Missed Doses and Missed Appointments: Adherence to ART among Adult Patients in Uganda
Identifieur interne : 002481 ( Pmc/Corpus ); précédent : 002480; suivant : 002482Missed Doses and Missed Appointments: Adherence to ART among Adult Patients in Uganda
Auteurs : C. Shumba ; L. Atuhaire ; R. Imakit ; R. Atukunda ; P. MemiahSource :
- ISRN AIDS [ 2090-939X ] ; 2013.
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DOI: 10.1155/2013/270914
PubMed: 24052886
PubMed Central: 3767323
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Missed Doses and Missed Appointments: Adherence to ART among Adult Patients in Uganda</title><author><name sortKey="Shumba, C" sort="Shumba, C" uniqKey="Shumba C" first="C." last="Shumba">C. Shumba</name></author><author><name sortKey="Atuhaire, L" sort="Atuhaire, L" uniqKey="Atuhaire L" first="L." last="Atuhaire">L. Atuhaire</name></author><author><name sortKey="Imakit, R" sort="Imakit, R" uniqKey="Imakit R" first="R." last="Imakit">R. Imakit</name></author><author><name sortKey="Atukunda, R" sort="Atukunda, R" uniqKey="Atukunda R" first="R." last="Atukunda">R. Atukunda</name></author><author><name sortKey="Memiah, P" sort="Memiah, P" uniqKey="Memiah P" first="P." last="Memiah">P. Memiah</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24052886</idno><idno type="pmc">3767323</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767323</idno><idno type="RBID">PMC:3767323</idno><idno type="doi">10.1155/2013/270914</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002481</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002481</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Missed Doses and Missed Appointments: Adherence to ART among Adult Patients in Uganda</title><author><name sortKey="Shumba, C" sort="Shumba, C" uniqKey="Shumba C" first="C." last="Shumba">C. Shumba</name></author><author><name sortKey="Atuhaire, L" sort="Atuhaire, L" uniqKey="Atuhaire L" first="L." last="Atuhaire">L. Atuhaire</name></author><author><name sortKey="Imakit, R" sort="Imakit, R" uniqKey="Imakit R" first="R." last="Imakit">R. Imakit</name></author><author><name sortKey="Atukunda, R" sort="Atukunda, R" uniqKey="Atukunda R" first="R." last="Atukunda">R. Atukunda</name></author><author><name sortKey="Memiah, P" sort="Memiah, P" uniqKey="Memiah P" first="P." last="Memiah">P. Memiah</name></author></analytic><series><title level="j">ISRN AIDS</title><idno type="eISSN">2090-939X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. Missed doses and appointments are predictors of incomplete adherence among patients on ART. The AIDSRelief model emphasizes treatment preparation and continuous treatment support for ART patients including community followup. <italic>Methods</italic>. In August 2008, a survey was conducted among patients on antiretroviral therapy (ART) (interquartile range for duration of ART = 29–46 months, median = 33 months, <italic>n</italic> = 763, age >16 years), in 15 health facilities in Uganda. Missed doses and appointments among adult patients on ART and the factors most associated with these were identified. Reasons for missed doses were also explored. <italic>Results</italic>. The survey revealed that 97% of the patients had not missed their doses in the last week while 93% had not missed their appointments in the last three months. For those who had missed their doses, the most common reasons were travel (48%) and forgetfulness (28%). There was a significant association between missing doses and missing appointments (<italic>P</italic> = 0.0004) and between alcohol use and missed doses (<italic>P</italic> < 0.005). <italic>Conclusions</italic>. The level of adherence to medication and clinic appointments for patients on ART in the study population was very high. It is important to strengthen adherence strategies at both facility and community levels to assist patients that are likely to miss their doses or appointments.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Knodel, J" uniqKey="Knodel J">J Knodel</name></author><author><name sortKey="Kespichayawattana, J" uniqKey="Kespichayawattana J">J Kespichayawattana</name></author><author><name sortKey="Saengtienchai, C" uniqKey="Saengtienchai C">C Saengtienchai</name></author><author><name sortKey="Wiwatwanich, S" uniqKey="Wiwatwanich S">S Wiwatwanich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laniece, I" uniqKey="Laniece I">I Lanièce</name></author><author><name sortKey="Ciss, M" uniqKey="Ciss M">M Ciss</name></author><author><name sortKey="Desclaux, A" uniqKey="Desclaux A">A 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Nachega</name></author><author><name sortKey="Mills, Ej" uniqKey="Mills E">EJ Mills</name></author><author><name sortKey="Schechter, M" uniqKey="Schechter M">M Schechter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biadgilign, S" uniqKey="Biadgilign S">S Biadgilign</name></author><author><name sortKey="Reda, Aa" uniqKey="Reda A">AA Reda</name></author><author><name sortKey="Deribew, A" uniqKey="Deribew A">A Deribew</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">ISRN AIDS</journal-id><journal-id journal-id-type="iso-abbrev">ISRN AIDS</journal-id><journal-id journal-id-type="publisher-id">ISRN.AIDS</journal-id><journal-title-group><journal-title>ISRN AIDS</journal-title></journal-title-group><issn pub-type="epub">2090-939X</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24052886</article-id><article-id pub-id-type="pmc">3767323</article-id><article-id pub-id-type="doi">10.1155/2013/270914</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Missed Doses and Missed Appointments: Adherence to ART among Adult Patients in Uganda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shumba</surname><given-names>C.