SidaSubSaharaV1, Pmc, Corpus, bibRecord, 002044

Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study☆

Identifieur interne : 002044 ( Pmc/Corpus ); précédent : 002043; suivant : 002045

Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study☆

Auteurs : Charles S. Chasela ; Patrick Wall ; Jan Drobeniuc ; Caroline C. King ; Eyasu Teshale ; Mina C. Hosseinipour ; Sascha R. Ellington ; Mary Codd ; Denise J. Jamieson ; Rodney J. Knight ; Patricia Fitzpatrick ; Athena P. Kourtis ; Irving F. Hoffman ; Dumbani Kayira ; Noel Mumba ; Deborah D. Kamwendo ; Francis Martinson ; William Powderly ; Charles Van Der Horst ; Saleem Kamili

Source :

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2012.

RBID : PMC:3652577

Abstract

Background

In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely.

Objectives

To assess the prevalence of HCV infection among HIV-infected, pregnant women screened for a large clinical trial in Lilongwe, Malawi.

Study design

Plasma from 2041 HIV-infected, pregnant women was screened for anti-HCV IgG using a chemiluminiscent immunometric assay (CIA). Specimens with a signal-cut-off ratio ≥ 1.00 were considered reactive and those with S/Co ratio < 1.00 non-reactive. All CIA-reactive specimens were tested by a recombinant immunoblot assay (RIBA) for anti-HCV and by PCR for HCV RNA.

Results

Of 2041 specimens, 110 (5.3%, 95% CI: 4.5–6.5%) were CIA reactive. Of the 109 CIA reactive specimens available for RIBA testing, 2 (1.8%) were positive, 28 (25.7%) were indeterminate, and 79 (72.5%) were negative. All CIA-reactive specimens were HCV RNA negative (n = 110). The estimated HCV prevalence based on the screening assay alone was 5.3%; based on supplemental RIBA testing, the status of HCV infection remained indeterminate in 1.4% (28/2040, 95% CI: 0.1–2.0) and the prevalence of confirmed HCV infections was 0.1% (2/2040, 95% CI: 0–0.4%).

Conclusions

HCV seroprevalence among HIV-infected, pregnant women in Malawi confirmed by supplemental RIBA HCV 3.0 is low (0.1%); CIA showed a high false-reactivity rate in this population.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652577

