><td valign="top" align="left" rowspan="1" colspan="1">116 (95.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sepsis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">1 (1.6)</td><td valign="top" align="left" rowspan="1" colspan="1">8 (6.6)</td><td valign="top" align="left" rowspan="1" colspan="1">0.235</td><td valign="top" align="left" rowspan="1" colspan="1">0.029–1.927</td><td valign="top" align="left" rowspan="1" colspan="1">0.272</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">60 (98.4)</td><td valign="top" align="left" rowspan="1" colspan="1">113 (93.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sickle-cell disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">3 (4.9)</td><td valign="top" align="left" rowspan="1" colspan="1">6 (5.0)</td><td valign="top" align="left" rowspan="1" colspan="1">0.991</td><td valign="top" align="left" rowspan="1" colspan="1">0.239–4.107</td><td valign="top" align="left" rowspan="1" colspan="1">0.990</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">58 (95.1)</td><td valign="top" align="left" rowspan="1" colspan="1">115 (95.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Pneumonia</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">3 (4.9)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (4.1)</td><td valign="top" align="left" rowspan="1" colspan="1">1.200</td><td valign="top" align="left" rowspan="1" colspan="1">0.277–5.196</td><td valign="top" align="left" rowspan="1" colspan="1">0.807</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">58 (95.1)</td><td valign="top" align="left" rowspan="1" colspan="1">116 (95.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Anemia (<8 g/dL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">40 (65.6)</td><td valign="top" align="left" rowspan="1" colspan="1">69 (57.0)</td><td valign="top" align="left" rowspan="1" colspan="1">0.697</td><td valign="top" align="left" rowspan="1" colspan="1">0.368–1.320</td><td valign="top" align="left" rowspan="1" colspan="1">0.267</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">21 (34.4)</td><td valign="top" align="left" rowspan="1" colspan="1">52 (43.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn1-ijgm-8-131"><p><bold>Abbreviations:</bold> AOR, adjusted odds ratio; CI, confidence interval; EBF, exclusive breast feeding; EBMS, exclusive breast-milk-substitute feeding; HAART, highly active antiretroviral therapy; IQR, interquartile range; MF, mixed feeding; N, number; OR, odds ratio; Ref, reference group; SD, standard deviation; WAZ-score, weight-for-age Z-score; WHO, World Health Organization.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t3-ijgm-8-131" position="float"><label>Table 3</label><caption><p>Prevalence and risk factors of wasting among subjects aged under 5 years old</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" valign="top" align="left" colspan="1">Clinical variable</th><th rowspan="2" valign="top" align="left" colspan="1">Wasted (WHZ-score < −2 SD)<break></break>N (%)</th><th rowspan="2" valign="top" align="left" colspan="1">Not wasted (WHZ-score ≥ −2 SD)<break></break>N (%)</th><th colspan="3" valign="top" align="left" rowspan="1">Bivariate analysis
<hr></hr></th><th colspan="3" valign="top" align="left" rowspan="1">Multivariate analysis
<hr></hr></th></tr><tr><th valign="top" align="left" rowspan="1" colspan="1">OR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th><th valign="top" align="left" rowspan="1" colspan="1">AOR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Demography</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Age (months)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median</td><td valign="top" align="left" rowspan="1" colspan="1">2.00</td><td valign="top" align="left" rowspan="1" colspan="1">3.00</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.022</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 0–23</td><td valign="top" align="left" rowspan="1" colspan="1">8 (36.4)</td><td valign="top" align="left" rowspan="1" colspan="1">26 (16.3)</td><td valign="top" align="left" rowspan="1" colspan="1">2.945</td><td valign="top" align="left" rowspan="1" colspan="1">1.122–7.729</td><td valign="top" align="left" rowspan="1" colspan="1">0.048</td><td valign="top" align="left" rowspan="1" colspan="1">0.362</td><td valign="top" align="left" rowspan="1" colspan="1">0.042–3.082</td><td valign="top" align="left" rowspan="1" colspan="1">0.352</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 24–59 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">14 (63.6)</td><td valign="top" align="left" rowspan="1" colspan="1">134 (83.8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sex</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Male</td><td valign="top" align="left" rowspan="1" colspan="1">13 (59.1)</td><td valign="top" align="left" rowspan="1" colspan="1">75 (46.