</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Atuhaire</surname><given-names>L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Imakit</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Atukunda</surname><given-names>R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Memiah</surname><given-names>P.</given-names></name></contrib></contrib-group><aff id="I1">Uganda Program, Institute of Human Virology, University of Maryland, 124 Luthuli Avenue, Bugolobi, Kampala, Uganda</aff><author-notes><corresp id="cor1">*C. Shumba: <email>konstansezw@googlemail.com</email></corresp><fn fn-type="other"><p>Academic Editors: F. Krebs and H. C. Mwandumba</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>14</day><month>1</month><year>2013</year></pub-date><volume>2013</volume><elocation-id>270914</elocation-id><history><date date-type="received"><day>4</day><month>12</month><year>2012</year></date><date date-type="accepted"><day>19</day><month>12</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2013 C. Shumba et al.</copyright-statement><copyright-year>2013</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Background</italic>. Missed doses and appointments are predictors of incomplete adherence among patients on ART. The AIDSRelief model emphasizes treatment preparation and continuous treatment support for ART patients including community followup. <italic>Methods</italic>. In August 2008, a survey was conducted among patients on antiretroviral therapy (ART) (interquartile range for duration of ART = 29–46 months, median = 33 months, <italic>n</italic> = 763, age >16 years), in 15 health facilities in Uganda. Missed doses and appointments among adult patients on ART and the factors most associated with these were identified. Reasons for missed doses were also explored. <italic>Results</italic>. The survey revealed that 97% of the patients had not missed their doses in the last week while 93% had not missed their appointments in the last three months. For those who had missed their doses, the most common reasons were travel (48%) and forgetfulness (28%). There was a significant association between missing doses and missing appointments (<italic>P</italic> = 0.0004) and between alcohol use and missed doses (<italic>P</italic> < 0.005). <italic>Conclusions</italic>. The level of adherence to medication and clinic appointments for patients on ART in the study population was very high. It is important to strengthen adherence strategies at both facility and community levels to assist patients that are likely to miss their doses or appointments.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Background</title><p>Uganda has more than 1.2 million people living with HIV infection and in 2010 more than 120,000 got infected with HIV [<xref rid="B1" ref-type="bibr">1</xref>]. Although there are various efforts to scale up AIDS treatment, many HIV-infected people are unable to access treatment and the increasing new HIV infections still exceed the government's capacity to provide treatment [<xref rid="B2" ref-type="bibr">2</xref>]. While attempts are being made to reduce new infections and to scale up antiretroviral therapy (ART), it is equally important to improve adherence to regimens among the few who are already accessing ART for successful treatment [<xref rid="B3" ref-type="bibr">3</xref>]. ART delays progression to AIDS and death, hence, improved the quality of life for people living with HIV [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B5" ref-type="bibr">5</xref>]. Maintaining good adherence has been found to be difficult to achieve and sustained by both patients and health care providers [<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B7" ref-type="bibr">7</xref>]. A major concern with the use of ART is the emergence of viral resistance, which is mainly due to insufficient compliance [<xref rid="B8" ref-type="bibr">8</xref>].</p><p>Different tools have been used to determine ART adherence rates and on average the rate of adherence to ART is about 70% [<xref rid="B9" ref-type="bibr">9</xref>]. A meta-analysis found adherence rates for African patients to be approximately 77% [<xref rid="B10" ref-type="bibr">10</xref>]. A study by Oyugi et al., that assessed correspondence between multiple measures of adherence and viral load suppression, found that the mean adherence was 91–94% by all measures [<xref rid="B11" ref-type="bibr">11</xref>]. Patients' adherence is dynamic either improving or declining over time. A prospective study conducted in southwest Ethiopia showed that adherence had declined by 3% by the third month of follow-up visit compared to the results of the baseline study at month zero [<xref rid="B6" ref-type="bibr">6</xref>]. ART is a long-term treatment, and sustaining acceptable level of drug adherence poses a challenge for both the patient and health care workers [<xref rid="B12" ref-type="bibr">12</xref>]. Therefore, the benefits of ART can only be achieved if health providers realize that adherence is a dynamic process, complex, and cannot be predicted by only patient characteristics, but continuous monitoring and integration into regular clinic followup [<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B12" ref-type="bibr">12</xref>]. Different studies have revealed predictors of adherence success. These are a combination of patient demographic and behavioral factors and disease characteristics, medication factors and health systems factors [<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B13" ref-type="bibr">13</xref>–<xref rid="B16" ref-type="bibr">15</xref>]. </p><p>The aim of this study is to describe the factors associated with incomplete adherence among adult patients on ART in 15 health facilities in Uganda.