DOI: 10.1016/j.jcv.2012.05.003
PubMed: 22658797
PubMed Central: 3652577

Links to Exploration step

PMC:3652577

Le document en format XML

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</sup>
</title>
<author><name sortKey="Chasela, Charles S" sort="Chasela, Charles S" uniqKey="Chasela C" first="Charles S." last="Chasela">Charles S. Chasela</name>
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</affiliation>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">University of Witwatersrand, School of Public Health, Johannesburg, South Africa</nlm:aff>
</affiliation>
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<author><name sortKey="Wall, Patrick" sort="Wall, Patrick" uniqKey="Wall P" first="Patrick" last="Wall">Patrick Wall</name>
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<author><name sortKey="Drobeniuc, Jan" sort="Drobeniuc, Jan" uniqKey="Drobeniuc J" first="Jan" last="Drobeniuc">Jan Drobeniuc</name>
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<author><name sortKey="King, Caroline C" sort="King, Caroline C" uniqKey="King C" first="Caroline C." last="King">Caroline C. King</name>
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<author><name sortKey="Teshale, Eyasu" sort="Teshale, Eyasu" uniqKey="Teshale E" first="Eyasu" last="Teshale">Eyasu Teshale</name>
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<author><name sortKey="Hosseinipour, Mina C" sort="Hosseinipour, Mina C" uniqKey="Hosseinipour M" first="Mina C." last="Hosseinipour">Mina C. Hosseinipour</name>
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</affiliation>
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<author><name sortKey="Ellington, Sascha R" sort="Ellington, Sascha R" uniqKey="Ellington S" first="Sascha R." last="Ellington">Sascha R. Ellington</name>
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<author><name sortKey="Codd, Mary" sort="Codd, Mary" uniqKey="Codd M" first="Mary" last="Codd">Mary Codd</name>
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</affiliation>
</author>
<author><name sortKey="Jamieson, Denise J" sort="Jamieson, Denise J" uniqKey="Jamieson D" first="Denise J." last="Jamieson">Denise J. Jamieson</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knight, Rodney J" sort="Knight, Rodney J" uniqKey="Knight R" first="Rodney J." last="Knight">Rodney J. Knight</name>
<affiliation><nlm:aff id="A5">Principia International, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, Patricia" sort="Fitzpatrick, Patricia" uniqKey="Fitzpatrick P" first="Patricia" last="Fitzpatrick">Patricia Fitzpatrick</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kourtis, Athena P" sort="Kourtis, Athena P" uniqKey="Kourtis A" first="Athena P." last="Kourtis">Athena P. Kourtis</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffman, Irving F" sort="Hoffman, Irving F" uniqKey="Hoffman I" first="Irving F." last="Hoffman">Irving F. Hoffman</name>
<affiliation><nlm:aff id="A6">University of North Carolina, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kayira, Dumbani" sort="Kayira, Dumbani" uniqKey="Kayira D" first="Dumbani" last="Kayira">Dumbani Kayira</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mumba, Noel" sort="Mumba, Noel" uniqKey="Mumba N" first="Noel" last="Mumba">Noel Mumba</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamwendo, Deborah D" sort="Kamwendo, Deborah D" uniqKey="Kamwendo D" first="Deborah D." last="Kamwendo">Deborah D. Kamwendo</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinson, Francis" sort="Martinson, Francis" uniqKey="Martinson F" first="Francis" last="Martinson">Francis Martinson</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Powderly, William" sort="Powderly, William" uniqKey="Powderly W" first="William" last="Powderly">William Powderly</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Horst, Charles" sort="Van Der Horst, Charles" uniqKey="Van Der Horst C" first="Charles" last="Van Der Horst">Charles Van Der Horst</name>
<affiliation><nlm:aff id="A6">University of North Carolina, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamili, Saleem" sort="Kamili, Saleem" uniqKey="Kamili S" first="Saleem" last="Kamili">Saleem Kamili</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study<sup><xref ref-type="fn" rid="FN2">☆</xref>
</sup>
</title>