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Female (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (40.9)</td><td valign="top" align="left" rowspan="1" colspan="1">85 (53.1)</td><td valign="top" align="left" rowspan="1" colspan="1">1.637</td><td valign="top" align="left" rowspan="1" colspan="1">0.662–4.046</td><td valign="top" align="left" rowspan="1" colspan="1">0.282</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Orphanhood</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">11 (50.0)</td><td valign="top" align="left" rowspan="1" colspan="1">38 (23.8)</td><td valign="top" align="left" rowspan="1" colspan="1">3.211</td><td valign="top" align="left" rowspan="1" colspan="1">1.290–7.989</td><td valign="top" align="left" rowspan="1" colspan="1">0.009</td><td valign="top" align="left" rowspan="1" colspan="1">7.939</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.998</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">11 (50.0)</td><td valign="top" align="left" rowspan="1" colspan="1">122 (76.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Family/socioeconomic factors</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Mode of HIV transmission</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Vertical</td><td valign="top" align="left" rowspan="1" colspan="1">22 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">140 (87.5)</td><td valign="top" align="left" rowspan="1" colspan="1">0.864</td><td valign="top" align="left" rowspan="1" colspan="1">0.813–0.919</td><td valign="top" align="left" rowspan="1" colspan="1">0.079</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Blood</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (12.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">transfusion (ref)</td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Mode of infant feeding</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBMS</td><td valign="top" align="left" rowspan="1" colspan="1">4 (18.2)</td><td valign="top" align="left" rowspan="1" colspan="1">77 (48.1)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">1.125</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.996</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> MF</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">78 (48.8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4.524</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.995</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBF (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (81.8)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (3.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregivers’ HIV Status</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Infected</td><td valign="top" align="left" rowspan="1" colspan="1">22 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">142 (88.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.866</td><td valign="top" align="left" rowspan="1" colspan="1">0.815–0.920</td><td valign="top" align="left" rowspan="1" colspan="1">0.097</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Not infected (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (11.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregiver on HAART</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">12 (54.5)</td><td valign="top" align="left" rowspan="1" colspan="1">16 (11.3)</td><td valign="top" align="left" rowspan="1" colspan="1">9.450</td><td valign="top" align="left" rowspan="1" colspan="1">3.521–25.365</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">1.706</td><td valign="top" align="left" rowspan="1" colspan="1">0.117–24.960</td><td valign="top" align="left" rowspan="1" colspan="1">0.696</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">10 (45.5)</td><td valign="top" align="left" rowspan="1" colspan="1">126 (88.7)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Marital status of caregiver</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Without partner</td><td valign="top" align="left" rowspan="1" colspan="1">11 (50.0)</td><td valign="top" align="left" rowspan="1" colspan="1">14 (8.8)</td><td valign="top" align="left" rowspan="1" colspan="1">10.429</td><td valign="top" align="left" rowspan="1" colspan="1">3.838–28.336</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.998</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> With a partner (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">11 (50.0)</td><td valign="top" align="left" rowspan="1" colspan="1">146 (91.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Number of people in the household</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >5</td><td valign="top" align="left" rowspan="1" colspan="1">15 (68.2)</td><td valign="top" align="left" rowspan="1" colspan="1">81 (50.6)</td><td valign="top" align="left" rowspan="1" colspan="1">2.090</td><td valign="top" align="left" rowspan="1" colspan="1">0.809–5.400</td><td valign="top" align="left" rowspan="1" colspan="1">0.122</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤5 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">7 (31.8)</td><td valign="top" align="left" rowspan="1" colspan="1">79 (49.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Place of residence</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Urban</td><td valign="top" align="left" rowspan="1" colspan="1">2 (9.1)</td><td valign="top" align="left" rowspan="1" colspan="1">22 (13.