Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial
Identifieur interne : 001F90 ( Pmc/Corpus ); précédent : 001F89; suivant : 001F91Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial
Auteurs : Kathryn Therese Mngadi ; Silvia Maarschalk ; Anneke C. Grobler ; Leila E. Mansoor ; Janet A. Frohlich ; Bernadette Madlala ; Nelisiwe Ngcobo ; Salim S. Abdool Karim ; Quarraisha Abdool KarimSource :
- AIDS and behavior [ 1090-7165 ] ; 2014.
Abstract
Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %,
Url:
DOI: 10.1007/s10461-014-0696-0
PubMed: 24633715
PubMed Central: 4024486
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial</title><author><name sortKey="Mngadi, Kathryn Therese" sort="Mngadi, Kathryn Therese" uniqKey="Mngadi K" first="Kathryn Therese" last="Mngadi">Kathryn Therese Mngadi</name></author><author><name sortKey="Maarschalk, Silvia" sort="Maarschalk, Silvia" uniqKey="Maarschalk S" first="Silvia" last="Maarschalk">Silvia Maarschalk</name></author><author><name sortKey="Grobler, Anneke C" sort="Grobler, Anneke C" uniqKey="Grobler A" first="Anneke C." last="Grobler">Anneke C. Grobler</name></author><author><name sortKey="Mansoor, Leila E" sort="Mansoor, Leila E" uniqKey="Mansoor L" first="Leila E." last="Mansoor">Leila E. Mansoor</name></author><author><name sortKey="Frohlich, Janet A" sort="Frohlich, Janet A" uniqKey="Frohlich J" first="Janet A." last="Frohlich">Janet A. Frohlich</name></author><author><name sortKey="Madlala, Bernadette" sort="Madlala, Bernadette" uniqKey="Madlala B" first="Bernadette" last="Madlala">Bernadette Madlala</name></author><author><name sortKey="Ngcobo, Nelisiwe" sort="Ngcobo, Nelisiwe" uniqKey="Ngcobo N" first="Nelisiwe" last="Ngcobo">Nelisiwe Ngcobo</name></author><author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S." last="Abdool Karim">Salim S. Abdool Karim</name></author><author><name sortKey="Karim, Quarraisha Abdool" sort="Karim, Quarraisha Abdool" uniqKey="Karim Q" first="Quarraisha Abdool" last="Karim">Quarraisha Abdool Karim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24633715</idno><idno type="pmc">4024486</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024486</idno><idno type="RBID">PMC:4024486</idno><idno type="doi">10.1007/s10461-014-0696-0</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001F90</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F90</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial</title><author><name sortKey="Mngadi, Kathryn Therese" sort="Mngadi, Kathryn Therese" uniqKey="Mngadi K" first="Kathryn Therese" last="Mngadi">Kathryn Therese Mngadi</name></author><author><name sortKey="Maarschalk, Silvia" sort="Maarschalk, Silvia" uniqKey="Maarschalk S" first="Silvia" last="Maarschalk">Silvia Maarschalk</name></author><author><name sortKey="Grobler, Anneke C" sort="Grobler, Anneke C" uniqKey="Grobler A" first="Anneke C." last="Grobler">Anneke C. Grobler</name></author><author><name sortKey="Mansoor, Leila E" sort="Mansoor, Leila E" uniqKey="Mansoor L" first="Leila E." last="Mansoor">Leila E. Mansoor</name></author><author><name sortKey="Frohlich, Janet A" sort="Frohlich, Janet A" uniqKey="Frohlich J" first="Janet A." last="Frohlich">Janet A. Frohlich</name></author><author><name sortKey="Madlala, Bernadette" sort="Madlala, Bernadette" uniqKey="Madlala B" first="Bernadette" last="Madlala">Bernadette Madlala</name></author><author><name sortKey="Ngcobo, Nelisiwe" sort="Ngcobo, Nelisiwe" uniqKey="Ngcobo N" first="Nelisiwe" last="Ngcobo">Nelisiwe Ngcobo</name></author><author><name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S." last="Abdool Karim">Salim S. Abdool Karim</name></author><author><name sortKey="Karim, Quarraisha Abdool" sort="Karim, Quarraisha Abdool" uniqKey="Karim Q" first="Quarraisha Abdool" last="Karim">Quarraisha Abdool Karim</name></author></analytic><series><title level="j">AIDS and behavior</title><idno type="ISSN">1090-7165</idno><idno type="eISSN">1573-3254</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, <italic>p</italic> = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction. Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; <italic>p</italic> = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; <italic>p<</italic> 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9712133</journal-id><journal-id journal-id-type="pubmed-jr-id">21042</journal-id><journal-id journal-id-type="nlm-ta">AIDS Behav</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Behav</journal-id><journal-title-group><journal-title>AIDS and behavior</journal-title></journal-title-group><issn pub-type="ppub">1090-7165</issn><issn pub-type="epub">1573-3254</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24633715</article-id><article-id pub-id-type="pmc">4024486</article-id><article-id pub-id-type="doi">10.1007/s10461-014-0696-0</article-id><article-id pub-id-type="manuscript">NIHMS579205</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Mngadi</surname><given-names>Kathryn Therese</given-names></name><aff id="A1">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff><email>mngadik@ukzn.ac.za</email></contrib><contrib contrib-type="author"><name><surname>Maarschalk</surname><given-names>Silvia</given-names></name><aff id="A2">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Grobler</surname><given-names>Anneke C.</given-names></name><aff id="A3">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Mansoor</surname><given-names>Leila E.</given-names></name><aff id="A4">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Frohlich</surname><given-names>Janet A.</given-names></name><aff id="A5">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Madlala</surname><given-names>Bernadette</given-names></name><aff id="A6">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Ngcobo</surname><given-names>Nelisiwe</given-names></name><aff id="A7">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa</aff></contrib><contrib contrib-type="author"><name><surname>Abdool Karim</surname><given-names>Salim S.</given-names></name><aff id="A8">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA</aff></contrib><contrib contrib-type="author"><name><surname>Karim</surname><given-names>Quarraisha Abdool</given-names></name><aff id="A9">Centre for the AIDS Program of Research in South Africa, Doris, Duke Medical Research Institute, University of KwaZulu-Natal, Nelson R Mandela School of Medicine, 2nd Floor, Private Bag X7, Congella 4013, South Africa. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>3</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2015</year></pub-date><volume>18</volume><issue>5</issue><fpage>849</fpage><lpage>854</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10461-014-0696-0</pmc-comment>
<abstract><p id="P1">Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, <italic>p</italic> = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction. Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; <italic>p</italic> = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; <italic>p<</italic> 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence.</p></abstract><kwd-group><kwd>Adherence</kwd><kwd>Partner disclosure</kwd><kwd>HIV prevention</kwd><kwd>Microbicides</kwd><kwd>Pre-exposure prophylaxis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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