<author><name sortKey="Chasela, Charles S" sort="Chasela, Charles S" uniqKey="Chasela C" first="Charles S." last="Chasela">Charles S. Chasela</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">University of Witwatersrand, School of Public Health, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wall, Patrick" sort="Wall, Patrick" uniqKey="Wall P" first="Patrick" last="Wall">Patrick Wall</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Drobeniuc, Jan" sort="Drobeniuc, Jan" uniqKey="Drobeniuc J" first="Jan" last="Drobeniuc">Jan Drobeniuc</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="King, Caroline C" sort="King, Caroline C" uniqKey="King C" first="Caroline C." last="King">Caroline C. King</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teshale, Eyasu" sort="Teshale, Eyasu" uniqKey="Teshale E" first="Eyasu" last="Teshale">Eyasu Teshale</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hosseinipour, Mina C" sort="Hosseinipour, Mina C" uniqKey="Hosseinipour M" first="Mina C." last="Hosseinipour">Mina C. Hosseinipour</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ellington, Sascha R" sort="Ellington, Sascha R" uniqKey="Ellington S" first="Sascha R." last="Ellington">Sascha R. Ellington</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Codd, Mary" sort="Codd, Mary" uniqKey="Codd M" first="Mary" last="Codd">Mary Codd</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jamieson, Denise J" sort="Jamieson, Denise J" uniqKey="Jamieson D" first="Denise J." last="Jamieson">Denise J. Jamieson</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Knight, Rodney J" sort="Knight, Rodney J" uniqKey="Knight R" first="Rodney J." last="Knight">Rodney J. Knight</name>
<affiliation><nlm:aff id="A5">Principia International, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, Patricia" sort="Fitzpatrick, Patricia" uniqKey="Fitzpatrick P" first="Patricia" last="Fitzpatrick">Patricia Fitzpatrick</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kourtis, Athena P" sort="Kourtis, Athena P" uniqKey="Kourtis A" first="Athena P." last="Kourtis">Athena P. Kourtis</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hoffman, Irving F" sort="Hoffman, Irving F" uniqKey="Hoffman I" first="Irving F." last="Hoffman">Irving F. Hoffman</name>
<affiliation><nlm:aff id="A6">University of North Carolina, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kayira, Dumbani" sort="Kayira, Dumbani" uniqKey="Kayira D" first="Dumbani" last="Kayira">Dumbani Kayira</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mumba, Noel" sort="Mumba, Noel" uniqKey="Mumba N" first="Noel" last="Mumba">Noel Mumba</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamwendo, Deborah D" sort="Kamwendo, Deborah D" uniqKey="Kamwendo D" first="Deborah D." last="Kamwendo">Deborah D. Kamwendo</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinson, Francis" sort="Martinson, Francis" uniqKey="Martinson F" first="Francis" last="Martinson">Francis Martinson</name>
<affiliation><nlm:aff id="A1">UNC Project, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Powderly, William" sort="Powderly, William" uniqKey="Powderly W" first="William" last="Powderly">William Powderly</name>
<affiliation><nlm:aff id="A2">University College Dublin, Belfield, Dublin, Ireland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Der Horst, Charles" sort="Van Der Horst, Charles" uniqKey="Van Der Horst C" first="Charles" last="Van Der Horst">Charles Van Der Horst</name>
<affiliation><nlm:aff id="A6">University of North Carolina, Chapel Hill, NC, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamili, Saleem" sort="Kamili, Saleem" uniqKey="Kamili S" first="Saleem" last="Kamili">Saleem Kamili</name>
<affiliation><nlm:aff id="A4">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title>
<idno type="ISSN">1386-6532</idno>
<idno type="eISSN">1873-5967</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely.</p>
</sec>
<sec id="S2"><title>Objectives</title>
<p id="P2">To assess the prevalence of HCV infection among HIV-infected, pregnant women screened for a large clinical trial in Lilongwe, Malawi.</p>
</sec>
<sec id="S3"><title>Study design</title>
<p id="P3">Plasma from 2041 HIV-infected, pregnant women was screened for anti-HCV IgG using a chemiluminiscent immunometric assay (CIA). Specimens with a signal-cut-off ratio ≥ 1.00 were considered reactive and those with S/Co ratio < 1.00 non-reactive. All CIA-reactive specimens were tested by a recombinant immunoblot assay (RIBA) for anti-HCV and by PCR for HCV RNA.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Of 2041 specimens, 110 (5.3%, 95% CI: 4.5–6.5%) were CIA reactive. Of the 109 CIA reactive specimens available for RIBA testing, 2 (1.8%) were positive, 28 (25.7%) were indeterminate, and 79 (72.5%) were negative. All CIA-reactive specimens were HCV RNA negative (<italic>n</italic>
 = 110). The estimated HCV prevalence based on the screening assay alone was 5.3%; based on supplemental RIBA testing, the status of HCV infection remained indeterminate in 1.4% (28/2040, 95% CI: 0.1–2.0) and the prevalence of confirmed HCV infections was 0.1% (2/2040, 95% CI: 0–0.4%).</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">HCV seroprevalence among HIV-infected, pregnant women in Malawi confirmed by supplemental RIBA HCV 3.0 is low (0.1%); CIA showed a high false-reactivity rate in this population.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9815671</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21121</journal-id>
<journal-id journal-id-type="nlm-ta">J Clin Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Virol.</journal-id>
<journal-title-group><journal-title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1386-6532</issn>
<issn pub-type="epub">1873-5967</issn>