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.627</td><td valign="top" align="left" rowspan="1" colspan="1">0.137–2.873</td><td valign="top" align="left" rowspan="1" colspan="1">0.545</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Rural (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (90.9)</td><td valign="top" align="left" rowspan="1" colspan="1">138 (86.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Clinical/laboratory findings</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">WHO clinical staging</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 3 and 4</td><td valign="top" align="left" rowspan="1" colspan="1">16 (72.7)</td><td valign="top" align="left" rowspan="1" colspan="1">33 (20.6)</td><td valign="top" align="left" rowspan="1" colspan="1">10.263</td><td valign="top" align="left" rowspan="1" colspan="1">3.725–28.273</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">2.173</td><td valign="top" align="left" rowspan="1" colspan="1">0.000–10,622.45</td><td valign="top" align="left" rowspan="1" colspan="1">0.858</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 1 and 2 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">6 (27.3)</td><td valign="top" align="left" rowspan="1" colspan="1">127 (79.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">CD4 count</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">552.50 (268.00–938.75)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.025</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤200</td><td valign="top" align="left" rowspan="1" colspan="1">8 (36.4)</td><td valign="top" align="left" rowspan="1" colspan="1">24 (15.0)</td><td valign="top" align="left" rowspan="1" colspan="1">3.238</td><td valign="top" align="left" rowspan="1" colspan="1">1.226–8.551</td><td valign="top" align="left" rowspan="1" colspan="1">0.014</td><td valign="top" align="left" rowspan="1" colspan="1">0.890</td><td valign="top" align="left" rowspan="1" colspan="1">0.093–8.556</td><td valign="top" align="left" rowspan="1" colspan="1">0.919</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >200 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">14 (63.6)</td><td valign="top" align="left" rowspan="1" colspan="1">136 (85.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Viral load (copies/mL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median log10 (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">4.66 (3.716–5.315)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.516</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >10,000</td><td valign="top" align="left" rowspan="1" colspan="1">13 (59.1)</td><td valign="top" align="left" rowspan="1" colspan="1">111 (69.4)</td><td valign="top" align="left" rowspan="1" colspan="1">0.638</td><td valign="top" align="left" rowspan="1" colspan="1">0.256–1.590</td><td valign="top" align="left" rowspan="1" colspan="1">0.332</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> <10,000 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (40.9)</td><td valign="top" align="left" rowspan="1" colspan="1">49 (30.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis B surface antigen</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (18.2)</td><td valign="top" align="left" rowspan="1" colspan="1">14 (8.8)</td><td valign="top" align="left" rowspan="1" colspan="1">2.317</td><td valign="top" align="left" rowspan="1" colspan="1">0.688–7.805</td><td valign="top" align="left" rowspan="1" colspan="1">0.313</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (81.8)</td><td valign="top" align="left" rowspan="1" colspan="1">146 (91.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis C antibodies</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (3.1)</td><td valign="top" align="left" rowspan="1" colspan="1">1.143</td><td valign="top" align="left" rowspan="1" colspan="1">1.081–1.208</td><td valign="top" align="left" rowspan="1" colspan="1">0.399</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">22 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">154 (96.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Diagnosed comorbidities/opportunistic infections</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Tuberculosis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">14 (63.6)</td><td valign="top" align="left" rowspan="1" colspan="1">23 (14.4)</td><td valign="top" align="left" rowspan="1" colspan="1">10.424</td><td valign="top" align="left" rowspan="1" colspan="1">3.934–27.621</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.067</td><td valign="top" align="left" rowspan="1" colspan="1">0.000–375.863</td><td valign="top" align="left" rowspan="1" colspan="1">0.539</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">8 (36.4)</td><td valign="top" align="left" rowspan="1" colspan="1">137 (85.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Oropharyngeal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">2 (9.1)</td><td valign="top" align="left" rowspan="1" colspan="1">16 (10.0)</td><td valign="top" align="left" rowspan="1" colspan="1">0.900</td><td valign="top" align="left" rowspan="1" colspan="1">0.192–4.209</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (90.9)</td><td valign="top" align="left" rowspan="1" colspan="1">144 (90.