</p></sec><sec id="sec2"><title>2. Study Setting and Methods</title><p>The study was conducted in 15 faith-based and stand-alone HIV clinics that provide high-quality HIV care and treatment to rural and underserved communities in the northern, southern, central, eastern, and western regions of Uganda. The study setting is described in detail in another paper [<xref rid="B17" ref-type="bibr">16</xref>].</p><sec id="sec2.1"><title>2.1. Data Collection</title><p>Data was collected using the AIDSRelief Adherence Survey that has been piloted, validated, and used in six African countries. The survey was designed to identify specific indicators that influence the adherence to antiretroviral therapy and the increase in quality of life. The study assessed missed clinic appointments, missed doses, and whether patients had ever run out of medication as the measures of adherence. A sample of 763 patient adherence surveys were done to assess disease, treatment knowledge and services received between August 2008 and March 2009. In August 2008, we conducted a survey of patients having been on ART (interquartile range for duration of ART = 29–46 months, median=33 months, <italic>n</italic> = 763, >16 years), in 15 facilities in Uganda. </p><p>This survey was done as a part of a routine quality improvement program. The adherence survey questionnaire was administered by trained health staff. Informed consent forms were provided to the patients after full explanation from the health staff about the survey. The patients appended their signature indicating consent to participate in the survey. Each patient had the right to withdraw at anytime in the course of the survey. </p></sec><sec id="sec2.2"><title>2.2. Data Analysis</title><p>Data were entered, cleaned, and coded in to a computer and analyzed using Stata version 11. Bivariate analysis was carried out to determine the statistical significant association between explanatory variables and the outcome variable. Chi-square tests and their <italic>P</italic> values at the level of significance of 5%, as well as confidence intervals (CI), were used to define statistical associations between explanatory variables and outcomes. </p></sec></sec><sec id="sec3"><title>3. Results</title><p>Out of the 763 patients who participated in this study, 50.5% were in the age group of 16–39 years. About 70% of the total study participants were females. Most (66.6%) of the patients were engaged in an income generating activity before starting on ART. Over half (54%) of the patients owned a home, and 31.6% were renting at the time of the survey. Many of the patients (42.1%) had primary education and 38.4% had secondary education, while only 7.7% had attained university education. The 763 patients who participated in this study varied in age, gender, socioeconomic status, and education (<xref ref-type="table" rid="tab1">Table 1</xref>).</p><p>The survey revealed that 97% of the patients had not missed their doses in the last week and 93% of patients had not missed appointments in the past three months. There was no significant association between the measures of adherence in this study (missed doses, missed appointments, and ever run out of medication) and the sociodemographic factors namely age, gender, and education level (<xref ref-type="table" rid="tab2">Table 2</xref>). </p><p>Out of the patients who reported ever missing their doses for the period on ART, the most common reasons were travelled, forgot, work conflict, and felt unwell (<xref ref-type="table" rid="tab3">Table 3</xref>). </p><p>This study found that patients on ART that missed their appointments (29.2%) were more likely to miss their doses compared to those that did not (5.7%). The findings are depicted in <xref ref-type="table" rid="tab4">Table 4</xref>: <italic>P</italic> value = 0.0004, OR = 6.80, 95% CI (2.41–18.66).</p><p>Patients on ART who used alcohol were more likely to miss a dose during the course of their treatment compared to those who did not use alcohol (<xref ref-type="table" rid="tab5">Table 5</xref>: <italic>P</italic> value <0.005 with CI 2.40–27.83). </p></sec><sec id="sec4"><title>4. Discussion</title><p>This study found that patients on ART that missed their appointments were more likely to miss their doses compared to those that did not. While we explored the reasons for missed doses, we did not do the same for missed appointments, therefore, it is difficult to understand the reasons for missed appointments. However, what was clear is that missing a scheduled appointment is associated with missing ART doses. Other authors reported other common reasons responsible for nonadherence that are related to income and they include failure to get transport to reach ART clinics hence missing pharmacy refills, missed clinic appointments and missed doses [<xref rid="B10" ref-type="bibr">10</xref>, <xref