Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial
Identifieur interne : 001F92 ( Pmc/Corpus ); précédent : 001F91; suivant : 001F93Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial
Auteurs : Leila E. MansoorSource :
- AIDS and behavior [ 1090-7165 ] ; 2014.
Abstract
High adherence is key to microbicide effectiveness. Here we provide a description of adherence interventions and the adherence rates achieved in the CAPRISA 004 Tenofovir Gel Trial. Adherence support for the before-and-after dosing strategy (BAT 24) was provided at enrolment and at each monthly study visit. This initially comprised individual counselling and was replaced midway by a structured theory-based adherence support program (ASP) based on motivational interviewing. The 889 women were followed for an average of 18 months and attended a total of 17031 monthly visits. On average women reported 5 sex acts and returned 5.9 empty applicators per month. The adherence rate based on applicator count in relation to all reported sex acts was 72.2% compared to the 82.0% self-reported adherence during the last sex act. Adherence support activities, which achieve levels of adherence similar to or better than those achieved by the CAPRISA 004 ASP, will be critical to the success of future microbicide trials.
Url:
DOI: 10.1007/s10461-014-0751-x
PubMed: 24643315
PubMed Central: 4017080
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9712133</journal-id><journal-id journal-id-type="pubmed-jr-id">21042</journal-id><journal-id journal-id-type="nlm-ta">AIDS Behav</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Behav</journal-id><journal-title-group><journal-title>AIDS and behavior</journal-title></journal-title-group><issn pub-type="ppub">1090-7165</issn><issn pub-type="epub">1573-3254</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24643315</article-id><article-id pub-id-type="pmc">4017080</article-id><article-id pub-id-type="doi">10.1007/s10461-014-0751-x</article-id><article-id pub-id-type="manuscript">NIHMS577134</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mansoor</surname><given-names>Leila E</given-names></name><aff id="A1">Centre for the AIDS Program of Research in South Africa 2<sup>nd</sup> Floor, Doris Duke Medical Research Institute Nelson R Mandela School of Medicine University of KwaZulu-Natal Private Bag X7 Congella, 4013 South Africa</aff></contrib></contrib-group><author-notes><corresp id="CR1"><bold>Corresponding author:</bold> Leila E Mansoor Centre for the AIDS Program of Research in South Africa 2<sup>nd</sup> Floor, Doris Duke Medical Research Institute Nelson R Mandela School of Medicine University of KwaZulu-Natal Private Bag X7 Congella, 4013 South Africa Tel: +2731 260 4641 Fax: +2731 260 4549 <email>mansoor@ukzn.ac.za</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2015</year></pub-date><volume>18</volume><issue>5</issue><fpage>811</fpage><lpage>819</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10461-014-0751-x</pmc-comment>
<abstract><p id="P1">High adherence is key to microbicide effectiveness. Here we provide a description of adherence interventions and the adherence rates achieved in the CAPRISA 004 Tenofovir Gel Trial. Adherence support for the before-and-after dosing strategy (BAT 24) was provided at enrolment and at each monthly study visit. This initially comprised individual counselling and was replaced midway by a structured theory-based adherence support program (ASP) based on motivational interviewing. The 889 women were followed for an average of 18 months and attended a total of 17031 monthly visits. On average women reported 5 sex acts and returned 5.9 empty applicators per month. The adherence rate based on applicator count in relation to all reported sex acts was 72.2% compared to the 82.0% self-reported adherence during the last sex act. Adherence support activities, which achieve levels of adherence similar to or better than those achieved by the CAPRISA 004 ASP, will be critical to the success of future microbicide trials.</p></abstract><kwd-group><kwd>adherence</kwd><kwd>adherence support</kwd><kwd>adherence measures</kwd><kwd>Microbicides</kwd><kwd>clinical trial</kwd><kwd>HIV prevention</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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