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Esophageal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">1 (4.5)</td><td valign="top" align="left" rowspan="1" colspan="1">4 (2.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.857</td><td valign="top" align="left" rowspan="1" colspan="1">0.198–17.413</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">21 (95.5)</td><td valign="top" align="left" rowspan="1" colspan="1">156 (97.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Diarrheal disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">0 (0.0)</td><td valign="top" align="left" rowspan="1" colspan="1">7 (4.4)</td><td valign="top" align="left" rowspan="1" colspan="1">1.144</td><td valign="top" align="left" rowspan="1" colspan="1">1.081–1.210</td><td valign="top" align="left" rowspan="1" colspan="1">0.682</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">22 (100.0)</td><td valign="top" align="left" rowspan="1" colspan="1">153 (95.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sepsis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (18.2)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (3.1)</td><td valign="top" align="left" rowspan="1" colspan="1">6.889</td><td valign="top" align="left" rowspan="1" colspan="1">1.695–28.004</td><td valign="top" align="left" rowspan="1" colspan="1">0.011</td><td valign="top" align="left" rowspan="1" colspan="1">0.550</td><td valign="top" align="left" rowspan="1" colspan="1">0.000–2,425.15</td><td valign="top" align="left" rowspan="1" colspan="1">0.889</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">18 (81.8)</td><td valign="top" align="left" rowspan="1" colspan="1">155 (96.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sickle-cell disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">3 (13.6)</td><td valign="top" align="left" rowspan="1" colspan="1">6 (3.8)</td><td valign="top" align="left" rowspan="1" colspan="1">4.053</td><td valign="top" align="left" rowspan="1" colspan="1">0.936–17.548</td><td valign="top" align="left" rowspan="1" colspan="1">0.139</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">19 (86.4)</td><td valign="top" align="left" rowspan="1" colspan="1">154 (96.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Pneumonia</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">1 (4.5)</td><td valign="top" align="left" rowspan="1" colspan="1">7 (4.4)</td><td valign="top" align="left" rowspan="1" colspan="1">1.041</td><td valign="top" align="left" rowspan="1" colspan="1">0.122–8.885</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">21 (95.5)</td><td valign="top" align="left" rowspan="1" colspan="1">153 (95.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Anemia (<8 g/dL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">15 (68.2)</td><td valign="top" align="left" rowspan="1" colspan="1">94 (58.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.665</td><td valign="top" align="left" rowspan="1" colspan="1">0.257–1.720</td><td valign="top" align="left" rowspan="1" colspan="1">0.397</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">7 (31.8)</td><td valign="top" align="left" rowspan="1" colspan="1">66 (41.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn2-ijgm-8-131"><p><bold>Abbreviations:</bold> AOR, adjusted odds ratio; CI, confidence interval; EBF, exclusive breast feeding; EBMS, exclusive breast-milk-substitute feeding; HAART, highly active antiretroviral therapy; IQR, interquartile range; MF, mixed feeding; N, number; OR, odds ratio; Ref, reference group; SD, standard deviation; WHZ-score, weight-for-height Z-score; WHO, World Health Organization.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t4-ijgm-8-131" position="float"><label>Table 4</label><caption><p>Prevalence and risk factors of stunting among subjects aged under 5 years old</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" valign="top" align="left" colspan="1">Clinical variable</th><th rowspan="2" valign="top" align="left" colspan="1">Stunted (HAZ-score < −2SD)<break></break>N (%)</th><th rowspan="2" valign="top" align="left" colspan="1">Not stunted (HAZ-score ≥ −2SD)<break></break>N (%)</th><th colspan="3" valign="top" align="left" rowspan="1">Bivariate analysis
<hr></hr></th><th colspan="3" valign="top" align="left" rowspan="1">Multivariate analysis
<hr></hr></th></tr><tr><th valign="top" align="left" rowspan="1" colspan="1">OR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th><th valign="top" align="left" rowspan="1" colspan="1">AOR</th><th valign="top" align="left" rowspan="1" colspan="1">95% CI</th><th valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="9" valign="top" align="left" rowspan="1">Demography</td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Age (months)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median</td><td valign="top" align="left" rowspan="1" colspan="1">2.00</td><td valign="top" align="left" rowspan="1" colspan="1">3.00</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.053</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 0–23</td><td valign="top" align="left" rowspan="1" colspan="1">20 (20.2)</td><td valign="top" align="left" rowspan="1" colspan="1">14 (16.9)</td><td valign="top" align="left" rowspan="1" colspan="1">1.248</td><td valign="top" align="left" rowspan="1" colspan="1">0.586–2.656</td><td valign="top" align="left" rowspan="1" colspan="1">0.565</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 24–59 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">79 (79.8)</td><td valign="top" align="left" rowspan="1" colspan="1">69 (83.