rid="B18" ref-type="bibr">17</xref>]. However, another study found that patients in developing countries can achieve good adherence despite limited resources [<xref rid="B6" ref-type="bibr">6</xref>]. A study by Byakika-Tusiime et al. [<xref rid="B19" ref-type="bibr">18</xref>] showed that in ART centers, where patients were required to pay user fees, their adherence levels were low while Orrell et al.found that low socioeconomic status was not a predictor of adherence for patients with fully subsidized therapy [<xref rid="B20" ref-type="bibr">19</xref>]. This clearly applies to this study context where all the patients despite their low income have good access to fully subsidized therapy and exhibited high adherence comparable to high income settings. Notwithstanding, it is important to consider the fact that some patients may lack the means to access the fully subsidized therapy due to poverty. In this way, poverty acts as an intervening variable in hindering access to the much needed lifesaving therapy. Regardless, there would be need to further understand the experiences of the patients who miss appointments in order to tailor interventions that best suit them. </p><p>Our study was unique as it looked at patients who had been on treatment for a considerable amount of time. The study by Oyugi et al. followed up patients from baseline to 12 weeks [<xref rid="B11" ref-type="bibr">11</xref>] while in our study patient duration of ART was more than 2 years at least. Most studies have not considered patient adherence beyond 2 years after ART initiation [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B12" ref-type="bibr">12</xref>, <xref rid="B16" ref-type="bibr">15</xref>].</p><p>Our study is also the first of its kind that has explored the risk factors associated with incomplete adherence among elderly HIV patients. We found that there was no difference in adherence between the elderly who made up 12.5% of the study population and other age groups. However, this could be due to the small number of patients with nonadherence events to allow for risk factor analysis across all age groups including the elderly. </p><p>In our study, gender and disclosure were not associated with adherence. In contrast, another study found that women were more likely than men to forget to refill medications and not to know how to take the medications correctly [<xref rid="B21" ref-type="bibr">20</xref>]. A few studies have reported age as an influencing factor to adherence especially in infancy and adolescents [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B19" ref-type="bibr">18</xref>]. Generally however, it has been reported that sociodemographic factors seem not to predict adherence [<xref rid="B6" ref-type="bibr">6</xref>], although there are a few factors which have been reported to hinder adherence such as low income which has been cited as a strong predictor of failure to adhere to ART [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B10" ref-type="bibr">10</xref>]. </p><p>In general, patient self-reported adherence in this survey was very high (97%). Although self-reported outcomes of adherence may have a weakness of reliability, a study by Oyugi et al. found no significant difference between patient-reported and objective measures of adherence [<xref rid="B11" ref-type="bibr">11</xref>]. Our findings are higher than the average adherence rates for African patients [<xref rid="B10" ref-type="bibr">10</xref>] but consistent with those in a prospective observational cohort study conducted in Dakar, Senegal, where adherence was estimated to be over 91% and similar to the study by Oyugi et al. [<xref rid="B11" ref-type="bibr">11</xref>]. Our findings are consistent with follow-up cohorts that were done in developed countries such as the APROCO cohort study and the Ciel Bleu trial [<xref rid="B4" ref-type="bibr">4</xref>]. The high levels of adherence in this patient-population can be attributed to the model of HIV care and treatment that is used. The model emphasizes adherence as a therapeutic intervention with intensive treatment preparation, patient specific care and treatment plan, community-based treatment services with home-based followup during ART startup. Disclosure is highly encouraged and all clinics have well-defined catchment area as well as longitudinal medical records for all patients.</p><p>This study found an association between alcohol use and missed doses. This is similar to other studies where alcohol consumption has also been reported to affect adherence [<xref rid="B22" ref-type="bibr">21</xref>–<xref rid="B24" ref-type="bibr">23</xref>]. Alcohol use is known to be a proxy for loss of control, thus, affecting adherence. In a study done in Botswana, around 40% of the patients surveyed admitted missing a dose because of alcohol consumption [<xref rid="B25" ref-type="bibr">24</xref>]. Related studies also show that alcohol is greatly related to the reduced adherence [<xref rid="B26" ref-type="bibr">25</xref>, <xref rid="B27" ref-type="bibr">26</xref>]. A systematic review conducted in 2009 revealed that HIV/AIDS patients that used alcohol were 50–60% not likely to adhere to their medications [<xref rid="B28" ref-type="bibr">27</xref>]. </p><p>There was some association between the educational status and missed appointments in the last three months in this study (<italic>P</italic> < 0.1) although the population educational levels were generally