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<article-id pub-id-type="pmc">3652577</article-id>
<article-id pub-id-type="doi">10.1016/j.jcv.2012.05.003</article-id>
<article-id pub-id-type="manuscript">NIHMS465385</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study<sup><xref ref-type="fn" rid="FN2">☆</xref>
</sup>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chasela</surname>
<given-names>Charles S.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wall</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Drobeniuc</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>King</surname>
<given-names>Caroline C.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teshale</surname>
<given-names>Eyasu</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hosseinipour</surname>
<given-names>Mina C.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ellington</surname>
<given-names>Sascha R.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Codd</surname>
<given-names>Mary</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jamieson</surname>
<given-names>Denise J.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Knight</surname>
<given-names>Rodney J.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fitzpatrick</surname>
<given-names>Patricia</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kourtis</surname>
<given-names>Athena P.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoffman</surname>
<given-names>Irving F.</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kayira</surname>
<given-names>Dumbani</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mumba</surname>
<given-names>Noel</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamwendo</surname>
<given-names>Deborah D.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martinson</surname>
<given-names>Francis</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Powderly</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van der Horst</surname>
<given-names>Charles</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamili</surname>
<given-names>Saleem</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><collab>the BAN team</collab>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
UNC Project, Lilongwe, Malawi</aff>
<aff id="A2"><label>b</label>
University College Dublin, Belfield, Dublin, Ireland</aff>
<aff id="A3"><label>c</label>
University of Witwatersrand, School of Public Health, Johannesburg, South Africa</aff>
<aff id="A4"><label>d</label>
Centers for Disease Control and Prevention, Atlanta, GA, USA</aff>
<aff id="A5"><label>e</label>
Principia International, Chapel Hill, NC, USA</aff>
<aff id="A6"><label>f</label>
University of North Carolina, Chapel Hill, NC, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author at: Division of Viral Hepatitis, Centers for Disease Control &Prevention, Atlanta, GA, USA. Tel.: +1 4046394431; fax: +1 4046391563. <email>skamili@cdc.gov</email>
 (S. Kamili)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>1</day>
<month>5</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>02</day>
<month>6</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>54</volume>
<issue>4</issue>
<fpage>318</fpage>
<lpage>320</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely.</p>
</sec>
<sec id="S2"><title>Objectives</title>
<p id="P2">To assess the prevalence of HCV infection among HIV-infected, pregnant women screened for a large clinical trial in Lilongwe, Malawi.</p>
</sec>
<sec id="S3"><title>Study design</title>
<p id="P3">Plasma from 2041 HIV-infected, pregnant women was screened for anti-HCV IgG using a chemiluminiscent immunometric assay (CIA). Specimens with a signal-cut-off ratio ≥ 1.00 were considered reactive and those with S/Co ratio < 1.00 non-reactive. All CIA-reactive specimens were tested by a recombinant immunoblot assay (RIBA) for anti-HCV and by PCR for HCV RNA.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Of 2041 specimens, 110 (5.3%, 95% CI: 4.5–6.5%) were CIA reactive. Of the 109 CIA reactive specimens available for RIBA testing, 2 (1.8%) were positive, 28 (25.7%) were indeterminate, and 79 (72.5%) were negative. All CIA-reactive specimens were HCV RNA negative (<italic>n</italic>
 = 110). The estimated HCV prevalence based on the screening assay alone was 5.3%; based on supplemental RIBA testing, the status of HCV infection remained indeterminate in 1.4% (28/2040, 95% CI: 0.1–2.0) and the prevalence of confirmed HCV infections was 0.1% (2/2040, 95% CI: 0–0.4%).</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">HCV seroprevalence among HIV-infected, pregnant women in Malawi confirmed by supplemental RIBA HCV 3.0 is low (0.1%); CIA showed a high false-reactivity rate in this population.</p>
</sec>
</abstract>
<kwd-group><kwd>HIV</kwd>
<kwd>HCV</kwd>
<kwd>Pregnant women</kwd>
<kwd>Malawi</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>P30 AI050410 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study☆

Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study☆

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