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sex</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Male</td><td valign="top" align="left" rowspan="1" colspan="1">51 (51.5)</td><td valign="top" align="left" rowspan="1" colspan="1">37 (44.6)</td><td valign="top" align="left" rowspan="1" colspan="1">1.321</td><td valign="top" align="left" rowspan="1" colspan="1">0.736–2.372</td><td valign="top" align="left" rowspan="1" colspan="1">0.351</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Female (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">48 (48.5)</td><td valign="top" align="left" rowspan="1" colspan="1">46 (55.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Orphanhood</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">27 (27.3)</td><td valign="top" align="left" rowspan="1" colspan="1">22 (26.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.040</td><td valign="top" align="left" rowspan="1" colspan="1">0.538–2.008</td><td valign="top" align="left" rowspan="1" colspan="1">0.908</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">72 (72.7)</td><td valign="top" align="left" rowspan="1" colspan="1">61 (73.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Family/socioeconomic factors</bold></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Mode of HIV transmission</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">66 (79.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Vertical</td><td valign="top" align="left" rowspan="1" colspan="1">96 (97.0)</td><td valign="top" align="left" rowspan="1" colspan="1">17 (20.5)</td><td valign="top" align="left" rowspan="1" colspan="1">8.242</td><td valign="top" align="left" rowspan="1" colspan="1">2.322–29.255</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.999</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Blood transfusion (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">3 (3.0)</td><td valign="top" align="left" rowspan="1" colspan="1">66 (79.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Mode of infant feeding</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBMS</td><td valign="top" align="left" rowspan="1" colspan="1">68 (68.7)</td><td valign="top" align="left" rowspan="1" colspan="1">13 (15.7)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.136</td><td valign="top" align="left" rowspan="1" colspan="1">0.032–0.585</td><td valign="top" align="left" rowspan="1" colspan="1">0.007</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> MF</td><td valign="top" align="left" rowspan="1" colspan="1">15 (15.2)</td><td valign="top" align="left" rowspan="1" colspan="1">63 (75.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2.165</td><td valign="top" align="left" rowspan="1" colspan="1">0.481–9.758</td><td valign="top" align="left" rowspan="1" colspan="1">0.314</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> EBF (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">16 (16.2)</td><td valign="top" align="left" rowspan="1" colspan="1">7 (8.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregivers’ HIV Status</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Infected</td><td valign="top" align="left" rowspan="1" colspan="1">96 (97.0)</td><td valign="top" align="left" rowspan="1" colspan="1">68 (81.9)</td><td valign="top" align="left" rowspan="1" colspan="1">7.059</td><td valign="top" align="left" rowspan="1" colspan="1">1.967–25.335</td><td valign="top" align="left" rowspan="1" colspan="1">0.001</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Not infected (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">3 (3.0)</td><td valign="top" align="left" rowspan="1" colspan="1">15 (18.1)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Caregiver on HAART</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">21 (21.9)</td><td valign="top" align="left" rowspan="1" colspan="1">7 (10.3)</td><td valign="top" align="left" rowspan="1" colspan="1">2.440</td><td valign="top" align="left" rowspan="1" colspan="1">0.973–6.121</td><td valign="top" align="left" rowspan="1" colspan="1">0.052</td><td valign="top" align="left" rowspan="1" colspan="1">0.604</td><td valign="top" align="left" rowspan="1" colspan="1">0.166–2.199</td><td valign="top" align="left" rowspan="1" colspan="1">0.445</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">75 (78.1)</td><td valign="top" align="left" rowspan="1" colspan="1">61 (89.7)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Marital status of caregiver</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Without partner</td><td valign="top" align="left" rowspan="1" colspan="1">15 (15.2)</td><td valign="top" align="left" rowspan="1" colspan="1">10 (12.0)</td><td valign="top" align="left" rowspan="1" colspan="1">1.304</td><td valign="top" align="left" rowspan="1" colspan="1">0.552–3.079</td><td valign="top" align="left" rowspan="1" colspan="1">0.545</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> With a partner (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">84 (84.8)</td><td valign="top" align="left" rowspan="1" colspan="1">73 (88.