very low. A systematic review conducted in 2006, revealed that education and literacy levels are important predictors of adherence [<xref rid="B29" ref-type="bibr">28</xref>]. This paper found out that patient understanding of their medication regimen and their knowledge of the relationship between nonadherence and buildup of resistance to medication also predict better adherence. A patient's belief and self-determination to therapy influence adherence to medication. It is not clear however, what the optimal educational level would be to get better adherence but perhaps what is more important is the patient understanding of adherence on the disease mechanism. </p><p>While many studies have shown that disclosure is associated with adherence [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B29" ref-type="bibr">28</xref>, <xref rid="B30" ref-type="bibr">29</xref>], we did not find this association. The rate of disclosure to a friend or a relative in our patient pool for this study was quite high (99%) since patients are encouraged to disclose their HIV status to a treatment buddy before starting ART in order to improve the social support [<xref rid="B17" ref-type="bibr">16</xref>]. It is very important for health workers to find out the patients' disclosure before administering ART, while continuing to support those who would not have disclosed [<xref rid="B29" ref-type="bibr">28</xref>]. </p><p>Different studies have also revealed that when patients experience side effects of prescribed medication, they tend to stop treatment or take it irregularly [<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B19" ref-type="bibr">18</xref>]. In this study, only one patient out of those who missed their doses reported missing medication due to side effects and another due to pill fatigue. Similarly, patients have reported taking drug holidays as a result of pill fatigue [<xref rid="B29" ref-type="bibr">28</xref>]. Additionally, pill burden has been found to contribute to poor adherence [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B29" ref-type="bibr">28</xref>]. However, pill burden was not mentioned as a problem for the patients in our study.</p><p>A number of studies have reported on irregular drug supply as an important predictor of adherence to ART [<xref rid="B29" ref-type="bibr">28</xref>, <xref rid="B31" ref-type="bibr">30</xref>]. As far as the researchers know, drug stockouts in this study's patient population have never occurred but it is definitely appreciated that erratic drug supply can interrupt patient adherence. Some researchers have even argued that health care-related challenges could be the most important barriers to ART adherence in resource-limited settings [<xref rid="B32" ref-type="bibr">31</xref>]. Patient-provider relationships, the time spent at health facility, and opening hours can influence adherence to ART [<xref rid="B18" ref-type="bibr">17</xref>, <xref rid="B32" ref-type="bibr">31</xref>]. Future research will need to study how these factors may be viewed as affecting adherence in this setting. </p></sec><sec id="sec5"><title>5. Conclusion</title><p>While the level of good patient adherence to ART in this study was generally high, it is important to continue to reinforce the importance of adherence. High adherence rates can be achieved if HIV clinics and providers reduce the number of missed appointments as this study has shown that this is an important predictor of adherence. The model of treatment and care used in this population group is worth emulating. The reasons for missed appointments need to be explored to target interventions appropriately. Most patients reported that travelling and forgetfulness were important predictors of missed doses in this study. Thus, creativity in collaboration with the patients is required to design strategies to reduce this. Additionally, treatment and care providers need to strengthen patient education and counseling on the negative impact of alcohol use on adherence. </p></sec></body><back><ack><title>Conflict of Interests</title><p>The authors declare that they have no conflict of interests.</p></ack><ack><title>Authors' Contribution</title><p>C. Shumba participated in the coordination of the study and drafted the paper. L. Atuhaire participated in the coordination of the study and drafting of the paper. R. Atukunda participated in the coordination of the study and drafting of the paper. P. Memiah conceived of the study and designed the study and helped to draft the paper. R. Imakit performed statistical analysis. All authors read and approved the final paper.</p></ack><ref-list><ref id="B1"><label>1</label><element-citation publication-type="other"><comment>WHO, UNAIDS, and UNICEF. 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person-group-type="author"><name><surname>Biadgilign</surname><given-names>S</given-names></name><name><surname>Reda</surname><given-names>AA</given-names></name><name><surname>Deribew</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Knowledge and attitudes of caregivers of HIV-infected children toward antiretroviral treatment in Ethiopia</article-title><source><italic>Patient Education and Counseling</italic></source><year>2011</year><volume>85</volume><issue>2</issue><fpage>e89</fpage><lpage>e94</lpage><pub-id pub-id-type="pmid">21429696</pub-id></element-citation></ref></ref-list></back><floats-group><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Demographic characteristics of the study population.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Demographic characteristics</th><th align="center" rowspan="1" colspan="1">Frequency <break></break>(percentage)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Age</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> 16–39</td><td align="center" rowspan="1" colspan="1">384 (50.53)</td></tr><tr><td align="left" rowspan="1" colspan="1"> 40–50</td><td align="center" rowspan="1" colspan="1">281 (36.97)</td></tr><tr><td align="left" rowspan="1" colspan="1"> >50</td><td align="center" rowspan="1" colspan="1">95 (12.50)</td></tr><tr><td align="left" rowspan="1" colspan="1">Gender</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">528 (69.5%)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">232 (30.5%)</td></tr><tr><td align="left" rowspan="1" colspan="1">Socioeconomic status</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Engaged in any income generating activity before starting ART</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">258 (33.4)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">514 (66.6)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Living situation</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Own home</td><td align="center" rowspan="1" colspan="1">417 (54.02)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Rent</td><td align="center" rowspan="1" colspan="1">244 (31.60)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Living with friends</td><td align="center" rowspan="1" colspan="1">1 (0.13)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Living with relatives</td><td align="center" rowspan="1" colspan="1">71 (9.20)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Others</td><td align="center" rowspan="1" colspan="1">39 (5.05)</td></tr><tr><td align="left" rowspan="1" colspan="1">Education status</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> Primary</td><td align="center" rowspan="1" colspan="1">295 (42.1)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Secondary</td><td align="center" rowspan="1" colspan="1">269 (38.4)</td></tr><tr><td align="left" rowspan="1" colspan="1"> University</td><td align="center" rowspan="1" colspan="1">54 (7.7)</td></tr><tr><td align="left" rowspan="1" colspan="1"> Below primary school</td><td align="center" rowspan="1" colspan="1">83 (11.8)</td></tr></tbody></table></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Factors linked to the three measures of adherence in this study.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1">Adherence measure</th><th align="left" rowspan="2" colspan="1">Independent variables</th><th align="center" rowspan="1" colspan="1">No</th><th align="center" rowspan="1" colspan="1">Yes</th><th align="center" rowspan="1" colspan="1">OR </th><th align="center" rowspan="2" colspan="1"><italic>P</italic> value</th></tr><tr><th align="center" rowspan="1" colspan="1">Freq. (%)</th><th align="center" rowspan="1" colspan="1">Freq. (%)</th><th align="center" rowspan="1" colspan="1">(95% CI limits)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"> (1) Ever run out of medication(<italic>N</italic> = 444)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">418 (94.1)</td><td align="center" rowspan="1" colspan="1">26 (5.9)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" colspan="6" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Gender (<italic>N</italic> = 439)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">122 (92.4)</td><td align="center" rowspan="1" colspan="1">10 (7.6)</td><td align="center" rowspan="1" colspan="1">0.58 (0.24–1.46)</td><td align="center" rowspan="1" colspan="1">0.296</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">239 (95.4)</td><td align="center" rowspan="1" colspan="1">14 (4.6)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Age (<italic>N</italic> = 43)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 16–39</td><td align="center" rowspan="1" colspan="1">205 (96.61)</td><td align="center" rowspan="1" colspan="1">14 (6.39)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.656</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 40–50</td><td align="center" rowspan="1" colspan="1">157 (95.15)</td><td align="center" rowspan="1" colspan="1">8 (4.85)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> >50</td><td align="center" rowspan="1" colspan="1">53 (96.36)</td><td align="center" rowspan="1" colspan="1">2 (3.64)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Educational level (<italic>N</italic> = 419) </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Below primary </td><td align="center" rowspan="1" colspan="1">56 (94.92)</td><td align="center" rowspan="1" colspan="1">3 (5.08)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.629</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Primary</td><td align="center" rowspan="1" colspan="1">167 (95.98)</td><td align="center" rowspan="1" colspan="1">7 (4.02)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Secondary </td><td align="center" rowspan="1" colspan="1">145 (94.16)</td><td align="center" rowspan="1" colspan="1">9 (5.84)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> University</td><td align="center" rowspan="1" colspan="1">29 (90.63)</td><td align="center" rowspan="1" colspan="1">3 (9.38)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" colspan="6" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"> (2) Doses