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Number of people in the household</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >5</td><td valign="top" align="left" rowspan="1" colspan="1">53 (53.5)</td><td valign="top" align="left" rowspan="1" colspan="1">43 (51.8)</td><td valign="top" align="left" rowspan="1" colspan="1">1.072</td><td valign="top" align="left" rowspan="1" colspan="1">0.598–1.922</td><td valign="top" align="left" rowspan="1" colspan="1">0.816</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤5 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">46 (46.5)</td><td valign="top" align="left" rowspan="1" colspan="1">40 (48.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Place of residence</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Urban</td><td valign="top" align="left" rowspan="1" colspan="1">14 (14.1)</td><td valign="top" align="left" rowspan="1" colspan="1">10 (12.0)</td><td valign="top" align="left" rowspan="1" colspan="1">1.202</td><td valign="top" align="left" rowspan="1" colspan="1">0.504–2.869</td><td valign="top" align="left" rowspan="1" colspan="1">0.678</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Rural (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">85 (85.9)</td><td valign="top" align="left" rowspan="1" colspan="1">73 (88.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Clinical/laboratory findings</bold></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">WHO clinical staging</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 3 and 4</td><td valign="top" align="left" rowspan="1" colspan="1">29 (29.3)</td><td valign="top" align="left" rowspan="1" colspan="1">20 (24.1)</td><td valign="top" align="left" rowspan="1" colspan="1">1.305</td><td valign="top" align="left" rowspan="1" colspan="1">0.672–2.534</td><td valign="top" align="left" rowspan="1" colspan="1">0.431</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> 1 and 2 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">70 (70.7)</td><td valign="top" align="left" rowspan="1" colspan="1">63 (75.9)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">CD4 count</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">55.50 (268.0–938.75)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.066</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> ≤200</td><td valign="top" align="left" rowspan="1" colspan="1">20 (20.2)</td><td valign="top" align="left" rowspan="1" colspan="1">12 (14.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.498</td><td valign="top" align="left" rowspan="1" colspan="1">0.684–3.281</td><td valign="top" align="left" rowspan="1" colspan="1">0.311</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >200 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">79 (79.8)</td><td valign="top" align="left" rowspan="1" colspan="1">71 (85.5)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Viral load (copies/mL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Median log10 (IQR)</td><td valign="top" align="left" rowspan="1" colspan="1">4.66 (3.716–5.315)</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">0.149</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> >10,000</td><td valign="top" align="left" rowspan="1" colspan="1">72 (72.7)</td><td valign="top" align="left" rowspan="1" colspan="1">52 (62.7)</td><td valign="top" align="left" rowspan="1" colspan="1">1.590</td><td valign="top" align="left" rowspan="1" colspan="1">0.849–2.977</td><td valign="top" align="left" rowspan="1" colspan="1">0.146</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> <10,000 (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">27 (27.3)</td><td valign="top" align="left" rowspan="1" colspan="1">31 (37.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis B surface antigen</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">9 (9.1)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (10.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.822</td><td valign="top" align="left" rowspan="1" colspan="1">0.311–2.177</td><td valign="top" align="left" rowspan="1" colspan="1">0.693</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">90 (90.9)</td><td valign="top" align="left" rowspan="1" colspan="1">74 (89.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Hepatitis C antibodies</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">3 (3.0)</td><td valign="top" align="left" rowspan="1" colspan="1">2 (2.4)</td><td valign="top" align="left" rowspan="1" colspan="1">1.250</td><td valign="top" align="left" rowspan="1" colspan="1">0.204–7.666</td><td valign="top" align="left" rowspan="1" colspan="1">1.000</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">96 (97.00)</td><td valign="top" align="left" rowspan="1" colspan="1">80 (97.