missed in the last week (<italic>N</italic> = 763)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">739 (96.9)</td><td align="center" rowspan="1" colspan="1">24 (3.1)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" colspan="6" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Gender (<italic>N</italic> = 760) </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Male</td><td align="center" rowspan="1" colspan="1">222 (95.7)</td><td align="center" rowspan="1" colspan="1">10 (4.3)</td><td align="center" rowspan="1" colspan="1">0.60 (0.25–1.49)</td><td align="center" rowspan="1" colspan="1">0.228</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">514 (97.3)</td><td align="center" rowspan="1" colspan="1">14 (2.7)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Age (<italic>N</italic> = 760)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 16–39</td><td align="center" rowspan="1" colspan="1">370 (96.4)</td><td align="center" rowspan="1" colspan="1">14 (3.6)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.694</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 40–50</td><td align="center" rowspan="1" colspan="1">273 (97.2)</td><td align="center" rowspan="1" colspan="1">8 (2.8)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> >50</td><td align="center" rowspan="1" colspan="1">93 (97.9)</td><td align="center" rowspan="1" colspan="1">2 (2.1)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Disclosed HIV status to sexual partner (<italic>N</italic> = 714)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">426 (96.4)</td><td align="center" rowspan="1" colspan="1">16 (3.6)</td><td align="center" rowspan="1" colspan="1">0.60 (0.21–1.66)</td><td align="center" rowspan="1" colspan="1">0.402</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">266 (97.8)</td><td align="center" rowspan="1" colspan="1"> 6 (2.2)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Educational level (<italic>N</italic> = 419)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Below primary</td><td align="center" rowspan="1" colspan="1">55 (93.22)</td><td align="center" rowspan="1" colspan="1">4 (6.78)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.450</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Primary</td><td align="center" rowspan="1" colspan="1">170 (97.70)</td><td align="center" rowspan="1" colspan="1">4 (2.30)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Secondary </td><td align="center" rowspan="1" colspan="1">148 (96.10)</td><td align="center" rowspan="1" colspan="1">6 (3.90)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> University</td><td align="center" rowspan="1" colspan="1">31 (96.88)</td><td align="center" rowspan="1" colspan="1">1 (3.13)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" colspan="6" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"> (3) Appointments missed in the past 3 months (<italic>N</italic> = 763)</td><td align="left" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">706 (92.5)</td><td align="center" rowspan="1" colspan="1">57 (7.5)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" colspan="6" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Gender (<italic>N</italic> = 760) </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Male </td><td align="center" rowspan="1" colspan="1">217 (93.5)</td><td align="center" rowspan="1" colspan="1">15 (6.5)</td><td align="center" rowspan="1" colspan="1">1.00 (0.51–1.96)</td><td align="center" rowspan="1" colspan="1">0.989</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Female</td><td align="center" rowspan="1" colspan="1">494 (93.6)</td><td align="center" rowspan="1" colspan="1">34 (6.4)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Disclosed HIV status to sexual partner (<italic>N</italic> = 717)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">415 (93.0)</td><td align="center" rowspan="1" colspan="1">31 (7.0)</td><td align="center" rowspan="1" colspan="1">0.95 (0.50–1.80)</td><td align="center" rowspan="1" colspan="1">0.995</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">253 (93.4)</td><td align="center" rowspan="1" colspan="1">18 (6.6)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Age (<italic>N</italic> = 760)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 16–39</td><td align="center" rowspan="1" colspan="1">363 (94.5)</td><td align="center" rowspan="1" colspan="1">21 (5.5)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.540</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> 40–50</td><td align="center" rowspan="1" colspan="1">260 (92.5)</td><td align="center" rowspan="1" colspan="1">21 (7.5)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> >50</td><td align="center" rowspan="1" colspan="1">88 (92.6)</td><td align="center" rowspan="1" colspan="1">7 (7.4)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Educational level (<italic>N</italic> = 419)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Below Primary school</td><td align="center" rowspan="1" colspan="1">56 (94.92)</td><td align="center" rowspan="1" colspan="1">3 (5.08)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1">0.079</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Primary </td><td align="center" rowspan="1" colspan="1">163 (93.68)</td><td align="center" rowspan="1" colspan="1">11 (6.32)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Secondary</td><td align="center" rowspan="1" colspan="1">143 (92.86)</td><td align="center" rowspan="1" colspan="1">11 (7.14)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> University</td><td align="center" rowspan="1" colspan="1">26 (81.25)</td><td align="center" rowspan="1" colspan="1">6 (18.75)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr></tbody></table><table-wrap-foot><fn><p> *The differences in <italic>N</italic> are due to nonresponse.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tab3" orientation="portrait" position="float"><label>Table 3</label><caption><p>Reasons for missed doses.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1">Reasons for missing doses</th><th align="center" rowspan="1" colspan="1">No</th><th align="center" rowspan="1" colspan="1">Yes</th></tr><tr><th align="center" rowspan="1" colspan="1">Freq. (%)</th><th align="center" rowspan="1" colspan="1">Freq. (%)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Travelled (<italic>N</italic> = 58)</td><td align="center" rowspan="1" colspan="1">30 (50.8)</td><td align="center" rowspan="1" colspan="1">29 (49.2)</td></tr><tr><td align="left" rowspan="1" colspan="1">Forgot (<italic>N</italic> = 60)</td><td align="center" rowspan="1" colspan="1">43 (71.7)</td><td align="center" rowspan="1" colspan="1">17 (28.3)</td></tr><tr><td align="left" rowspan="1" colspan="1">Work conflict (<italic>N</italic> = 59)</td><td align="center" rowspan="1" colspan="1">57 (96.6)</td><td align="center" rowspan="1" colspan="1">2 (3.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Felt unwell (59)</td><td align="center" rowspan="1" colspan="1">57 (96.6)</td><td align="center" rowspan="1" colspan="1">2 (3.4)</td></tr><tr><td align="left" rowspan="1" colspan="1">Side effects (59)</td><td align="center" rowspan="1" colspan="1">58 (98.3)</td><td align="center" rowspan="1" colspan="1">1 (1.7)</td></tr><tr><td align="left" rowspan="1" colspan="1">Tired of taking medication (59)</td><td align="center" rowspan="1" colspan="1">58 (98.3)</td><td align="center" rowspan="1" colspan="1">1 (1.7)</td></tr></tbody></table></table-wrap><table-wrap id="tab4" orientation="portrait" position="float"><label>Table 4</label><caption><p>Relationship between missed appointments and missed doses.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1">Missed appointment</th><th align="center" colspan="2" rowspan="1">Missed doses</th><th align="center" rowspan="1" colspan="1">Total</th></tr><tr><th align="center" rowspan="1" colspan="1">No</th><th align="center" rowspan="1" colspan="1">Yes</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">No</td><td align="center" rowspan="1" colspan="1">694 (94.3)</td><td align="center" rowspan="1" colspan="1">42 (5.7)</td><td align="center" rowspan="1" colspan="1">736</td></tr><tr><td align="left" rowspan="1" colspan="1">Yes</td><td align="center" rowspan="1" colspan="1">17 (70.8)</td><td align="center" rowspan="1" colspan="1">7 (29.2)</td><td align="center" rowspan="1" colspan="1">24</td></tr></tbody></table></table-wrap><table-wrap id="tab5" orientation="portrait" position="float"><label>Table 5</label><caption><p>Relationship between alcohol use and adherence.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1"></th><th rowspan="2" colspan="1">Adherence measure</th><th align="left" rowspan="1" colspan="1">Yes</th><th align="center" rowspan="1" colspan="1">No</th><th align="center" rowspan="1" colspan="1">OR </th><th align="center" rowspan="2" colspan="1"><italic>P</italic> value</th></tr><tr><th align="left" rowspan="1" colspan="1">Freq.</th><th align="center" rowspan="1" colspan="1">Freq.</th><th align="center" rowspan="1" colspan="1">95% CI limits</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Missing doses (<italic>N</italic> = 417)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">OR = 7.92</td><td align="center" rowspan="1" colspan="1"><bold><0.01</bold></td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">64</td><td align="center" rowspan="1" colspan="1">338</td><td align="center" rowspan="1" colspan="1">CI (2.40–27.83)</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Missing appointment (<italic>N</italic> = 417)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1">Alcohol use</td><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">23</td><td align="center" rowspan="1" colspan="1">OR = 1.72</td><td align="center" rowspan="1" colspan="1">0.206</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">65</td><td align="center" rowspan="1" colspan="1">321</td><td align="center" rowspan="1" colspan="1">CI (0.63–4.19)</td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1">Ever run out off medication (<italic>N</italic> = 417)</td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td><td align="center" rowspan="1" colspan="1"> </td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> Yes</td><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">16</td><td align="center" rowspan="1" colspan="1">OR = 1.84</td><td align="center" rowspan="1" colspan="1">0.215</td></tr><tr><td align="left" rowspan="1" colspan="1"> </td><td align="left" rowspan="1" colspan="1"> No</td><td align="center" rowspan="1" colspan="1">67</td><td align="center" rowspan="1" colspan="1">328</td><td align="center" rowspan="1" colspan="1">CI (0.57–5.16)</td><td align="center" rowspan="1" colspan="1"> </td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour 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