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1"><bold>Diagnosed comorbidities/opportunistic infections</bold></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Tuberculosis</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">1.127</td><td valign="top" align="left" rowspan="1" colspan="1">0.545–2.334</td><td valign="top" align="left" rowspan="1" colspan="1">0.747</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">21 (21.2)</td><td valign="top" align="left" rowspan="1" colspan="1">16 (19.3)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">78 (78.8)</td><td valign="top" align="left" rowspan="1" colspan="1">67 (80.7)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Oropharyngeal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">9 (9.1)</td><td valign="top" align="left" rowspan="1" colspan="1">9 (10.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.822</td><td valign="top" align="left" rowspan="1" colspan="1">0.311–2.177</td><td valign="top" align="left" rowspan="1" colspan="1">0.693</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">90 (90.9)</td><td valign="top" align="left" rowspan="1" colspan="1">74 (89.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Esophageal candidiasis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (4.0)</td><td valign="top" align="left" rowspan="1" colspan="1">1 (1.2)</td><td valign="top" align="left" rowspan="1" colspan="1">3.453</td><td valign="top" align="left" rowspan="1" colspan="1">0.378–31.509</td><td valign="top" align="left" rowspan="1" colspan="1">0.244</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">95 (96.0)</td><td valign="top" align="left" rowspan="1" colspan="1">82 (98.8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Diarrheal disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">5 (5.1)</td><td valign="top" align="left" rowspan="1" colspan="1">2 (2.4)</td><td valign="top" align="left" rowspan="1" colspan="1">2.154</td><td valign="top" align="left" rowspan="1" colspan="1">0.407–11.404</td><td valign="top" align="left" rowspan="1" colspan="1">0.356</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">94 (94.9)</td><td valign="top" align="left" rowspan="1" colspan="1">81 (97.6)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sepsis</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">3 (3.0)</td><td valign="top" align="left" rowspan="1" colspan="1">6 (7.2)</td><td valign="top" align="left" rowspan="1" colspan="1">0.401</td><td valign="top" align="left" rowspan="1" colspan="1">0.097–1.656</td><td valign="top" align="left" rowspan="1" colspan="1">0.193</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">96 (97.0)</td><td valign="top" align="left" rowspan="1" colspan="1">77 (92.8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Sickle-cell disease</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (4.0)</td><td valign="top" align="left" rowspan="1" colspan="1">5 (6.0)</td><td valign="top" align="left" rowspan="1" colspan="1">0.657</td><td valign="top" align="left" rowspan="1" colspan="1">0.171–2.530</td><td valign="top" align="left" rowspan="1" colspan="1">0.539</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">95 (96.0)</td><td valign="top" align="left" rowspan="1" colspan="1">78 (94.0)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Pneumonia</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">4 (4.0)</td><td valign="top" align="left" rowspan="1" colspan="1">4 (4.8)</td><td valign="top" align="left" rowspan="1" colspan="1">0.832</td><td valign="top" align="left" rowspan="1" colspan="1">0.201–3.432</td><td valign="top" align="left" rowspan="1" colspan="1">0.798</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No (ref)</td><td valign="top" align="left" rowspan="1" colspan="1">95 (96.0)</td><td valign="top" align="left" rowspan="1" colspan="1">79 (95.2)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td colspan="9" valign="top" align="left" rowspan="1">Anemia (<8 g/dL)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> Yes</td><td valign="top" align="left" rowspan="1" colspan="1">62 (62.6)</td><td valign="top" align="left" rowspan="1" colspan="1">47 (56.6)</td><td valign="top" align="left" rowspan="1" colspan="1">0.779</td><td valign="top" align="left" rowspan="1" colspan="1">0.430–1.413</td><td valign="top" align="left" rowspan="1" colspan="1">0.411</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td><td valign="top" align="left" rowspan="1" colspan="1">–</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"> No</td><td valign="top" align="left" rowspan="1" colspan="1">37 (37.4)</td><td valign="top" align="left" rowspan="1" colspan="1">36 (43.4)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn3-ijgm-8-131"><p><bold>Abbreviations:</bold> AOR, adjusted odds ratio; CI, confidence interval; EBF, exclusive breast feeding; EBMS, exclusive breast-milk-substitute feeding; HAART, highly active antiretroviral therapy; IQR, interquartile range; MF, mixed feeding; N, number; OR, odds ratio; Ref, reference group; SD, standard deviation; HAZ-score, height-for-age Z-score; WHO, World Health Organization.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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